ライフサイエンスコーパス: chemical library

1 was demonstrated by screening the Prestwick Chemical Library.

2 d via high-throughput screening of a diverse chemical library.

3 d via high-throughput screening of a diverse chemical library.

4 random search through a large pre-fabricated chemical library.

5 o examine any set of proposed molecules in a chemical library.

6 culture system to screen an uncharacterized chemical library.

7 Wee1-luciferase, to screen a kinase-directed chemical library.

8 step in drug discovery is the screening of a chemical library.

9 riments for metabolites not available in our chemical library.

10 generate pseudotype viruses for screening of chemical libraries.

11 tors has been to screen large to medium-size chemical libraries.

12 of high-throughput target-based screening of chemical libraries.

13 l inhibitors despite availability of diverse chemical libraries.

14 ethod's applicability to hit triage in large chemical libraries.

15 assay for high-throughput screening (HTS) of chemical libraries.

16 biological activities associated with large chemical libraries.

17 or structure-based focusing of combinatorial chemical libraries.

18 ow throughput and cannot be applied to large chemical libraries.

19 nding, structurally varied series of organic chemical libraries.

20 inal chemists from random screening of large chemical libraries.

21 ing high-throughput screens of combinatorial chemical libraries.

22 oncentrations from screening of the in-house chemical libraries.

23 nerate concentration-response data for large chemical libraries.

24 imized via solid-phase parallel synthesis of chemical libraries.

25 cal assays and imaging of spatially resolved chemical libraries.

26 f biologically active compounds from complex chemical libraries.

27 computer-aided drug design (CADD) screens of chemical libraries.

28 analyze and visualize the results of HTS of chemical libraries.

29 ng methods were applied, together with large chemical libraries.

30 put in silico screening of large and diverse chemical libraries.

31 ed a cell-based high-throughput screening of chemical libraries.

32 irtual screening to identify true binders in chemical libraries.

33 eta17-40 peptide by screening two commercial chemical libraries.

34 For quality control of chemical libraries, 1D NMR spectra are acquired under fu

35 lowing a high throughput screen of a diverse chemical library, a structure-activity relationship stud

36 phenotypic screening of natural products or chemical libraries against established cancer cell lines

37 We screened a chemical library against CQ(s) and CQ(r) lines and disco

38 We apply this method to screen a chemical library against protease activity of anthrax le

39 del organism assays to interrogate important chemical libraries and computationally analyze bioactivi

40 of gamma-secretase specificity, we screened chemical libraries and consequently developed a di-couma

41 ghput screening of commercial and 'in-house' chemical libraries and modification of promising hits.

42 By screening a small molecule chemical library and chemical optimization, we identifie

43 Using this platform, we screened a pilot chemical library and found five new inhibitors of DnaK a

44 vation, we performed a random screening of a chemical library and identified 3 compounds (JH1, JH4, a

45 Using this pharmacophore, we screened a chemical library and were able to identify novel cationi

46 Using this technology, we screened a chemical library, and identified novel histone deacetyla

47 plementary approaches-one an assessment of a chemical library, and the other a genome-wide CRISPR scr

48 cal target-based drug discovery, where large chemical libraries are screened using inhibitory assays

49 pase-8 cleavage, we screened a subset of the chemical library at the Harvard NeuroDiscovery Center's

50 Focused chemical libraries based on a plethora of scaffolds have

51 ation, we performed a screening of a defined chemical library based on proliferation of mouse pluripo

52 By selection from a two million entry chemical library based on the efficacy and safety, we id

53 ng compound collections, the design of novel chemical libraries biased towards allosteric regulators

54 cific inhibitors, identified by screening of chemical libraries, blocked parasite invasion of host er

55 eir DRBDs using high-throughput screening of chemical libraries by homogeneous time-resolved fluoresc

56 , high-throughput screening was performed on chemical libraries by using fluorescence resonance energ

57 dentified from the National Cancer Institute chemical libraries by using structure-based virtual scre

58 dentification of a lead compound from a vast chemical library by any number of screening techniques.

59 was identified as the result of screening a chemical library by using a whole-virus infected-cell as

60 bicity index (CHI) on a subset of the French chemical library Chimiotheque Nationale (CN).

61 In drug discovery, chemical library compounds are usually dissolved in DMSO

62 ere then used in the de novo design of seven chemical libraries consisting of 20-50 compounds each.

63 ialkylamino-2,4-dinitrobenzene combinatorial chemical library consisting of 155 parental amines and u

64 as preliminarily demonstrated by screening a chemical library consisting of 31 compounds against c-Ab

65 We screened a chemical library constructed using a hybrid approach tha

66 and stereochemical outcomes of reactions in chemical library construction.

