ライフサイエンスコーパス: chemo-

1 OS at 3 years: 58% vs 70% (5-FU) vs 84% (no-chemo)].

2 aged patients were rituximab/chemotherapy (R-chemo; 28%), XRT (27%), observation (17%), systemic ther

3 y of stimuli, including thermal, mechanical, chemo, and photo.

4 inacolato)diboron, and imines allows regio-, chemo-, and diastereoselective assembly of branched alph

5 nzophospholes become accessible in a regio-, chemo-, and diastereoselective way.

6 xcellent yields as well as with high regio-, chemo-, and diastereoselectivity as a result of the comb

7 Mouse lemurs are basal primates that rely on chemo- and acoustic signalling for social interactions i

8 the vagus and activation of cardiopulmonary, chemo- and baroreceptor reflexes.

9 ciency gains that innovative developments in chemo- and biocatalysis can have on the synthesis of pha

10 lights the importance of selecting from both chemo- and biocatalysts for optimal results.

11 ence, and time course; radiosensitization by chemo- and biologic therapy; and the addition of novel,

12 rganic molecules and proteins with excellent chemo- and bioselectivity.

13 ic devices like field effect transistors, as chemo- and biosensors, catalysts, or in energy material

14 on of an advanced enone intermediate and the chemo- and diastereoselective addition of trimethylalumi

15 via radical intermediates under mild regio-, chemo- and diastereoselective conditions that are fully

16 A highly chemo- and diastereoselective protocol toward amino-subs

17 eoselective modified Claisen condensation, a chemo- and diastereoselective reduction of a beta-keto e

18 appropriate oxocarbenium cation and a highly chemo- and diastereoselective ring-closing metathesis pr

19 This highly chemo- and diastereoselective transformation underscores

20 s produced with high efficiency and complete chemo- and diastereoselectivity by diversification of an

21 derivatives in excellent yields, with total chemo- and diastereoselectivity.

22 ds some small-molecule SGLT2 inhibitors by a chemo- and diastereospecific palladium-catalyzed arylati

23 A highly reactive, chemo- and enantioselective addition of diphenylphosphin

24 This paper describes a highly chemo- and enantioselective epoxidation of conjugated ci

25 g efficient O-O cleavage and creating highly chemo- and enantioselective epoxidizing species which pr

26 mild step and atom-economical nonepimerizing chemo- and enantioselective N-alkylating procedure has b

27 the capability of our catalyst to perform a chemo- and enantioselective process while using simple a

28 Reported herein are chemo- and enantioselective silver-catalyzed aminations

29 t high C horizontal lineO/C horizontal lineC chemo- and enantioselectivities.

30 This system may provide both chemo- and enantioselectivity toward multiple analytes s

31 earing a variety of substituents in terms of chemo- and enantioselectivity.

32 dating a broad range of substrates with high chemo- and enantioselectivity.

33 broadly applicable to alternative systems of chemo- and haptotaxis such as cells migrating along grad

34 t to treatment of hematologic neoplasms with chemo- and immunotherapy.

35 er, although anatomically closely connected, chemo- and mechano-sensory neurons are functionally segr

36 The vagus nerve supplies low-threshold chemo- and mechanosensitive afferents to the mucosa of t

37 ed with diverse sensory bristles of both the chemo- and mechanosensory systems.

38 at selective silencing of this pathway using chemo- and optogenetic approaches impaired fear memory r

39 le to domains linked by alpha-helices and to chemo- and photosensors.

40 s sulfide oxidation during sulfide-dependent chemo- and phototrophic growth in bacteria.

41 th stage IB-IVA cervical cancer treated with chemo- and radiation therapy in 2009-2013.

42 previously unknown role for normal cells in chemo- and radiation therapy of cancer.

43 hese changes could promote responses to both chemo- and radiation therapy.

44 vical cancers that makes tumors resistant to chemo- and radiation therapy.

45 ocally advanced cervical cancer treated with chemo- and radiation therapy.

46 kappaB is also crucial to oncogenesis and to chemo- and radio-resistance in cancer.

47 Hypoxia confers chemo- and radio-resistance, and alongside PDGF, is impl

48 gulation, cell proliferation, DNA repair and chemo- and radio-resistance.

