ライフサイエンスコーパス: chemically-modified

1 structure-activity correlation, mahanine was chemically modified.

2 lated grafted sites when silica surfaces are chemically modified.

3 f RNA-based therapeutics, even when they are chemically modified.

4 internal space whilst outer surfaces can be chemically modified.

5 ng mechanism to access the target base being chemically modified.

6 r scrambled or if a critical Lys residue was chemically modified.

7 w selective regions of a nanostructure to be chemically modified.

8 , which are smaller in size and easier to be chemically modified.

9 Here we develop a chemically modified, 29-nucleotide synthetic CRISPR RNA

10 A series of chemically modified 7-phenylpyrrolo[3,2-f]quinolinones w

11 ncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were hi

12 Most proteins in nature are chemically modified after they are made to control how,

13 e toward carbohydrates-on native agarose and chemically modified agarose in the gel phase for the fir

14 These chemically modified amino acids are used for the introdu

15 In previous work, our group chemically modified an antimicrobial peptidomimetic moti

16 ablished as a platform for bio-conversion of chemically modified analogues of pleuromutilin intermedi

17 firefly emitter oxyluciferin and two of its chemically modified analogues revealed that in the excit

18 effects, hence the continuous development of chemically modified analogues with dissociated profiles.

19 rated silencing miRNA function in mice using chemically modified and cholesterol-conjugated RNAs term

20 lpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally respon

21 In brief, the NC surface was chemically modified and then was decorated with silver a

22 Intravenous administration of 2 mg kg(-1) chemically modified anti-miR-122 complexed with iNOP-7 r

23 ring mice with miR-10b antagomirs-a class of chemically modified anti-miRNA oligonucleotide-suppresse

24 The resulting chemically modified antibody fragment, RGD-Man(5)-IgG1 F

25 A chemically modified antisense oligonucleotide (ASO) that

26 induction of differentiation using a novel, chemically modified antisense oligonucleotide.

27 Chemically modified antisense oligonucleotides (ASOs) ar

28 Chemically modified antisense oligonucleotides (ASOs) de

29 echanism of inhibition of gene expression by chemically modified antisense oligonucleotides (ASOs) ha

30 mouse cells by conventional transfection of chemically modified antisense oligonucleotides (ASOs) th

31 In this work, we utilized very short chemically modified antisense oligonucleotides composed

32 As an alternative to chemically modified antisense oligonucleotides, we devel

33 of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides.

34 ess microRNA targets at least as strongly as chemically modified antisense oligonucleotides.

35 s after attenuating pitx2c mRNA levels using chemically modified antisense oligonucleotides.

36 ils the structure-activity relationships for chemically modified apelin peptides and recent disclosur

37 ritical active site cysteine predicted to be chemically modified as a formylglycine in vivo.

38 t cell types and species upon treatment with chemically modified ASOs targeting 5' UTR inhibitory reg

39 TCRI) and its 3-cyano homologue (CTCRI) were chemically modified at the 3-position.

40 gRNAs of Cas9 and Cpf1, and donor DNA can be chemically modified at their terminal positions without

41 -protamine-RNA nanoparticles encapsulating a chemically modified ATF mRNA resulted in inhibition of o

42 -OP with the original K90C mutant, with K90C chemically modified back to a lysine analog (K90C-AE), a

43 The chemically modified base is an N(2)-alkyl-8-oxo-7,8-dihy

44 ent a novel strategy using oligos containing chemically modified bases (2'-Fluoro-Uridine, 5-Methyl-d

45 afeguard the genome by locating and excising chemically modified bases from DNA.

46 sylases help maintain the genome by excising chemically modified bases from DNA.

47 DNA glycosylases catalyze the excision of chemically modified bases from DNA.

48 ch would enable the incorporation of various chemically modified bases throughout long stretches of D

49 By using chemically modified bases, we show electron trapping on

50 responsible for correcting a large number of chemically modified bases.

