ライフサイエンスコーパス: chemical modification

1 er state (MLCT) energetics are tuned through chemical modification.

2 eractions without any protein engineering or chemical modification.

3 ition of Cu(2+) without the need for further chemical modification.

4 rease in the canonical nucleoside undergoing chemical modification.

5 R due to their poor swelling ability without chemical modification.

6 he macromolecule more accessible for further chemical modification.

7 the drugs or the carrier nanoparticle to any chemical modification.

8 terogeneous conjugates formed by nonspecific chemical modification.

9 was dependent on the kind of starch and its chemical modification.

10 ), is performed using neat sulfatide without chemical modification.

11 tion (P320C) were also light sensitive after chemical modification.

12 ytic susceptibility but does not lead to CTT chemical modification.

13 from those formed on surfaces with different chemical modification.

14 -translational processes such as folding and chemical modification.

15 a low immunogenicity and finally an ease of chemical modification.

16 cluding internalization, hydrophobicity, and chemical modification.

17 he part of the antigen that is stabilized by chemical modification.

18 l) pentacene (TIPS-Pn), without the need for chemical modifications.

19 ed mainly through irreversible structural or chemical modifications.

20 ich the 3 and 3' positions are available for chemical modifications.

21 led carbon nanotubes (MWCNTs) with different chemical modifications.

22 us glycoconjugates with most sugar types and chemical modifications.

23 cific protein and ligand binding events, and chemical modifications.

24 and the ways of modulating it by introducing chemical modifications.

25 Nucleic acids undergo naturally occurring chemical modifications.

26 ergo numerous posttranscriptional nucleotide chemical modifications.

27 etic short interfering RNAs (siRNAs) require chemical modifications.

28 RNA contains over 150 types of chemical modifications.

29 ance and stoichiometry of post-translational chemical modifications across temporal and steady-state

30 lf-stimulation in rats to understand how the chemical modifications affect abuse liability.

31 ent antitubercular agent, and the subsequent chemical modifications aimed at establishing a prelimina

32 Our results provide the basis for further chemical modifications aimed at identifying novel antitr

33 rRNA chemical modification analyses reveals allosteric intera

34 ally obsolete drugs like kanamycin by simple chemical modification and an alternative strategy for di

35 dicinal chemists have identified a number of chemical modification and conjugation strategies which c

36 a more reproducible bioorthogonal method of chemical modification and facile expression in bacteria,

37 By comparing the voltage dependences of chemical modification and gating charge displacement, he

38 Chemical modification and mutational analyses of the lon

39 Structural variations induced by chemical modification and physical pressure, coupled wit

40 After separate chemical modification and pooling, mixed-modified librar

41 properties and is an excellent candidate for chemical modification and reconfiguration.

42 The precision commonly exercised in their chemical modification and the ability to expand their me

43 s, given numerous advancements made to their chemical modifications and delivery methods.

44 tant to mammalian serum nucleases by various chemical modifications and flanked with a fluorophore an

45 cleic acid binding domains for ASO depend on chemical modifications and further demonstrate how ASO-p

46 t the 5'-position provides limited space for chemical modifications and identify 6ha as a potent wate

47 A combination of chemical modifications and LC-tandem MS was used for the

48 sider formulations as a potential source for chemical modifications and product heterogeneity.

49 epicistrome incorporates tissue-specific DNA chemical modifications and TF-specific chemical sensitiv

50 hylation (2'-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in

51 Through de novo sequencing MS, chemical modification, and mutagenesis, we have pinpoint

52 directed evolution, saturation mutagenesis, chemical modification, and rational drug design to obtai

53 nformation on polymer chain length, possible chemical modifications, and impurities is strongly requi

54 chnical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs

55 eresting hit was taken as starting point for chemical modification applying a ligand-based approach.

56 tructure analysis in which multiple sites of chemical modification are identified in single RNA stran

57 r movement, raising the question of how such chemical modifications are balanced in these essential s

58 Many of the enzymes that add or remove such chemical modifications are known, or might be suspected,

59 ve RNA structure limit drug development, and chemical modifications are necessary.