49 on of C53 may represent a novel approach for chemo- and radio-sensitization of cancer cells.

50 umented for male rodents that treatment with chemo- and radio-therapeutic agents before mating can ca

51 leads in part to resistance to some existing chemo- and radiological treatments.

52 IL-1 has putative chemo- and radioprotective properties, but its effects o

53 tumor cells, activation of NRF2 may lead to chemo- and radioresistance and thus affect patient outco

54 and may become a prerequisite for overcoming chemo- and radioresistance using radiosensitizing drugs

55 thermore, CSCs are believed to contribute to chemo- and radioresistance.

56 gh elevated PUMA expression elicits profound chemo- and radiosensitization in cancer cells, inhibitio

57 ered as therapeutic targets with a promising chemo- and radiosensitizing potential.

58 food intake and the toxicity and efficacy of chemo- and radiotherapeutic agents.

59 ne response is key to the success of various chemo- and radiotherapeutic regimens.

60 Chemical and physical treatments such as chemo- and radiotherapies have also made a major contrib

61 sed invasive capacity and resistance to both chemo- and radiotherapies, and therefore represent an at

62 ion may enhance the effectiveness of current chemo- and radiotherapies.

63 o increase the efficacy of such compounds as chemo- and radiotherapies.

64 in tumor cells or sensitize these tumors for chemo- and radiotherapies.

65 It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth

66 nal cell carcinoma (RCC) is polyresistant to chemo- and radiotherapy and biologicals, including TNF-r

67 Most modern chemo- and radiotherapy treatments of human cancers use

68 l invasion, metastatic spread, resistance to chemo- and radiotherapy, and is an independent, negative

69 is not only resistant to androgen ablation, chemo- and radiotherapy, but also highly metastatic.

70 ancy characterized by frequent resistance to chemo- and radiotherapy, poor outcome, and limited thera

71 tic mechanisms render GBM cells resistant to chemo- and radiotherapy, we hypothesized that these anti

72 Tumor hypoxia contributes resistance to chemo- and radiotherapy, while oxygenated tumors are sen

73 ve tumors that are resistant to conventional chemo- and radiotherapy.

74 s as well as to their limited sensitivity to chemo- and radiotherapy.

75 on in HNSCC and renders cancers resistant to chemo- and radiotherapy.

76 growth in metastatic sites and responses to chemo- and radiotherapy.

77 as well as its role in sensitizing cells to chemo- and radiotherapy.

78 ll as adversely influence tumor responses to chemo- and radiotherapy.

79 by excellent efficiency as well as complete chemo- and regio-selectivity in both simple and complex

80 These results could be explained through a chemo- and regioselective 5-exo aminocyclization to the

81 nt step, the enyne-urea derivative undergoes chemo- and regioselective 6-endo cyclization to afford O

82 ns furnished 3,6-dihydro-2H-pyrans through a chemo- and regioselective 6-endo cycloetherification.

83 he electron-deficient alkene and undergoes a chemo- and regioselective [3 + 2] cycloaddition.

84 ochrome P450 enzyme was employed to effect a chemo- and regioselective allylic C-H oxidation in the p

85 A unique chemo- and regioselective alpha- and gamma-arylation of

86 The reaction is highly chemo- and regioselective and offers a new approach to t

87 This strategy has been applied to the chemo- and regioselective assembly of indanone arrays an

88 A chemo- and regioselective auxiliary-mediated peptide lig

89 minotetrazole, as a directing group, for the chemo- and regioselective C-H halogenation of arenes.

90 ohydrate moiety and the advantages of highly chemo- and regioselective click chemistry, such as mild

91 A chemo- and regioselective copper-catalyzed cross-couplin

92 [reaction, structure: see text] A chemo- and regioselective copper-catalyzed cross-couplin

93 A new chemo- and regioselective coupling protocol between 3-ar

94 inocyclopentadienones have been subjected to chemo- and regioselective cycloadditions with dienophile

95 a single compound, beta-caryophyllene, via a chemo- and regioselective ene reaction.

