ライフサイエンスコーパス: chemical library

1 step in drug discovery is the screening of a chemical library.

2 riments for metabolites not available in our chemical library.

3 was demonstrated by screening the Prestwick Chemical Library.

4 d via high-throughput screening of a diverse chemical library.

5 d via high-throughput screening of a diverse chemical library.

6 random search through a large pre-fabricated chemical library.

7 o examine any set of proposed molecules in a chemical library.

8 culture system to screen an uncharacterized chemical library.

9 Wee1-luciferase, to screen a kinase-directed chemical library.

10 nstructed a 9.8-million-membered DNA-encoded chemical library.

11 ng methods were applied, together with large chemical libraries.

12 put in silico screening of large and diverse chemical libraries.

13 ed a cell-based high-throughput screening of chemical libraries.

14 irtual screening to identify true binders in chemical libraries.

15 eta17-40 peptide by screening two commercial chemical libraries.

16 generate pseudotype viruses for screening of chemical libraries.

17 of high-throughput target-based screening of chemical libraries.

18 l inhibitors despite availability of diverse chemical libraries.

19 ethod's applicability to hit triage in large chemical libraries.

20 biological activities associated with large chemical libraries.

21 or structure-based focusing of combinatorial chemical libraries.

22 nding, structurally varied series of organic chemical libraries.

23 inal chemists from random screening of large chemical libraries.

24 ing high-throughput screens of combinatorial chemical libraries.

25 oncentrations from screening of the in-house chemical libraries.

26 imized via solid-phase parallel synthesis of chemical libraries.

27 cal assays and imaging of spatially resolved chemical libraries.

28 ss in this endeavor lies in sampling diverse chemical libraries.

29 f biologically active compounds from complex chemical libraries.

30 so report problems that arise when screening chemical libraries.

31 dentifying leads from the screening of large chemical libraries.

32 tors has been to screen large to medium-size chemical libraries.

33 assay for high-throughput screening (HTS) of chemical libraries.

34 ow throughput and cannot be applied to large chemical libraries.

35 nerate concentration-response data for large chemical libraries.

36 computer-aided drug design (CADD) screens of chemical libraries.

37 analyze and visualize the results of HTS of chemical libraries.

38 For quality control of chemical libraries, 1D NMR spectra are acquired under fu

39 We screened the Tox21 chemical library (8,305 unique structures) in a quantita

40 lowing a high throughput screen of a diverse chemical library, a structure-activity relationship stud

41 We found that screening chemical libraries across neuroblastoma (NBL) tumor subt

42 phenotypic screening of natural products or chemical libraries against established cancer cell lines

43 We screened a chemical library against CQ(s) and CQ(r) lines and disco

44 A screening of our in-house chemical library against poliovirus Sabin strains led to

45 We apply this method to screen a chemical library against protease activity of anthrax le

46 del organism assays to interrogate important chemical libraries and computationally analyze bioactivi

47 of gamma-secretase specificity, we screened chemical libraries and consequently developed a di-couma

48 Although a number of chemical libraries and databases contain dietary phytoch

49 We performed predictions on multiple chemical libraries and discovered a molecule from the Dr

50 ghput screening of commercial and 'in-house' chemical libraries and modification of promising hits.

51 Recent work leveraging a large in silico chemical library and a rapid in vivo screen has expanded

52 By screening a small molecule chemical library and chemical optimization, we identifie

53 Using this platform, we screened a pilot chemical library and found five new inhibitors of DnaK a

54 vation, we performed a random screening of a chemical library and identified 3 compounds (JH1, JH4, a

55 Using this pharmacophore, we screened a chemical library and were able to identify novel cationi

56 Using this technology, we screened a chemical library, and identified novel histone deacetyla

57 plementary approaches-one an assessment of a chemical library, and the other a genome-wide CRISPR scr

58 DNA-encoded chemical libraries are collections of compounds individu

59 DNA-encoded chemical libraries are increasingly used in pharmaceutic

60 cal target-based drug discovery, where large chemical libraries are screened using inhibitory assays

61 pase-8 cleavage, we screened a subset of the chemical library at the Harvard NeuroDiscovery Center's

62 Focused chemical libraries based on a plethora of scaffolds have

63 ation, we performed a screening of a defined chemical library based on proliferation of mouse pluripo

64 By selection from a two million entry chemical library based on the efficacy and safety, we id

65 ng compound collections, the design of novel chemical libraries biased towards allosteric regulators

66 cific inhibitors, identified by screening of chemical libraries, blocked parasite invasion of host er

67 eir DRBDs using high-throughput screening of chemical libraries by homogeneous time-resolved fluoresc

68 , high-throughput screening was performed on chemical libraries by using fluorescence resonance energ

69 dentified from the National Cancer Institute chemical libraries by using structure-based virtual scre

70 dentification of a lead compound from a vast chemical library by any number of screening techniques.

