ライフサイエンスコーパス: chemical synthesis

1 nm) of natural collagen are recalcitrant to chemical synthesis.

2 izations of alkenes are highly desirable for chemical synthesis.

3 out homogeneous counterparts for sustainable chemical synthesis.

4 but becomes a disadvantage and challenge in chemical synthesis.

5 alysts are critically needed for sustainable chemical synthesis.

6 er reaction has proven a great challenge for chemical synthesis.

7 aditionally avoided reactive intermediate in chemical synthesis.

8 halides are important C-C bond formations in chemical synthesis.

9 s and allenes, opening new opportunities for chemical synthesis.

10 novel approaches to challenging problems in chemical synthesis.

11 ill provide scalability and availability, is chemical synthesis.

12 lizations known, providing a unique tool for chemical synthesis.

13 hK polypeptide chains were prepared by total chemical synthesis.

14 organoboron species with great potential in chemical synthesis.

15 carbon-heteroatom bond-forming reactions in chemical synthesis.

16 ound them suggested promising candidates for chemical synthesis.

17 d organic building blocks in the large-scale chemical synthesis.

18 r of opportunities in the field of selective chemical synthesis.

19 ly, they present a substantial challenge for chemical synthesis.

20 cules, and they are useful intermediates for chemical synthesis.

21 n product species not directly accessible by chemical synthesis.

22 retical prediction can be tested directly by chemical synthesis.

23 age motif of AlbD with substrates derived by chemical synthesis.

24 sed earth-abundant catalysts for sustainable chemical synthesis.

25 ontaining protein 2 (ATAD2) was targeted for chemical synthesis.

26 Cycloaddition is an essential tool in chemical synthesis.

27 ower of rhodium carbene chemistry in organic chemical synthesis.

28 l gold atoms, created in nanowires by direct chemical synthesis.

29 ns and is expected to lead to novel forms of chemical synthesis.

30 ions is a critical challenge to contemporary chemical synthesis.

31 c character makes them difficult targets for chemical synthesis.

32 s ranging from nuclear magnetic resonance to chemical synthesis.

33 ries of unnatural analogues obtained through chemical synthesis.

34 the scope of aerobic oxidation chemistry in chemical synthesis.

35 (icn-LSMESB) was obtained by conjugated wet-chemical synthesis.

36 convenient approach will find general use in chemical synthesis.

37 arynes, such as indolynes and pyridynes, in chemical synthesis.

38 e knot topologies have been realized through chemical synthesis.

39 challenge that has redirected efforts toward chemical synthesis.

40 itute an important class of intermediates in chemical synthesis.

41 s to achieve different product outcomes from chemical synthesis.

42 is precluded by the impracticality of their chemical synthesis.

43 o(B29)]ester insulin) were prepared by total chemical synthesis.

44 with a series of 4-fluoroprolines via total chemical synthesis.

45 ch involves rather complicated and laborious chemical synthesis.

46 ed from cloned synthase genes or prepared by chemical synthesis.

47 oducts, as well as impurities resulting from chemical synthesis.

48 its effective use as a reducing agent in wet-chemical synthesis.

49 r the evolution (and at times revolution) in chemical synthesis.

50 r of reactivity that governs our approach to chemical synthesis.

51 beled proteins with a minimum of unnecessary chemical synthesis.

52 most synthetic siRNAs have been produced by chemical synthesis.

53 groups is of paramount importance in modern chemical synthesis.

54 le either through biosynthetic precursors or chemical synthesis.

55 oligonucleotide at a fraction of the cost of chemical synthesis.

56 etic materials produced by stereo-controlled chemical synthesis.

57 and catalytic membrane reactors for greener chemical synthesis.

58 rfect example of the intersection of art and chemical synthesis.

59 t, its low reactivity has limited its use in chemical synthesis.

60 natural sources, recombinant expression, or chemical synthesis.

61 poised to realize the potential of solar-to-chemical synthesis.

62 ysts with enormous potential for sustainable chemical synthesis.

63 aximize atom- and step-economy, and simplify chemical synthesis.

64 l main group solid catalysts for sustainable chemical synthesis.

65 ide the inspiration for critical advances in chemical synthesis.

66 new types of one-pot biotransformations for chemical synthesis.

67 oselectivity is of fundamental importance in chemical synthesis.

68 ative fashion is an important goal in modern chemical synthesis.

69 ystems is of utmost importance in nature and chemical synthesis.

70 nce their catalytic performance in fuels and chemicals synthesis.

