ライフサイエンスコーパス: chemist

1 are a constant source of inspiration to the chemist.

2 s has much to offer to the synthetic organic chemist.

3 hile pursuit for the skills of the medicinal chemist.

4 l suited to the sensibilities of the organic chemist.

5 , is well suited to the sensibilities of the chemist.

6 y depend on whether you ask a physicist or a chemist.

7 ent significant challenges for any synthetic chemist.

8 worked at du Pont for 42 years as a research chemist.

9 challenging goal for the synthetic inorganic chemist.

10 y applied to problems of interest to organic chemists.

11 e-containing chemical entities for medicinal chemists.

12 complex dataset to materials scientists and chemists.

13 rings has become a key objective for organic chemists.

14 to address the needs of practicing medicinal chemists.

15 s that make it possible, challenge prebiotic chemists.

16 from a curiosity to a reality for synthetic chemists.

17 s remain a continuous challenge to synthetic chemists.

18 , provides a synthetic challenge for organic chemists.

19 hallenging problems facing synthetic organic chemists.

20 imagination of both material scientists and chemists.

21 d by pharmaceutical, biological, and organic chemists.

22 ingle step--that are accessible to synthetic chemists.

23 considerable interest to a broader field of chemists.

24 able catalytic transformations discovered by chemists.

25 shion has been the focus of numerous organic chemists.

26 active yet challenging targets for medicinal chemists.

27 itutes a significant challenge for synthetic chemists.

28 is a challenging goal facing supramolecular chemists.

29 mportant goal for medicinal and agricultural chemists.

30 long-standing challenge to synthetic organic chemists.

31 so extend the intuitive knowledge of trained chemists.

32 only a fraction of those accessible to bulk chemists.

33 o has presented many challenges to medicinal chemists.

34 poses an exceptional challenge to analytical chemists.

35 ules remains an important goal for synthetic chemists.

36 as targets represent a notable challenge to chemists.

37 he center of much debate among environmental chemists.

38 oduce an alkene is a challenge for synthetic chemists.

39 es a fascinating challenge to supramolecular chemists.

40 nge for industrial, biological and synthetic chemists.

41 d new questions and targets for coordination chemists.

42 opics likely to be of particular interest to chemists.

43 analysis will be useful tools for medicinal chemists.

44 to becoming a mainstream tool for medicinal chemists.

45 cognosists, natural products, and ecological chemists.

46 th ease, it remains a difficult task for the chemists.

47 have attracted the interest of many organic chemists.

48 synthetic value for academic and industrial chemists.

49 ns have become an important tool for organic chemists.

50 ed drug design approaches can help medicinal chemists a long way toward discovering better drugs.

51 veloped in our laboratory broadens synthetic chemists' access to classes of photochemical cycloadditi

52 in the life sciences; for this reason, many chemists aim to discover catalysts that allow for prepar

53 dings will inform clinicians and therapeutic chemists alike as they strive to develop novel therapies

54 s of synthetic chemistry by chemists and non-chemists alike, what restrictions remain that constrain

55 oal of inorganic, solid-state, and materials chemists alike.

56 red the interest of synthetic and biological chemists alike.

57 um anions attracted attention of theoretical chemists already in the late 1990s to predict their phys

58 is precocious youth to becoming a celebrated chemist and emphasizes his dedication to forseeing likel

59 te to re-examine the life of this remarkable chemist and his legacy to heterocyclic chemistry.

60 acteria present an ongoing challenge to both chemists and biologists as they seek novel compounds and

61 eresting biological properties have inspired chemists and biologists for decades.

62 cyclase (OSC) has stimulated the interest of chemists and biologists for over a half century.

63 and practical route adds to the arsenals of chemists and biologists interested in the synthesis and

64 years and has attracted attention from many chemists and biologists owing to its intriguing chemical

65 cel, a familiar, easily accessed program for chemists and biologists.

66 tory in the pocket: An international team of chemists and biophysicists have resolved the long-standi

67 as part of the toolkit of synthetic organic chemists and biotechnologists.

68 this area as well as to encourage synthetic chemists and chemical engineers to address the challenge

69 to offer an appropriate means to assist/aid chemists and material designers alike to rationally cons

70 Chemists and material scientists have often focused on t

71 reaction pathways is a fundamental goal for chemists and material scientists to produce innovative m

72 ules are of particular interest to medicinal chemists and materials scientists.