71 was identified as the result of screening a chemical library by using a whole-virus infected-cell as

72 red whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achiev

73 mentary approach is virtual screening, where chemical libraries can be efficiently screened against p

74 bicity index (CHI) on a subset of the French chemical library Chimiotheque Nationale (CN).

75 In drug discovery, chemical library compounds are usually dissolved in DMSO

76 ere then used in the de novo design of seven chemical libraries consisting of 20-50 compounds each.

77 ialkylamino-2,4-dinitrobenzene combinatorial chemical library consisting of 155 parental amines and u

78 as preliminarily demonstrated by screening a chemical library consisting of 31 compounds against c-Ab

79 We screened a chemical library constructed using a hybrid approach tha

80 and stereochemical outcomes of reactions in chemical library construction.

81 by parallel synthesis of two representative chemical libraries containing 847 compounds with favorab

82 have enabled researchers to generate virtual chemical libraries containing billions of molecules.

83 the synthesis and screening of a DNA-encoded chemical library containing 76230 compounds.

84 When a chemical library containing approximately 1200 off-paten

85 d new inhibitors for use in human therapy, a chemical library containing highly diverse chemical stru

86 the UCSF DOCK 6.1 program suite and the NCI chemical library database.

87 DNA-Encoded Chemical Library (DECL) screening provided two novel che

88 DNA-encoded chemical library (DECL) technology has emerged as a new

89 In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable a

90 of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do s

91 DNA-encoded chemical libraries (DELs) consist of large chemical comp

92 DNA encoded chemical libraries (DELs) link the powers of genetics an

93 "Liability Predictor" may be used as part of chemical library design or for triaging HTS hits.

94 ography, structure-based design, and focused chemical library design were used to identify novel inhi

95 property ranges generally guide DNA-encoded chemical library design, recent reports have highlighted

96 p) became the basis for a series of parallel chemical libraries designed to generate SAR data.

97 concentrations of the solvent used for many chemical libraries did not interfere with the assay.

98 esigns may not exploit the full potential of chemical libraries due to false negatives.

99 accelerate virtual screening of ultra-large chemical libraries, enabling the evaluation of billions

100 To this end, we have developed the in silico chemical library engine (ISiCLE), a high-performance com

101 generate highly focused subsets of the input chemical library, enriched 33- to 100-fold for all but o

102 We screened a chemical library focused on the ZnF-UBD of USP5, crystal

103 imilar regions using in silico searches of a chemical library, followed by cell-based biological assa

104 arget for compounds found by screening large chemical libraries for a desired biological effect and,

105 By screening chemical libraries for BMP-2 mimics using a cell-based a

106 Our approach of screening chemical libraries for compounds causing synthetic genet

107 s study set the stage for screening of large chemical libraries for discovery of novel compounds that

108 is suitable for high-throughput screening of chemical libraries for DNMT inhibition activity.

109 nucleic acids, high-throughput screening of chemical libraries for drug discovery, and DNA amplifica

110 ounds can assist in creation of high-quality chemical libraries for drug screening and in application

111 rgy transfer and have screened combinatorial chemical libraries for inhibitors of dimerization.

112 y lack the throughput needed to screen large chemical libraries for interactions across the proteome.

113 hese two strains may be useful for screening chemical libraries for Nmt-based fungicidal compounds wi

114 regulation may be advantageous for screening chemical libraries for novel antineoplastic candidates t

115 have the specificity required for screening chemical libraries for novel protease inhibitors in a hi

116 vitro have laid the groundwork for screening chemical libraries for PSD inhibitors.

117 opment of new databases, software tools, and chemical libraries for the food metabolome; and shared r

118 eat promise for high-throughput screening of chemical libraries for unknown activators, inhibitors, o

119 ules involved in cardiac fate by screening a chemical library for activators of the signature gene Nk

120 eening assay to interrogate a 1,200-compound chemical library for anti-HCV activity, we identified a

121 virus type A were identified by screening a chemical library for antiviral activity.

122 be a protocol for screening compounds from a chemical library for effects on early zebrafish developm

123 d assay was used to screen a 10,000-compound chemical library for ER agonists.

