ライフサイエンスコーパス: chelation

1 on in JNCL cells could be reversed by Ca(2+) chelation.

2 kinase kinase (MEK) activity through copper chelation.

3 ron-rich media, failed to prosper under iron chelation.

4 erent approaches: click labeling and surface chelation.

5 eatments that may incorporate selective iron chelation.

6 reduction in cardiovascular events with EDTA chelation.

7 genous zinc application and enhanced by zinc chelation.

8 Ca(2+) channels prevented the effect of zinc chelation.

9 ransferrin- and/or lactoferrin-mediated iron chelation.

10 ine kinase or p38 MAPK inhibition or calcium chelation.

11 F during apoptosis and was blocked by Ca(2+) chelation.

12 eloped parkinsonism that was rescued by iron chelation.

13 peripheralization was blocked by calcium ion chelation.

14 ncreased resistance to disruption by calcium chelation.

15 potassium, but not by intracellular calcium chelation.

16 f short half-life, drug resistance, and iron chelation.

17 y either antioxidant supplementation or Ca2+ chelation.

18 hly transfusions plus daily deferasirox iron chelation.

19 increase in the average lifetime upon Ca(2+) chelation.

20 ent cells are particularly sensitive to iron chelation.

21 se (IN) and influenza endonuclease via metal chelation.

22 n conformational rearrangements enable Ca(2+)chelation.

23 n microscopy, which depolymerized after zinc chelation.

24 ntrol of a kinetic anomeric effect and metal chelation.

25 can be significantly improved without copper chelation.

26 Intracellular Ca(2+) chelation (1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetra

27 o, 8%; HR, 0.77 [95% CI, 0.54-1.11]; stroke: chelation, 1.2%; placebo, 1.5%; HR, 0.77 [95% CI, 0.34-1

28 CI, 0.64-1.02]; hospitalization for angina: chelation, 1.6%; placebo, 2.1%; HR, 0.72 [95% CI, 0.35-1

29 All-cause mortality was reduced by EDTA chelation (10% versus 16%; hazard ratio, 0.57; 95% CI, 0

30 CI, 0.34-1.76]; coronary revascularization: chelation, 15%; placebo, 18%; HR, 0.81 [95% CI, 0.64-1.0

31 similar magnitude as its overall effect (MI: chelation, 6%; placebo, 8%; HR, 0.77 [95% CI, 0.54-1.11]

32 There was no effect on total mortality (chelation: 87 deaths [10%]; placebo, 93 deaths [11%]; HR

33 ane was Ca(2+) dependent, as BAPTA-AM Ca(2+) chelation abrogated the response.

34 ound carbonyl groups, thiol groups and metal chelation activities in addition to phenolic, total flav

35 evaluated the effects of molecules with iron chelation activity on neuroblastoma (NB) cell lines.

36 pacity (TEAC), reducing power (RP) and metal chelation activity were used for all fractions.

37 ocytes was inhibited by intracellular Ca(2+) chelation, aggravated by thapsigargin, and unaffected by

38 Although intracellular calcium chelation almost completely blocked the induction of man

39 Calcium chelation also abrogated the gossypol-induced increase i

40 Mitochondrial iron chelation also alleviated CS-induced impairment of MCC,

41 Intracellular calcium chelation also inhibited EGF-induced activation of signa

42 gly on geometric factors such as sterics and chelation, although also on the hard/soft match with the

43 acrocycle, although the pathway must involve chelation, amidation, macrocyclic ring reduction, lactam

44 tical for the sulfone-metal exchange because chelation anchors the organometallic proximal to the ele

45 orating structural components for both metal chelation and Abeta interaction.

46 ow that this site is essential for magnesium chelation and allosterically regulates Mg(2+) and MgATP(

47 Metal chelation and aromatic diacylation resulted in the most

48 e C13-C15 diene, the identification of alpha-chelation and dipole minimization models for diastereose

49 iation-based therapies; nutritional therapy; chelation and heavy metal therapy; and biological and ph

50 ity and selectivity can be increased through chelation and here we theoretically explore the possibil

51 l balanced in the 451 patients randomized to chelation and in the 460 patients randomized to placebo.

52 ble mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catech

53 Chelation and luminescence sensitization of Tb(3+) allow

54 in the same predictable manner controlled by chelation and negative hyperconjugation.

