ライフサイエンスコーパス: chemically

1 igned as 707,459 base pairs, was synthesized chemically.

2 ide (CPS) from B. pseudomallei was purified, chemically activated, and covalently linked to recombina

3 In addition, the multiple chemically active components in these particles (iron, o

4 ive in catalysing oxidation and reduction of chemically active groups in surface-anchored N-heterocyc

5 ageously, the nano-assembly PM-GSH-CuNCs was chemically adsorbed over the cellulosic strips and appli

6 erences used to train the sensory panel were chemically analysed and employed to reduce the number of

7 cretions of P. shermani, its components were chemically analysed by energy dispersive X-ray spectrosc

8 while following a national sampling plan and chemically analyzed for vitamin and mineral content with

9 The identified and chemically and biologically characterized active compoun

10 ative to DNA and RNA probes because they are chemically and biologically stable, easily synthesized,

11 thyl)-5-norbornene-exo-2,3-dicarboximide), a chemically and electrochemically active polymer layer.

12 t that this failure can be overcome by using chemically and geometrically accurate representations of

13 Here we report a chemically and magnetically sensitive depth-dependent an

14 integrated cellular response elicited by two chemically and pharmacodynamically diverse beta-adrenoce

15 Here, we show that TERS can chemically and spatially probe the site-specific chemica

16 We find that the ANs, powered chemically and/or by the energy of electromagnetic radia

17 e distinct mechanisms by which structurally, chemically, and functionally diverse ligands modulate GP

18 idth, and edge planarity could be controlled chemically at the atomic level.

19 This represents the first chemically based fly egg identification approach with ap

20 crostructure, well-interconnected scaffolds, chemically bonded interface, and coupled strengthening e

21 tes are strongly coupled with the NAC by the chemically bonded interface, exhibiting mutual strengthe

22 cted damage to the retina and optic nerve in chemically burned eyes.

23 t radionuclides from the Trinity device were chemically, but not isotopically, fractionated by conden

24 enzymatically by a norcoclaurine synthase or chemically by phosphate resulted in opposite stereoselec

25 lites as reported in literature, and quantum chemically calculated thermodynamics of hard-hard, hard-

26 cleotides, whether incorporated naturally or chemically, can provide insight into the stability of Wa

27 idic bonds, as cleavage of these linkages is chemically challenging and there is a paucity of informa

28 ewurztraminer and Riesling juices and wines, chemically characterised and studied using sensory time-

29 This study aimed to chemically characterize and evaluate the anti-inflammato

30 n (DESI) mass spectrometry (MS) to image and chemically characterize the metabolic profiles of HGSC,

31 species that could be spectroscopically and chemically characterized.

32 So far, however, a general, reliable, chemically clean approach to prepare single crystals sui

33 u protein analysis approach that is based on chemically cleavable fluorescent antibodies.

34 -catalyzed 1,3-dipolar cycloaddition is also chemically compatible with the BN core, further endorsin

35 ve pharmacodynamic interactions within other chemically complex systems, such as those found in count

36 lls, respectively, with potencies similar to chemically conjugated counterparts, and longer plasma ci

37 Our results suggest that YIGSR-A99 peptides, chemically conjugated to FHs and applied to wounded mSMG

38 coli, and chromatographically purified, then chemically conjugated to two different anti-HIV monoclon

39 We demonstrate that chemically-conjugated Qbeta VLPs elicited the highest qu

40 opagating influenza in host cells displaying chemically-controlled, divergent proteostasis environmen

41 Upon oxidation by H2 O2 both sensors are chemically converted to tetramethylrhodamine, producing

42 ell-free tissue expander comprised only of a chemically cross-linked biocompatible polymeric hydrogel

43 nozyme), we introduce for the first time the chemically cross-linked multilayer polyion complex in wh

44 pproach of vacancy-driven gelation to obtain chemically crosslinked hydrogels from defect-rich 2D mol

45 In contrast to the heat-treated chemically-crosslinked gels, the elastic modulus of the

46 for when considering ecological dynamics of chemically defended animals and coevolutionary predator-

