ライフサイエンスコーパス: chemical

1 feedstock for the synthesis of other valued chemicals.

2 due to their use of hazardous and explosive chemicals.

3 ramework for identifying endocrine bioactive chemicals.

4 the production of value added and speciality chemicals.

5 n models that explain the mass distribution, chemical abundances and planetary configuration of the S

6 ited to hydrocarbons and a fraction of known chemical additives.

7 mechanisms have been proposed: movement of a chemical agent and a pressure wave through the vasculatu

8 P expression sensitizes cells to a number of chemical agents, and mutations at predicted channel-faci

9 mammalian cells, we synthesized a series of chemical analogs that reduce host cell toxicity while ma

10 Chemical analysis of AMZ and bacteria showed that Al, P,

11 Chemical analysis showed chia is a source of protein (19

12 "pseudolaratriene." Combined NMR and quantum chemical analysis verified the structure of pseudolaratr

13 ave played an increasingly important role in chemical and biochemical analysis.

14 ricultural livestock operations contain both chemical and biological constituents that represent a po

15 lasmonic nanoparticle systems having similar chemical and colloidal properties.

16 or communication and they come in two types, chemical and electrical.

17 pdates the recent advances in the isolation, chemical and granular structures, physicochemical proper

18 Therefore, an in situ observation of chemical and mechanical characteristics during the photo

19 ht explanations for the origins of life from chemical and physical first principles.

20 ular structures, physicochemical properties, chemical and physical modifications, and food and non-fo

21 d to determine distinct forms of spider silk chemical and physical property variability.

22 ntal protection, mining accident prevention, chemical and process industry.

23 Chemical and radiochemical purity and serum stability we

24 ate and calcium lactobionate, on the physico-chemical and rheological properties of milk.

25 ter potential energy surface, which exhibits chemical and spectroscopic accuracy, are carried out to

26 se relative to the dissolved phase varied by chemical and tended to increase with their octanol-water

27 The capability of simultaneous chemical and topographic imaging of complex biological s

28 id interfaces is central to a broad range of chemical and transport phenomena.

29 r example, light, external modulation of the chemical and/or physical environment or catalysis of an

30 ient and sustainable microbial production of chemicals and fuels.

31 riiodide, the UV-photolysis does not require chemicals and is not affected by interferences of byprod

32 lity in nanostructures and related physical, chemical, and biological effects.

33 gnin into ccMA and pyrogallol as value-added chemicals, and more importantly demonstrates benign meth

34 ting the nuclear receptor's activity using a chemical antagonist abrogated not only the alterations i

35 This simple chemical approach addresses several key challenges, such

36 Libraries of chemicals are applied to living systems, and changes in

37 Consequently, many chemicals are falsely assigned as being potentially pers

38 d diphenyl ethers (PBDEs) in flame-retardant chemicals are measured ubiquitously in children.

39 The other, a chemical assay, is known as the Sakaguchi test and targe

40 tiple contacts with the protein, providing a chemical basis for the stabilizing effects of the glycan

41 hat would be of interest for applications in chemical biology and in a therapeutic setting.

42 h inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics.

43 is a host of methodological approaches from chemical biology, proteomics, genomics, cell biology, an

44 nd, the effects of various gene deletions or chemical blocking agents were tested by investigating th

45 Chemical bond energies can then be understood in terms o

46 Understanding the nature of chemical bonding and lattice dynamics together with thei

47 Here we show that iron forms chemical bonds of similar strengths in basaltic glasses

48 The EDA reveals distinguishing features of chemical bonds ranging across nonpolar, polar, ionic, an

49 perimental findings are supported by quantum chemical calculations and noncovalent interaction analys

50 The chemical changes (oxidation/nitrosation) of meat protein

51 statistical analysis identified significant chemical changes in pet food as a result of processing,

52 ns lacking polyphosphate, a newly recognized chemical chaperone.

53 re nonspecific methods based on physical and chemical characteristics are required instead of methods

54 Combined isotopic and chemical characteristics projected for these ancient dom

55 nd canola oil (CO), and compared for diverse chemical components and sensorial attributes, aiming to

56 images revealed the distribution changes of chemical components on the fiber bundle surface during t

57 dominated by the enrichment of high-density chemical components, probably related to subducted ocean

58 acterized regarding their nutritional value, chemical composition and bioactive properties.