55 In dichloromethane, reversible chelation and partial displacement of the P,N coordinati

56 The main step involved chelation and substrate-controlled diastereoselective re

57 tified Cys466 as a key residue for metal ion chelation and to be the core of an oligomerization motif

58 ry, we present a non-toxic strategy for iron chelation and urinary elimination, based on manipulating

59 Structural data, confirming aldehyde chelation, and a proposed mechanism are provided.

60 ne modifications, including oxidation, metal chelation, and inhibitor binding, within a physiological

61 tin, protein kinase C delta inhibitors, iron chelation, and intra-aortic balloon counterpulsation, pe

62 ost required regular blood transfusion, iron chelation, and intravenous immunoglobulin replacement.

63 um, statins, antidiabetic agents, FX06, iron chelation, and ranolazine).

64 voltage-gated channels, is blocked by BAPTA chelation, and recruits intracellular calcium release on

65 mise of an individually tailored approach to chelation, and subsequent reduction in morbidity and mor

66 The surface chelation approach proved to be superior in terms of rad

67 owed similar sensitivity to presynaptic Ca2+ chelation as evoked release, arguing for direct triggeri

68 Calcium chelation, as well as the blockade of the mitochondrial

69 ir effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Abet

70 N cross-coupling has been developed based on chelation-assisted amidation of readily available aryl b

71 This material is a rare example of chelation-assisted C-H functionalization performed by a

72 ith aryl isocyanates has been achieved via a chelation-assisted cationic ruthenium(II) complex cataly

73 tion mediated by enzymes (PRIME) followed by chelation-assisted copper-catalyzed azide-alkyne cycload

74 erivatized with an alkyne-probe conjugate by chelation-assisted CuAAC in the second step.

75 tation, we report here a palladium-catalyzed chelation-assisted ortho C-H bond olefination of phenyla

76 nitration of aromatic C(sp(2))-H bonds using chelation-assisted removable vicinal diamine directing g

77 9-methylamino-phenalen-1-one (4a), promoted chelation-assisted single electron transfer (SET) proces

78 neugenic activity, and 6) ethanol or calcium chelation attenuates lipoprotein-induced chromosome mis-

79 anism comprising the bidentate ligand-aided, chelation-based C-H functionalization was proposed for t

80 sed mechanism, and graminaceous plants use a chelation-based mechanism.

81 f cyclic esters that is enabled by transient chelation between a directing group and the lanthanide c

82 The frequency and magnitude of chelation between COO(-) pendant groups of PAA and In(3+

83 f colloidal nanoparticles involving strongly chelation between mercury ion and thiol(s) proved by con

84 are the driving force for the difference in chelation between the two adsorbates.

85 the fluoride adduct confirms fluoride anion chelation between the two antimony centers.

86 are facilitated by Et(2)AlCl, presumably via chelation between the two carbonyl groups of the N-formy

87 odulin-kinase II expression, whereas calcium chelation blunted leptin-mediated increases in CYP11B2,

88 Iron chelation by excess Ent or Ybt significantly increased L

89 We show that iron chelation by FQ leads to epigenetic effects through inhi

90 bility of A. fumigatus to zinc and manganese chelation by neutrophil-derived calprotectin.

91 e in control C3H mice, and in response to Cu chelation by penicillamine (PCA) and dietary supplementa

92 y for fluorescence emission on magnesium ion chelation by phosphorylated peptides carrying an artific

93 the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dN

94 The findings indicate that strong zinc chelation can promote gastric stability and impede intes

95 razilian and Uruguayan herbs had an 80% iron chelation capacity (p<0.001), while the iron chelation c

96 Finally, the correlation between the chelation capacity and ionophore activity is demonstrate

97 ffinity constant determined in SPR and metal chelation capacity determined from UV-visible spectropho

98 chelation capacity (p<0.001), while the iron chelation capacity of the Argentinean herb was lower but

99 O) radical-scavenging activities, ferric ion-chelation capacity, ferric- (FRAP), and phosphomolybdenu

100 tic compounds may also impart significant Pu chelation character to the colloid.

101 lity of transferrin to chelate iron, as iron chelation combined with sodium bicarbonate completely pr

102 site within a Cu(2+)*GTPgammaS or Cu(2+)*GTP chelation complex, and that Cu(2+)*nucleobase interactio

103 droxyl groups forming five- and six-membered chelation complexes with the iodine atom.

