ライフサイエンスコーパス: chemical chaperone

1 ns lacking polyphosphate, a newly recognized chemical chaperone.

2 eticulum stress inhibitor, ammonia sink, and chemical chaperone.

3 t-containing nAChRs, possibly by acting as a chemical chaperone.

4 n and markers of ER stress are reversed by a chemical chaperone.

5 inase and could be inhibited by an exogenous chemical chaperone.

6 nts are useful for developing an aS-specific chemical chaperone.

7 for therapeutic purposes with orally active chemical chaperones.

8 l and targetable to the plasma membrane with chemical chaperones.

9 gical correction of the processing defect by chemical chaperones.

10 egradation by using proteasome inhibitors or chemical chaperones.

11 mplications for the biological roles of such chemical chaperones.

12 rinated nondetergent surfactants that act as chemical chaperones.

13 We discovered that chemical chaperone 4-phenyl butyric acid and antioxidant

14 We have previously shown that the chemical chaperone 4-phenylbutyrate (4-PBA) promotes the

15 asma membrane localization for rescue by the chemical chaperone 4-phenylbutyrate (4-PBA).

16 Finally, we showed that administration of chemical chaperone 4-phenylbutyrate or genetic inhibitio

17 of Tat- or GFAP-induced UPR/ER stress by the chemical chaperone 4-phenylbutyrate significantly allevi

18 of miR-708 was blocked by treatment with the chemical chaperone 4-phenylbutyrate, uncovering the invo

19 Treatment of db/db mouse islets with the chemical chaperone 4-phenylbutyric acid partially restor

20 MCC was preserved in mice given the chemical chaperone 4-phenylbutyric acid, but was disrupt

21 Pretreatment with the chemical chaperone 4-phenylbutyric acid, the JNK inhibit

22 t the patient's fibroblasts treated with the chemical chaperones 4-phenylbutiric acid or curcumin inc

23 Administration of a chemical chaperone, 4-phenolbutyrate, was protective aga

24 were observed with a structurally unrelated chemical chaperone, 4-phenylbutyric acid (100 mg.kg(-)(1

25 e pathobiology of these lesions, we employed chemical chaperone, 4-phenylbutyric acid (4-PBA) which a

26 Two chemical chaperones, 4PBA and TUDCA, were used to amelio

27 We suggest that the chemical chaperones act to stabilize the alpha-helical c

28 estrin2 reconstitution, mTORC1 inhibition or chemical chaperone administration.

29 lead to pain behavior that is reversed by a chemical chaperone and an inhibitor of sEH.

30 Chemical chaperones and low temperature, which help prop

31 They also serve as chemical chaperones and maintain the functionality of ma

32 organic osmolytes, solutes that function as chemical chaperones and restore osmotic homeostasis.

33 athogenicity of D1080N substitution and that chemical chaperones are therapeutic candidates for the m

34 asizing the translational potential of small chemical chaperones as stress effectors.

35 ethylsulfoxide (DMSO), which we refer to as 'chemical chaperones' because of their influence on prote

36 eins are misfolded, but functional, and that chemical chaperones both correct the trafficking and fol

37 are small-molecule compounds that can act as chemical chaperones by altering the environment in a cel

38 The presence of chemical chaperones can sometimes alleviate or even rest

39 Our results show that sulfonylureas, as chemical chaperones, can dictate manifestation of the tw

40 In vitro, chemical chaperones caused a dramatic, rapid change in H

41 of ER stress by genetic deletion of CHOP or chemical chaperone conferred a resistance to the LPS-ind

42 escue provides a specific mechanism by which chemical chaperones could be developed for the correctio

43 CB4(S320F) and ABCB4(A953D), suggesting that chemical chaperones could be exploited for therapeutic b

44 We propose that these chemical chaperones could be used as alternative therape

45 portantly, treatment of patient cells with a chemical chaperone decreased intracellular COL4A2 levels

46 Although the chemical chaperones did not appear to affect the existin

47 ilizing the active conformation of MKP3, the chemical chaperone dimethyl sulfoxide was able to mimic

48 e use of 4-phenylbutyric acid (4-PBA), an ER chemical chaperone, diminished ER stress markers and abo

49 n aggregation is an important determinant of chemical chaperone efficiency under endogenous expressio

50 Our results demonstrate that chemical chaperones enhance the adaptive capacity of the

51 We propose that 6AHA and proline can act as chemical chaperones for apo(a).

52 ve shown previously to act as small molecule chemical chaperones for K(ATP) channels.