60 These chemical modifications are prerequisite, sometimes unavo

61 on, transfer into artificial environments or chemical modifications are therefore essential to analyz

62 Here, we perform chemical modifications around the irreversible inhibitor

63 c fibrosis patients, undergoes two different chemical modifications as it is synthesized that alter t

64 including reduced, oxidative, TET-assisted, chemical-modification assisted, and methylase-assisted b

65 Carbohydrates can have various chemical modifications at different positions, making th

66 A number of BVM analogs were synthesized by chemical modifications at the C-28 position to improve i

67 This is due to the broad diversity of chemical modifications available for the enone structura

68 Chemical modifications based on the crystal structure of

69 Eukaryotic mRNA undergoes chemical modification both at the 5' cap and internally.

70 All mutants were inaccessible toward chemical modification by membrane-impermeant MTSET reage

71 dentified sites on PAN either protected from chemical modification by protein binding or characterize

72 the most powerful expressions of how minute chemical modifications can affect electronic devices.

73 Chemical modifications can affect protein binding and un

74 Extrahelical structures and chemical modifications can be inserted at user-defined s

75 ring protein binding of ASOs using different chemical modifications can improve therapeutic performan

76 Chemical modifications can potentially change monoclonal

77 Chemical modifications can potentially induce conformati

78 zymes and substrates in multiple variants of chemical modification cascades.

79 Certain chemical modifications confer increased stability and lo

80 er and the serotonin transporter, and simple chemical modifications considerably alter target selecti

81 Here, we report a chemical modification, consisting of phosphorodithioate

82 Chemical modification did not significantly alter the po

83 This chemical modification drastically reduces the enzymatic

84 atural life is 120days) that are amenable to chemical modifications, drug loading and reinjection.

85 DNA constantly undergoes chemical modification due to endogenous and exogenous mu

86 Certain chemical modifications, e.g., methylation of the Watson-

87 many chemical and biological processes, and chemical modification enables control and modulation of

88 changes are the result of many physical and chemical modifications, especially structural and functi

89 Chemical modification experiments demonstrate that posit

90 ts demonstrate that stabilization of iChS by chemical modifications favors anion channeling at the ex

91 has continuously gained ground as a protein chemical modification, first as a tool to aid protein cr

92 ng from the native RNA structure necessitate chemical modification for drug development.

93 ts, and open up new possibilities of further chemical modification for the growing class of potent pl

94 without having to alter their structure with chemical modifications for conjugation of radiochelators

95 g activity, and we develop an optimal set of chemical modifications for in vivo applications.

96 tes and label their substrates with distinct chemical modifications for target elucidation.

97 One small chemical modification found frequently among pneumococca

98 switch these distortions on and off through chemical modification fundamentally expands the toolbox

99 ication of glycosylation types, sugar types, chemical modifications, glycosidic linkages, and anomeri

100 Gs-BA is not significantly destroyed by this chemical modification; Gs-BA retains the Gs electrical p

101 Although judicious use of chemical modifications has contributed to the success of

102 The tolerance of the gRNA and donor DNA to chemical modifications has the potential to enable new s

103 Over 100 types of chemical modifications have been identified in cellular

104 Chemical modifications have considerably improved oligon

105 The multitude of possible chemical modifications highlights the necessity to obtai

106 of some analytes either due to extraction or chemical modification (i.e., polar metabolites).

107 library for antimitotic activity followed by chemical modification identified 'Dosabulin', which caus

108 We present in-membrane chemical modification (IMCM) for obtaining selective chr

109 Ile-16 is significantly less protected from chemical modification in G221E than in wild-type HABP2,

110 of the tagged metabolite and its subsequent chemical modification in living culture can be achieved.

111 f peptide Ser-766-Leu-774 was protected from chemical modification in the presence of FVIII.

112 sults expand the role of small molecules and chemical modifications in immunity and underscore the ro

113 These treatments result in chemical modifications in milk proteins, mainly generate

114 cterizing noncanonical nucleobases and other chemical modifications in small RNAs, yielding rich chem

115 ammetry (CV) studies were used to follow the chemical modifications in the Au-SPE.

116 tructure of Ago2 is relatively unaffected by chemical modifications in the bound siRNA.

117 l for complex glycan structures with various chemical modifications in the PDB.

118 ns than did RT-qPCR, suggesting that certain chemical modifications in the RNA were not detected by t

119 ion that glycosyltransferases often tolerate chemical modifications in their sugar nucleotide substra

120 r characterization of post-translational and chemical modifications in therapeutic proteins.