47 Chemically defined (CD) and hydrolysate-supplemented med

48 The chemically defined components of the bacterial envelope

49 oculture with other cell types and relies on chemically defined conditions up to and including the ge

50 uded organic acids, observed particularly in chemically defined formulations, and furans, pyridines,

51 as a new, user-friendly route for supplying chemically defined human glycans simply by combining bio

52 supplements (Cholesterol Lipid Concentrate, Chemically Defined Lipid Concentrate, Lipid Mixture 1, G

53 Thus, the incorporation of chemically defined LN-511-E8 into biosynthetic scaffolds

54 Here we show that a chemically defined maturation medium supplemented with t

55 n adipogenesis induction medium, but also in chemically defined medium specifically for osteogenesis,

56 Using a chemically defined medium, we found that (p)ppGpp accumu

57 , and TGFbeta pathway activity in a minimal, chemically defined medium, we show parallel, robust, and

58 We describe here a chemically defined natural N-linked glycan scaffold that

59 into complexes for fusion can be studied in chemically defined reactions.

60 e media, including non-toxicological and non-chemically deleterious effects.

61 paired by the absence of an efficient way to chemically deliver them into the cytosol of cells.

62 mechanisms centres on reversible folding of chemically denatured membrane proteins.

63 yes to the experimental values RG and RE For chemically denatured proteins we obtain mutual consisten

64 n the biochemical route 1, alkali lignin was chemically depolymerized into vanillin and syringate as

65 tions in a membrane environment to develop a chemically detailed model of the E5 protein/PDGFbetaR co

66 spines in morphologically, electrically, and chemically detailed pyramidal neuronal models based on r

67 The results of chemically detailed simulations presented here show that

68 By chemically detecting 5hmU we present a method to provide

69 Here instead we find that rather than chemically detecting prey, hydrodynamics forces BV into

70 sect and mammalian life cycle stages possess chemically different lipid rafts due to different sterol

71 Here, we performed laboratory experiments on chemically different organic materials in order to simul

72 d resonance Raman spectroscopy highlight the chemically different reaction options influenced by the

73 ated sulphur-containing aldoximes containing chemically different side chains, whose break-down produ

74 e compositions represent monoisotopic (i.e., chemically different) species.

75 uld result in compressed detection times for chemically discerning measurements that probe disease.

76 By capturing cells without chemically disrupting their potential function, our meth

77 structure is accessed by inclusion of three chemically distinct anions, which are accommodated by al

78 electrochemical reduction gave a mixture of chemically distinct clusters on the surface, (Cu) m ,(Ag

79 n cloud droplets are highly concentrated and chemically distinct from the underlying bulk or overlyin

80 ry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl aceta

81 The ability of chemically distinct ligands to produce different effects

82 the input of disproportionate quantities of chemically distinct litter, invasive plants may potentia

83 ining the activity and binding properties of chemically distinct macrolide inhibitors of translation,

84 aneously measure the biodistribution of many chemically distinct nanoparticles.

85 Finally, chemically distinct Panx1 inhibitors blocked development

86 cal heterogeneities as a function of size or chemically distinct particle surfaces can determine the

87 20 nm) NPs suppress allergic response to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobe

88 iences where thin, highly turbid layers mask chemically distinct subsurface structures.

89 blocks to produce microcapsules covered in a chemically distinct, dense network of hair-like outgrowt

90 Large collections of chemically diverse boronic acid fragments are commercial

91 the active site to regioselectively oxidize chemically diverse compounds is critical for better unde

92 Three chemically diverse ERG channel blockers (terfenadine, Er

93 We examined the effects of a broad range of chemically diverse general anesthetics and related nonan

94 is their ability to couple the transport of chemically diverse ligands to an inwardly directed proto

95 These findings should inspire the design of chemically diverse ligands with distinct pharmacological

96 al-organic frameworks (MOFs) are a family of chemically diverse materials, with applications in a wid

97 gs demonstrated that MR1 was able to capture chemically diverse structures, spanning mono- and bicycl

98 analytical challenge, as cells are dynamic, chemically diverse, and fragile.