71 5'pp-RNAs made by in vitro transcription or chemical synthesis, all bind to RIG-I and serve as RIG-I

72 library of thiopeptide analogues produced by chemical synthesis alone, which demonstrates the robustn

73 topologies present an unusual challenge for chemical synthesis and an opportunity for innovation.

74 nfluenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activit

75 For miniaturization and integration of chemical synthesis and analytics on small length scales,

76 g efficient chemical reactions for the total chemical synthesis and assembly of genes and genomes.

77 We describe the in silico design, chemical synthesis and binding analysis of a trivalent g

78 vity relationships, which was facilitated by chemical synthesis and biochemical activity analysis, in

79 Here we report the structure-guided design, chemical synthesis and biological investigations of biva

80 This review focuses on the chemical synthesis and biology of anticancer nucleoside,

81 ucts were unambiguously assigned both by the chemical synthesis and by X-ray structure analysis.

82 We report the chemical synthesis and characterization of 20 new E2-der

83 We first carried out a chemical synthesis and complete spectroscopic structure

84 y synthesized through stringently controlled chemical synthesis and could serve as a new generation o

85 inding useful applications in small-molecule chemical synthesis and detection.

86 ectrides offer physical properties useful in chemical synthesis and electronics.

87 The powerful synergy of chemical synthesis and ENGase-mediated biocatalysis enab

88 The chemical synthesis and functionalization of magnetic and

89 While chemical synthesis and gel or chromatographic purificati

90 for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of singl

91 ific binding of Ts1 toxin to Nav, successful chemical synthesis and labeling of Ts1 toxin provides an

92 loped a potent IRE-1 RNase inhibitor through chemical synthesis and modified the structure to facilit

93 cular machines may have significant roles in chemical synthesis and molecular manufacturing.

94 describe the close connection between novel chemical synthesis and optimized light emission by collo

95 NTES-PF4 heterodimer (termed OPRAH) by total chemical synthesis and oxime ligation, with an accelerat

96 The different steps from chemical synthesis and physicochemical characterization

97 ructurally simpler, making it attractive for chemical synthesis and potential applications in biology

98 emselves valuable chiral building blocks for chemical synthesis and precursors to numerous important

99 s an opportunity to test current methods for chemical synthesis and provides an inspiration for new r

100 tural simplification permitted the expedient chemical synthesis and rapid discovery of MTSB-6, a mito

101 We report here a methodology for chemical synthesis and screening of large combinatorial

102 Recent developments in the area of chemical synthesis and semisynthesis of proteins offer g

103 ure prominently as chiral building blocks in chemical synthesis and serve as precursors to numerous i

104 The simplicity in chemical synthesis and the fungal specific property make

105 of polymers have been used to revolutionize chemical synthesis and the selection of functional nucle

106 By integrating chemical synthesis and two types of O-sulfo transferases

107 o expand the applications of biocatalysis in chemical synthesis and will enhance our understanding of

108 Here, we report the design, chemical synthesis, and biological profiling of natural

109 MF-based applications, including proteomics, chemical synthesis, and clinical diagnostics.

110 cysteine makes the molecule more amenable to chemical synthesis, and coupled with its increased class

111 etry (MS), nuclear magnetic resonance (NMR), chemical synthesis, and MTT (3-(4,5-dimethylthiazol-2-yl

112 e designed CovCore proteins were prepared by chemical synthesis, and their structures were determined

113 The chemical synthesis approach that enables the preparation

114 shown to be superior compared to traditional chemical synthesis approaches, especially in C-O functio

115 Heterologously produced enzymes and chemical synthesis are employed herein to fully reconsti

116 ed extraction from food/non-food sources and chemical synthesis are often expensive, exhaustive, and

117 terpenes obtained from natural sources or by chemical synthesis are often insufficient for large-volu

118 imple hydrocarbons, yet applications to fine chemical synthesis are rare.

119 ted Ser-CCL1 that had been prepared by total chemical synthesis as a homogeneous compound containing

120 es recent advances on use of vinyl azides in chemical synthesis as a radical acceptor and an enamine-

121 alyzed (NHC) transformations are valuable to chemical synthesis, as they can generate high enantiosel

122 amongst which 15 peptides were selected for chemical synthesis based on their predicted ACE-I inhibi

123 atom in a target molecule can complicate its chemical synthesis because of the basicity of nitrogen a

124 Using a combination of chemical synthesis, biological evaluation, molecular dyn

125 pplications in the field of enzyme catalyzed chemical synthesis but also enzyme based fuel cells.