67 by parallel synthesis of two representative chemical libraries containing 847 compounds with favorab

68 the synthesis and screening of a DNA-encoded chemical library containing 76230 compounds.

69 When a chemical library containing approximately 1200 off-paten

70 d new inhibitors for use in human therapy, a chemical library containing highly diverse chemical stru

71 the UCSF DOCK 6.1 program suite and the NCI chemical library database.

72 DNA-encoded chemical library (DECL) technology has emerged as a new

73 In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable a

74 of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do s

75 ography, structure-based design, and focused chemical library design were used to identify novel inhi

76 p) became the basis for a series of parallel chemical libraries designed to generate SAR data.

77 concentrations of the solvent used for many chemical libraries did not interfere with the assay.

78 esigns may not exploit the full potential of chemical libraries due to false negatives.

79 generate highly focused subsets of the input chemical library, enriched 33- to 100-fold for all but o

80 imilar regions using in silico searches of a chemical library, followed by cell-based biological assa

81 arget for compounds found by screening large chemical libraries for a desired biological effect and,

82 By screening chemical libraries for BMP-2 mimics using a cell-based a

83 Our approach of screening chemical libraries for compounds causing synthetic genet

84 is suitable for high-throughput screening of chemical libraries for DNMT inhibition activity.

85 ounds can assist in creation of high-quality chemical libraries for drug screening and in application

86 rgy transfer and have screened combinatorial chemical libraries for inhibitors of dimerization.

87 hese two strains may be useful for screening chemical libraries for Nmt-based fungicidal compounds wi

88 regulation may be advantageous for screening chemical libraries for novel antineoplastic candidates t

89 have the specificity required for screening chemical libraries for novel protease inhibitors in a hi

90 opment of new databases, software tools, and chemical libraries for the food metabolome; and shared r

91 eat promise for high-throughput screening of chemical libraries for unknown activators, inhibitors, o

92 ules involved in cardiac fate by screening a chemical library for activators of the signature gene Nk

93 eening assay to interrogate a 1,200-compound chemical library for anti-HCV activity, we identified a

94 virus type A were identified by screening a chemical library for antiviral activity.

95 be a protocol for screening compounds from a chemical library for effects on early zebrafish developm

96 d assay was used to screen a 10,000-compound chemical library for ER agonists.

97 We evaluated a chemical library for its potential to induce cardiac dif

98 ing of organic compounds generates a focused chemical library for multiple biological effects that ar

99 To this end, we screened a chemical library for new anticancer agents and identifie

100 ned more than 8000 compounds in the DIVERSet chemical library for repressors of a matrix metalloprote

101 reveal this mechanism, we screened a diverse chemical library for small molecules capable of restorin

102 ll zebrafish, we have screened the Prestwick chemical library for small molecules that modulate the m

103 By screening a chemical library for the compounds protecting cells from

104 t mass screening assay and used it to screen chemical library for Wee1 inhibitors.

105 ric modulators as safer antiobesity drugs, a chemical library from Vivia Biotech was screened using E

106 ssay allowed rapid screening of a 500 member chemical library from which several new inhibitors of to

107 wed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through th

108 accurately profiling every compound in large chemical libraries (>10(5) compounds).

109 Empirical screening of small-molecule chemical libraries has thus far failed to provide succes

110 High-throughput screening of combinatorial chemical libraries identified triazaspirodimethoxybenzoy

111 High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid

112 o determine the composition of combinatorial chemical libraries in a quantitative manner, determining

113 -throughput screening of large combinatorial chemical libraries in biochemical assays will benefit fr

114 imental platform can be used to screen large chemical libraries in search of novel compounds to repla

115 ts in human cells, we screened the Prestwick chemical library in a moderately high-throughput assay a

116 bility assays were performed to evaluate the chemical library in a normal cell line and a panel of ca

117 led by a high-throughput screen of a diverse chemical library in a panel of human cancer cell lines c

118 HTS of a 30,176 small-molecule chemical library in cell culture identified a compound,

119 High-throughput screening (HTS) of chemical libraries is indispensable for drug discovery r

120 In these screens, each small molecule from a chemical library is applied to each cell type from a lib

121 Screening for novel anticancer drugs in chemical libraries isolated from marine organisms, we id

122 Applied to a chemical library, it showed a good hit-to-lead ratio and

123 itutes of Health, Developmental Therapeutics chemical library, leading to the identification of two n

124 l cells with a secondary structure-templated chemical library, looking for compounds that inhibit a b

125 As a result of the increasing size of chemical libraries, more rapid and highly sensitive stra

126 Small chemical libraries of 5'-modified oligonucleotides beari

127 To characterize combinatorial chemical libraries of small drug compounds, an automated

128 ur assay is well-suited for the screening of chemical libraries of SphK inhibitors.