96 + 1 cycloetherification pathways in a highly chemo- and regioselective fashion to obtain skeletally a

97 and alkyne partners in good yield, and in a chemo- and regioselective fashion, despite the significa

98 A new concept of highly chemo- and regioselective formation of the benzene ring

99 ht-step synthetic strategy involves a highly chemo- and regioselective gold-catalyzed cycloisomerizat

100 We report the chemo- and regioselective hydrogenolysis of the C-O bond

101 A rhodium-catalyzed chemo- and regioselective intermolecular decarboxylative

102 A chemo- and regioselective intermolecular sp(3) C-H and s

103 A novel simple, mild chemo- and regioselective method has been developed for

104 ne directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C-H alkenylation of aren

105 An efficient Cu-catalyzed chemo- and regioselective ortho-nitration of N,1-diaryl-

106 An efficient Cu-catalyzed chemo- and regioselective ortho-nitration of N,1-diaryl-

107 -((2,6-diisopropylphenyl)-imino)-2-pentene], chemo- and regioselective polymerizations of lactide (LA

108 zines were prepared from a sequence of three chemo- and regioselective reactions combining amination

109 iodides has been developed, enabling highly chemo- and regioselective synthesis of unsymmetrical dia

110 The reaction is both chemo- and regioselective, as only 4,6-disubstituted 2-a

111 The reaction is chemo- and regioselective, displaying wide substrate sco

112 that the ring closure of these diols is both chemo- and regioselective.

113 are few catalytic aerobic examples that are chemo- and regioselective.

114 The reaction proceeds chemo- and regioselectively in an atom-economic way, gen

115 The chemo- and regioselectivities are controlled by the enha

116 could be easily prepared with high levels of chemo- and regioselectivities by hydrofluorination of re

117 a highly enantioselective fashion with good chemo- and regioselectivities.

118 including substituent effects on reactivity, chemo- and regioselectivity and the effects of oxidant i

119 This process displays exceptional chemo- and regioselectivity as well as high diastereosel

120 Many strategies developed to date lack chemo- and regioselectivity as well as result in non-nat

121 Chemo- and regioselectivity depend on both linker elonga

122 hyl-1-piperidinyl-N-oxyl) displays excellent chemo- and regioselectivity for the oxidation of less hi

123 The excellent chemo- and regioselectivity highlights the synthetic pot

124 yrroles has been achieved through switchable chemo- and regioselectivity in the metal-catalyzed heter

125 The high chemo- and regioselectivity observed for these reactions

126 The chemo- and regioselectivity of the initial attack in ski

127 The chemo- and regioselectivity of the reaction may be tuned

128 Achieving chemo- and regioselectivity simultaneously is challengin

129 lation of vinyl 2- and 3-carboxyarenes, with chemo- and regioselectivity up to 100%.

130 To account for the chemo- and regioselectivity, the initial formation of th

131 eactions require exquisite control over both chemo- and regioselectivity, under ambient, aqueous cond

132 method in moderate to good yields with high chemo- and regioselectivity.

133 wing the transformation to proceed with high chemo- and regioselectivity.

134 rapidly affording acrylamides with excellent chemo- and regioselectivity.

135 with each other in good yield and excellent chemo- and regioselectivity.

136 formed in moderate to good yields with high chemo- and regioselectivity.

137 ross-coupling of different phenols with high chemo- and regioselectivity.

138 While 1 catalyzes the rapid chemo- and shape-selective oxidation of thiols to disulf

139 l-containing natural products involving both chemo- and site-selective ("chemosite" selective) and si

140 Chemo- and site-selectivity was studied with a diverse l

141 rward access to ketopyranosides with a large chemo- and stereodiversity at position 2.

142 An efficient and chemo- and stereoselective access to various tri- and te

143 Transition-metal-free chemo- and stereoselective addition of 5-aminoindole (1a

144 ds by S-alkylation has been developed, using chemo- and stereoselective alkylation of a C2-thiolated

145 these supported Cu nanoparticles into highly chemo- and stereoselective catalysts for the preparation

146 hly refined protecting group strategy, and a chemo- and stereoselective epoxidation at C(18,19).

147 carbon introduced in the Prins-pinacol step; chemo- and stereoselective hydroxyl-directed epoxidation

148 Other key transformations include chemo- and stereoselective hydroxyl-directed epoxidation

149 d secondary 3 beta-alcohol 11 and the highly chemo- and stereoselective isomerization of dieneoxide e

150 carbinol and the cyclopropane determine both chemo- and stereoselective outcomes.

