ライフサイエンスコーパス: chemical biology

1 a significant challenge at the forefront of chemical biology.

2 s to address a wide range of applications in chemical biology.

3 biotechnology, transplantation medicine and chemical biology.

4 tant role of protein-protein interactions in chemical biology.

5 macological agents is a longstanding goal in chemical biology.

6 nic chemistry but have untapped potential in chemical biology.

7 reactivity could have substantial utility in chemical biology.

8 nt and improvement of intein-based tools for chemical biology.

9 many outstanding questions in biophysics and chemical biology.

10 ic cellular proteins are essential tools for chemical biology.

11 become one of the great frontiers of modern chemical biology.

12 enetic alphabet has been a long-time goal of chemical biology.

13 ew lead identification in drug discovery and chemical biology.

14 the future use of carrier protein fusions in chemical biology.

15 ule interfaces represents a powerful tool of chemical biology.

16 catalysts remains a formidable challenge for chemical biology.

17 common to model self-replication systems in chemical biology.

18 emerging field of RNA splicing chemistry and chemical biology.

19 lex biomolecules has become a cornerstone of chemical biology.

20 ter of what, 30 years later, would be called chemical biology.

21 binatorial chemistry, organic synthesis, and chemical biology.

22 cks for medicinal chemistry and as tools for chemical biology.

23 ellular functions is commonly referred to as chemical biology.

24 organic synthesis, medicinal chemistry, and chemical biology.

25 creasingly important topic in structural and chemical biology.

26 ufficiently validated, compounds employed in chemical biology.

27 on should find applications in many areas of chemical biology.

28 those of the azido group for applications in chemical biology.

29 pects on the possible further development of chemical biology.

30 nt roles as drug candidates and as tools for chemical biology.

31 drug discovery, proteomics, metabolomics and chemical biology.

32 s a classical model system for environmental chemical biology.

33 s powerfully enabling for drug discovery and chemical biology.

34 on in organic synthesis, drug discovery, and chemical biology.

35 e a stabilized diazo group as a reporter for chemical biology.

36 computational drug discovery and systems and chemical biology.

37 ing workflows relevant to drug discovery and chemical biology.

38 l for developing therapeutics and probes for chemical biology.

39 ndly affect the future of drug discovery and chemical biology.

40 synthetic chemistry, materials science, and chemical biology.

41 g drug discovery, ecology, biosynthesis, and chemical biology, among others.

42 ression in living cells is a central goal of chemical biology and antisense therapeutic development.

43 ation of proteins plays an important role in chemical biology and biomaterials science.

44 menon has found a variety of applications in chemical biology and biotechnology, precious little is k

45 FRET can be generalized with applications in chemical biology and biotechnology, such as target engag

46 ly split inteins has found widespread use in chemical biology and biotechnology.

47 by split inteins has found widespread use in chemical biology and biotechnology.

48 In recent years, chemical biology and chemical genomics have been increas

49 ill find significant utility in the areas of chemical biology and chemically enabled/enhanced biother

50 inescent reporter enzyme, is broadly used in chemical biology and drug discovery assays.

51 is outlined and will be of value to both the chemical biology and drug discovery fields.

52 oteases, the undisputed potential of GTs for chemical biology and drug discovery has remained largely

53 e importance of alpha-helix-mediated PPIs to chemical biology and drug discovery with a focus on desi

54 ical activities is an important step in both chemical biology and drug discovery.

55 icine, and its research is a top priority in chemical biology and drug discovery.

56 tions (PPIs) represents a major challenge in chemical biology and drug discovery.

57 r quality and utility across a wide range of chemical biology and drug-discovery research problems.

58 netics and drug discovery, but the fields of chemical biology and genetics have evolved to a point wh

59 hat would be of interest for applications in chemical biology and in a therapeutic setting.

60 be used to identify innovative compounds in chemical biology and in the early stages of drug discove

61 Chirality is a major field of research of chemical biology and is essential in pharmacology.

62 a "click" reaction with many applications in chemical biology and materials science.