104 The chelation-controlled arylation reaction of chiral, enant

105 lyzed alcohol CH syn crotylation followed by chelation-controlled carbonyl dienylation.

106 The key step is a regioselective chelation-controlled lithiation of the (Z)-configured br

107 ctive reactions, including an intramolecular chelation-controlled Michael spirocyclization of an N-Cb

108 The key transformations rely on chelation-controlled organometallic additions and a Peta

109 The process couples a chelation-controlled reduction of the hydrazone with an

110 eaction, as only the E-isomers could undergo chelation-controlled reduction.

111 n the initial stereocenter by means of a 1,3-chelation-controlled Reetz-Keck-type allylation.

112 Intracellular Ca(2+) chelation decreased VDCC mobility.

113 Twenty children aged </= 5 y who commenced chelation died during the period studied, with lead pois

114 Taking advantage of phosphine chelation, direct evidence for oxidative addition of Csp

115 s: primary extraction using a divalent metal chelation disk followed by anion-exchange chromatography

116 Moreover, we show that iron chelation disrupts mitochondrial homeostasis and trigger

117 lective fluorescent sensors that operate via chelation enhanced fluorescence (CHEF).

118 nse brightness and fluorescence enhancement (chelation-enhanced fluorescence = 85 for 3 and 92 for 4)

119 nd continuous PLD assay that is based on the chelation-enhanced fluorescence property of 8-hydroxyqui

120 gh an intermolecular H-bonding induced CHEF (chelation-enhanced fluorescence) process, established by

121 Iron chelation experiments demonstrate a relocation of the cl

122 rom dentate fast-spiking interneurones, zinc chelation facilitated T-type Ca(2+) currents, increased

123 although some patients may require intensive chelation for a limited duration.

124 have been proposed; one involves direct iron chelation from beta(2), whereas a second involves Y. des

125 Pre-chelation geometric mean blood lead levels for children

126 imary end point occurred in 222 (26%) of the chelation group and 261 (30%) of the placebo group (haza

127 nt discontinued infusions (n=38 [16%] in the chelation group and n=41 [15%] in the placebo group) bec

128 The primary use of chelation has been transfusional iron overload.

129 inding sites of a multivalent receptor (i.e. chelation) has been proven to have a strong impact.

130 , IC50 of 12.5 vs 30 muM for ADP, and Fe(II)-chelation, IC50 of 80 vs >200 muM for ADP (ferrozine ass

131 of PrOF NMR for efficiently analyzing metal chelation, identifying new binding modes, and studying p

132 sphazene bases and Alder's concept of proton chelation in a constrained geometry regime of basic cent

133 ng body of evidence for the benefits of iron chelation in myelodysplasia, pre-stem cell transplantati

134 l trials into the potential benefits of iron chelation in PD.

135 cle H2 macropa was investigated for (225) Ac chelation in targeted alpha therapy (TAT).

136 allenges of cancer, in nitrogen fixation and chelation, in the production of antibiotics, and in coll

137 Al(3+) chelation increased absorbance 2-42x and lambdamax great

138 DPPH scavenging and metal ion chelation increased significantly (p<0.05) from 29-40% t

139 udy of the safety and efficacy of EDTA-based chelation infusions in 1708 post-myocardial infarction (

140 M) or intra-endosomal (Rhod-dextran) calcium chelation inhibited SV generation from bulk endosomes, i

141 -1,9'-xanthen]-3(2H)-one (DEMAX) for Al(III) chelation is described herein.

142 stereochemical outcome of the reaction, and chelation is favored over the natural tendency of this t

143 r data suggest that a pH increase and Ca(2+) chelation lead primarily to a loosening of contacts with

144 Depletion of endogenous Hp and Cp via copper chelation leads to the reduction of hBMVEC Fpn protein l

145 stabilization of allenylzinc derivatives by chelation, made possible by the selection of appropriate

146 Removal of soluble metals by chelation markedly diminished the pulmonary PM-mediated

147 Recent research suggests that EDTA chelation may be a well-tolerated and effective treatmen

148 ased its effectiveness, suggesting that iron chelation may play some role in its antimycobacterial ef

149 A chelation mechanism was initially proposed to explain th

150 pported adsorption steps including a citrate chelation method developed to remove >99.9% of the bariu

151 d (64)Cu labeling was obtained by a standard chelation method.