121 thermore, stabilization of wild-type SOD1 by chemical modification including cisplatination, inhibits

122 onoclonal antibodies (mAbs) caused by common chemical modifications including methionine (Met) oxidat

123 oved and now identifies most sugar types and chemical modifications (including various glycolipids) i

124 d by synthetic and hydrolytic enzymes and by chemical modifications, including O-acetylation of MurNA

125 RNAs besides tRNA and rRNA contain chemical modifications, including the recently described

126 Despite the chemical modification increasing the density of the bead

127 The chemical modification induced following treatments and a

128 roNaV2 allows for the assessment of chemical modification induced in fluorescence microscopy

129 approach, we incorporated various non-native chemical modifications into chromatin in vivo with tempo

130 specific sequences, tertiary structures, and chemical modifications into lambda-DNA remains technical

131 l factors, as well as methods to incorporate chemical modifications into sequences, in order to descr

132 ms for RNAi reagent design, incorporation of chemical modifications into siRNAs, and the use of vario

133 Incorporation of chemical modifications into small interfering RNAs (siRN

134 Ps with target-antigens by genetic fusion or chemical modification is time-consuming and often leads

135 biological contributions of these different chemical modifications is beginning to take shape, but i

136 thesis of ribonucleic acids (RNA) with novel chemical modifications is largely driven by the motivati

137 eting PGC-1alpha acetylation in the liver, a chemical modification known to inhibit hepatic gluconeog

138 Incorporation of rational chemical modifications known to protect against nuclease

139 ion, sulfenic acid rapidly undergoes further chemical modification, leading to irreversible protein m

140 Herein, extensive chemical modifications led to the development of a new a

141 Using a combination of chemical modifications, mass spectrometric techniques, s

142 irst in this class, when combined with other chemical modifications may have potential for future PNA

143 licing if applicable, while multiple complex chemical modifications occur throughout the process.

144 gle attachment site on the protein, based on chemical modification of a disulfide bond and pH-control

145 However, the chemical modification of anthocyanins and procyanidins (

146 Well-established techniques for chemical modification of biomolecules will also provide

147 Chemical modification of both the cyclosporine and sangl

148 Yet, chemical modification of complex structures represents a

149 adenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs and is importan

150 We used the reaction for site-specific chemical modification of glyoxyl- and formylglycine-func

151 .2%), hematopoietic development (29.7%), and chemical modification of histones (48.6%).

152 Here, we demonstrate a strategy for the chemical modification of insulin intended to promote bot

153 Here, we combined chemical modification of lysines and multiple-reaction m

154 Methods for direct chemical modification of native RNA would provide an att

155 Targeted chemical modification of peptides and proteins by laser

156 including osmotic disruption of the BBB and chemical modification of prodrugs.

157 enotype that could be reproduced in vitro by chemical modification of protein thiol residues.

158 e roles in biochemistry, including selective chemical modification of proteins and improved oral abso

159 Chemical modification of proteins and peptides represent

160 nally, current delivery strategies involving chemical modification of proteins and use of particle-ba

161 Chemical modification of proteins is an important tool f

162 Chemical modification of proteins is essential for a var

163 Technologies that allow the efficient chemical modification of proteins under mild conditions

164 Posttranscriptional chemical modification of RNA bases is a widespread and p

165 denosine (m(6)A) is a widespread, reversible chemical modification of RNA molecules, implicated in ma

166 he FFPE process results in fragmentation and chemical modification of RNA, rendering it less suitable

167 r RNA therapeutics have shown that judicious chemical modification of RNAs can improve therapeutic ef

168 In the current study, the chemical modification of single wall carbon nanotubes (S

169 The chemical modification of structurally complex fermentati

170 ocesses, independent of oxygen, that lead to chemical modification of the biomolecules, with formatio

171 selectivity than the factors attributable to chemical modification of the catalyst.

172 Covalent and post-translational chemical modification of the chromatin template can sens

173 monomethyl ester is described involving the chemical modification of the commercially available glut

174 eract across very long distances without any chemical modification of the environment.

175 s, without the need for added surfactants or chemical modification of the graphene.

176 Chemical modification of the gRNA and donor DNA has grea

177 MA inhibitor variants showed that systematic chemical modification of the linker has a significant im

178 and pharmacokinetic properties by systematic chemical modification of the linker region.