73 Organic chemists and metabolic engineers use orthogonal technolo

74 mote a closer interaction between analytical chemists and modellers to identify models for biochemica

75 Chemists and non-allopathic practitioners do not treat w

76 st practiced forms of synthetic chemistry by chemists and non-chemists alike, what restrictions remai

77 ent applications will be useful to medicinal chemists and other investigators interested in the lates

78 ce is an important objective that challenges chemists and physicists in order to access an entirely n

79 ts and a mutual consensus now shared by both chemists and physicists, a nanoperiodic/systematic frame

80 enormous amount of attention from synthetic chemists and played an important role in the development

81 obust and therefore widely used by medicinal chemists and radiochemists alike.

82 des of natural products discovery by organic chemists and research by chemical ecologists, our unders

83 by AOAC (Association of Official Analytical Chemists) and HPLC (High Performance Liquid Chromatograp

84 source for medicinal chemists, computational chemists, and DMPK scientists working in drug design to

85 ors, including public and private providers, chemists, and non-allopathic practitioners.

86 clinicians, microbiologists, natural product chemists, and pharmacologists together with pharmaceutic

87 quire strategic alignments among clinicians, chemists, and toxicologists.

88 his Review will be useful to a wide range of chemists, and will spur further research in this promisi

89 ) and the Association of Official Analytical Chemists (AOAC) - with the original Ough method.

90 ally used Association of Official Analytical Chemists (AOAC) acid hydrolysis method, the reaction tim

91 method of Association of Official Analytical Chemists (AOAC).

92 ording to the Association of Official Racing Chemists (AORC) requirements.

93 Organic chemists are able to synthesize molecules in greater num

94 Inspired by the properties of graphene, chemists are also designing graphene-like molecules in w

95 However, inspired by Nature, chemists are beginning to turn their attention to the de

96 Chemists are contributing to incremental improvements of

97 b) to problems of interest to organometallic chemists are described.

98 econanotoxicity, challenges that analytical chemists are expertly poised to address.

99 o optimize drug candidates, modern medicinal chemists are increasingly turning to an unconventional s

100 Medicinal chemists are often guided by the physicochemical propert

101 The biocatalytic transformations used by chemists are often restricted to simple functional-group

102 ries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained biois

103 this field, further work is required because chemists are still faced with the challenge of developin

104 Chemists are still far from achieving the most obvious a

105 ange in large pharma including how medicinal chemists are trained.

106 Many organic chemists around the world synthesize medicinal compounds

107 to stimuli have been developed by synthetic chemists as building blocks for molecular machines.

108 hlorides (e.g. Ts-Cl) are beloved of organic chemists as the most commonly used S(VI) electrophiles,

109 f this emerging field to organic and polymer chemists as well as materials scientists.

110 duate and postgraduate training of medicinal chemists at GSK is also briefly described.

111 phisticated catalysts are rarely employed by chemists, because the substrate scope, selectivity and r

112 the big challenge particularly for medicinal chemists being to design and synthesise the ideal chemop

113 ussion on what might lie ahead for medicinal chemists, biologists, and physicians as they try to impr

114 Since the discovery of these pigments, chemists, biologists, medical professionals and material

115 hat have attracted widespread attention from chemists, biologists, physicists, and engineers.

116 should appeal to the supramolecular organic chemist but also to the broader community.

117 framework that has been adopted not only by chemists, but also by design practitioners and decision-

118 ide a practical "tool box" for the synthetic chemist by mapping the advantages and disadvantages asso

119 hose that do are often tested long after the chemist can incorporate the results into synthetic plann

120 addition, the needs of the synthetic organic chemist can often be met by flow cells operating with re

121 laboration between synthetic and theoretical chemists (cf. the cerocene problem).

122 Chemists classify molecules according to characteristics

123 Antimatter is barely known by the chemist community and this article has the vocation to e

124 The present review apprises the chemists' community of the past, present and future scop

125 -PK should serve as a resource for medicinal chemists, computational chemists, and DMPK scientists wo

126 munities of organic, inorganic, and physical chemists, crystallographers, and solid state scientists.

127 useful and valuable tool for those medicinal chemists dealing with research programs focused on NS4B

128 How do skilled synthetic chemists develop good intuitive expertise?

129 Our mapping may also be of interest to chemists directly as it defines a dictionary from electr

130 Medicinal chemists do not yet completely understand the nuances of

131 tracted significant attention from synthetic chemists due primarily to the historically synthetically

132 mides are attractive candidates to synthetic chemists due to the ability of the motif to access a wid

133 nascency and remain perplexing for medicinal chemists due to their poor drug-like nature.