152 mmatory activity of UC and 14 controls using chelation method.

153 The thioenolate is found to bind via di-zinc chelation, mimicking the binding of intermediates in bet

154 dy-based agents, we designed a multimodality chelation (MMC) scaffold which combined a radiometal che

155 dual-labeling approach with a multimodality chelation (MMC) scaffold would minimize steric effects o

156 yridone analogues designed using a two-metal chelation model of the integrase catalytic active site.

157 ive C-H activation was conducted without any chelation moieties.

158 al Ca(2+) increases, whereas luminal calcium chelation (N-(2-hydroxyetheyl)-ethylendiamin-N,N,N'-tria

159 ing of NOTA to a unique cysteine residue and chelation of (18)F-AlF.

160 ctrum centered at 530 nm attributed to metal chelation of 2-OG bound to JBP, a spectroscopic signatur

161 of the metallocavitand involved the initial chelation of a Ru(III) chloride complex by the tpy ligan

162 tants in subunits a and c is inhibited after chelation of Ag(+) and/or Cd(+2) with the substituted su

163 Early chelation of blood-derived iron and antioxidant treatmen

164 the amnioserosa during closure, whereas the chelation of Ca(2+) slows closure.

165 f the enzyme pectin methyl-esterase, and the chelation of calcium by pectic acids.

166 Chelation of calcium ions by 1,2-bis(2-aminophenoxy)etha

167 is further stabilized by disulfide bonds and chelation of calcium ions.

168 by its cuprous oxidase activity but also by chelation of copper ions before they can enter the cytop

169 acterised as being the most effective in the chelation of copper ions.

170 Histamine chelation of copper(I) by a terminal histidine residue i

171 o-surface attachment was blocked by specific chelation of copper.

172 uptake in the fine lateral root tips and (b) chelation of Cr(III) to the cell wall both of which redu

173 Furthermore, chelation of cytoplasmic Ca(2+), but not inhibition of p

174 Instead, pharmacological depletion or chelation of Endoplasmic Reticulum (ER) Ca(2+) prevented

175 ola spatulata mechanotoxin 4 (GsMTx-4) or by chelation of extracellular Ca(2+) Thrombus formation was

176 l adhesion, as reducing cadherin binding via chelation of extracellular calcium inhibits chondrocyte

177 Substitution of extracellular Na(+) or chelation of intracellular Ca(2+) abolished both sADP an

178 el inhibitor l-cis-diltiazem, as well as the chelation of intracellular Ca(2+) with BAPTA, or the abs

179 , PS exposure in platelets was suppressed by chelation of intracellular Ca(2+), whereas caspase inhib

180 Removal of extracellular calcium, or chelation of intracellular calcium did not normalize the

181 lockade of voltage-gated calcium channels or chelation of intracellular calcium, but were blocked by

182 the compounds, CPX, were indeed dependent on chelation of intracellular iron and mediated by both G0/

183 Moreover, chelation of intracellular zinc alone was sufficient to

184 ETs in neutrophils, thus indicating that the chelation of iron may largely explain their inhibitory e

185 ne that induces apoptosis in cancer cells by chelation of labile inhibitory zinc from procaspase-3.

186 procaspases to their active cleaved forms by chelation of labile zinc ions.

187 th the sieving mechanism of the membrane and chelation of lead with AG macromolecules incorporated in

188 he accumulation of Cd in grains, such as the chelation of light Cd isotopes by thiol-containing pepti

189 The effects of chelation of metal ions (Mg(2+), Al(3+), Cr(3+), Fe(3+),

190 ature hydroxamate moieties to facilitate the chelation of metal ions in the catalytic center of targe

191 lavour stability: use of antioxidant crowns, chelation of pro-oxidants, and varying plant content in

192 Whereas in situ chelation of PyED leads to considerable degradation in t

193 is216 were identified as essential for metal-chelation of sirohydrochlorin.

194 s has been synthesized and evaluated for the chelation of Th(4+).