179 Here, we report that through chemical modification of the linker-drug and antibody en

180 talyzes the reactive oxygen species-mediated chemical modification of the mitochondrial lipid cardiol

181 that leptin analogs can be developed through chemical modification of the native leptin with P85 to o

182 nd potentially spintronic, functionality via chemical modification of the organic ligand.

183 o-tubule transition under the influence of a chemical modification of the polymeric bilayer.

184 Chemical modification of the PP scaffold to increase hal

185 Here, through chemical modification of the primary amines to aromatic

186 glutathione-specific antibody to confirm the chemical modification of the sample surface.

187 parahydrogen and the substrate, the partial chemical modification of the substrate via hydrogen exch

188 hout the need for any base, pretreatment, or chemical modification of the underlying surface.

189 NPs into water-soluble DNA-UCNPs without any chemical modification of UCNPs or oligonucleotides.

190 Chemical modifications of a nicked-site substrate at the

191 helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides.

192 Chemical modifications of components of the bacterial ce

193 discovery in psychiatry has been limited to chemical modifications of compounds originally discovere

194 These programs are carried out through chemical modifications of DNA and proteins such as histo

195 Chemical modifications of DNA have been recognized as ke

196 genetic and environmental effects as stable chemical modifications of DNA.

197 Chemical modifications of gelatin from New Zealand hoki

198 Chemical modifications of histones and nucleic acids con

199 ity to recognize small organic molecules and chemical modifications of host molecules is an essential

200 tant for pan opioid receptor activity, using chemical modifications of key pharmacophoric groups.

201 mtosecond laser pulses to produce controlled chemical modifications of non-photosensitive peptides an

202 Using a series of mutations and chemical modifications of our fluorescent peptide substr

203 Chemical modifications of potentially redox-active amino

204 Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and small nuclear RN

205 Chemical modifications of RNA allow rapid cellular respo

206 Exploiting chemical modifications of silk further modulated the dru

207 y crystallography to study the impact of the chemical modifications of the antigen on type I NKT cell

208 Chemical modifications of the backbone of the nucleic ac

209 omplement proteins, but the effects of small chemical modifications of the capsule on its function ha

210 Here, we prepare several chemical modifications of the carboxyl moiety of CFDA, i

211 neralization exhibit distinct and observable chemical modifications of the collagen prior to the onse

212 nfluences gene function, and is regulated by chemical modifications of the core histone proteins.

213 Remodeling is often mediated through chemical modifications of the DNA template, DNA-associat

214 ere designed using a combination of rational chemical modifications of the endogenous neuropeptide ki

215 On the basis of these findings, specific chemical modifications of the ligand could be shown to y

216 Chemical modifications of the parent scaffold along with

217 Chemical modifications of the pendant side chains do not

218 ation forces for three tip geometries and 18 chemical modifications of the probe surface, and in all

219 Additional chemical modifications of the remaining active surface g

220 ease states, (2) that positions and types of chemical modifications of tRNA-derived RNAs vary by cell

221 gh permeability, processability, and ease of chemical modification offer considerable potential for l

222 Chemical modifications on DNA molecules, such as 5-methy

223 s simulations to identify the time-dependent chemical modifications on GSH and GSSG that are caused b

224 Chemical modifications on protein biopharmaceuticals int

225 thophysiological consequences of HNE-induced chemical modifications on specific target proteins in ce

226 ule acceptors (SMAs) are realized via subtle chemical modifications on strong electron-withdrawing en

227 omers, as well as to establish the effect of chemical modifications on the conformational integrity o

228 to investigate the effects of metabolic and chemical modifications on the estrogenicity of AOH.

229 be used as grown, i.e., they do not require chemical modification or cleanup.

230 nt silver nanoclusters formation without any chemical modification or DNA labeling.

231 All four structures confirm that chemical modification or mutation at this particular cys

232 Chemical modification or radiation can cause DNA damage,

233 These include harsh heat treatments, chemical modifications or biocatalysis.

234 A simple two-step chemical modification process is designed to improve the

235 tumor suppressor protein p53 by mutagenesis, chemical modification, protein-protein interaction, or a

236 electivity, along with the ease in medicinal chemical modification, provides a key opportunity to des

237 Here we explore the chemical modification rates of introduced cysteines alon

238 s spectrometry, CD spectroscopy, and protein chemical modification reactions (protein footprinting).

239 , as well as for the optimization of protein chemical modification reactions.