99 an be used to form a library of independent, chemically driven actuators for use in such microrobotic

100 Here we describe chemically-driven artificial rotary and linear molecular

101 Herein, a chemically enabled volumetric 3D digital light photoacti

102 Our results indicate that DARs can be chemically engineered for selective remote control by li

103 bacterial fluids, active liquid crystals or chemically engineered motile colloids.

104 sion of bulk g-C3N4 with 10% mass loading of chemically exfoliated carbon nitride.

105 ts that metastable and temperature-sensitive chemically exfoliated MoS2 (ce-MoS2 ) can be made into e

106 tion of electrode films formed by restacking chemically exfoliated nanosheets of two-dimensional meta

107 Chemically exfoliated, metallic MoS2 nanosheets are func

108 Unlike chemically-exfoliated monolayer nanoparticles, the litho

109 GO) sheets with lateral sizes >10 mum, using chemically expanded graphite as the starting material.

110 We also examine chemically exposed TMD films intermittently interrogated

111 Analyses of the chemically-extractable fraction show that supplementatio

112 The hydrocarbons were chemically extracted and analysed using Gas Chromatograp

113 -density carbohydrate microarrays containing chemically extracted cell wall polysaccharides collected

114 -performance atomic Fe catalyst derived from chemically Fe-doped zeolitic imidazolate frameworks (ZIF

115 onfocal mu-X-ray fluorescence imaging upon a chemically fixed and air-dried C. dubia specimen.

116 Phase contrast microCT of chemically fixed yet unstained samples resolved the nucl

117 d to elevated Cu, Ni, and Zn concentrations, chemically fixed, dehydrated, stained, and embedded, pri

118 Using a chemically-fixed HeLa cell labeled with fluorescent core

119 nd other differentiated planetary bodies are chemically fractionated compared to primitive, chondriti

120 -1), pH 9), representing a simple, cheap and chemically friendly sample preparation method.

121 s of the salamander Plethodon clearly differ chemically from those shown for other glue-producing ter

122 including out-of-equilibrium self-assembly, chemically fuelled molecular motion, compartmentalised c

123 The resulting Pt NP microwires were chemically functionalized to allow the covalent immobili

124 ted solely by surface functional groups in a chemically gated-all-around configuration.

125 Finally, the chemically generated radical anion and polyanion states,

126 The use of chemically grown nanoparticles in whole tissues can ampl

127 This "chemically guided functional profiling" workflow can the

128 tagged synthetic peptides and recombinant or chemically H6-modified proteins.

129 We study dissolution in a chemically heterogeneous medium consisting of two minera

130 Plant specialized metabolites are chemically highly diverse, play key roles in host-microb

131 Seven chemically identified sites (Ser-487, Ser-497, Thr-500,

132 Finally, the separated TLC spots were chemically identified using high-performance liquid chro

133 , 11, and 10 metabolites, respectively, were chemically identified; r-range: -0.30 to 0.20; P = 6 x 1

134 We find that a chemically improved member, RU.521, is active and select

135 high sensitivity and detected ROS generated chemically in solution and in actual cell environments.

136 When we vaccinated mice, chemically inactivated BNSP333-S1 induced high-titer neu

137 g the extrapolation to the low dose exposure chemically inconsistent.

138 Conduction velocity remained constant at chemically increased network activity levels.

139 These results suggest that chemically increasing the net negative surface charge of

140 Because propagation-active fibrils are chemically indistinguishable from innocuous aggregates a

141 Using a system to chemically induce activity in exogenously expressed Rac1

142 Finally, we chemically induce hypoxemia via hemolytic anemia resulti

143 t protein mCherry can be brought to a purely chemically induced blue-fluorescent state by incubation

144 These two reversible processes allow for a chemically induced breathing of the flexible structures.

145 he pressures of reduced oxygen, nutrients or chemically induced cell death, but the mechanisms drivin

146 Chemically induced conformational changes are studied an

147 l and can partly reverse the consequences of chemically induced diabetes.