129 studies involving screening of comprehensive chemical libraries of synthetic inhibitors.

130 in signal intensity as a readout to screen a chemical library of 16,320 compounds and identified two

131 and uncover novel TLR2 agonists, a synthetic chemical library of 24,000 compounds was screened using

132 ed activity and substrate promiscuity over a chemical library of 313 ncAAs.

133 ghly sensitive and reproducible: screening a chemical library of 6280 compounds identified three nove

134 We used this system to screen a chemical library of 704 compounds against protein tyrosi

135 A unique chemical library of approximately 51,000 compounds was c

136 Institutes of Health Clinical Collection, a chemical library of bioavailable drugs considered clinic

137 icomponent reactions, we developed a focused chemical library of bromodomain inhibitors around a 3,5-

138 o generate all conceivable MOFs from a given chemical library of building blocks (based on the struct

139 The compounds were discovered by screening a chemical library of compounds for blocking of entry of H

140 inverse agonists through the screening of a chemical library of drug-like small-molecule entities.

141 Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynth

142 We screened a chemical library of marine organism-derived extracts and

143 e-linked immunosorbent assay, we evaluated a chemical library of over 80,000 compounds for their capa

144 s efficient N-heteroarylation leads to (i) a chemical library of putative peptidomimetics combining d

145 In this report, we screened a chemical library of small molecules and identified numer

146 luciferase-based high-throughput screen to a chemical library of small-molecule compounds in order to

147 st cells loaded with BCECF to screen a small chemical library of structurally diverse compounds to id

148 ments for activity by synthesizing a focused chemical library of substituted pyrazolines.

149 The screening of the ICSN chemical library on various disease-relevant protein kin

150 pplications for high throughout screening of chemical libraries or natural product extracts.

151 Chemical libraries paired with phenotypic screens can no

152 s from the array in parallel against a large chemical library permitted identification of new inhibit

153 ISA screening, carried out on the Prestwick Chemical Library(R) (1120 compounds), identified 36 comp

154 Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task

155 Both methods allow for in vivo screening of chemical libraries, requiring only 0.1 mumol of drug per

156 hermal denaturation assay was used to screen chemical libraries, resulting in the discovery of a nove

157 Our screening of chemical libraries revealed that N-alkyl 5-arylidene-2-t

158 on, including a new compound identified in a chemical library screen and a combination regimen of an

159 Previously, a chemical library screen identified inhibitors of LRRK2 k

160 We conducted a chemical library screen to identify nontoxic AhR ligands

161 , we report the outcome of a high-throughput chemical library screen to identify small-molecule compo

162 ormed an unbiased cell-based high-throughput chemical library screen using NF1-deficient malignant pe

163 2 activators in keratinocytes, we combined a chemical library screen with computer-based virtual scre

164 By performing a chemical library screen, we identified histone deacetyla

165 Through a chemical library screen, we identified the anti-parasiti

166 ntegrated with results from a small-molecule chemical library screen.

167 novel regulators of Tau phosphorylation in a chemical library screen.

168 may significantly enhance the reliability of chemical library screening and identify false positives

169 Our study demonstrates that chemical library screening combined with advanced comput

170 ffective molecular filter during the virtual chemical library screening process to select molecules w

171 Using high-throughput chemical library screening targeting Orai1, we identifie

172 rate-limiting step that hampers large-scale chemical library screening to identify novel small-molec

173 Based on these results, we used DNA-encoded chemical library screening to identify starting points f

174 Chemical library screening was used to identify hit comp

175 st-effective approach, in which leads from a chemical library screening were analyzed and computation

176 By chemical library screening, we identified suberoylanilid

177 cyclin D genes we conducted high-throughput chemical library screens for compounds that induce suppr

178 By iterating chemical library synthesis and biological screening, pot

179 several novel products of the combinatorial chemical library synthesis with EC(50)s between 10 and 1

180 vivo models, and the design of "a-la-carte" chemical libraries tailored for individual kinases.

181 A chemical library targeting a novel hydrophobic pocket in

182 eutical discovery relies on the screening of chemical libraries that are as diverse as possible yet c

183 e universe, and it facilitates the mining of chemical libraries that do not yet exist, providing a ne

184 iscovery is the construction of high quality chemical libraries that generate bioactive molecules at

185 were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, a

186 An annotated chemical library, the library of pharmacologically activ

187 issed, increasing the hit frequency from the chemical library three-fold.

