ライフサイエンスコーパス: chemoattractant receptor

1 sents the first successful purification of a chemoattractant receptor.

2 MP did inhibit the response to formylpeptide chemoattractant receptor.

3 s, we disrupted a gene that encodes a single chemoattractant receptor.

4 CL12 (SDF-1) but does not act as a classical chemoattractant receptor.

5 gand binding pocket of an eicosanoid-binding chemoattractant receptor.

6 in transcriptional regulation downstream of chemoattractant receptors.

7 r of seven-membrane span receptors including chemoattractant receptors.

8 of intracellular calcium, and exocytosis by chemoattractant receptors.

9 ory effect was specific for some but not all chemoattractant receptors.

10 yotic cells does not require polarization of chemoattractant receptors.

11 ed from murine eosinophils to identify novel chemoattractant receptors.

12 one of the most thoroughly studied leukocyte chemoattractant receptors.

13 gradient-induced asymmetric distribution of chemoattractant receptors.

14 the family of leukocyte, G protein-coupled, chemoattractant receptors.

15 human L-selectin along with human leukocyte chemoattractant receptors.

16 ty of G alpha(i2) protein that is coupled to chemoattractant receptors.

17 al RBL cells or cells transfected with other chemoattractant receptors.

18 seudopod region induced by G-protein coupled chemoattractant receptors.

19 otrimeric G protein that couples to the cAMP chemoattractant receptors.

20 to the lung is mediated by G alpha i-coupled chemoattractant receptors.

21 o the lung is an active process dependent on chemoattractant receptors.

22 expression of 'tissue-specific' adhesion and chemoattractant receptors.

23 Human leukocyte chemoattractant receptors activate chemotactic and cytot

24 As PAF and formylpeptide chemoattractant receptors activate PLC via different G p

25 We propose that for chemoattractant receptors agonist-induced phosphorylatio

26 Chemoattractant receptors also control leukocyte egress

27 odes a 130-kD cytosolic protein required for chemoattractant receptor and G protein-mediated activati

28 Chemoattractant receptors and G proteins are fairly even

29 involved in PLC beta2 activation by the two chemoattractant receptors and suggest that in COS-7 cell

30 an be phosphorylated following engagement of chemoattractant receptors and suggest that this may be a

31 A wide array of chemoattractants, chemoattractant receptors, and adhesion molecules expres

32 differences in mRNA for adhesion molecules, chemoattractant receptors, and cytokines compared with o

33 id and selective cross-inactivation of other chemoattractant receptors, and suggest that FPR1 is able

34 tivation and heterologous desensitization of chemoattractant receptors are involved in the inhibition

35 ts at the leading edge of a cell even though chemoattractant receptors are uniformly distributed on t

36 ation of cell surface adhesion molecules and chemoattractant receptors as the cells mature.

37 Thus neutrophils do not actively concentrate chemoattractant receptors at the leading edge during che

38 These observations elucidate a novel role of chemoattractant receptor, BLT-1, in promoting monocyte t

39 The G protein-coupled 7 transmembrane (STM) chemoattractant receptors can be inactivated by heterolo

40 Several chemoattractant receptors can support agonist-induced, i

41 lpha and beta chemokine as well as classical chemoattractant receptors can trigger robust adhesion as

42 Unlike most other cellular proteins, the chemoattractant receptor, cAR1, of Dictyostelium is resi

43 The cAMP chemoattractant receptor, cAR1, of Dictyostelium transdu

44 hat 6CK/SLC is an agonist for the lymphocyte chemoattractant receptor, CCR7 (EBI-1, BLR-2), previousl

45 ere enriched in their expression of specific chemoattractant receptors compared with peripheral blood

46 tor shares greatest sequence similarity with chemoattractant receptors compared with prostanoid recep

47 Unlike Gi-coupled chemoattractant receptors, D2R activated NF-kappaB witho

48 To visualize a chemoattractant receptor directly during chemotaxis, we

49 The PAFR and the peptide chemoattractant receptors do not cross-regulate each oth

50 mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels by ess

51 myl peptide receptor (FPR) is a prototypical chemoattractant receptor expressed in neutrophils.

52 ide receptor 1 (FPR1) is a G protein-coupled chemoattractant receptor expressed mainly on leukocytes.

53 es calcium signaling of a discrete subset of chemoattractant receptors expressed by human leukocytes.

54 n atopic asthmatics to define the pattern of chemoattractant receptor expression on recruited T cells

55 The cAMP chemoattractant receptor family of Dictyostelium discoid

56 n of CMKLR1 (chemokine-like receptor 1), the chemoattractant receptor for chemerin, and was abrogated

57 s conclusively demonstrate that CB2 is not a chemoattractant receptor for murine macrophages.

58 ch requires that leukocytes display multiple chemoattractant receptors for successful homing and prov

59 n sites is partly driven by N-formyl peptide chemoattractant receptors (FPRs).