51 appealing substrates for the development of chemically modified biotherapeutics and protein-based ma

52 For chemically modified BNNTs with various amino functional

53 We have investigated properties of chemically modified boron nitride nanotubes (BNNTs) with

54 Carbon nanotubes can be chemically modified by attaching various functionalities

55 and aS fibrils, testing their ability to be chemically modified by DHA.

56 The first mirror is chemically modified by hydrosilylation with dodecene bef

57 The CH3 NH3 PbI3 perovskite is chemically modified by introducing SrCl2 in the precurso

58 orted dibenzepinones and dibenzoxepines were chemically modified by introduction of functional groups

59 Cellular RNAs are chemically modified by many RNA modification enzymes; ho

60 Proteins bearing this "aldehyde tag" were chemically modified by selective reaction with hydrazide

61 Membranes coated with SiNPs and chemically modified by the FAS with a longer fluoroalkyl

62 plausibility that the diamond surface can be chemically modified by the well-known carbene addition c

63 stal structure of DHQ1 from Salmonella typhi chemically modified by this ammonium derivative revealed

64 In this protocol, externalized APLs are chemically modified by using a cell-impermeable reagent

65 Their surface can be chemically modified, by either covalent or non-covalent

66 urther demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protei

67 ral requirements by assessing the ability of chemically modified C4S to inhibit IRBC binding to the p

68 ary electrochromatography (CEC) using etched chemically modified capillaries as the separation medium

69 and long-term reproducibility of the etched chemically modified capillaries to be documented.

70 lated peptides with several different etched chemically modified capillaries.

71 Chemically modified carbon nanotube fibers enable unique

72 of epinephrine (EP) at a gold nanoparticles chemically modified carbon paste electrode (AuNPs/CPE).

73 The proposed chemically modified carbon paste electrode was used for

74 thesized and applied to the fabrication of a chemically modified carbon paste electrode.

75 ernative as compared to macro-electrodes and chemically modified carbon paste electrodes in stripping

76 The method used a chemically modified CE capillary to prevent protein adso

77 The study also presents chemically-modified cellulosic paper strips with the pyr

78 sense mediated reduction of Ago proteins and chemically modified cleavage- and binding-deficient siRN

79 The chemically modified cNW-FET arrays function as decoder c

80 and to glucosaminoglycans, was adsorbed on a chemically modified CPLL solid phase, and the behavior o

81 pitope may be present in both the native and chemically modified CPS fragments.

82 Therefore, our major goal was to develop a chemically modified cyclodextrin which gives a more stab

83 le of these amino acids present in HcRed, we chemically modified Cys and His residues using iodoaceta

84 horing Escherichia coli 70S ribosomes onto a chemically modified, cysteine-reactive glass surface.

85 as developed based on one-shot adsorption of chemically-modified cytochrome c (cyt c) onto bare gold

86 n (hAGT) bound to double-stranded DNA with a chemically modified cytosine base.

87 In this study, we chemically modified DAFP-1 using the arginine-specific r

88 e binding of HCV envelope glycoproteins with chemically modified derivatives of heparin.

89 implications for understanding the states of chemically modified DNA bases in health and disease.

90 Chemically modified DNA oligonucleotides have been cruci

91 translesion synthesis across a wide range of chemically modified DNA templates.

92 e for traceability of highly-degraded and/or chemically-modified DNA material.

93 Exogenous administration of chemically modified EGSs in inducing RNase P-mediated cl

94 The proposed chemically modified electrode was used to the determinat

95 ach allows electrode cleaning and the use of chemically modified electrodes; however, the designs gen

96 Both, the chemically modified enzyme (GOx-FS) and the UCLNPs are i

97 Chemically modified enzyme was also delivered more effec

98 In this respect, the chemically modified enzyme was superior to native beta-g

99 uraminic acid lyase (NAL), and the resulting chemically modified enzymes were screened for activity w

100 Similarly, chemically modified flavin analogs showed high affinity

101 lly occurring flavin derivatives and several chemically modified flavin analogs.