126 -metal catalysis has become indispensable to chemical synthesis, but homogeneous high-valent transiti

127 elopment of large-scale solar fuel and solar chemical synthesis, but the poor photovoltages often rep

128 onalization of C(sp(3) )-H bonds streamlines chemical synthesis by allowing the use of simple molecul

129 Obtaining such compounds by chemical synthesis can be further complicated by the pre

130 f natural products, here we demonstrate that chemical synthesis can provide important insights into b

131 The bacteria require no chemical synthesis, come in variable sizes and shapes, d

132 ophysical characterization against tractable chemical synthesis: Complexity-building nitro-Mannich/la

133 Chemical synthesis confirms hinokiflavone is the active

134 ,9-EET in this COX pathway were confirmed by chemical synthesis: ct-8,9-epoxy-11-hydroxy-eicosatrieno

135 products represent useful intermediates for chemical synthesis due to the versatility of the C-B bon

136 We have used chemical synthesis, electron paramagnetic resonance (EPR

137 Chemical synthesis enabled identification of isocyanoter

138 Chemical synthesis enabled the development of the first

139 Here, solid-supported chemical synthesis enabled the total synthesis of the la

140 The complexity of chemical synthesis for HCV DAAs was ranked from lowest t

141 applications of fluorous and multicomponent chemical synthesis for the development of novel epigenet

142 ive screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform

143 erials can be produced by a room temperature chemical synthesis from earth-abundant precursors.

144 Chemical synthesis from ribose and 2,6-dichloropurine pr

145 Computer design and chemical synthesis generated viable variants of poliovir

146 ation of potent, drug-like molecules through chemical synthesis has been challenging.

147 Despite efforts spanning 40 years, chemical synthesis has been unable to compete with these

148 explored class of natural products for which chemical synthesis has no practical solution.

149 Recent advances in chemical synthesis have yielded new nanoscale materials

150 recently intensified, thanks to advances in chemical synthesis, improved understanding of charged st

151 il our efforts to prepare these molecules by chemical synthesis, including a photochemical approach,

152 entified one hit, which was expanded through chemical synthesis into a small panel of potent compound

153 ilico discovered hits have been optimized by chemical synthesis into selective nanomolar compounds, t

154 re l-sugar building blocks through efficient chemical synthesis is a crucial step toward the synthesi

155 Although any chemical synthesis is broadly useful for its versatility

156 el, we developed a modular approach in which chemical synthesis is limited to the selectivity filter

157 Chemical synthesis is the most creative and critical asp

158 ds for the pharmaceutical industry but their chemical synthesis is very challenging.

159 Chemical synthesis led to further compound collections t

160 Hit expansion of 2 by chemical synthesis led to improved thiazolidine inhibito

161 tilization of carbon dioxide as feedstock in chemical synthesis, low-energy-barrier CO2 activation is

162 Here, we report a cost-effective chemical synthesis method to produce antimicrobial cockt

163 The development of chemical synthesis methods allowing for the precise cont

164 Colloid-based chemical synthesis methods of bimetallic alloy nanoparti

165 rides in peptoid monomer model systems using chemical synthesis, NMR spectroscopy, and X-ray crystall

166 Herein we report the first chemical synthesis of (+)-pseudoanisatin from the abunda

167 Here, we report a short chemical synthesis of (+)-ryanodol that proceeds in only

168 We describe the chemical synthesis of 23 novel mycolactone analogues tha

169 We report the total chemical synthesis of a 312-residue GroEL/ES-dependent p

170 of an important body of earlier work on the chemical synthesis of a designed EPO analogue that had f

171 e to activate Al as a reducing agent for wet-chemical synthesis of a diverse array of metals and allo

172 In silico docking and screening, followed by chemical synthesis of a library of quinazolinones, led t

173 g approach would appear to be the design and chemical synthesis of a mimotope peptide simulating myco

174 to the complex peptide substrate, relying on chemical synthesis of a modified C-terminal fragment and

175 Recently, chemical synthesis of a range of large nanographene mole

176 accharide-iteration-based approach for rapid chemical synthesis of a structurally defined heparin-rel

177 It is based on the chemical synthesis of a tetra-antennary glycan that has

178 Chemical synthesis of a uniformly (13)C-labeled octasacc

179 Chemical synthesis of about 25 derivatives culminated in

180 We have solved both problems through the chemical synthesis of all four PLB species.

181 Herein, we report a total chemical synthesis of all-l- and all-d-amino acid biotin

182 Despite advances in the chemical synthesis of alpha-syn and other proteins, the

183 based self-assembled nanoparticles, from the chemical synthesis of AMPDs, through nanoparticle prepar

184 Chemical synthesis of an analog library combined with in

185 Here we report the wet-chemical synthesis of asymmetric one-dimensional (1D) si

186 , catalytic, and general methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl

187 Among the bottlenecks in the chemical synthesis of complex glycans is the preparation

188 difficult for cost-effective production, and chemical synthesis of complex isoprenoids is impractical

189 has long served as a starting point for the chemical synthesis of complex natural products, includin

190 ) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic,

191 The first chemical synthesis of ECA-derived oligosaccharides for t

192 Chemical synthesis of elemental selenium nanoparticles i

193 protein science.3 Here we describe the total chemical synthesis of enzymatically active sortase A.