60 bits chemotaxis of neutrophils by preventing chemoattractant receptors from activating trimeric G pro

61 o IL-8 does not appear to be due to impaired chemoattractant receptor function, as the number of IL-8

62 ing the involvement of G protein subunits in chemoattractant receptor function.

63 ion, a phenomenon found in analysis of other chemoattractant receptor genes.

64 The orphan chemoattractant receptor GPR15 mediates regulatory T cel

65 , D-type prostanoid (DP) and, in particular, chemoattractant receptor homologous molecule expressed o

66 The D-prostanoid receptor and the chemoattractant receptor homologous molecule expressed o

67 Pathogenic responses--chemoattractant receptor homologous molecule expressed o

68 ly mediated by the prostaglandin D2 receptor chemoattractant receptor homologous molecule on T(H)2 ce

69 15dPGJ2 is a ligand for the Chemoattractant Receptor Homologous to the T helper 2 ce

70 ecules such as thymic stromal lymphopoietin, chemoattractant-receptor homologous molecule expressed o

71 CRTh2 (chemoattractant-receptor homologous molecule expressed o

72 established that interaction of PGD(2) with chemoattractant receptor- homologous molecule expressed

73 hymic stromal lymphopoietin, as well as oral chemoattractant receptor-homologous molecule expressed o

74 of CD203c(bright), CD63(+), and CD107a(+) on chemoattractant receptor-homologous molecule expressed o

75 D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed o

76 as tested by using TM30089, an antagonist of chemoattractant receptor-homologous molecule expressed o

77 Chemoattractant receptor-homologous molecule expressed o

78 Dexamethasone inhibited (P = .04) chemoattractant receptor-homologous molecule expressed o

79 on 3 G protein-coupled receptors, including chemoattractant receptor-homologous molecule expressed o

80 ses through a high-affinity interaction with chemoattractant receptor-homologous molecule expressed o

81 mbrane-spanning/G protein-coupled receptors, chemoattractant receptor-homologous molecule expressed o

82 The chemoattractant receptor-homologous molecule expressed o

83 n eosinophil/mast cell densities, density of chemoattractant receptor-homologous molecule expressed o

84 ndin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed o

85 The chemoattractant receptor-homologous molecule expressed o

86 oid receptors (DPs) DP1 and DP2 (also called chemoattractant receptor-homologous molecule expressed o

87 The chemoattractant receptor-homologous molecule expressed o

88 peT(H)2 cells were identified as chemoattractant receptor-homologous molecule expressed o

89 4 and IL-5) and chemotactic receptors (CCR4, chemoattractant receptor-homologous molecule expressed o

90 Chemoattractant receptor-homologous molecule on Th2 cell

91 bitors that suppress inflammation (targeting chemoattractant receptor-homologous molecules expressed

92 roperties of a series of clinically relevant chemoattractant receptor-homologous molecules expressed

93 However, the ability of CB2 to act as a chemoattractant receptor in macrophages remains largely

94 To study the biology of individual leukocyte chemoattractant receptors in a defined lymphoid environm

95 tissue, we performed expression analyses of chemoattractant receptors in a related family that inclu

96 ctions resulting from Galpha(16) coupling of chemoattractant receptors in a transfected cell model sy

97 view recent advances in our understanding of chemoattractant receptors in disease pathogenesis, with

98 G-protein-coupled receptors that function as chemoattractant receptors in innate immune responses.

99 s, LPS selectively modulates the function of chemoattractant receptors in microglia and may promote h

100 e receptor-mediated desensitization of bound chemoattractant receptors in neutrophils.

101 mphocyte trafficking, but the involvement of chemoattractant receptors in the physiologic recruitment

102 or CCR6 and CXCR3, in conjunction with other chemoattractant receptors, in the recruitment of inflamm

103 eutrophils infiltrate the joint via multiple chemoattractant receptors, including the leukotriene B(4

104 These data indicate that chemoattractant receptors induce chemokine production in

105 inhibitor, staurosporine, completely blocked chemoattractant receptor-induced phosphorylation of L-se

106 is study, we have investigated whether human chemoattractant receptors internalize via clathrin-coate

107 cking, we integrate a number of nonchemokine chemoattractant receptors into our discussion.

108 tion of siRNA to silence a G protein-coupled chemoattractant receptor involved in inflammation and su

109 Signaling through chemoattractant receptors involves a standard G-protein-

110 A family of G-protein-coupled chemoattractant receptors is known to mediate the transp

111 Leukocyte activation through chemoattractant receptors leads to Pak activation and tr

112 eraction with D prostanoid receptor (DP) and chemoattractant receptor-like molecule expressed on Th2

113 or receptors, D prostanoid receptor (DP) and chemoattractant receptor-like molecule on the Th2 cell.