59 Analyses of their chemical composition and solid-state structures demonstr

60 ine vehicle, and dust sources was similar in chemical composition between cities, but PM2.5 from coal

61 ion, the results of this study indicate that chemical composition of C. spinosum is highly depended o

62 In the present work, we studied the chemical composition of Chinese artichoke (S. affinis tu

63 We determined how the chemical composition of primary ambient PM2.5 sources va

64 al methods have been developed to relate the chemical composition of the coffee grain to the beverage

65 The morphology, microstructure, and chemical composition of the gate dielectric and CuPc fil

66 The chemical composition of the polymeric ionic liquid (PIL)

67 ibunda fruit was studied to characterize its chemical composition.

68 Botanical origins and chemical compositions including sugars were evaluated us

69 associated with both parasite infection and chemical contaminants, but that their relative importanc

70 Fish can be exposed to a complex mixture of chemical contaminants, including pharmaceuticals, presen

71 their relative velocities change in various chemical contexts.

72 r specificity, safety and the move away from chemical control agents.

73 The use of mass spectrometry coupled with chemical cross-linking of proteins has become a powerful

74 ssembly of elastic fibers in vivo, preceding chemical cross-linking.

75 s on the structural information derived from chemical cross-linking/MS experiments.

76 Here we present a chemical crosslinking strategy that incorporates a photo

77 We extend this by demonstrating that this chemical cue is preserved in humans as well; E2D induces

78 complete picture of how diverse physical and chemical cues act upon individual cells to ensure coordi

79 ains unclear to what degree, if any, BV uses chemical cues to target its prey.

80 It has been suggested that sea-salt-induced chemical cycling of Hg (through 'atmospheric mercury dep

81 Tetrodotoxin (TTX) is a key chemical defense trait in North American and Eurasian ne

82 Products of chemical degradation and compounds contained within the

83 inated groundwater sites as a consequence of chemical degradation of trichloroethene (TCE) by in situ

84 Elucidation of the mechanism by which chemical denaturants unfold proteins is crucial; this st

85 The ExsY array is stable to heat and chemical denaturants, forming a robust layer that would

86 dvantages over other similar (i) compared to chemical denitrosation with copper monochloride or triio

87 ing the identification of designer drugs and chemical derivatives not present in the library.

88 les (which are being incorporated into their chemical design), their modularity in being fused to cre

89 Some key chemical differences between actinides and lanthanides-a

90 earchers and patent attorneys from different chemical disciplines.

91 Fate and bioaccumulation models describe how chemicals distribute in the environment and accumulate t

92 catalytic mechanisms that showcase both the chemical diversity in natural product biosynthesis as we

93 ion mass spectrometry analyses reveal a huge chemical diversity in the two taxa.

94 Glycans possess significant chemical diversity; glycan binding proteins (GBPs) recog

95 hem and the tunability to superconductors by chemical doping or application of external pressure.

96 ughput UV-vis titrations in combination with chemical double-mutant cycles (DMCs) have been used to s

97 Exposure to chemicals during critical windows of development may re-

98 ssential for sustaining far-from-equilibrium chemical dynamics, given their functional relevance in a

99 pmental processes, little is known about the chemicals' effects on adult adipose tissue.

100 The chemical energy and radicals from an oscillating chemica

101 with force generation and the conversion of chemical energy into mechanical work.

102 We demonstrate that two distinct chemical entities contribute to the temporal evolution a

103 appropriate design of the electrostatic and chemical environment.

104 using visible light while withstanding harsh chemical environments.

105 ct of environmental changes on an artificial chemical evolving system outside of computer simulations

106 often on the basis of individual studies or chemical experience, little has been done so far to syst

107 s applied to the data from the environmental chemical exposure study, we detected a few important miR

108 Challenges include accurately estimating chemical exposure, confounding from causes of both expos

109 ting the disruption of miRNA activity due to chemical exposure.

110 fying periods of heightened vulnerability to chemical exposures, and determining the effects of chemi

111 hieved significantly better performance than chemical feature based approach (accuracy 85.5% versus 7

112 When both chemical features and clinical phenotypes were available

113 rts two major greenhouse gases into a useful chemical feedstock.

114 The chemical fingerprints of three milk types, five fish spe

115 solution for valorizing lignin into valuable chemicals for a potential lignocellulosic biorefinery an

116 otopic composition of HONO for studying HONO chemical formation pathways, as well as atmospheric sour

117 Annotation with predicted chemical formulas is also not implemented and semiquanti

118 larger polysulfur aerosols, thus providing a chemical framework for understanding the formation mecha

119 elegans, to explore these issues using three chemical-free specimen preparations: lyophilization, cry

120 d membrane scale formation decreased after a chemical-free, thermal precipitation pretreatment.

121 s the collection and analysis of rhizosphere chemicals from different plant species.

122 o semi-metallic, depending on the substrate, chemical functionalization and strain.