151 tereoselective alkylation of (+)-nopinone, a chemo- and stereoselective reduction of an oxime to an a

152 A method has been developed for the chemo- and stereoselective Suzuki-Miyaura cross-coupling

153 ith excellent functional group tolerance and chemo- and stereoselectivities.

154 use of 2-deoxy-d-glucose resulted in reduced chemo- and stereoselectivity and the formation of four p

155 The redox-economy, chemo- and stereoselectivity embodied by this new class

156 formation, which displayed good to excellent chemo- and stereoselectivity for a broad array of substr

157 ity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitut

158 roducts in fewer steps and with the pristine chemo- and stereoselectivity that is a hallmark of bioca

159 hiazolines (oxidized to thiazoles) with high chemo- and stereoselectivity.

160 zed pyrrolidines and dihydrofurans with high chemo- and stereoselectivity.

161 bits apoptosis induced by a wide spectrum of chemo- and targeted therapies upstream of Bcl2-associate

162 the sensitivity of breast cancer patients to chemo- and targeted therapies.

163 hrough the application of specific targeted, chemo- and/or immune-therapies.

164 ts with abnormal posture who did not receive chemo- and/or radiation therapy included the fastigial a

165 are exposed to known mutagens in the form of chemo- and/or radiotherapy for cancer in the States.

166 ly strongly resistant to currently available chemo- and/or radiotherapy regimens, including targeted

167 es were acquired 3 weeks after initiation of chemo- and/or radiotherapy.

168 Here we describe the topography, the chemo-, cyto-, and myeloarchitectonics, and the ultrastr

169 A highly chemo-, diastereo- and enantioselective catalytic method

170 ha-keto ester reduction, excellent levels of chemo-, diastereo-, and enantiocontrol can be realized i

171 um ion, chlorolactonization suffers from low chemo-, diastereo-, and enantioselectivities.

172 substituted beta-amino ynones with excellent chemo-, diastereo-, and enantioselectivity.

173 nverted to unsaturated diboronates with high chemo- (>98% reaction of alkyne; <2% at alkene) and enan

174 y: HR, 0.59; 95% CI, 0.42-0.84; surgery plus chemo: HR, 0.19; 95% CI, 0.07-0.46).

175 A ligandomes of patients undergoing standard chemo-/immunotherapy.

176 ectal cancer response to preoperative RT +/- chemo, only one patient has died as a consequence of can

177 No efficacious chemo- or immunotherapies have been identified for crypt

178 ng tumor progression and after recovery from chemo- or immunotherapy.

179 RC(POMC) neurons, rapidly cause satiety when chemo- or optogenetically manipulated.

180 ug target whose inhibitors have potential as chemo- or radiation sensitizers or as monotherapy in tum

181 enal cell carcinoma (RCC) responds poorly to chemo- or radiation therapy but appears to respond to sy

182 ensitizing agents to act in conjunction with chemo- or radiation therapy of cancer cells.

183 impaired in those patients who had received chemo- or radiation therapy.

184 n the pre-clinical setting as a strategy for chemo- or radio-potentiation.

185 s closely associated with poor prognosis and chemo- or radiotherapeutic resistance.

186 or can enhance target cell susceptibility to chemo- or radiotherapeutics by effecting the modulation

187 intervention, especially in combination with chemo- or radiotherapies.

188 TRAIL treatment in combination with chemo- or radiotherapy enhances TRAIL sensitivity or rev

189 rior chemo- or radiotherapy, timing of prior chemo- or radiotherapy in relation to RAIT, type and num

190 tes to tumorigenesis, tumor progression, and chemo- or radiotherapy resistance.

191 , bone or marrow (or both) metastases, prior chemo- or radiotherapy, timing of prior chemo- or radiot

192 uman tumors and contributes to an aggressive chemo- or radiotherapy-resistant phenotype, therefore pr

193 umor growth, pathogenesis, and resistance to chemo- or radiotherapy.

194 53, as well as for the response of tumors to chemo- or radiotherapy.