124 We evaluated a chemical library for its potential to induce cardiac dif

125 ing of organic compounds generates a focused chemical library for multiple biological effects that ar

126 To this end, we screened a chemical library for new anticancer agents and identifie

127 ned more than 8000 compounds in the DIVERSet chemical library for repressors of a matrix metalloprote

128 reveal this mechanism, we screened a diverse chemical library for small molecules capable of restorin

129 ll zebrafish, we have screened the Prestwick chemical library for small molecules that modulate the m

130 By screening a chemical library for the compounds protecting cells from

131 t mass screening assay and used it to screen chemical library for Wee1 inhibitors.

132 ric modulators as safer antiobesity drugs, a chemical library from Vivia Biotech was screened using E

133 ssay allowed rapid screening of a 500 member chemical library from which several new inhibitors of to

134 wed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through th

135 accurately profiling every compound in large chemical libraries (>10(5) compounds).

136 Empirical screening of small-molecule chemical libraries has thus far failed to provide succes

137 Industry screens of large chemical libraries have traditionally relied on rich med

138 Thus, structurally focused DNA-encoded chemical libraries have tremendous potential to find cli

139 hods to study the effects of RNAi, cDNA, and chemical libraries, have evolved to encompass a larger b

140 As applied to chemical library high throughput screening, we can obser

141 High-throughput screening of combinatorial chemical libraries identified triazaspirodimethoxybenzoy

142 High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid

143 o determine the composition of combinatorial chemical libraries in a quantitative manner, determining

144 -throughput screening of large combinatorial chemical libraries in biochemical assays will benefit fr

145 dvances in the generation and use of virtual chemical libraries in medicinal chemistry.

146 imental platform can be used to screen large chemical libraries in search of novel compounds to repla

147 ts in human cells, we screened the Prestwick chemical library in a moderately high-throughput assay a

148 bility assays were performed to evaluate the chemical library in a normal cell line and a panel of ca

149 led by a high-throughput screen of a diverse chemical library in a panel of human cancer cell lines c

150 HTS of a 30,176 small-molecule chemical library in cell culture identified a compound,

151 High-throughput screening (HTS) of chemical libraries is indispensable for drug discovery r

152 In these screens, each small molecule from a chemical library is applied to each cell type from a lib

153 Screening for novel anticancer drugs in chemical libraries isolated from marine organisms, we id

154 Applied to a chemical library, it showed a good hit-to-lead ratio and

155 itutes of Health, Developmental Therapeutics chemical library, leading to the identification of two n

156 l cells with a secondary structure-templated chemical library, looking for compounds that inhibit a b

157 n "unbiased" and "kinase-biased" DNA-encoded chemical library molecules, we identified hits CDD-1115

158 As a result of the increasing size of chemical libraries, more rapid and highly sensitive stra

159 Small chemical libraries of 5'-modified oligonucleotides beari

160 To characterize combinatorial chemical libraries of small drug compounds, an automated

161 ur assay is well-suited for the screening of chemical libraries of SphK inhibitors.

162 studies involving screening of comprehensive chemical libraries of synthetic inhibitors.

163 in signal intensity as a readout to screen a chemical library of 16,320 compounds and identified two

164 A chemical library of 160 million compounds was computatio

165 onic acid derivative 1 was identified from a chemical library of 20 000 compounds, by performing a ce

166 and uncover novel TLR2 agonists, a synthetic chemical library of 24,000 compounds was screened using

167 ed activity and substrate promiscuity over a chemical library of 313 ncAAs.

168 ghly sensitive and reproducible: screening a chemical library of 6280 compounds identified three nove

169 We used this system to screen a chemical library of 704 compounds against protein tyrosi

170 A unique chemical library of approximately 51,000 compounds was c

171 Institutes of Health Clinical Collection, a chemical library of bioavailable drugs considered clinic

172 icomponent reactions, we developed a focused chemical library of bromodomain inhibitors around a 3,5-

173 o generate all conceivable MOFs from a given chemical library of building blocks (based on the struct

174 The compounds were discovered by screening a chemical library of compounds for blocking of entry of H

175 inverse agonists through the screening of a chemical library of drug-like small-molecule entities.

176 Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynth

177 We screened a chemical library of marine organism-derived extracts and

178 e-linked immunosorbent assay, we evaluated a chemical library of over 80,000 compounds for their capa

179 s efficient N-heteroarylation leads to (i) a chemical library of putative peptidomimetics combining d

180 In this report, we screened a chemical library of small molecules and identified numer

181 By screening a chemical library of small molecules, a series of structu

182 luciferase-based high-throughput screen to a chemical library of small-molecule compounds in order to

183 st cells loaded with BCECF to screen a small chemical library of structurally diverse compounds to id

184 ments for activity by synthesizing a focused chemical library of substituted pyrazolines.