134 resent a significant challenge for synthetic chemists due to their structural complexity and chemical

135 rface between computational and experimental chemists, emphasizing the need for computation to predic

136 Contemporary organic chemists employ a broad range of catalytic and stoichiom

137 l nomenclature systems inorganic and organic chemists employ to describe these phenomena.

138 canon of reactions available to the organic chemist engaged in total synthesis, the Diels-Alder reac

139 This has brought together biologists, chemists, engineers, physicists, and mathematicians to s

140 Synthetic chemists exploit inteins in the semisynthesis of protein

141 uity, experience, and intuition of medicinal chemists, focusing on the key question of which compound

142 )F NMR offers opportunities to the medicinal chemist for characterizing and ultimately discovering ne

143 o be of particular interest to the medicinal chemist for other reasons.

144 d porphyrins have attracted the attention of chemists for a long time in view of their diverse applic

145 ms and approaches employed by supramolecular chemists for anion sensing and the wide structural varie

146 biotechnology but has eluded supramolecular chemists for decades.

147 zed cross-coupling of nitroarenes has eluded chemists for decades.

148 , this reaction cannot be used by analytical chemists for determination of one of the studied compoun

149 cerning the best approach to train medicinal chemists for drug discovery.

150 e isotope of hydrogen, is known to medicinal chemists for its utility in mechanistic, spectroscopic,

151 anic molecules has fascinated and confounded chemists for over a century.

152 erature, solvent, additives, etc., dissuades chemists from employing light-initiated reactions as a r

153 their anticipated instability dissuaded most chemists from exploring their behavior.

154 tical analysis methods in a manner such that chemists gain further insight into approaches that optim

155 Prior to the 1970s, chemists generally believed that reactants had to collid

156 Here, the synthetic chemist has a significant role to play, both in the desi

157 cule HCV therapeutics, designed by medicinal chemists, has been hailed as "the arc of a medical trium

158 Synthetic organic chemists have a long-standing appreciation for transitio

159 Chemists have achieved a predictable control over variou

160 Medicinal chemists have been encouraged in recent years to embrace

161 Chemists have been inspired by those phenomena found in

162 Inspired by nature, chemists have been interested in developing synthetic cy

163 Chemists have created molecular machines and switches wi

164 In an attempt to mimic nature, chemists have developed a large set of reactions that en

165 Over decades chemists have developed a nuanced understanding of stere

166 Chemists have developed mechanistic insight into numerou

167 ering our understanding of these glycocodes, chemists have developed new creative tools that included

168 the discovery of these compounds, synthetic chemists have developed new methodologies that are mainl

169 directly at ostensibly unreactive C-H bonds, chemists have discovered reaction conditions that enable

170 s Perspective is to illustrate how medicinal chemists have elegantly employed the gem-dimethyl group

171 Synthetic chemists have focused on preparing such model compounds,

172 During the 42 symposia, 332 chemists have given 549 plenary lectures.

173 Over the past two decades, medicinal chemists have identified a number of chemical modificati

174 Aiming to maximize selectivity, medicinal chemists have largely sought to create TKIs that bind to

175 While chemists have leveraged the unique capabilities of biolo

176 Chemists have long aspired to synthesize molecules the w

177 Chemists have long sought sequence-controlled synthetic

178 So far, chemists have only been able to synthesize monomer seque

179 nistic steps during biological N2 reduction, chemists have prepared iron complexes that mimic various

180 ry, physics and material sciences, synthetic chemists have produced systems suitable for detailed stu

181 Biologists and chemists have put forth a lot of effort toward understan

182 ive enzymatic reactions that occur in water, chemists have rarely capitalized on the unique propertie

183 For such reasons, synthetic chemists have sought catalysts that directly convert C-H

184 e to have a profound impact on human health, chemists have succeeded in generating semisynthetic anal

185 Recently, chemists have turned their attention to the development

186 spired by this time-tested moiety, medicinal chemists have widely explored its use in developing bioa

187 I began my research career as a synthetic chemist in organometallic chemistry and homogeneous cata

188 controlled to the advantage of the synthetic chemist in the design of single-molecule magnets with en

189 ce for both FBDD practitioners and medicinal chemists in general.