102 d abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthe

103 evaluation of ordered pillar arrays that are chemically modified for planar chromatography and inspec

104 PI3K inhibitor was generated by coupling the chemically modified form of the quercetin analogue LY294

105 he stability of added cyanocobalamin (CNCbl, chemically modified form) and hydroxocobalamin (OHCbl, n

106 re much lower and much more uniform than for chemically modified fused silica.

107 The chemically modified gelatins exhibited better physical p

108 DNA ligation for the enzyme-free assembly of chemically modified genes and genomes.

109 Electrostatic-gated transport in chemically modified glass nanopore electrodes with orifi

110 , anti-EGFR RNA aptamers were immobilized on chemically modified glass surfaces.

111 Using microfluidic protein deposition onto chemically modified glass, we achieve the controlled gro

112 RNA microarrays were created on chemically modified gold surfaces using a novel surface

113 hemical contrast in STM images obtained with chemically modified gold tips.

114 of multiwalled carbon nanotubes (MWCNT) and chemically modified graphene (rGO)-composite spray coati

115 present a potentiometric aptasensor based on chemically modified graphene (transducer layer of the ap

116 The ease of its conversion to chemically modified graphene could enable new opportunit

117 umber of methods for generating graphene and chemically modified graphene from graphite and derivativ

118 Additional experiments on chemically modified graphene oxide membranes, with ring-

119 nd molecular-level dispersion of individual, chemically modified graphene sheets within polymer hosts

120 templates and the controlled segregation of chemically modified graphene to liquid interfaces.

121 port across the interfaces of physically and chemically modified graphene with two metals, Al and Cu,

122 oduce new materials composed of graphene and chemically modified graphene.

123 king a hydrogen bonding polymer network with chemically-modified graphene oxide.

124 ted here is likely to be applicable to other chemically modified graphenes and graphite-based systems

125 Chemically modified graphenes and other graphite-based m

126 n-13-labeled graphite can be used to prepare chemically modified graphenes for 13C SSNMR analysis wit

127 hite almost 150 years ago and a precursor to chemically modified graphenes, has not been previously r

128 ments for a nanoscale probe tip sliding on a chemically modified graphite surface in an atomic force

129 ies of alternative substrates that contained chemically modified guanidinium moieties provides eviden

130 When chemically modified, HA can be transformed into many phy

131 ochemical data on the cleavage properties of chemically modified hammerheads.

132 f copper addition on the fluorescence of the chemically modified HcRed was investigated.

133 polymer-encapsulated and additional forms of chemically modified hemoglobins are being developed and

134 fate and heparin oligosaccharides as well as chemically modified heparin oligomers have been successf

135 Surprisingly, heparin, chemically modified heparinoids, and monoclonal antibodi

136 ved oligosaccharides (4-22 saccharides), and chemically modified heparins (2-O-, 6-O-, O-, and N-desu

137 Chemically modified heparins lacking N-sulfate and 2-O-s

138 ighly oriented pyrolytic graphite (HOPG) and chemically modified HOPG.

139 Both genetically and chemically modified HSs were subsequently assessed in a

140 SEM, and nitrogen sorption analysis and were chemically modified in a two-step process using octadecy

141 In this labeling method, peptides are chemically modified in solution and the modified peptide

142 end, lysine amino acid residues of VWF were chemically modified in the presence of FVIII or activate

143 Chemically modified indium tin oxide nanoparticle modifi

144 teinogenic amino acids and for the design of chemically modified inhibitors.

145 We describe a novel, chemically modified, insect-based liquid culture medium

146 O and a hole-transport overlayer through the chemically-modified interface.

147 the synthesis of antibiotics via a series of chemically modified intermediates, with removal of the p

148 Additional injury by chemically modified lipoproteins disrupts the continuous

149 or drug delivery system in tumor cells using chemically modified liposomes for loading with chemother

150 roitin sulfate (CS) glycosaminoglycans using chemically modified liposomes.

151 ked to an adaptive immunological response to chemically modified MBP.