188 er potential heteroactivators from a virtual chemical library through efficient sorting of >40,000 co

189 , highlighting the power of relatively small chemical libraries to accelerate gene discovery and dise

190 as a preamble for the construction of large chemical libraries to be synthesized under the same cond

191 is platform may also be useful for screening chemical libraries to discover new antibiotics that evad

192 le hypothesis is then used to search virtual chemical libraries to identify compounds for synthesis.

193 ased assays for high throughput screening of chemical libraries to identify MDMX inhibitors and ident

194 often used for high throughput screening of chemical libraries to identify new receptor ligands.

195 s antagonists of various GPCRs by subjecting chemical libraries to in silico docking in the X-ray str

196 dels and using them for virtual screening of chemical libraries to prioritize the compound selection

197 docking program to screen a large "druglike" chemical library to define small molecules capable of oc

198 ployed structure-based design with a focused chemical library to discover specific MRE11 endo- or exo

199 s we conducted a high-throughput screen of a chemical library to search for compounds that acidify th

200 perform a large high-throughput screen of a chemical library to successfully identify and characteri

201 Several chemical libraries totaling more than 106,000 compounds

202 The generation of diverse chemical libraries using the "libraries from libraries"

203 By screening a chemical library using a cell-based assay for inhibition

204 Screening of our chemical library using a rat corticotropin-releasing hor

205 esent the results of screening the Prestwick Chemical Library using a recently developed assay for th

206 ) assay was screened against a 69,137-member chemical library using quantitative high-throughput scre

207 ected high throughput screening of a defined chemical library utilizing an hPR-B cotransfection assay

208 have accomplished the synthesis of a complex chemical library via elaboration of angular epoxyquinol

209 A cell-based screen of chemical libraries was carried out to identify small mol

210 protease identified by random screening of a chemical library was 1,4-dihydro-7,8-dimethyl 6H-pyrimid

211 ning the mechanism(s) of AFABP/aP2 action, a chemical library was screened and identified 1 (HTS01037

212 fy small molecules promoting this process, a chemical library was screened by using a myeloid leukemi

213 nd using a cell-based reporter gene assay, a chemical library was screened for K6a inhibitors.

214 at can induce beta-cell replication, a large chemical library was screened for proliferation of growt

215 A systematic screen of the chemical library was then performed, using luciferase ac

216 High-throughput screening of a large chemical library was used to identify new ligands for fi

217 After screening the small molecule chemical libraries, we have obtained a compound (5,8-dia

218 By screening chemical libraries, we identified the CapD inhibitor cap

219 By screening a chemical library, we find that the natural product tanni

220 high-throughput in vitro mass screen of our chemical library, we identified 4-[5-[(2R,6S)-2, 6-dimet

221 ational Cancer Institute (NCI) Diversity Set chemical library, we identified 8-hydroxy-7-(6-sulfonaph

222 ning a large (approximately 40,000-compound) chemical library, we identified a noncytotoxic inhibitor

223 ographic data and the virtual screening of a chemical library, we identified a set of heterocyclic sm

224 By screening a 9600-compound chemical library, we identified a small molecule [5-(3,4

225 In an initial screening of a chemical library, we identified a synthetic compound who

226 In screening a small chemical library, we identified compounds that suppress

227 Through screening of a chemical library, we initially identified the [2,3-d]pyr

228 Here, from an uncharacterized chemical library, we isolated a structurally new compoun

229 high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to t

230 Focused chemical libraries were designed and assessed for inhibi

231 In this study, chemical libraries were screened for modulators of ATF4

232 Chemical libraries were screened for NF-kappa B-inhibito

233 gous to compounds derived from combinatorial chemical libraries which have specific binding or inhibi

234 identified by high-throughput screening of a chemical library, which contained 220,000 drug-like mole

235 n efficient strategy to a skeletally diverse chemical library, which entailed a sequence of enyne cyc

236 means to increase structural diversity in a chemical library while maintaining a bias toward compoun

237 ism that high-throughput screenings of large chemical libraries will produce a new generation of anti

238 creening step comprised the exploration of a chemical library with 11,000 compounds that were docked

239 bstrate could also be used for the screening chemical library with high accuracy and with a Z' value

240 to a screening campaign to assess a diverse chemical library with over 142,000 entries.

241 ed binding modes and analogs from commercial chemical libraries yielded nanomolar inhibitors.

242 Medium-size chemical libraries yielded new specific inhibitors of hu

243 10,000 small molecules from a combinatorial chemical library yielded 42 potential Kir2.1 inhibitors.

244 n assay-based high throughput screening of a chemical library yielded several small molecule antagoni