114 phosphorylation in cross-desensitization of chemoattractant receptors, M2CXCR1 was coexpressed with

115 is that interaction between autoantigens and chemoattractant receptors may be an important step in th

116 zed that signaling through G protein-coupled chemoattractant receptors may stimulate cytokine product

117 ver, the regulatory role of TRPC channels in chemoattractant receptor-mediated signaling has not yet

118 ymmetric macromolecular complex formation of chemoattractant receptors mediates gradient sensing and

119 ress this issue, we purified cAR1, the major chemoattractant receptor of Dictyostelium discoideum by

120 ere that elimination of phosphorylation of a chemoattractant receptor of Dictyostelium, either by sit

121 ormyl peptide receptor 2 (FPR2), a classical chemoattractant receptor of G-protein-coupled receptors,

122 Chemoattractant receptors of the serpentine, heterotrime

123 g with HIV-1 fusion cofactors, downregulates chemoattractant receptors on monocytes by a CD4-dependen

124 While the localization of chemoattractant receptors on randomly oriented cells has

125 20, implying the contribution of alternative chemoattractant receptors other than spingosine 1-phosph

126 he apparent functional redundancy with other chemoattractant-receptor pairs in vitro, LTB(4) and BLTR

127 mediated through additional Galphai-coupled chemoattractant receptor pathways, including CCR5.

128 Leukocyte chemoattractant receptors play key roles in the pathogen

129 Chemoattractant receptors regulate leukocyte accumulatio

130 Since many of the chemoattractant receptors regulated by cADPR bind to lig

131 To define the molecular basis of human chemoattractant receptor regulation, rat basophilic leuk

132 While chemoattractant receptors rely upon canonical G-protein

133 Therefore, we conclude that chemoattractant receptors require Galphai subunits only

134 These findings suggest that chemoattractant receptors require PANX1 to trigger excit

135 High-affinity chemoattractant receptors responsible for PMN chemotaxis

136 G-protein-coupled chemoattractant receptors signal transiently upon ligand

137 ould explain the inhibition of formylpeptide chemoattractant receptor signaling by cAMP.

138 pear to be critical downstream components of chemoattractant receptor signaling in human neutrophils,

139 Here we show how LN anatomy and chemoattractant receptor signaling organize B lymphocyte

140 sensitivity to background signals, prolonged chemoattractant receptor signaling, and inappropriate CX

141 ein kinase A (PKA) activation, which blocked chemoattractant receptor signaling.

142 nits remain GTP bound, RGS proteins modulate chemoattractant receptor signaling.

143 or chemotaxis and phagocytosis indicate that chemoattractant receptor-signaling is not essential for

144 These data suggest that of the chemoattractant receptors studied, G-protein usage varie

145 esponding to fMLF, a peptide agonist for two chemoattractant receptor subtypes, formyl peptide recept

146 egulation of Th1/2 effector tissue-targeting chemoattractant receptors such as CCR4, CCR5, CXCR6, and

147 Galphai-coupled chemoattractant receptors, such as the 5-oxo-6E,8Z,11Z,1

148 B4, did not inhibit the responses of peptide chemoattractant receptors, suggesting distinct signaling

149 The selectin adhesion molecules and chemoattractant receptors synergistically regulate leuko

150 lls that differentially express adhesion and chemoattractant receptors targeting them to the correspo

151 rect T cell expression of these adhesion and chemoattractant receptors, targeting the resulting effec

152 Formyl peptide receptor 2 (FPR2) is a chemoattractant receptor that recognizes proinflammatory

153 GPR15 is the chemoattractant receptor that regulates T-cell migration

154 he innate immune system express adhesion and chemoattractant receptors that allow them to migrate dir

155 To identify chemoattractant receptors that control this homing patte

156 uishable by their expression of adhesion and chemoattractant receptors that directed their homing to

157 cking programs (combinations of adhesion and chemoattractant receptors) that target their migration t

158 geted disruption of two abundantly expressed chemoattractant receptors, the receptors for C3a and C5a

159 the expression and function of a variety of chemoattractant receptors through a process of heterolog

160 CAM-1, suggesting common mechanisms coupling chemoattractant receptors to activation of distinct inte

161 Redistribution of chemoattractant receptors to the anterior pole of a pola

162 The signaling pathways that link chemoattractant receptors to the cytoskeleton and cellul

163 aling pathway leading from G protein-coupled chemoattractant receptors to the generation of oxidants

164 gest that Rho participates in signaling from chemoattractant receptors to trigger rapid adhesion in l

165 Activation of G-protein-coupled chemoattractant receptors triggers dissociation of Galph

166 of the overall structure of other chemokine/chemoattractant receptors, underscoring an important evo

167 ally expressed in neutrophils, and acts as a chemoattractant receptor via an Akt-dependent pathway.

168 vation takes place through G protein-coupled chemoattractant receptors via a pathway that requires ho

169 , following segmental allergen challenge, no chemoattractant receptor was specifically increased.

170 Interactions between L-selectin and chemoattractant receptors were therefore examined using