152 Treatment with a chemically modified miR-21 inhibitor led to significant

153 ivo blockade of both miRNAs via antagomiR (a chemically modified miRNA inhibitor) injection after sep

154 Chemically modified mRNA is capable of inducing therapeu

155 e and specific enzyme immunoassay (EIA) with chemically modified, multiple antigenic peptides (MAPs)

156 electron microscopy, we have characterized a chemically modified mutant of GroEL (EL43Py) that is tra

157 Here we use a chemically modified mutant of GroEL (EL43Py) to uncouple

158 e show that adsorption of the protein to the chemically modified nanopores slows down the translocati

159 hSOx was adsorbed onto this chemically modified nanostructured electrode with high s

160 ganic compounds that adsorbed onto naked and chemically modified NP alumina coatings was measured usi

161 ls that predict the properties of native and chemically modified nucleic acids and assist in their de

162 tides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion

163 s that protect genomic stability by excising chemically modified nucleobases that alter normal DNA me

164 n of the sugar conformational preferences of chemically modified nucleosides in solution.

165 Unnatural chemically modified nucleotide sugars UDP-4-N3-GlcNAc an

166 Chemically modified nucleotides containing 1-aminonaphth

167 indings provide information on incorporating chemically modified nucleotides into siRNAs for potent,

168 The capability of DNA polymerases to accept chemically modified nucleotides is of paramount importan

169 , often requiring the use of radiolabeled or chemically modified nucleotides to detect reaction produ

170 ll interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stabi

171 y ESI-FTMS to obtain the correct position of chemically modified nucleotides.

172 reaction products by using radio-labeled or chemically modified nucleotides.

173 ptic intermediate or "D-loop." Sequentially, chemically modified oligonucleotide probes anneal to the

174 A chemically modified oligonucleotide targeting lnc-MGC in

175 nambiguous sequence assignment of an unknown chemically modified oligonucleotide.

176 inducible RNAi platform in which orthogonal chemically modified oligonucleotides are used to trigger

177 could potentially be avoided by introducing chemically modified oligonucleotides into the MB design.

178 Chemically modified oligonucleotides that disrupt the in

179 e tool to provide high sequence coverage for chemically modified oligonucleotides, and such detailed

180 assay suitable for the detection of heavily chemically modified oligonucleotides, which we termed Ch

181 limitations of IT-CID in sequencing such 2'-chemically modified oligonucleotides.

182 ysis program for confirmation of sequence of chemically modified oligonucleotides.

183 When delivered by nucleofection, chemically modified ON of both types effected a >90% kno

184 Glycans were enzymatically or chemically modified on solid phase before releasing from

185 The lanthanum oxide is chemically modified on the surface of silica and charact

186 PAHs, including the large variety of chemically modified or substituted PAHs, are naturally o

187 Cellular RNAs can be chemically modified over a hundred different ways.

188 In vitro selection of chemically modified peptide libraries presented on phage

189 We report the development of chemically modified peptide nucleic acids (PNAs) as prob

190 st the DNA binding and sliding activities of chemically modified peptides and analogs, and show that

191 Using truncated and chemically modified peptides, we show that abasic site c

192 s for efficient delivery of conventional and chemically-modified peptides nucleic acids.

193 r membrane localization of proteins by using chemically modified phospholipid anchors capable of cova

194 Here, we report the effect of chemically modified phytoglycogen, a dendrimer-like alph

195 e qualitative and quantitative properties of chemically modified PNA for nucleic acid detection and p

196 Chemically modified polystyrene-based composite fiber re

197 Concomitant isolation of both chemically modified precursors is followed by tandem mas

198 Chemically modified proteins are increasingly important

199 Chemically modified proteins are invaluable tools for st

200 ailable, enabling absolute quantification of chemically modified proteoforms, and therefore systems-l

201 Chemically modified PS-ASOs can mediate efficient target

202 The chemically modified PSMA inhibitor PSMA-617 demonstrated

203 We have constructed chemically modified, psoralen-linked TFOs that mediate s

204 Different methods to design the chemically-modified QDs hybrid structures for sensing lo

205 The chemically modified reaction intermediate is consistent

206 con oxycarbide glass particles embedded in a chemically-modified reduced graphene oxide matrix.