63 ural products is of particular relevance for chemical biology and medicinal chemistry.

64 tissues, providing an innovative platform in chemical biology and molecular medicine.

65 e nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas

66 noparticles, with widespread applications in chemical biology and nanotechnology.

67 s for further investigation of this strain's chemical biology and potential for interaction with its

68 emporary translational science tools such as chemical biology and real-time imaging.

69 AURKA inhibitors, with implications for the chemical biology and selective therapeutic targeting of

70 s an important technique for drug discovery, chemical biology and structural biology.

71 eral fields: materials science, nanoscience, chemical biology and supramolecular chemistry.

72 Recent advances in chemical biology and the advantages presented by in vivo

73 n of new lead scaffolds for targeting DNA in chemical biology and therapeutic applications.

74 case the potential of organic synthesis for (chemical) biology and immunology.

75 We have used a combination of cell biology, chemical biology, and enzymology approaches to analyze t

76 sition in synthetic and medicinal chemistry, chemical biology, and materials science.

77 We combined yeast genetic engineering, chemical biology, and multiwavelength fluorescence micro

78 ations driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with

79 en inhibitor candidates for therapeutics and chemical biology, and to unravel the diverse signaling c

80 Chemical-biology- and live cell-imaging techniques revea

81 useful photophysical properties for further chemical biology applications.

82 e as scaffolds for the display of ligands in chemical-biology applications and as spacers and constru

83 The chemical biology approach described here can be used to

84 We undertook a chemical biology approach for investigating mechanisms o

85 A chemical biology approach identifies a beta 2 adrenergic

86 ese phenotypes were recapitulated by using a chemical biology approach in which pyrazolopyrimidine-de

87 Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic aci

88 This synthetic chemical biology approach may be extended to understand

89 sults demonstrate that CHAMP is a successful chemical biology approach that can provide specific tool

90 Accordingly, we describe herein a chemical biology approach that enabled the reconstitutio

91 This chemical biology approach to defining drug-enzyme intera

92 Here, we used a chemical biology approach to demonstrate that binding an

93 Here, we develop a chemical biology approach to determine mammalian nucleos

94 Here, we report an integrated chemical biology approach to explore protein myristoylat

95 Here we use a chemical biology approach to map the binding interface o

96 As such, we provide proof of concept of this chemical biology approach to screen for inhibitors of li

97 We describe here a chemical biology approach to structural analysis of Abet

98 Here we employed a chemical biology approach using selective small molecule

99 Using a chemical biology approach, it was determined that compou

100 c investigation of the WaaL function using a chemical biology approach, providing a system that could

101 Using a complementary chemical biology approach, we developed a new class of s

102 Using an unbiased chemical biology approach, we identified a novel role fo

103 Through a targeted chemical biology approach, we identify ROD as the Spindl

104 Using a chemical biology approach, we purified the sigma2 recept

105 Using a chemical biology approach, we show that ORC-Cdc6-Cdt1-de

106 rlying the mammalian circadian clock using a chemical biology approach.

107 Therefore, by using a rational chemical-biology approach, we derived antiapoptotic comp

108 We highlight some of these chemical biology approaches across three areas.

109 We used chemical biology approaches and live-cell microscopy to

110 biosynthesis and function are emerging, and chemical biology approaches are accelerating the pace of

111 Conventional structural and chemical biology approaches are applied to macromolecule

112 foundation for further exploration utilizing chemical biology approaches focusing on validating this

113 l properties, H2S is an appealing target for chemical biology approaches to elucidate its production,

114 ion of high quality chemical tools and other chemical biology approaches to target validation in canc

115 molecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and

116 hosphorylation have been obtained with these chemical biology approaches, but continuing opportunitie

117 an array of spectroscopic, theoretical, and chemical biology approaches.

118 he recent development of biotherapeutics and chemical biology approaches.

119 and practical significance in structural and chemical biology as well as in nanobiotechnology.

120 ument its current status with an emphasis on chemical biology aspects of modulating its activity to g

121 sumption by combining laser microsurgery and chemical biology assays in cultured mammalian cells.