185 The screening of the ICSN chemical library on various disease-relevant protein kin

186 pplications for high throughout screening of chemical libraries or natural product extracts.

187 Chemical libraries paired with phenotypic screens can no

188 s from the array in parallel against a large chemical library permitted identification of new inhibit

189 hrough systematic drug screening using large chemical libraries provide hope for improvement.

190 ISA screening, carried out on the Prestwick Chemical Library(R) (1120 compounds), identified 36 comp

191 Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task

192 Both methods allow for in vivo screening of chemical libraries, requiring only 0.1 mumol of drug per

193 hermal denaturation assay was used to screen chemical libraries, resulting in the discovery of a nove

194 Our screening of chemical libraries revealed that N-alkyl 5-arylidene-2-t

195 on, including a new compound identified in a chemical library screen and a combination regimen of an

196 A chemical library screen identified Am80, a synthetic, no

197 Previously, a chemical library screen identified inhibitors of LRRK2 k

198 in the use of targeted drugs, we performed a chemical library screen to identify drug sensitivities i

199 We conducted a chemical library screen to identify nontoxic AhR ligands

200 , we report the outcome of a high-throughput chemical library screen to identify small-molecule compo

201 ormed an unbiased cell-based high-throughput chemical library screen using NF1-deficient malignant pe

202 2 activators in keratinocytes, we combined a chemical library screen with computer-based virtual scre

203 By performing a chemical library screen, we identified histone deacetyla

204 Through a chemical library screen, we identified the anti-parasiti

205 novel regulators of Tau phosphorylation in a chemical library screen.

206 ntegrated with results from a small-molecule chemical library screen.

207 may significantly enhance the reliability of chemical library screening and identify false positives

208 We used a chemical library screening approach to demonstrate that

209 Our study demonstrates that chemical library screening combined with advanced comput

210 say system with applications to high-content chemical library screening of new antiplatelet therapies

211 ffective molecular filter during the virtual chemical library screening process to select molecules w

212 Using high-throughput chemical library screening targeting Orai1, we identifie

213 We employed chemical library screening to identify and optimize meth

214 rate-limiting step that hampers large-scale chemical library screening to identify novel small-molec

215 Based on these results, we used DNA-encoded chemical library screening to identify starting points f

216 Chemical library screening was used to identify hit comp

217 st-effective approach, in which leads from a chemical library screening were analyzed and computation

218 By chemical library screening, we identified suberoylanilid

219 -infections and holds promise for performing chemical library screens and improving our understanding

220 cyclin D genes we conducted high-throughput chemical library screens for compounds that induce suppr

221 HT (high-throughput), and DECL (DNA-encoded chemical library) screens offered means to evaluate larg

222 struction of selenium-containing DNA-encoded chemical libraries (SeDELs), and lays the foundation for

223 pilot hit-finding campaign using DNA-encoded chemical library selection followed by machine learning

224 By iterating chemical library synthesis and biological screening, pot

225 several novel products of the combinatorial chemical library synthesis with EC(50)s between 10 and 1

226 vivo models, and the design of "a-la-carte" chemical libraries tailored for individual kinases.

227 A chemical library targeting a novel hydrophobic pocket in

228 this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-l

229 ed to dramatically increase the diversity of chemical libraries tested and get outside of the histori

230 identify substrates of P-gp from a series of chemical libraries, testing a total of 10,804 compounds,

231 eutical discovery relies on the screening of chemical libraries that are as diverse as possible yet c

232 ghlighted the utility of focused DNA-encoded chemical libraries that are structurally biased for a cl

233 e universe, and it facilitates the mining of chemical libraries that do not yet exist, providing a ne

234 iscovery is the construction of high quality chemical libraries that generate bioactive molecules at

235 were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, a

236 tified 17 of 1280 compounds in the Prestwick Chemical Library that could suppress seizures.

237 An annotated chemical library, the library of pharmacologically activ

238 issed, increasing the hit frequency from the chemical library three-fold.

239 er potential heteroactivators from a virtual chemical library through efficient sorting of >40,000 co

240 , highlighting the power of relatively small chemical libraries to accelerate gene discovery and dise

241 as a preamble for the construction of large chemical libraries to be synthesized under the same cond

242 is platform may also be useful for screening chemical libraries to discover new antibiotics that evad

243 le hypothesis is then used to search virtual chemical libraries to identify compounds for synthesis.