194 de nucleic acids (PNA), we herein report the chemical synthesis of fluorinated PNA monomers and bioph

195 Herein, we report the total chemical synthesis of four candidate Ts3 toxin protein m

196 upled with recent advances in controlled wet-chemical synthesis of functional nanocrystals, opens new

197 The method includes the chemical synthesis of glycan oxazolines with varied numb

198 The chemical synthesis of highly stable linker-drugs and the

199 Here, we report a new method for the total chemical synthesis of IGF-1 analogs, which entails the s

200 of organocatalytic methods for enabling the chemical synthesis of important medicinal targets will b

201 The chemical synthesis of insulin has been a longstanding ch

202 We report a concise chemical synthesis of kalihinol C via a possible biosynt

203 structure-activity relationships enabled the chemical synthesis of LCL204, with enhanced inhibitory p

204 protocol consists of four major stages: (i) chemical synthesis of MPNs, (ii) conjugation with DNA an

205 The wet chemical synthesis of nanostructures has many crucial ad

206 Chemical synthesis of nearly 30 derivatives has resulted

207 mounts of free-volume are based primarily on chemical synthesis of new polymers.

208 nventional methods for natural extraction or chemical synthesis of O-PS are technically demanding, in

209 The chemical synthesis of oligonucleotides and their enzyme-

210 This has led to an impetus for the chemical synthesis of oligosaccharide fragments of these

211 General strategies for the chemical synthesis of organic compounds, especially of a

212 Meanwhile, the chemical synthesis of organized 3D structures with a per

213 Chemical synthesis of PAR is an attractive alternative t

214 We have established a scalable chemical synthesis of Park's nucleotide-N(epsilon)-dansy

215 he first example of the use of non-enzymatic chemical synthesis of phospholipids to prepare proteolip

216 The chemical synthesis of phosphoramidite derivatives of all

217 The chemical synthesis of poly(gamma-butyrolactone) (PgammaB

218 This involves (i) chemical synthesis of precursor N-acetyl-D-galactosamine

219 We applied the total chemical synthesis of proteins to prepare H2AY57p effici

220 e mass spectrometry experiments to guide the chemical synthesis of proteolysis-resistant analogs (i.e

221 However, wet chemical synthesis of Pt-containing nanoparticles (NPs)

222 The chemical synthesis of ribonucleic acids (RNA) with novel

223 The first chemical synthesis of SB is reported, which enables furt

224 The routes that have been taken for the chemical synthesis of such nucleoside derivatives are de

225 is a powerful synthetic methodology for the chemical synthesis of technologically important biodegra

226 It is then applied to the challenging chemical synthesis of the 97-residue co-chaperonin GroES

227 Here we describe the chemical synthesis of the ADP-ribose dimer, and we use t

228 A unified strategy for the chemical synthesis of the chivosazoles is described.

229 The first chemical synthesis of the complete protective O-antigen

230 Chemical synthesis of the deuterium isotope desmosine-d4

231 This protocol covers the chemical synthesis of the fluorogenic amino acid Fmoc-Tr

232 Chemical synthesis of the L- and D-enantiomeric forms of

233 We also describe the HDDA-enabled chemical synthesis of the natural product alkaloids maha

234 Additionally, research toward chemical synthesis of the prodiginine alkaloids over the

235 The chemical synthesis of the repeating unit of S. aureus ca

236 rted here, we established an efficient total chemical synthesis of the Ts1 protein using modern chemi

237 at we validated through performing the first chemical synthesis of the two natural products Tasipepti

238 a promising green alternative to the current chemical synthesis of these esters of unquestionable nut

239 el of structural complexity that renders the chemical synthesis of these natural products challenging

240 ix different research groups have reported a chemical synthesis of this compound, five of which used

241 Here we report a new strategy for the chemical synthesis of ubiquitinated proteins to generate

242 h-resolution mass spectrometry platform, and chemical synthesis of well-defined HS oligosaccharides f

243 tions including the destruction of hazardous chemicals, synthesis of organic compounds, and many othe

244 eotide, which is incorporated into RNA using chemical synthesis or biochemical techniques.