195 DFS at 3 years: 14% vs 38% (5-FU) vs 45% (no-chemo), OS at 3 years: 58% vs 70% (5-FU) vs 84% (no-chem

196 current rectal carcinoma (after neoadjuvant (chemo)-radiation, with or without intraoperative radioth

197 n, and metastasis and lowers the efficacy of chemo-, radio-, and immunotherapies.

198 gy, multi-targeting and multi-drug strategy, chemo-/radio-/photodynamic-/ultrasound-/thermo-combined

199 is a melanoma antigen overexpressed in most chemo-/radiotherapeutic stress-resistant tumor clones, a

200 s stages: initial diagnosis, during therapy (chemo-, radiotherapy, surgery), and in the post-therapy

201 allenes poses several challenges in terms of chemo-, regio- and enantio-selectivity.

202 mining both the catalytic efficiency and the chemo-, regio- and enantioselectivity of enzymes, thus e

203 nsformation of synthetic chemicals with high chemo-, regio- and enantioselectivity.

204 ieving high rate-enhancements with excellent chemo-, regio- and stereoselectivities.

205 lkyne starting materials with high levels of chemo-, regio- and stereoselectivity.

206 umerous transition-metal complexes to effect chemo-, regio-, and diastereoselective NT.

207 Excellent chemo-, regio-, and diastereoselectivities are observed

208 benzoxa[3.2.1]octane scaffold with excellent chemo-, regio-, and diastereoselectivity under exception

209 under surprisingly mild conditions with high chemo-, regio-, and diastereoselectivity, while tolerati

210 nes under mild conditions and with excellent chemo-, regio-, and diastereoselectivity.

211 Herein we describe a highly chemo-, regio-, and enantioselective bromochlorination r

212 s has been enabled by our recently developed chemo-, regio-, and enantioselective dihalogenation reac

213 (DAAA) of allyl enol carbonates as a highly chemo-, regio-, and enantioselective process for the syn

214 go facile Nazarov cyclization with excellent chemo-, regio-, and stereocontrol.

215 n alternative approach is to employ a highly chemo-, regio-, and stereocontrolled allene oxidation th

216 This domino process proved to be chemo-, regio-, and stereoselective and allows the forma

217 ique (E)-chlorovinyl sulfate is created by a chemo-, regio-, and stereoselective E2 elimination of HC

218 borylation protocol proceeds in a remarkably chemo-, regio-, and stereoselective fashion to afford 1,

219 the C7 tertiary hydroxyl center of 1 and 8; chemo-, regio-, and stereoselective intramolecular oxyme

220 A chemo-, regio-, and stereoselective iron-catalyzed 1,4-h

221 ze the aziridination of 2,4-diene-1-ols in a chemo-, regio-, and stereoselective manner to give vinyl

222 Transition-metal-free chemo-, regio-, and stereoselective synthesis of (Z) and

223 One-pot chemo-, regio-, and stereoselective synthesis of series

224 e place under mild conditions and are highly chemo-, regio-, and stereoselective with up to 99% Z-sel

225 The chemo-, regio-, and stereoselectivities of multicomponen

226 These effects are manifested by the unusual chemo-, regio-, and stereoselectivities shown by the sup

227 Good chemo-, regio-, and stereoselectivities were observed wi

228 The factors controlling chemo-, regio-, and stereoselectivity in a cascade of re

229 s and aldimines as nucleophiles to engage in chemo-, regio-, diastereo- and enantioselective C-C bond

230 uction of amino alcohols with high levels of chemo-, regio-, diastereo- and enantioselectivity.

231 ariably formed in good yields, with rigorous chemo-, regio-, diastereo-, and enantiocontrol.

232 ers, with one being quaternary, in excellent chemo-, regio-, diastereo-, and enantioselectivities in

233 uring substrate oxidation; and modulation of chemo-, regio-, or stereoselectivity of a reaction.

234 rapidly, with exquisite regio, and sometimes chemo, selectivity.

235 l-product settings with predictable and high chemo-, site-, and even diastereoselectivities.

236 a variety of reactions with a high degree of chemo-, stereo- and regioselectivity in most of the reac

237 in animals, protists, and fungi are primary chemo-, thermo-, or mechanosensors.

238 tments using DNA-targeted therapy (radiation/chemo) together with antiangiogenic therapies reduced GB