195 uction of N2 under mild conditions, and then chelation of the alkali metal cation uncovers a highly r

196 0 consists of a monomer in which C,N and N,O chelation of the lithium cations generates a system cont

197 to be increased, probably due to compromised chelation of the metals in the stratum corneum of patien

198 DPPH and hydroxyl radicals, as well as metal chelation of the soluble fraction from PS, were higher t

199 rsus hydroxamate inhibitors reveals that the chelation of the zinc ion is slightly different, leading

200 s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive stra

201 A reduction of oxidative stress by chelation of toxic metals has been proposed as a possibl

202 avenging of reactive oxygen species, and (3) chelation of traces of transition metal ions, which is s

203 -reducing antioxidant power (FRAP) and metal chelation of VH were comparable to those of NH.

204 In granule cells, chelation of zinc reduced the time window for the integr

205 g of the chip to yield a 3-D support for the chelation of Zn(2+) ions (ZnCl2) and the subsequent immo

206 Chelation of Zn(2+) with N,N,N',N'-tetra-2-picolylethyle

207 Chelation of Zn(2+) with the membrane-permeable chelator

208 nd Pb(II) by 1f, as determined by FT-IR, and chelation of Zn(II), but not Ca(II), by 1b, as determine

209 The effect of EDTA chelation on the components of the primary end point oth

210 was achieved by reducing inflammation by Cu chelation or by providing methyl groups.

211 Ca(2+) chelation or calpain inhibition prevented SA processing

212 ificantly inhibited by intracellular Ca(2+)i chelation or CaM inhibition.

213 ption of these labile copper stores by acute chelation or genetic knockdown of the CTR1 (copper trans

214 Zn(2+) chelation or loading in cells to alter Zn(2+) availabili

215 Patients received 40 infusions of EDTA chelation or placebo.

216 rments in neurite outgrowth caused by Zn(2+) chelation or ZIP12 knockdown.

217 Accordingly, iron chelation, or overexpression of a truncated AFT1 allele

218 ression, was blocked by postsynaptic calcium chelation, our findings suggest that endogenous NT may a

219 eatment-related difference (mean difference [chelation.placebo] during follow-up, 0.9 [95% confidence

220 mmune response to Ent and Lcn2 requires iron chelation rather than the Ent+Lcn2 complex itself and al

221 lements for Abeta aggregation control, metal chelation, reactive oxygen species (ROS) regulation, and

222 abilization (LMP) that relied on copper (Cu) chelation, reactive oxygen species generation, and incre

223 However, iron chelation reduced the oxidation rate.

224 Chelation reduced the primary composite end point of mor

225 tes and may provide an adjuvant treatment to chelation, reducing myocardial iron uptake.

226 with a history of MI, use of an intravenous chelation regimen with disodium EDTA, compared with plac

227 /day or placebo in addition to their current chelation regimen.

228 an iron overload (for which the role of iron chelation remains debated).

229 Aspergillus fumigatus and found that calcium chelation severely impedes hyphal growth indicating a cr

230 Chelation should be considered in patients with iron ove

231 the calcium signal by intracellular calcium chelation significantly reduced epidermal growth factor

232 cation (VO(+2)) through 4-carbonyl-5-hydroxy chelation site in the two luteolin molecule.

233 rference, and identifies potential magnesium chelation sites while characterizing their coordinated r

234 Both modes of Ca(2+) chelation slow gastric repair.

235 ndomized to receive 40 infusions of a 500-mL chelation solution (3 g of disodium EDTA, 7 g of ascorba

236 010) to 40 infusions ofa multicomponent EDTA chelation solution or placebo.

237 nction as we observed only modest effects of chelation strategies on the growth of these cells in vit

238 evaluated whether addition of amlodipine to chelation strategies would reduce myocardial iron overlo

239 referred to as "nutritional immunity." This chelation strategy ultimately starves invading pathogens

240 In addition, the zinc chelation strength of the polyphenols was also tested in

241 nvolves various mechanisms, among them metal chelation, studied by UV-visible spectrophotometry.

242 le size regulation were eliminated by Ca(2+) chelation, suggesting a requirement for TRPML1-mediated

243 C inhibition but not by intracellular Ca(2+) chelation, suggesting Ca(2+) independent activation of n

244 eta)-activated kinase 1 (TAK1) or by calcium chelation, suggesting potential linkage to the mitogen-a

245 ch for individuals under chronic transfusion/chelation support therapy is allogeneic stem cell transp

246 ted from the rabbit intestine using the Ca++ chelation technique.