245 Unlike starting material obtained by chemical synthesis or direct isolation from natural sour

246 The INSL3 is typically prepared using chemical synthesis or overexpression in Escherichia coli

247 ging task due to the complexity in multistep chemical synthesis or the inability of the biosynthetic

248 ke features, and synthetic accessibility for chemical synthesis, out of 593 hits, 39 were left top hi

249 tensely investigated from both medicinal and chemical-synthesis perspectives for decades.

250 methods, this is a renewable and sustainable chemical synthesis process for future.

251 In chemical synthesis, protected or unprotected nucleosides

252 Here, we report a highly optimized chemical synthesis protocol for constructing multigram q

253 ssion levels in bacterial cultures, improved chemical synthesis protocols for the pentasaccharide rep

254 Chemical synthesis provides the only means to achieve th

255 aldehyde tag, unmasked in the final step of chemical synthesis, providing a generic end group for la

256 aightforward regulatory path associated with chemical synthesis rather than human sourcing.

257 ts the most efficient route of human insulin chemical synthesis reported to date.

258 n, we report on a first direct aqueous-phase chemical synthesis route to NIR PLNPs and present their

259 ched between two layers of graphene oxide by chemical synthesis route.

260 s play an important role such as fuel cells, chemical synthesis, self-assembly, catalysis and surface

261 Structural verification and modification by chemical synthesis showed that O4I1 and its derivatives

262 Subsequent NMR and mass spectrometry and chemical synthesis showed that the main product was the

263 ily, was prepared for the first time through chemical synthesis starting from 2,3-dimethylbutadiene.

264 kit for complex oxide design, we developed a chemical synthesis strategy for single-phase multifuncti

265 While the biosynthesis and chemical synthesis studies performed to date have provid

266 d edge structures were created using various chemical synthesis techniques.

267 arative scale, represents a new strategy for chemical synthesis that combines organic chemistry and m

268 Here, we describe an advance in chemical synthesis that has established an enantiospecif

269 ediate to many potent Illicium terpenes make chemical synthesis the unquestionable method for accessi

270 amongst the most studied reactions in all of chemical synthesis, the number of reactions that apply t

271 Using the powerful tools of chemical synthesis, the work presented herein focuses on

272 ional groups, rarely does one consider using chemical synthesis to add molecular complexity to the na

273 eve that the strategic application of modern chemical synthesis to antibacterial drug discovery must

274 erent extraction approaches from tea shoots, chemical synthesis to microbial transformation have been

275 We used whole-genome design and complete chemical synthesis to minimize the 1079-kilobase pair sy

276 Use of chemical synthesis to prepare the monomers suggests broa

277 extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation.

278 essed in Escherichia coli requires efficient chemical synthesis to produce large quantities of the am

279 e M-MoS2 has not been previously prepared by chemical synthesis, to the best of our knowledge.

280 ctionalization is a powerful addition to the chemical synthesis toolkit.

281 The present work gives chemical synthesis tools for the synthesis of selectivel

282 t they present challenging issues of complex chemical synthesis, undesirable physical properties, and

283 x molecules highlight the power of iterative chemical synthesis using boronic esters.

284 Chemical synthesis using petrochemical-derived precursor

285 The chemical synthesis utilizes salt by-products as internal

286 erials synthesis in the liquid phase, or wet-chemical synthesis, utilizes a solution medium in which

287 Herein, we report total chemical synthesis, via native chemical ligation, and fu

288 Chemical synthesis was combined with endo-beta-N-acetylg

289 Chemical synthesis was used to increase the potency of t

290 Modular total chemical synthesis was used to prepare the wild-type [Gl

291 a combination of recombinant engineering and chemical synthesis, we show that the disulfide of N-pant

292 iven to some of the recent advances in their chemical synthesis which allows not only the preparation

293 esponsive materials offers simple design and chemical synthesis while enabling different stimuli to p

294 igomers and unnatural variants produced from chemical synthesis will allow for further detailed struc

295 e use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthe

296 ages of systematic modifications possible by chemical synthesis with heterogeneous reactivity.

297 nt two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced

298 This approach combined the flexibility of chemical synthesis with the selectivity of enzyme-cataly

299 Here we combine the flexibility of chemical synthesis with the specificity of a programmabl

300 zyme activities that have been exploited for chemical synthesis, with an emphasis on reactions that d