190 hronicle the successful efforts of synthetic chemists in the construction of these biologically activ

191 complexity, are a source of inspiration for chemists in the field of total synthesis for the develop

192 g adequate credit to the great creativity of chemists in the field.

193 es as an important inspiration for materials chemists in the quest for new and improved organic-inorg

194 unities that have been under-investigated by chemists in the selective probe and sensor field.

195 s and thereby serve as an efficient tool for chemists, including those interested in synthesis.

196 ations outlined here will reignite medicinal chemists' interest in NPs and their derivatives.

197 A replicase ribozyme has long been sought by chemists interested in the origin of life.

198 try will garner high interest from medicinal chemists involved in either file enhancement or specific

199 A classic strategy of physical organic chemists is to probe reaction mechanisms using linear fr

200 esents a resource for a practicing medicinal chemist looking for new opportunities to combat cancers

201 ith better potency: selection by a medicinal chemist, manual modeling, docking followed by manual fil

202 aterial scientists and in particular polymer chemists may build on chemistry, physics and biology for

203 5th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his deat

204 Physical-chemists, (micro)biologists, and ecologists need to cond

205 nterest for structural biologists, medicinal chemists, molecular modellers and teachers.

206 ron chemistry emerge, process and analytical chemists must develop approaches to rapidly solve proble

207 lenes is an appealing topic which fascinates chemists nowadays.

208 have been available to alchemists and colour chemists of the nineteenth century.

209 Medicinal chemists often want to know which atoms of a molecule-it

210 This collective information will inform chemists on different aspects of FtsZ that can be (and h

211 of these salts were primarily the domain of chemists or chemical engineers who desired to manipulate

212 e considered and explained, from a synthetic chemists perspective, after a general introduction to th

213 1%, as a result of synergistic efforts among chemists, physicists, and engineers.

214 These developments will benefit biologists, chemists, physicists, and materials scientists alike.

215 attract the interest of synthetic Inorganic Chemists promise a brilliant future for this class of co

216 c molecular scaffolds available to medicinal chemists remains limited, and simple structures such as

217 For decades medicinal chemists replenished the arsenal of antibiotics by semis

218 apping and visualization tools in analytical chemists' research.

219 derscored this critical gap in the synthetic chemist's arsenal.

220 RBF3 K is a chemist's BFF: A metal-free synthetic route to unprecede

221 preciated interactions from a supramolecular chemist's point of view.

222 Correction for 'The medicinal chemist's toolbox for late stage functionalization of dr

223 d on unraveling the content of the medicinal chemist's toolbox.

224 panding synthetic methodologies, a medicinal chemist's toolkit continues to swell.

225 posed a considerable challenge to medicinal chemists seeking to develop highly selective inhibitors

226 ment, PSYCHEDELIC offers a robust method for chemists seeking to exploit couplings for structural, co

227 s interest from condensed matter physicists, chemists, semiconductor device engineers, and material s

228 our work, we argue that the modern aspiring chemist should in addition be concerned with attaining (

229 avier group 14 multiple bonds have intrigued chemists since more than a century.

230 Morphine has been a target for synthetic chemists since Robinson proposed its correct structure i

231 ave attracted the interest of supramolecular chemists since the early beginnings of the field.

232 ural products have captured the attention of chemists since the isolation of the first members of the

233 alytical Communities (AOAC) and American Oil Chemists' Society (AOCS), and two colorimetric methods,

234 Clandestine chemists synthesize novel stimulant drugs by exploiting

235 ften provide stimulating targets for organic chemists that are engaged in the development of new meth

236 ontradict the notion, widely held by organic chemists, that radical aromatic substitution reactions a

237 This strategy gives chemists the tools to design and refine vast libraries,

238 We hope to offer chemists the tools to have a good grasp of this singular

239 From the perspective of the medicinal chemist, the GRI is also important as a generalized mode

240 bond-containing products and may impact how chemists think of multistep synthetic sequences in the f

241 the accomplishments of our fellow analytical chemists through the years, and the impact we have had o

242 Polymer chemists, through advances in controlled polymerization

243 nism offers an opportunity for the medicinal chemist to discover pathway-selective ligands for GPCRs.

244 isualization methods often require an expert chemist to interpret the patterns.