53 The chemical chaperone glycerol produced a redistribution of

54 The chemical chaperone glycerol was found to improve the exp

55 After growth of cells for 48 h in the chemical chaperone glycerol, AQP2 mutants T126M and A147

56 degradation is blunted by treatment with the chemical chaperone glycerol, which retains SM N100-GFP i

57 correctable, cells were incubated with the "chemical chaperone" glycerol for 48 h.

58 In this study we show that the chemical chaperone, glycerol, and the transcriptional re

59 Reduced growth temperature and the chemical chaperone, glycerol, were found to correct the

60 Treatment with chemical chaperones, growth at permissive temperature, o

61 Chemical chaperones have been shown to stabilize various

62 ew study highlights a critical role for this chemical chaperone in energy-independent maintenance of

63 tance, detailed studies on the role of these chemical chaperones in modulating structure and dimensio

64 stration of sodium 4-phenylbutyrate (PBA), a chemical chaperone, increased protein stability, enzymat

65 roblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by i

66 In contrast, chemical chaperones inhibited conversion.

67 ization of the dissociated PTS1 subunit with chemical chaperones inhibited toxin export to the cytoso

68 We hypothesized that chemical chaperones known to suppress ER stress signalin

69 g the efficiency of tyrosinase folding using chemical chaperones led to a reduction in the level of s

70 cells initially accumulate both protein and chemical chaperones, like Hsp104 and trehalose, respecti

71 Attenuating ER stress with clinically used chemical chaperones may be a novel therapeutic strategy

72 propriate specificity and affinity acting as chemical chaperones may find application for increasing

73 ailure in Wolfram syndrome and indicate that chemical chaperones might have therapeutic relevance und

74 Neither chemical chaperones nor CHOP gene deficiency reduced dia

75 ogical manipulation of this pathway by using chemical chaperones offers a therapeutic option for trea

76 J, indicated a rather indirect effect of the chemical chaperones on folding of CBS mutants.

77 have thoroughly characterized the effects of chemical chaperones on Hmg2p.

78 Reduction of ER stress by treatment with chemical chaperones or overexpression of ER chaperone pr

79 Chemical chaperones or the antioxidant N-acetylcysteine

80 C) inhibitors, but not other antipsychotics, chemical chaperones, or VPA structural analogues.

81 l taurine, an amino acid that functions as a chemical chaperone/osmolyte and enhances cellular antiox

82 Treatment of the mice with a chemical chaperone partially corrected stability, enzyma

83 in-1 expression, while administration of the chemical chaperone PBA to ob/ob mice led to amelioration

84 from protein misfolding, as treatment with a chemical chaperone permits it to exit the endoplasmic re

85 Reduction of ER stress with a chemical chaperone, phenylbutyric acid (PBA), prevented

86 Pretreatment with a chemical chaperone, phenylbutyric acid, or adenoviral tr

87 In conclusion, the chemical chaperones present in the expression medium wer

88 ar basis for the ability of TMAO to act as a chemical chaperone remains unknown.

89 h a US Food and Drug Administration-approved chemical chaperone resulted in a decreased collagen intr

90 we show that mitigation of ER stress with a chemical chaperone results in marked protection against

91 Conversely, reduction of ER stress with a chemical chaperone significantly protected against both

92 Modulating ER stress using chemical chaperones significantly reduced the induction

93 ro studies reported a positive effect of the chemical chaperone sodium 4-phenylbutyrate (4-PBA) on mu

94 Treatment of those cells with the chemical chaperone sodium 4-phenylbutyrate could partial

95 The chemical chaperones sodium 4-phenylbutyrate and taurours

96 f hyperostosis that can be suppressed with a chemical chaperone, sodium 4-phenobutyrate (4-PBA).