122 mulated interest for various applications in chemical biology, bioseparations, drug delivery, and sen

123 ights will advance the utility of inteins in chemical biology, biotechnology, and medicine.

124 nes has found widespread use in the field of chemical biology, but the mechanism of the transformatio

125 The combination of stem cell and chemical biology can provide novel approaches to investi

126 s of research involving medicinal chemistry, chemical biology, cancer biology, and molecular imaging.

127 Recently, the power of chemical biology, combined with model systems like zebra

128 PubChem also collaborates with other chemical biology database stakeholders with data exchang

129 Recent chemical biology developments are beginning to demonstra

130 y split inteins have found widespread use in chemical biology due to their ability to drive the ligat

131 tional group has assumed a prominent role in chemical biology efforts in recent years.

132 Through chemical biology efforts involving the design and synthe

133 een used to impact actual drug discovery and chemical biology efforts.

134 ul in organic synthesis, drug discovery, and chemical biology endeavors.

135 A particularly challenging problem in chemical biology entails developing systems for modulati

136 advances in terpenoid cyclase structural and chemical biology, focusing mainly on terpenoid cyclases

137 rterial-venous identity and the potential of chemical biology for providing new insights into this fi

138 induced dimerization is an important tool in chemical biology for the analysis of protein function in

139 Recent advances in chemical biology have produced light-sensitive compounds

140 gulon in P. aeruginosa by using genetics and chemical biology in combination with transcriptomics and

141 lockworks and highlight the effectiveness of chemical biology in exploring unidentified mechanisms of

142 ontext of the role of structural biology and chemical biology in innovative drug discovery.

143 upramolecular chemistry, in nanosciences, in chemical-biology, in polymers and materials science.

144 l to other protein-tagging methods in modern chemical biology including activity-based protein profil

145 catalytic X-H insertion towards problems in chemical biology indicate that this field has ample room

146 fluorescent dyes, and highlight the relevant chemical biology innovations that can be instrumental fo

147 me one of the main driving forces in current chemical biology, inspiring the search for novel biocomp

148 ulators of 14-3-3 are much needed agents for chemical biology investigations and therapeutic developm

149 the complementary approaches of genetics and chemical biology, involving a variety of model organisms

150 Increasingly, chemical biology is being used in the context of bacteri

151 Chemical biology is efficient to dissect molecular mecha

152 the complementary strengths of genetics and chemical biology, it is hoped that novel therapeutic app

153 pportunities between synthetic chemistry and chemical biology labs interested in creating first-in-cl

154 ility, and is moving towards applications in chemical biology, nanotechnology and material science.

155 a foundation for studying the structural and chemical biology of arginase I in the immune response, a

156 this work sets a foundation for studying the chemical biology of autophagy through the structure-base

157 e literature also implies that the mammalian chemical biology of CS2 has broader implications from in

158 disclose our complete studies regarding the chemical biology of diazonamide A and its structural con

159 been hampered by a poor understanding of the chemical biology of inflammation, the lack of sensitive

160 solution and is a viable participant in the chemical biology of nitric oxide and derivatives.

161 However, the chemical biology of NO- remains largely unknown.

162 We cover the chemical biology of persulfides and the chemical probes

163 r chaperones and assess the potential of the chemical biology of proteostasis.

164 cial to a comprehensive understanding of the chemical biology of psymberin and related compounds that

165 This article surveys the chemical biology of quadruplexes.

166 as playing important roles in the mammalian chemical biology of the ubiquitous bioregulator nitric o

167 Aspects of the pharmacokinetic behavior and chemical biology of these drug candidates are also descr

168 his Review highlights both the chemistry and chemical biology of this fascinating natural product, an

169 et GAG-binding protein(s), which may lead to chemical biology or drug discovery tools.

170 d discoveries stemming from these innovative chemical biology platforms.

171 research is important for the development of chemical biology probes.