245 es related to immunization allows the modern chemist to rationally design carbohydrate vaccines with

246 layed in a convenient format that allows the chemist to see all of the chemical shift perturbations a

247 esign and development challenge to medicinal chemists to achieve acceptable oral pharmacokinetics.

248 untered in research laboratories by enabling chemists to adopt a more holistic systems approach in th

249 ases, it will become increasingly useful for chemists to adopt the knot terminology employed by other

250 der community of environmental engineers and chemists to adopt those tools.

251 In this review, we encourage medicinal chemists to also consider the dynamics of this pocket as

252 lamines (NAEs) were considered by many lipid chemists to be biological 'artifacts' of tissue damage,

253 cal and readily available tool for medicinal chemists to better characterize how their compounds beha

254 nalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage fu

255 new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with ar

256 ve-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be

257 into the design of network motifs, enabling chemists to develop "molecular software" to create funct

258 c understanding of such reactions has helped chemists to develop further improvements, modifications

259 ncovalent bonding interactions, has inspired chemists to devise artificial systems that mimic their f

260 site of the enzyme nitrogenase has inspired chemists to explore iron and molybdenum complexes in tra

261 onclude that qualitative statements enabling chemists to focus on promising regions of chemical space

262 ubstitution (SNAr) is widely used by organic chemists to functionalize aromatic molecules, and it is

263 s that have proven challenging for synthetic chemists to incorporate since the discovery of this natu

264 The Matsy algorithm allows medicinal chemists to integrate activity trends from diverse medic

265 ially in the biological world, has motivated chemists to mimic such systems with synthetic molecular

266 essential properties has inspired synthetic chemists to mimic these properties in artificial one-dim

267 ould serve as a practical tool for medicinal chemists to monitor compound attributes in aqueous solut

268 We expect that this approach will enable chemists to more broadly apply their detailed understand

269 h catalysts have been implemented by polymer chemists to post-modify polymers in high yields, as well

270 as severely limited the ability of inorganic chemists to predict or rationalize the formation of comp

271 ibition of single SCs has driven clandestine chemists to produce analogues of increasing structural d

272 velopment of theoretical methods has allowed chemists to reproduce and explain almost all of the expe

273 tics is also due to the attempt of medicinal chemists to stabilize candidates toward cytochrome P450

274 The analytical toolbox available for chemists to study atmospheric organic components has exp

275 g asymmetric carbon-carbon bonds has enabled chemists to synthesize a broad range of important carbon

276 iving systems and have been long mimicked by chemists to synthesize new artificial systems endowed wi

277 an attractive proposition because it allows chemists to synthetically tweak various kinetic and ther

278 These features allow chemists to tackle unexploited challenges in their work,

279 nd heterodimers, and approaches of medicinal chemists to target these receptor complexes with homo- a

280 control over the outcome of reactions entice chemists to use biocatalysts in organic synthesis.

281 tions between computational and experimental chemists toward collaborative development and use of QSA

282 However, chemoinformaticians and medicinal chemists typically perceive similarity in different ways

283 ral overview of the possibilities offered to chemists using complementary modes of catalysis and to e

284 within the binding site, directing medicinal chemists where to grow the molecule and alerting them to

285 Here, we write to introduce analytical chemists who are new to the open-source movement to best

286 This protocol is intended to provide chemists who discover or make new organic compounds with

287 This builds upon earlier work of physical chemists who extensively studied inorganic CRNs and show

288 computation of chemical shifts tractable for chemists who may otherwise have only rudimentary computa

289 pect that should be considered by analytical chemists who use MCR methods.

290 haviour presents a considerable challenge to chemists, who lack the 'biological machinery' used in na

291 Most synthetic chemists will have at some point utilized a sterically d

292 self to his students, colleagues, and fellow chemists with an aura of nobility and romanticism.

293 its druglike properties, providing medicinal chemists with an unconventional strategy for replacing a

294 oss batch, analyst, and instrument; enabling chemists with discretionary decisions specific to every

295 countercurrent separation apparatus provide chemists with efficient ways to work with complex matrix

296 ester structural motif continues to intrigue chemists with its electrophilic and nucleophilic sites.

297 vated photoredox catalysts provide synthetic chemists with the unprecedented capability to harness re

298 Flow equipment provides chemists with unique control over reaction parameters en

299 More recently, however, supramolecular chemists - with their expertise in macrocyclic synthesis

300 a specific and major challenge for medicinal chemists working in CNS drug discovery.