123 al-organic frameworks (MOFs) can be tuned by chemical functionalization of the organic ligands that c

124 cellular communities, where the formation of chemical gradients leads to resource limitation for cell

125 Dynamins are mechano-chemical GTPases involved in the remodeling of cellular

126 Chemical guidelines for achieving the targeted compounds

127 The robotic system combines chemical handling, in-line spectroscopy and real-time fe

128 ctive electrocatalysts for CO2RR to valuable chemicals (HCOx), a critical need for practical environm

129 amples were poorly predicted suggesting that chemical heterogeneities as a function of size or chemic

130 Among the chemicals identified from the headspace of infected host

131 onal framework to annotate ions for possible chemical identity using a multistage clustering algorith

132 systemic problems plaguing the regulation of chemicals in food.

133 s also indicated the presence of nontargeted chemicals including chemotherapeutics consistent with a

134 Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estr

135 d 12 gestational wk (GW 10-12), to screen 27 chemicals individually for their possible anti-androgeni

136 Endocrine disrupting chemicals induce endoplasmic reticulum stress, perturb N

137 Using a new chemical-induced proximity assay, we find that BAF direc

138 Fkbp/Frb dimerizing fusion proteins to allow chemical-induced proximity of a desired chromatin regula

139 H1 was observed in patient fibroblasts after chemical induction of the Hh pathway.

140 same animal from other etiologies including chemical inflammation (turpentine) and cancer (breast ca

141 Efficient access to chemical information contained in scientific literature,

142 Genetic, physiological, or chemical inhibition of respiratory processes elicited in

143 osis and to determine the effectiveness of a chemical inhibitor for FAP in mice.

144 Here the authors show that a chemical inhibitor to a viral fusion protein is effectiv

145 have properties similar to those of another chemical inhibitor, AS-48, which appears to interfere wi

146 r a 72-hour transient incubation in the four chemical inhibitors (4i)-naive reprogramming medium and

147 t pest management programs largely depend on chemical insecticides, resulting in high economic and en

148 34 species, and augmented data for priority chemicals involved in accidental chemical releases.

149 atic beta-C-H hydroxylation of the feedstock chemical isobutyric acid has enabled the asymmetric synt

150 The use of chemical kinetics has recently enabled highly accurate q

151 represents a significant step forward in the chemical knowledge of this material.

152 To address this, and to develop new chemical ligation strategies for assembly of biocompatib

153 This review provides the underlying chemical logic to remind how these seven key molecules f

154 n hippocampal neurons abolishes NMDA-induced chemical long-term depression.

155 Despite no novel chemical marker has been identified, the (1)H NMR chemom

156 achieving unequivocal detection of multiple chemical markers known for their use in the adulteration

157 te in tracer formation via both physical and chemical mechanisms.

158 To identify and measure recently described chemical mediators, termed specialized pro-resolving med

159 Some chemical migration limits cannot be enforced because ana

160 al exposures, and determining the effects of chemical mixtures.

161 he FFPE process results in fragmentation and chemical modification of RNA, rendering it less suitable

162 s, without the need for added surfactants or chemical modification of the graphene.

163 oved and now identifies most sugar types and chemical modifications (including various glycolipids) i

164 unctions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes.

165 Major efforts toward the identification of chemical modulators of the hedgehog pathway have yielded

166 drug resistance mechanisms using genome-wide chemical mutagenesis allied to next-generation sequencin

167 ghlights the importance of the atomistic and chemical nature of the tunneling medium at short biologi

168 This allows the automatic navigation of a chemical network, leading to previously unreported molec

169 fuelled molecular motion, compartmentalised chemical networks and designed oscillators.

170 one due to a combination of the reduction of chemical noise and separation of coeluting isobaric spec

171 anistic insights into the emergence of plant chemical novelty, and offers a template for investigatin

172 erent media and its effectiveness depends on chemical-nutritional characteristics of the sample.

173 parallel or opposing gradients of gases and chemicals offers the potential for a wide range of appli

174 ssing both anion-vacancy order and Sr and Ca chemical order at the subnanometer scale, confirmed thro

175 ad, our strengthening mechanism exploits the chemical ordering effect that creates backstresses (the

176 Persulfate (S2O8(2-))-based in situ chemical oxidation (ISCO) has gained more attention in r

177 Conventional chemical oxidation routes for the production of graphene

178 , with exquisite control over structural and chemical parameters at multiple length scales.

179 wo-phase reactions, which are widely used in chemical, pharmaceutical, and polymer manufacturing.

180 lastic nanoparticles, despite their distinct chemical, physical and mechanical properties.