207 nscription proceeds until it is blocked by a chemically modified residue.

208 al and in vivo bone regenerative capacity of chemically modified ribonucleic acid (cmRNA) (encoding B

209 internal mismatch pairs involving native or chemically modified RNA.

210 terference has reinvigorated the interest in chemically modified RNA.

211 regulation has reinvigorated the interest in chemically modified RNA.

212 ) were used, for the first time, to assemble chemically modified Screen Printed Electrodes (SPEs) sel

213 Functional and structural studies based on chemically modified semisynthetic KcsA channels along th

214 Co-delivering chemically modified sgRNAs with Cas9 mRNA or protein is

215 The efficacy of lipid-encapsulated, chemically modified short interfering RNA (siRNA) target

216 ations of the two 21-mer single strands of a chemically modified short interfering RNA containing 2'-

217 liver has been through the administration of chemically modified short interfering RNAs.

218 Measurement of the surface area of chemically modified silica-based adsorbents is discussed

219 structure-activity relationships correlating chemically modified single strands and Argonaute 2 (AGO2

220 Chemically modified single-walled carbon nanotubes (SWNT

221 tility of these grids by aligning DNA on the chemically modified SiO2 surface in order to direct the

222 ased and in vivo assays to rationally design chemically modified siRNA destined for therapeutic use.

223 ry N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein

224 g 2'-O-methyl and 2'-deoxy-2'-fluoro (OMe/F) chemically modified siRNA targeting PTEN and Eg5.

225 The optimally chemically modified siRNA-GalNAc conjugates are hepatotr

226 Chemically modified siRNAs are necessary that maintain m

227 Because chemically modified siRNAs are poor substrates for phosp

228 Chemically modified siRNAs exhibited binding affinities

229 ited success in enhancing siRNA potency with chemically modified siRNAs, our findings represent an im

230 e of gene silencing after treatment with the chemically modified siRNAs.

231 These include chemically-modified siRNAs and analogues, aptamer-siRNA

232 tion events, while others represent putative chemically modified sites of unknown types.

233 s bearing positive and negative charges onto chemically modified SPR sensors in two separate SPR chan

234 Chemically modified ss-siRNA targeting human apoC III mR

235 These data demonstrate that chemically modified ss-siRNAs function through the RNAi

236 mization and alternative routes of delivery, chemically modified ssRNAs could represent a powerful RN

237 Inclusion complexes with chemically modified starch showed a lower range of therm

238 ng efficiency 3% and 10% higher than PVA and chemically modified starch sizes on polyester/cotton fab

239 /4 type resistant starch (retrograded starch/chemically-modified starch) with good texture-forming pr

240 Chemically modified STM tips can be fabricated by formin

241 satisfied hydrogen bonding groups by placing chemically modified substituents in select internal posi

242 A series of chemically modified substrate molecules with altered sub

243 The chemically modified surface shows strong affinity toward

244 of new substrates for the direct imaging of chemically modified surfaces by TEM.

245 on with a novel motility assay that employed chemically modified surfaces to probe the mechanochemist

246 Macaques immunized with Tat or chemically modified Tat toxoid having the same clade B s

247 ficantly after sepsis, and pretreatment with chemically modified tetracycline (CMT-3) inhibited these

248 echanism of protection for mice treated with chemically modified tetracycline 3, appeared to be relat

249 cal inhibitors of MMP (MMPi; captopril and a chemically modified tetracycline) and reserved infected

250 , and -9 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial

251 dentified 3-cyano-4,6-diphenyl-pyridines, we chemically modified this scaffold and explored its struc

252 sevenfold symmetrical cyclodextrin molecule chemically modified to add seven positive charges, was g

253 es of sevenfold symmetry, beta-cyclodextrins chemically modified to add seven positive charges.