148 erates the normalization of hyperglycemia in chemically induced diabetic recipient mice, which can al

149 In this study, we used chemically induced dimerization to rapidly relocalize pr

150 oth human liver disease and a mouse model of chemically induced liver injury despite marked activatio

151 proliferative bipotent cells, which we term chemically induced liver progenitors (CLiPs).

152 face AMPA receptor down-regulation evoked by chemically induced long-term depression.

153 e use a flow cytometry-based method to track chemically induced LTP by detecting surface AMPA recepto

154 GPBAR1 in mediating leukocyte trafficking in chemically induced models of colitis and investigate the

155 n of C3 and CFB mRNA expression was noted in chemically induced mouse cSCCs, compared to benign papil

156 o be overrepresented metabolic pathways in a chemically induced murine model of colitis.

157 Chemically induced osmotic diarrhea reduced colitis seve

158 system integrating dCas9-based targeting and chemically induced proximity technologies to allow small

159 s, and Atf3 knockout mice develop aggressive chemically induced skin tumors with enhanced CAF activat

160 This mutant, Reln(CTRdel), carries a chemically induced splice-site mutation that truncates t

161 We found that chronic DBS or chemically induced synaptic stimulation reduced accumula

162 Thermally or chemically induced unfolding has previously been employe

163 We used chemically-induced dimerization to translocate inositol

164 Then, chemically-induced epithelial tumors in the hamster chee

165 e phosphatase (TC-PTP), encoded by Ptpn2, in chemically-induced skin carcinogenesis via the negative

166 We developed a chemically inducible Cas9 (ciCas9) and a droplet digital

167 rogels inside living cells that explores the chemically inducible dimerization paradigm.

168 two molecules-that collide with a third and chemically inert 'bath gas' molecule that simply transfe

169 ve formation of a primary amide group from a chemically inert alkyl group.

170 Helium is generally understood to be chemically inert and this is due to its extremely stable

171 Chemically inert F2PhEtyCbl resisted thermolysis of its

172 Crystalline surfaces of gold are chemically inert, whereas nanoparticles of gold are exce

173 f DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or when the DNA-PKcs gene is delete

174 Nanoscale chemically inhomogeneous surfaces comprising of gold, pa

175 However, the content of total chemically intact omega-3 fatty acids was higher in the

176 It is common and chemically intuitive to assign cations electrophilic and

177 The result set is chemically intuitive, naturally grouped by substitution

178 condary phase of structurally disordered and chemically labile Co(OH)2 is introduced to ensure a high

179 discovered a cyclic form of t6A (ct6A) as a chemically labile derivative of t6A in tRNAs from bacter

180 sed on the intrinsic delithiation process of chemically leaching lithium from the Li13 Si4 alloy.

181 thermore, as the side chains are constructed chemically, many unnatural modifications can also be dir

182 metry (ToF-SIMS) as a label-free approach to chemically map small molecules in aggregated and single

183 ZnSnxGe1-xN2 alloys are chemically miscible semiconductor compounds with potenti

184 e toward carbohydrates-on native agarose and chemically modified agarose in the gel phase for the fir

185 ablished as a platform for bio-conversion of chemically modified analogues of pleuromutilin intermedi

186 In brief, the NC surface was chemically modified and then was decorated with silver a

187 of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides.

188 t cell types and species upon treatment with chemically modified ASOs targeting 5' UTR inhibitory reg

189 gRNAs of Cas9 and Cpf1, and donor DNA can be chemically modified at their terminal positions without

190 and aS fibrils, testing their ability to be chemically modified by DHA.

191 The CH3 NH3 PbI3 perovskite is chemically modified by introducing SrCl2 in the precurso

192 urther demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protei

193 uraminic acid lyase (NAL), and the resulting chemically modified enzymes were screened for activity w

194 Chemically modified indium tin oxide nanoparticle modifi

195 s that protect genomic stability by excising chemically modified nucleobases that alter normal DNA me

196 n of the sugar conformational preferences of chemically modified nucleosides in solution.