97 of mice carrying the I4895T mutation with a chemical chaperone, sodium 4-phenylbutyrate (4PBA), redu

98 by co-treatment with either of two different chemical chaperones, sodium 4-phenylbutyrate and taurour

99 s a novel target to ameliorate OI phenotype; chemical chaperones such as 4PBA may be, alone or in com

100 ght CBS mutants expressed in the presence of chemical chaperones such as ethanol, dimethyl sulfoxide,

101 y shown that Hmg2p is strongly stabilized by chemical chaperones such as glycerol, which stabilize mi

102 The above in vitro results offer the use of chemical chaperones such as TMAO as an approach to mitig

103 Chemical chaperones such as TUDCA and PBA alleviate diff

104 Treatment with chemical chaperones, such as sodium 4-phenylbutyrate (PB

105 Chemical chaperones, such as trimethylamine N-oxide (TMA

106 In addition, these chemical chaperones suppressed proliferation and induced

107 ent of cells expressing C321R-LAMB2 with the chemical chaperone taurodeoxycholic acid (TUDCA), which

108 The chemical chaperones tauroursodeoxycholate (TUDCA) and 4-

109 ced chaperone response and the orally active chemical chaperones tauroursodeoxycholate (TUDCA) and 4-

110 is study is to examine the efficacy of an ER chemical chaperone, tauroursodeoxycholic acid (TUDCA), i

111 wild-type phenotype with the addition of the chemical chaperone, tauroursodexycholic acid (TUDCA).

112 Among various chemical chaperones tested in cell culture, betaine subs

113 Of four chemical chaperones tested, 4-phenylbutyric acid (4-PBA)

114 hermore, following treatment with a panel of chemical chaperones (thapsigargin, glycerol or sodium 4-

115 Tauroursodeoxycholic acid (TUDCA), a chemical chaperone that alleviates ER stress, was used t

116 We propose that polyphosphate acts as a chemical chaperone that helps refold MetA and/or may sti

117 ministration of tauroursodeoxycholic acid, a chemical chaperone that inhibits ER stress, significantl

118 Pretreatment of cells with glycerol, a chemical chaperone that reduces the extent of stress-ind

119 he defects are not reversed with glycerol, a chemical chaperone that rescues channel function in some

120 Most importantly, we found that chemical chaperones that alleviate ER and oxidative stre

121 f these conditions has led to the search for chemical chaperones that can slow, arrest or revert dise

122 UDCA), a bile acid derivative that acts as a chemical chaperone to enhance protein folding and amelio

123 Thus, the use of a CA inhibitor as a chemical chaperone to reduce ER stress may delay or prev

124 ian cells and degraded but can be rescued by chemical chaperones to function as plasma membrane water

125 The ability of chemical chaperones to overcome the dominant negative ef

126 re, we assessed the therapeutic potential of chemical chaperones to relieve plectinopathies.

127 Here we demonstrate the potential for chemical chaperones to rescue cell-surface expression of

128 ort here that sulfonylureas also function as chemical chaperones to rescue K(ATP) channel trafficking

129 cancer: from the structure-guided design of chemical chaperones to restore the function of conformat

130 Finally, chemical chaperone treatment protects cells from ER stre

131 onse involves a dramatic accumulation of the chemical chaperone trehalose and induction of trehalose-

132 The chemical chaperone trehalose has been used effectively t

133 Treatment of S. cerevisiae with the chemical chaperone trimethylamine-N-oxide resulted in ne

134 A chemical chaperone, trimethylamine oxide, administered f

135 le to demonstrate that administration of the chemical chaperone TUDCA helped to maintain lymphocyte h

136 ent with 4-phenylbutyric acid, a nonspecific chemical chaperone used in other protein-folding disorde

137 s in the living cell, the in vitro action of chemical chaperones was highly specific for Hmg2p and co

138 that changes similar to those observed with chemical chaperones were brought about by alteration of

139 In this study, we show that several "chemical chaperones," which have been shown to reverse t