254 adation rates from hours to years and can be chemically modified to alter surface properties or to im

255 Two different sequences of siRNA were chemically modified to be randomly copolymerized in a si

256 throcyte anion transporter AE1 that has been chemically modified to convert glutamate 681 to an alcoh

257 PerT-GUS, a form of beta-glucuronidase (GUS) chemically modified to eliminate its uptake and clearanc

258 veness of "self-delivery" siRNA (i.e., siRNA chemically modified to enhance cellular uptake).

259 endent antisense oligonucleotides (ASOs) are chemically modified to enhance pharmacological propertie

260 ional evidence that long-circulating enzyme, chemically modified to escape carbohydrate-mediated clea

261 (amidoamine) dendrimers were dye-labeled and chemically modified to have terminal carboxyl groups and

262 The tip end is chemically modified to hybridize only to the target mRNA

263 therefore designed a c-Fos peptide receptor chemically modified to incorporate a thiophenol (TP) gro

264 and Pinto bean starches were physically and chemically modified to investigate the effect of modific

265 nsport material into cells, the rotaxane was chemically modified to lock it in the closed conformatio

266 rporate a non-natural amino acid that can be chemically modified to modulate FcRn interaction in vitr

267 Transcription factors must often be chemically modified to perform their functions.

268 ls containing interconnected porosity can be chemically modified to promote stimulus-driven (light, m

269 etyl-Gly-Lys-O-methyl ester (dipeptide) were chemically modified to yield CEP-modified HSA (CEP-HSA)

270 rus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reac

271 ) resins containing olefin repeat units were chemically modified using hydrogenation, hydrofluorinati

272 HLA-DR1, a common class II MHC variant, were chemically modified using the side chain-specific chemic

273 A chemically modified variant of CSN5 siRNA was then selec

274 Duplex dsP21-322 and its chemically modified variants are examples of RNAa-based

275 Analysis of chemically modified variants of the closing base pair sh

276 ct energetics of basic RNA motifs, including chemically modified variants, with consistently better t

277 ular proteomes, increasingly including their chemically modified variants.

278 We established that the chemically modified VoltageFluor is a substrate for PLE

279 These chemically modified water soluble PHAs have significant

280 approximately 50 microm-thick glass membrane chemically modified with a 3-cyanopropyldimethylchlorosi

281 erials composed of a functional protein core chemically modified with a dense shell of oligonucleotid

282 rescence of the enzyme glucose oxidase (GOx) chemically modified with a fluorescein derivative (FS) a

283 study, a 2-helix small protein, MUT-DS, was chemically modified with a metal chelator, 1,4,7,10-tetr

284 by intramolecular CT states when the NNI is chemically modified with an electron donor.

285 The azide group can be chemically modified with biotin for detection, affinity

286 embly of two sets of 5 nm gold nanoparticles chemically modified with DNA bearing complementary stick

287 PEDF chemically modified with fluorescein retained the capaci

288 rein, a carbon-paste electrode (CPE) that is chemically modified with gold nanoparticles (nAu) was fa

289 stals made of 470 nm silica spheres that are chemically modified with hydrocarbon, giving enhanced vo

290 Hyaluronic acid was chemically modified with hydroxyethyl methacrylate to fo

291 eported to date represent actin complexed or chemically modified with molecules that prevent its poly

292 A carbon-paste electrode chemically modified with multiwalled carbon nanotubes wa

293 The surface of the silica sphere is chemically modified with oligonucleotides.

294 n number and length vary, and lipid A can be chemically modified with phosphoethanolamine, aminoarabi

295 , benzonaphthyridine (BZN) TLR7 agonists are chemically modified with phosphonates to allow adsorptio

296 internal surfaces of the microchannels were chemically modified with polyethyleneimine (PEI), which

297 Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucos

298 The purified protein was then chemically modified with the biocompatible moiety retina

299 Paper fibers were chemically modified with thiol ligands to immobilize CdS

300 rge surface areas, high stability and can be chemically modified with various functional groups.