172 eveloped through a collaboration between the Chemical Biology Program and Platform at the Broad Insti

173 The results provide a novel integrative chemical biology proof in support of the neuroinflammati

174 is a host of methodological approaches from chemical biology, proteomics, genomics, cell biology, an

175 erdisciplinary and promises to revolutionize chemical biology, radiochemistry and materials science.

176 Modern high-throughput discovery efforts in chemical biology rely heavily upon this principle.

177 ng experiments, medicinal chemistry studies, chemical biology research and drug discovery programs.

178 uest for novel bioactive small molecules for chemical biology research and drug discovery.

179 As an information resource for the chemical biology research community, it routinely receiv

180 ation resource supporting drug discovery and chemical biology research.

181 d tools that leverage this carefully curated chemical biology resource.

182 In this work, we used a high-throughput chemical biology screen to identify a small-molecule pro

183 Advances in somatic cell genetics and chemical biology should facilitate the development of a

184 lucidated through a combination of genetics, chemical biology, solution biochemistry, and crystallogr

185 Finally, new chemical biology strategies are being used to probe the

186 We argue that complementary biological and chemical biology strategies are essential for robust tar

187 ate the effects of AEE788 on T. brucei using chemical biology strategies.

188 synthetic antagonists, thus demonstrating a chemical biology strategy of using chemically engineered

189 In this study, we used a chemical biology strategy to experimentally characterize

190 engineered KAT enzymes, provide a versatile chemical biology strategy to label and profile cellular

191 Here we apply a multilayered chemical biology strategy to unravel the mode of action

192 gest the method could be a valuable tool for chemical biology studies of proteins.

193 tion of Shp2 as a therapeutic target and for chemical biology studies of Shp2 function.

194 tational analysis, cell-free, cell-based and chemical biology studies that have sought to elucidate t

195 d cellular assays, as a negative control for chemical biology studies.

196 Our findings demonstrate the utility of chemical biology techniques in analysis of infection pro

197 Herein, we examine the chemical biology that confers NDRG1 responsiveness at th

198 e findings thus define a G-CSF effect on MPO chemical biology that endows unsuspected functional vers

199 al review focuses on an important example of chemical biology-the melding of old and new chemical kno

200 for use in fundamental biophysical studies, chemical biology, therapeutic protein development, and b

201 We used a combination of genetics and chemical biology to characterize the mechanism of depupy

202 research areas ranging from bioanalysis and chemical biology to drug discovery and probing of cell-m

203 for the application of chemical ecology and chemical biology to human health.

204 stry, synthetic chemistry, biochemistry, and chemical biology to identify the substrates of peptidase

205 We applied chemical biology to screen small molecules that regulate

206 Using a novel chemical biology tool that allows rapidly tunable manipu

207 FabI inhibitor, AFN-1252, was deployed as a chemical biology tool to determine whether Neisseria can

208 zyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two li

209 rescent inhibitors that we show to be useful chemical biology tools especially in determination of di

210 it SPase, suggesting that they may be useful chemical biology tools for characterizing the secretome.

211 it SPase, suggesting that they may be useful chemical biology tools for characterizing the secretome.

212 s are amenable for bioconjugation, providing chemical biology tools for thaumatin:taste receptor inte

213 gest that the arylomycins should be valuable chemical biology tools for the study of protein secretio

214 5'-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca(2+) release

215 Thus, we advance first generation chemical biology tools to aid in the identification of k

216 h inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics.

217 By using genetic and chemical biology tools, we show that EYA contributes to

218 h inhibitors have the potential to be useful chemical biology tools.

219 of new transition-state analogues for use as chemical biology tools.

220 ties to study challenging targets or provide chemical biology tools.

221 ceptualizing the powerful proximity-enhanced chemical biology toolsets into two paradigms: "multifunc

222 Specifically, the concepts of chemical biology were used to develop synthetically and

223 lded in the areas of systems, synthetic, and chemical biology, where the need for comprehensive, hypo

224 In the future, the utility of chemical biology will grow as technologies for rapid ide

225 provide researchers new to the field of H2S chemical biology with practical considerations, pitfalls

226 The final products are of interest to chemical biology, with a platform for Zn-aminopeptidase