197 Chemically modified oligonucleotides that disrupt the in

198 ailable, enabling absolute quantification of chemically modified proteoforms, and therefore systems-l

199 Chemically modified PS-ASOs can mediate efficient target

200 Functional and structural studies based on chemically modified semisynthetic KcsA channels along th

201 ry N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein

202 ular proteomes, increasingly including their chemically modified variants.

203 Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucos

204 The study also presents chemically-modified cellulosic paper strips with the pyr

205 e for traceability of highly-degraded and/or chemically-modified DNA material.

206 New methods to chemically modify streptogramins would enable structural

207 ape the bactericidal action of vancomycin by chemically modifying their cell-wall precursors.

208 fer hints on the targeted cultivation of the chemically most prolific microorganisms known from micro

209 used comparative whole-genome sequencing of chemically mutagenized and natural Pgt isolates to ident

210 We show that chemically mutagenizing the genome of cancer cells drama

211 s is controlled with precision by relying on chemically nanopatterned surfaces, leading to macroscopi

212 Advancing biosensing nanotechnologies in chemically "noisy" bioenvironments require careful engin

213 ur development and characterization of three chemically novel AEs that effectively suppress prolifera

214 bubioside and cyanidin-3-O-sambubioside were chemically obtained for the first time, and characterize

215 complexes are generally not thought to react chemically on collision with a third molecule in the gas

216 g nucleic acids, aptamers can be synthesized chemically or enzymatically.

217 Chemically or optically powered active matter plays an i

218 The resulting chemically ordered surface regions acts as an effective

219 are visually oriented while Scleroglossa are chemically-oriented, given that Iguania doubles Sclerogl

220 Our results show that chemically orthogonal electrolytes based on HFE solvents

221 hway engineering can be employed to insert a chemically orthogonal tag into a complex natural scaffol

222 A chemically patterned microfluidic paper-based analytical

223 The topcoat, in conjunction with a chemically patterned substrate, directs the assembly of

224 Furthermore, we found that chemically perturbing Fus3 dynamics with a specific inhi

225 Here, we describe the chemically precise immobilization of an enzyme on an eng

226 on selected fish samples after an enzymatic-chemically pretreatment.

227 Thus, the focus of the work here is to chemically probe the range of thermodynamically stable t

228 By chemically processing biomass, and employing nanometrolo

229 Moreover, the use of a chemically programmable ligand, such as DNA, would allow

230 sulfide-containing compounds, but is able to chemically react with them without addition of any catal

231 s are unable to preserve the native state of chemically reactive and beam-sensitive battery materials

232 the formation of highly reactive compounds (chemically reactive metabolites, CRMs) that can lead to

233 rikes are known to morphologically alter and chemically reduce geologic formations and deposits, form

234 thermal activity, high CO2, As emissions and chemically reduced fluids.

235 those measured in studies with biologically/chemically reduced model clays.

236 (antiHER2/Hyd@AuNPs-APTMS-Fe3O4) containing chemically reduced silver ions, as a label bioconjugate

237 Fe(II) associated with NOM (as-received and chemically reduced) at pH 7, and investigated the effect

238 ntrast between the neural representations of chemically related odorants in females compared to males

239 the original sample aliquot, O-glycans were chemically released from urinary exosomes and profiled,

240 erized 101 Mass2Motifs with biochemically or chemically relevant substructures.

241 this protein complex, either genetically or chemically, removed ABCC4 from the plasma membrane, incr

242 information can be rewritten, resulting in a chemically rewritable BCP SC display.

243 Other than being chemically robust enough to be incorporated into macrocy

244 Recently, chemically robust heptazine-based polymers known as grap

245 of 10 coupled with a maximum of the 10 most chemically selective m/z (requiring a minimum of 3 m/z),

246 ductor substrates, and enhance durability of chemically sensitive interfaces.