240 DNA chemical modifications regulate genomic function.

241 act cargo molecules without the necessity of chemical modification, releases them with tissue-penetra

242 eptides, which were linked to biological and chemical modifications representing 523 distinct mass bi

243 s and subsequently creating and guarding the chemical modification responsible for blocking release,

244 The chemical modifications result in favorable changes to th

245 Previous work using limited proteolysis and chemical modification revealed that Redbeta consists of

246 oses and emphasizes more particularly on the chemical modification routes developed so far for their

247 This chemical modification scheme spontaneously forms phospho

248 ts of a complex mixture without resorting to chemical modification, separation, or other perturbation

249 Using a combination of methods including chemical modification, site-directed mutagenesis, and fl

250 ic systems provide an excellent diversity of chemical modifications, stability, controlled release, h

251 ide detailed information about the shape and chemical modification status of genomic DNA.

252 izing proteins typically require physical or chemical modification steps or cannot be used to examine

253 We adjusted the chemical modification strategy to obtain various configu

254 Through a "tag-and-modify" protein chemical modification strategy, we site-selectively phos

255 of a mAb and identified correlations between chemical modification, structure, and function of the th

256 Chemical modification studies confirm the requirement fo

257 Chemical modification studies showed that the enzyme con

258 saccharides that were subjected to selective chemical modifications such as regioselective O- and N-s

259 tic histones carry a diverse set of specific chemical modifications that accumulate over the life-tim

260 at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.

261 The large number of chemical modifications that are found on the histone pro

262 terest, preserving cell- and tissue-specific chemical modifications that are known to affect TF bindi

263 the vast diversity of post-translational and chemical modifications that are unaccounted in a typical

264 on of the mechanism of action, the impact of chemical modifications that stabilize and reduce nonspec

265 These observations enabled the design of chemical modifications that substantially alter a modula

266 Cellular RNAs carry diverse chemical modifications that used to be regarded as stati

267 Although an apparently simple chemical modification, the presence of the 2'OH in RNA h

268 field that are shaping our understanding of chemical modifications, their impact on development and

269 stalline, porous, and accessible for further chemical modification through postsynthetic modification

270 sidues can propagate the molecular impact of chemical modifications throughout a protein and influenc

271 we use a combinatorial approach for covalent chemical modification to generate a large library of var

272 Coupling of structure-specific in vivo chemical modification to next-generation sequencing is t

273 chanisms and; and (iv) it is possible to use chemical modification to optimize ss-siRNA properties an

274 sphorylation assays demonstrate that despite chemical modification to the quinazoline core these prob

275 In this study, we explored the effects of chemical modifications to a natural product macrocycle u

276 very of conjugated siRNAs requires extensive chemical modifications to achieve stability in vivo.

277 , we used peptide design to perform targeted chemical modifications to Ang II to generate conformatio

278 dulate domain communication, suggesting that chemical modifications to carrier proteins during NRPS s

279 Natural RNAs utilize extensive chemical modifications to diversify their structures and

280 Genetic and chemical modifications to plant-generated VLPs serve as

281 netic alphabet but rather by the addition of chemical modifications to proteins associated with the a

282 algorithms and speculate that the ubiquitous chemical modifications to receptors during signaling act

283 unctions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes.

284 gation into the interfacial effects of small chemical modifications to substrate surfaces.

285 d scalable fabrication, high flux, efficient chemical modification, tunable channel size, etc.

286 he structural and functional impact of these chemical modifications underlie these arguments.

287 The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase trunca

288 cesses for prebuilding reporting moieties or chemical modifications using active groups to integrate

289 The behavior of peptides after this chemical modification was simulated at the pH range used

290 Chemical modification was used to quantitatively determi

291 Although many of these chemical modifications were discovered several decades a

292 Chemical modifications were guided by measuring interact

293 Different chemical modifications were made on substrates to provid

294 Acetylation and oxidation are chemical modifications which alter the properties of sta

295 abrupt modulation with increasing degrees of chemical modification, which decreases at first and then

296 Subsequent chemical modification with silanes, followed by the immo

297 as an alternative to either encapsulation or chemical modifications with polymers.

298 side chain, lysine is particularly prone to chemical modifications with the formation of Amadori pro

299 impact on mAb attributes induced by specific chemical modifications within the CDR, hydrogen-deuteriu

300 iscrimination by positional incorporation of chemical modifications within the oligonucleotide to lim