247 to be a highly promising ligand for (225) Ac chelation that will facilitate the clinical development

248 After Pb(2+) chelation, the conjugation system of the PDA was perturb

249 overload correlated with lower compliance to chelation therapy (P<0.013).

250 Institutes of Health.funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stablecoronary

251 The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an E

252 y reduced cardiac iron more effectively than chelation therapy alone.

253 aken together, these results suggest that Cu-chelation therapy could be repurposed to treat cancers c

254 The trial to assess chelation therapy demonstrated a significant (P=0.035) 1

255 with a history of myocardial infarction,EDTA chelation therapy did not have a detectable effect on QO

256 ient evidence to indicate the routine use of chelation therapy for all post-myocardial infarction pat

257 not sufficient to support the routine use of chelation therapy for treatment of patients who have had

258 Recent developments in gene and chelation therapy give hope of better prognosis for pati

259 EDTA chelation therapy has been in off-label use for the trea

260 Mitochondrial iron chelation therapy improved colitis and demonstrated an e

261 After institution of iron chelation therapy in 2010, no child with thalassemia maj

262 etrospective analysis demonstrates that iron chelation therapy is associated with prolonged survival

263 cardiac siderosis, amlodipine combined with chelation therapy reduced cardiac iron more effectively

264 eposits was associated with lower anti-tumor chelation therapy response.

265 The trial to assess chelation therapy was a $30 million National Institutes

266 derate strength recommendation to begin iron chelation therapy when indicated.

267 Chelation therapy with disodium EDTA has been used for m

268 ly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data s

269 ent primarily relies on transfusion and iron-chelation therapy, as well as splenectomy in specific ca

270 es an update on advances in the area of iron chelation therapy, including new indications and uses of

271 measures included environmental remediation, chelation therapy, public health education, and control

272 to 2012 after universal availability of iron chelation therapy.

273 t side effects associated with systemic EDTA chelation therapy.

274 last decade has ushered in a new era in iron chelation therapy.

275 = 45 microg/dL, the threshold for initiating chelation therapy.

276 Eight patients had siderosis and underwent chelation therapy.

277 WiTCH) trial compared standard (transfusions/chelation) to alternative (hydroxyurea/phlebotomy) treat

278 l comparing standard treatment (transfusions/chelation) to alternative treatment (hydroxyurea/phlebot

279 7,000 lead poisoned villagers, to facilitate chelation treatment of children </= 5 years old, and to

280 y as feasible without sedation to tailor the chelation treatment.

281 who underwent between one and 15 courses of chelation treatment.

282 trations by 89%, and 2,349 children received chelation treatment.

283 Fe3O4@Al2O3 MNPs through aluminum phosphate chelation under microwave heating within 1.5 min.

284 We examine the history of chelation up through the report of TACT.

285 es the intention-to-treat comparison of EDTA chelation vs placebo.

286 The antiproliferative effect of copper chelation was enhanced when combined with inhibitors of

287 expression, function, and mitochondrial iron chelation were assessed in a colitis-associated colon ca

288 idation-induced degradable nanogels for iron chelation were rationally designed by simultaneously pol

289 tion of each chain align, facilitating metal chelation when the residues are good ligands such as his

290 Current therapy is based on copper chelation, which decreases the manifestations of liver d

291 osely bound copper that can be attenuated by chelation, which define a labile copper pool.

292 ion to be efficient, probably because of its chelation with cesium ion.

293 While early, presymptomatic detection and chelation with conventional copper-binding molecules ena

294 Chelation with disodium calcium edetate lowers blood man

295 ced PI(4,5)P2 hydrolysis, followed by Ca(2+) chelation with excess EGTA.

296 f arsenite species [As(III)] was achieved by chelation with sodium diethyldithiocarbamate (DDTC) foll

297 rize the mechanisms by which Ag(+) or Cd(2+) chelation with the Cys thiolates caused inhibition.

298 by having a hydroxamate group essential for chelation with the zinc ion in the active site of HDAC a

299 Chelation with three representative styrenes has been de

300 Similarly, INDF was blocked by Ca(2+) chelation without a block in ICAD cleavage or caspase-3