247 Chemically similar but morphologically distinct nanocarr

248 suggesting that low-chi interactions between chemically similar or distinct blocks intimately influen

249 Interestingly, resveratrol is chemically similar to ICRF-187, a clinically approved ch

250 s represents a step forward in the search of chemically simple, potent, and selective antagonists for

251 ate and dynamic XB behavior were measured in chemically skinned myocardial preparations isolated from

252 trate that thermophoresis enables robust and chemically specific directed motion of liposomes, which

253 component of the refractive index (i.e., the chemically specific information) is provided to overcome

254 ging is a highly sensitive, solid-state (and chemically) specific, rapid, and versatile imaging techn

255 mechanism of internalization of asymmetric, chemically stabilized, cholesterol-modified siRNAs (sd-r

256 lithium metal, this LiF coating serves as a chemically stable and mechanically strong interphase, wh

257 Both reagents were shown to be chemically stable and nontoxic to HEK293T cells at conce

258 This carbide is chemically stable in alkaline media and over the potenti

259 ery systems were non-toxic to the RPE cells, chemically stable in porcine vitreous and delivered carg

260 n fluorescence but otherwise leptosperin was chemically stable over prolonged storage at 37 degrees C

261 tic acid, and 4-hydroxyphenyllactic acid are chemically stable over prolonged storage, but not 2-meth

262 Thermodynamically and chemically stable RNA nanoparticles derived from the thr

263 rfluorocyclobutyl polymers are thermally and chemically stable, may be produced without a catalyst vi

264 tural bioactives possible to be refined into chemically standardized mixtures for biological applicat

265 These novel constructs are synthesized in a chemically straightforward process that involves interca

266 in the McMurdo Dry Valleys, Antarctica, are chemically stratified with depth and have distinct biolo

267 heparan sulfate) and compared our results to chemically sulfated hyaluronan.

268 eaction is one of the most common methods to chemically synthesize a six-membered carbocycle.

269 apparent biological activity, we set out to chemically synthesize d-allo-ShK and determine its X-ray

270 hey are typically prohibitively expensive to chemically synthesize, and unlike longer RNAs, they are

271 ns into the beta scorpion toxin Ts1, we have chemically synthesized a novel binder [S14R, W50Pra]Ts1

272 These and other derivatives are now chemically synthesized and remain the mainstay of therap

273 Partially N-glycolylated-CS was chemically synthesized as a standard for mass spectromet

274 ral and bioactive vitamin D3 metabolite, was chemically synthesized for the first time.

275 Therefore, these peptides were chemically synthesized for validation purposes.

276 le strain by "endoreduplication intercross." Chemically synthesized genomes like Sc2.0 are fully cust

277 We exploit these findings to design a chemically synthesized peptide corresponding to RH5Nt, w

278 Using chemically synthesized short RNA corresponding to the fi

279 Both genes were separately suppressed using chemically synthesized siRNAs.

280 s study, a single injection of inclisiran, a chemically synthesized small interfering RNA designed to

281 y calibrating the fluorescent signal against chemically synthesized standards.

282 These structures are then chemically synthesized to give synthetic-bioinformatic n

283 class of affinity reagents because they are chemically synthesized, thus making them highly reproduc

284 t and its human equivalent SAA1(47-104) were chemically synthesized.

285 s and four other unique hexasaccharides were chemically synthesized.

286 This work opens opportunities to chemically tailor SWCNTs at the single chirality level f

287 ariety of functions and it is the ability to chemically tailor the type, population and distribution

288 These chemically tailorable framework materials are the subjec

289 Analogous chemically termolecular reactions mediated by ephemeral

290 Such 'chemically termolecular' reactions, in which all three m

291 The identification and prioritization of chemically tractable therapeutic targets is a significan

292 particle formation and the heat treatment to chemically transform particles into an oxide strongly in

293 ated with ionic exchange membranes (MCDI) or chemically treated (inverted-CDI or i-CDI).

294 in situ modification and affords a route to chemically trigger deaggregation and droplet dispersion.

295 based on low-cost, solution-processable and chemically tunable organic materials, are promising alte

296 Finally, the ability to chemically tune the 2P absorption profile through the us

297 Using a chemically tuned kinetochore-targeting assay, we show th

298 Amiclenomycin (ACM) is a chemically unstable antibiotic with selective activity a

299 a very attractive route to locally produce a chemically valuable product from an abundant resource.

300 that cryo-concentrated acidic brines rapidly chemically weather olivine minerals and form sulfate min