ライフサイエンスコーパス: chemical genetics

1 atic chemical approach to exploring biology (chemical genetics).

2 leads and tools to dissect function through chemical genetics.

3 unction through small-molecule evolution and chemical genetics.

4 ncluding zebrafish, a model for genetics and chemical genetics.

5 proaches to modulate neuronal activity using chemical genetics.

6 yet present challenging targets for reverse chemical genetics.

7 activity towards MEK1 by in vitro assays and chemical genetics.

8 nce, we dissect their activation pathways by chemical genetics.

9 lk1-depleted cells, is readily revealed with chemical genetics.

10 all molecules has been a technical hurdle of chemical genetics.

11 small molecules in conjunction with genetics-chemical genetics.

12 chanisms of cellular events-a process termed chemical genetics.(1) Unfortunately, the majority of cur

13 Thus, our chemical genetics analysis demonstrates the utility of t

14 Our studies exemplify the combined power of chemical genetics and biochemical analyses for discoveri

15 loped screen takes advantage of the power of chemical genetics and combines it with the known substra

16 n (BET) proteins in DLBCL, using integrative chemical genetics and functional epigenomics.

17 Therefore, by combining chemical genetics and homologous gene replacement in som

18 We further employed chemical genetics and identified NDR1/2 substrates in th

19 Here we use chemical genetics and optogenetic techniques to dissect

20 Our results illustrate the combined use of chemical genetics and proteomics in biological discovery

21 ctivity in RPE1 human epithelial cells using chemical genetics and verifying results in additional li

22 Using chemical-genetics and mass spectrometry, we identified s

23 nge of novel applications in drug discovery, chemical genetics, and proteomics research.

24 nt modifiers of diverse protein families for chemical genetics applications.

25 Here, we have initiated a chemical genetics approach and isolated compounds that i

26 Our analysis illustrates the power of a chemical genetics approach for the analysis of signal tr

27 Therefore, our cell-based chemical genetics approach for the discovery of apoptosi

28 bulky N(6)-substituted ATP analogs, using a chemical genetics approach initially pioneered with v-Sr

29 Here we describe a chemical genetics approach that overcomes this limitatio

30 We used a chemical genetics approach to identify SIR1, a regulator

31 In summary, we used a chemical genetics approach to reveal STAT3 as a novel ne

32 Here we use a chemical genetics approach using knock-in mice in which

33 To overcome this barrier, a chemical genetics approach was employed in which 43,783

34 Using a chemical genetics approach, the Saccharomyces cerevisiae

35 Using a chemical genetics approach, which combined a pH-homeosta

36 t might be encountered upon adopting a given chemical genetics approach.

37 iosynthesis in Arabidopsis thaliana, using a chemical genetics approach.

38 Using this chemical-genetics approach, we assign particular amino a

39 Combining chemical manipulations and chemical genetics at the photoautotrophic transition che

40 imed at promoting the development and use of chemical genetics by scientists worldwide.

41 Chemical genetics employs diverse small-molecule compoun

42 d compounds, we applied phage-based, reverse chemical genetics for the discovery of caveolin-1 ligand

43 To study neurobiology using chemical genetics, high-throughput cell and organismal a

44 Cancer Institute created the Initiative for Chemical Genetics (ICG), to enable public research using

45 Here, we have used chemical genetics in a human cell line to address these

46 al changes that promote cytokinesis, we used chemical genetics in Dictyostelium to identify genetic s

47 Specific inhibition by chemical genetics in MEFs confirmed the involvement of J

48 ng approaches followed by drug optimization, chemical genetics in plant systems tends to be fueled by

49 ovide an overview of the current progress in chemical genetics in plants, with a focus on the discove

50 For instance, chemical genetics involves the discovery of small-molecu

51 Chemical genetics is a biochemical approach to develop s

52 pound affecting plant immunity indicate that chemical genetics is a powerful tool to study whole-orga

53 Chemical genetics is an emerging technology for revealin

54 The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the developme

55 ful screening campaigns in drug discovery or chemical genetics is the availability of structurally an

56 Chemical genetics, or the specific modulation of cellula

57 ation of deep metric learning to large-scale chemical genetics projects highlights the utility of thi

58 in this issue of Cell in which a new type of chemical genetics revealed the function of a new outer m

59 Here we use a chemical genetics screen to identify direct substrates o

60 ated immunity, we designed and carried out a chemical genetics screen to search for small molecules t

61 In a chemical genetics screen we identified the small-molecul

62 In contrast to RID(WT) and RID(D1114G), chemical genetics shows that the interaction of RID(Delt

63 Using a chemical genetics strategy wherein Bur1 kinase was engin

64 conserved cysteines and data from different chemical genetics studies, we suggest that CYSTM protein

65 uman Aurora A kinase (as-AurA) engineered by chemical genetics techniques.

66 ryonic tissues with genetic manipulation and chemical genetics thus provides a powerful approach to u

67 We used chemical genetics to control the activity of budding yea

68 so demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern ver

69 We previously used chemical genetics to dissect auxin-signaling mechanisms

70 Using chemical genetics to reversibly inhibit Cdk1, we find th

71 In this study, we use chemical genetics to show that the protein kinase Mps1 r

72 have applications in medicinal chemistry and chemical genetics too.

73 Chemical genetics uncovered requirements for the metazoa

74 mimicked the effects of BRD0476, and reverse chemical genetics using a known inhibitor of USP9X block

75 Using chemical genetics, we discovered thirteen candidate MST3

76 Using chemical genetics, we show that kinase inhibitors bypass

77 Using chemical genetics, we show that kinase-active Plk4 is in

78 ic synthesis offers the promise of advancing chemical genetics, where small molecules are used to exp

79 By combining chemical genetics with multimodal imaging, we have ident