181 ic acids) cannot occur without enrichment of chemical precursors before initiating polymerization, an

182 amagnetic compound in agreement with quantum chemical predictions.

183 collection sites, but the concentrations of chemicals present in horizontal products were up to 3 or

184 article, we describe the discovery of a new chemical probe, bisamide (CCT251236), identified using a

185 libraries have accelerated the discovery of chemical probes for studying biological processes.

186 Chemical probes have also achieved greater prominence al

187 for enzymatic assays, potent inhibitors, and chemical probes to detect, track, and characterize the r

188 electivity for ALDH1A1 or ALDH2 and generate chemical probes to examine the unique and overlapping fu

189 the metal carbonyl, explain the ease of the chemical processes and the stabilities of the resulting

190 the application of SERS for understanding of chemical processes at the nanoscale, with special intere

191 ilization, enhance CO2 fixation and increase chemical production.

192 about the toxicity of the growing number of chemical products coming from different origins that can

193 on, levels and toxicological profiles of the chemical products in the aerosols (i.e., vapor plus part

194 Chemical profiling and gene expression studies showed th

195 s in synthesis as a result of their inherent chemical properties and established reactivity patterns.

196 The physico-chemical properties and functional role of these intrace

197 The physical and chemical properties of metal oxides are dramatically inf

198 eight tissues simultaneously, we identified chemical properties promoting delivery to some tissues r

199 polymer layers to control their physical and chemical properties, but little is understood about the

200 ut also its therapeutic, pharmacological and chemical properties, thereby substantially expediting th

201 or LSBs strongly depends on its physical and chemical properties, which is heavily controlled by its

202 e to investigate their effect on its physico-chemical properties.

203 the hydropathy index, Van der Waals volume, chemical property and occurrence frequency of amino acid

204 This chemical property is manifested at physiological concent

205 Here, we report a chemical proteomic platform for the global and quantitat

206 ical energy and radicals from an oscillating chemical reaction are used to synthesize a polymer vesic

207 r observed in living systems by constructing chemical reaction networks (CRNs) with well-defined dyna

208 Finally, the chemical reaction of [C2mim][OAc] with a cysteine-contai

209 ggregates is an important property governing chemical reactions and fluid flow in low-permeability ge

210 The dynamics of chemical reactions are often governed by transient speci

211 ecies on the dielectric surface and not from chemical reactions between NO2 and the dielectric/semico

212 even larger systems.The competition between chemical reactions critically affects our natural enviro

213 produced from a variety of sources including chemical reactions due to exposure to stress (UV, heat)

214 ls, evidence for acid production from indoor chemical reactions with ozone was found.

215 ser-matter interactions often lead to exotic chemical reactions.

216 s able to catalyse specific enantioselective chemical reactions.

217 model of fibrinolysis that includes the main chemical reactions: the microscale model represents a si

218 ze past DNA adducts that result from diverse chemicals, reactive oxygen species or UV light.

219 fic molecular targets (irrespective of their chemical reactivity) in situ in the living body.

220 properties are affected by spore density and chemicals released from spores, germination interactions

221 or priority chemicals involved in accidental chemical releases.

222 contact materials' safety is evaluated using chemical risk assessment (RA).

223 sential before the cells are introduced into chemical safety assessment.

224 o aromatic rings has enabled every branch of chemical science.

225 From these, the secondary chemical screen identified SETD8, the H4(K20me1) methylt

226 al revision of the current definition of the chemical senses based upon spatial criteria.

227 Highly promising photonics-based chemical sensing opened up by the new guest@MOF composit

228 plications in the biomedical field including chemical sensing, biological imaging, drug delivery, and

229 arness them for gas storage and separations, chemical sensing, drug delivery, catalysis, and nanoscal

230 ld vast potential for near-infrared imaging, chemical sensing, materials engineering, and quantum inf

231 oximately 300 nm spatial resolution and high chemical sensitivity.

232 After data analysis, we have prioritized the chemical series of N-phenyl-4H-thieno[3, 2-b]pyrrole-5-c

233 From this set, a diprolyl chemical series was modeled using docking simulations.

234 the relative orientations between bonds and chemical shielding tensors, respectively, regardless of

235 Residual dipolar couplings and residual chemical shift anisotropy provide a spatial view of the

236 -(13)C(alpha) dipolar tensor and carboxylate chemical shift anisotropy tensor of aspartate.

237 , X-ray crystallography, and structure-based chemical shift predictions to explore the structural bas

238 To provide chemical shift reference data suitable for comparison wi

239 A spin system matrix that parametrizes chemical shifts and coupling constants among spins provi

240 PMAS shows two neighboring resonances, whose chemical shifts are consistent with carbamate (at 165 pp

241 (1)H chemical shifts up to 11.8 ppm revealed that certain che

242 raints for the bound state are obtained from chemical shifts, and site-specific dynamics of the bound

243 are scaffolds that integrate mechanical and chemical signaling.