244 ased assays for high throughput screening of chemical libraries to identify MDMX inhibitors and ident

245 often used for high throughput screening of chemical libraries to identify new receptor ligands.

246 s antagonists of various GPCRs by subjecting chemical libraries to in silico docking in the X-ray str

247 dels and using them for virtual screening of chemical libraries to prioritize the compound selection

248 docking program to screen a large "druglike" chemical library to define small molecules capable of oc

249 ployed structure-based design with a focused chemical library to discover specific MRE11 endo- or exo

250 rformed high-throughput screening (HTS) of a chemical library to identify binders of mircoRNA-15b whi

251 s we conducted a high-throughput screen of a chemical library to search for compounds that acidify th

252 perform a large high-throughput screen of a chemical library to successfully identify and characteri

253 Several chemical libraries totaling more than 106,000 compounds

254 of false positive results, depending on the chemical library used.

255 The generation of diverse chemical libraries using the "libraries from libraries"

256 By screening a chemical library using a cell-based assay for inhibition

257 Screening of our chemical library using a rat corticotropin-releasing hor

258 esent the results of screening the Prestwick Chemical Library using a recently developed assay for th

259 ) assay was screened against a 69,137-member chemical library using quantitative high-throughput scre

260 ected high throughput screening of a defined chemical library utilizing an hPR-B cotransfection assay

261 have accomplished the synthesis of a complex chemical library via elaboration of angular epoxyquinol

262 A cell-based screen of chemical libraries was carried out to identify small mol

263 protease identified by random screening of a chemical library was 1,4-dihydro-7,8-dimethyl 6H-pyrimid

264 Herein, a protease-focused DNA-encoded chemical library was designed that utilizes chemotypes k

265 ning the mechanism(s) of AFABP/aP2 action, a chemical library was screened and identified 1 (HTS01037

266 fy small molecules promoting this process, a chemical library was screened by using a myeloid leukemi

267 lastoma cell line, Neuro-2a, the ToxCast(TM) chemical library was screened for compounds that impact

268 nd using a cell-based reporter gene assay, a chemical library was screened for K6a inhibitors.

269 at can induce beta-cell replication, a large chemical library was screened for proliferation of growt

270 A systematic screen of the chemical library was then performed, using luciferase ac

271 High-throughput screening of a large chemical library was used to identify new ligands for fi

272 After screening the small molecule chemical libraries, we have obtained a compound (5,8-dia

273 By screening chemical libraries, we identified the CapD inhibitor cap

274 By screening a chemical library, we find that the natural product tanni

275 high-throughput in vitro mass screen of our chemical library, we identified 4-[5-[(2R,6S)-2, 6-dimet

276 ational Cancer Institute (NCI) Diversity Set chemical library, we identified 8-hydroxy-7-(6-sulfonaph

277 ning a large (approximately 40,000-compound) chemical library, we identified a noncytotoxic inhibitor

278 ographic data and the virtual screening of a chemical library, we identified a set of heterocyclic sm

279 By screening a 9600-compound chemical library, we identified a small molecule [5-(3,4

280 In an initial screening of a chemical library, we identified a synthetic compound who

281 In screening a small chemical library, we identified compounds that suppress

282 Through screening of a chemical library, we initially identified the [2,3-d]pyr

283 Here, from an uncharacterized chemical library, we isolated a structurally new compoun

284 high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to t

285 Focused chemical libraries were designed and assessed for inhibi

286 In this study, chemical libraries were screened for modulators of ATF4

287 Chemical libraries were screened for NF-kappa B-inhibito

288 gous to compounds derived from combinatorial chemical libraries which have specific binding or inhibi

289 identified by high-throughput screening of a chemical library, which contained 220,000 drug-like mole

290 n efficient strategy to a skeletally diverse chemical library, which entailed a sequence of enyne cyc

291 means to increase structural diversity in a chemical library while maintaining a bias toward compoun

292 ism that high-throughput screenings of large chemical libraries will produce a new generation of anti

293 creening step comprised the exploration of a chemical library with 11,000 compounds that were docked

294 bstrate could also be used for the screening chemical library with high accuracy and with a Z' value

295 to a screening campaign to assess a diverse chemical library with over 142,000 entries.

296 ed binding modes and analogs from commercial chemical libraries yielded nanomolar inhibitors.

297 Medium-size chemical libraries yielded new specific inhibitors of hu

298 10,000 small molecules from a combinatorial chemical library yielded 42 potential Kir2.1 inhibitors.

299 High-throughput screening of a chemical library yielded a small molecule inhibitor of N

300 n assay-based high throughput screening of a chemical library yielded several small molecule antagoni