244 ngs suggest species' degree of investment in chemical signalling, and not foraging behaviour, as a le

245 Transmission and amplification of chemical signals across lipid bilayer membranes is of pr

246 Neuropeptides are peptide hormones used as chemical signals by the neuroendocrine system to communi

247 and scripting) providing highly informative chemical signatures for quality assessment.

248 We further detected novel cardiac chemical signatures related to the severity and ultimate

249 of application reduces the flux of reactive chemical species reaching the sample, potentially limiti

250 Specific chemical species that were determined by the feature sel

251 the experimentally measured coordinates and chemical species with 22 picometre precision can be used

252 is synchronized with bulk homogenization of chemical species, yielding two distinct processes that a

253 therefore ideal for label-free detection of chemical species.

254 Chemical-specific AWBCs are compared with measured water

255 predict 26 relevant properties for nonpolar chemicals, specifically: partition coefficients for dive

256 Through thermal and chemical spectromicroscopy and numerical simulations, we

257 We expect that the higher mechanical and chemical stability of block copolymer membranes and thei

258 e viral proteins, which likely increased the chemical stability of the capsid toward ClO2.

259 ent heterogeneity in the electrochemical and chemical stability of these films.

260 Chemical stabilization of HIF-1alpha by Dimethyloxalylgl

261 epithelial clock is regulated by the mechano-chemical stiffness of the cellular microenvironment in p

262 eactive metabolite formation in APAP-induced chemical stress, both the hepatotoxicity and localised N

263 Their chemical structure allows the insertion of reporter mole

264 omain in E. coli was necessary to facilitate chemical structure analysis and to produce a mimetic Kdo

265 y and potency are derived primarily from the chemical structure of the oligonucleotide whereas their

266 ed nanoparticles without modification of the chemical structure.

267 scaffold queries increasingly abstract from chemical structures.

268 Text-based search on rich metadata and chemical substructure search allow precise identificatio

269 coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled int

270 Neurons communicate through chemical synapses and electrical synapses (gap junctions

271 In contrast, disrupting chemical synapses has no effect on the electrical coupli

272 Nerve tissue contains a high density of chemical synapses, about 1 per microm(3) in the mammalia

273 cular machines may have significant roles in chemical synthesis and molecular manufacturing.

274 Recent advances in chemical synthesis have yielded new nanoscale materials

275 It is based on the chemical synthesis of a tetra-antennary glycan that has

276 based self-assembled nanoparticles, from the chemical synthesis of AMPDs, through nanoparticle prepar

277 This protocol covers the chemical synthesis of the fluorogenic amino acid Fmoc-Tr

278 ke features, and synthetic accessibility for chemical synthesis, out of 593 hits, 39 were left top hi

279 tensely investigated from both medicinal and chemical-synthesis perspectives for decades.

280 e are used to influence a variety of electro-chemical systems such as applications related to water s

281 ide mapping of 5hmU-modified loci based on a chemical tagging strategy for the hydroxymethyl group.

282 es have been annealed to achieve alternating chemical terminations and thus enable selective epitaxy

283 ethod for botanical drugs is mainly based on chemical testing.

284 Linear alkyl benzenes (LAB) are global chemicals that are produced by acid-catalyzed reactions

285 ed biphenyls (PCBs) are persistent hazardous chemicals that are still detected in the atmosphere and

286 te-a well-characterized endocrine-disrupting chemical-to vulnerable populations is representative of

287 One major reason for this is the absence of chemical tools designed as selective inhibitors for IKKa

288 Many important chemical transformations occur in two-phase reactions, w

289 diffraction to observe crystal structure and chemical transition of perovskites.

290 ve textile functionality that do not involve chemical treatment.

291 cture but also is vital for devising optimum chemical treatments.

292 iocarbamates (DTCs) are important industrial chemicals used extensively as pesticides and in a variet

293 ility of block copolymer membranes and their chemical versatility for adaptation will open new opport

294 Together, our results highlight the chemical versatility of artificial aldolases for the pra

295 fication of biomarkers of public exposure to chemicals via combined human metabolism and urban water

296 Using a set of chemical warfare agent simulants with nominally the same

297 ing and formation during the hydrolysis of a chemical warfare nerve agent simulant over a polyoxometa

298 om high-income countries, or if they were of chemical weapons.

299 Rosemary extract and its major constituent chemicals were tested for their cytotoxicity by colony f

300 Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties,