ライフサイエンスコーパス: chemokine CXCL1

1 timulating factor (G-CSF) and the ELR(+) CXC chemokine CXCL1.

2 inflammatory cytokines IL1beta, IL6, and the chemokine CXCL1.

3 opoietic tissue of the neutrophil-recruiting chemokine CXCL1.

4 t through seed-derived factors including the chemokine CXCL1.

5 on in response to both retinoic acid and the chemokine CXCL1.

6 bility through secreted products such as the chemokines CXCL1, 2, 3, and 8, through adhesion-dependen

7 ast, cathepsins specifically process ELR CXC chemokines CXCL1, -2, -3, -5, and -8 N-terminally to the

8 n-coupled receptor (GPCR) that binds the CXC chemokines, CXCL1-3 and CXCL5-8, and induces intracellul

9 lm infection led to significant increases in chemokine (CXCL1 and CCL2) and proinflammatory cytokine

10 Here we demonstrate a role for the chemokine CXCL1 and its receptor CXCR2 in patterning the

11 ptor family, induced potent secretion of the chemokines CXCL1 and CCL2 as well as expression of induc

12 ated with marked astrocytic synthesis of the chemokines CXCL1 and CCL2 in response to both cytokine c

13 teria has higher levels of mRNA encoding the chemokines CXCL1 and CCL2 than does tissue isolated from

14 optosis, and expression of mRNA encoding the chemokines CXCL1 and CXCL10.

15 ts demonstrated diminished production of the chemokines CXCL1 and CXCL2 and delayed neutrophil and T

16 The ELR(+) CXC chemokines CXCL1 and CXCL2 are up-regulated in the centr

17 eased mRNA expression of neutrophil-specific chemokines CXCL1 and CXCL2 in the lungs of C57BL/6 and I

18 he melanoma growth and migration stimulatory chemokines CXCL1 and CXCL2 were significantly up-regulat

19 d T cells, whereas the neutrophil-attracting chemokines CXCL1 and CXCL2 were up-regulated in the CNS

20 -protein-coupled receptor CXCR2 (recognizing chemokines CXCL1 and CXCL2) as another arm feeding into

21 steoblasts constitutively expressed the ELR+ chemokines CXCL1 and CXCL2, and CXCL2 expression was ind

22 uced expression of the neutrophil-attracting chemokines CXCL1 and CXCL5 in kidney cells.

23 Here we demonstrate that chemokines CXCL1 and CXCL8 chemoattract ASC by signallin

24 es expression of Bcl-2 and the proangiogenic chemokines CXCL1 and CXCL8 in HNSCC cells.

25 stinctly different compared with the related chemokines CXCL1 and CXCL8.

26 we found that expression of 2 PMN-attracting chemokines, Cxcl1 and Cxcl2, was rapidly and dramaticall

27 ogenous luminal restoration of IL-17-related chemokines, CXCL1 and CXCL5, improves host defenses agai

28 motactic chemokines KC (keratinocyte-derived chemokine) (CXCL1) and MIP-2 (macrophage inflammatory pr

29 es, TNF-alpha elicited marked release of the chemokine CXCL1, and the release was blocked by carbenox

30 In rodents, the chemokine CXCL1 both induces the proliferation and inhib

31 nflammatory cytokines (sICAM-1 and IL-6) and chemokines (CXCL1, CCL1, CCL2 and CCL5) that are hallmar

32 ng showed many up-regulated genes, including chemokines (Cxcl1, Ccl7), cytokines (tumor necrosis fact

33 TNF-alpha, IL1-b, IFN-gamma, and IL-12), and chemokines (CXCL1, CXCL2, CCL2, CCL3, CCL4, and CXCL10).

34 tory molecules (CD80, CD86, CD40, and CD70), chemokines (CXCL1, CXCL2, CXCL3, CCL12, CCL17), as well

35 ted in the generation of neutrophil-specific chemokines CXCL1, CXCL2 as well as TNFalpha.

36 6, IL-23, IL-1beta, as well as IL-17 and the chemokines CXCL1, CXCL2, and CCL2, whereas similarly tre

37 d endothelial expression of the neutrophilic chemokines CXCL1, CXCL2, and CXCL5 and led to a function

38 Substantial induction of the chemokines CXCL1, CXCL2, and S100A8; the acute-phase pro

39 d deficit in their capability to release the chemokines CXCL1, CXCL2, CCL3, and CCL4 and TNF-alpha in

40 These cytokine genes included chemokines (Cxcl1, Cxcl3, Cxcl5, Ccl2, and Ccl3), ILs (I

41 F], interleukin-17 [IL-17], and IL-1beta) or chemokine (CXCL1, CXCL5, CXCL9, and CXCL10) induction.

42 gories: proangiogenic factors (MMP9, VEGFA), chemokines (CXCL1, CXCL5, IL8, CCL2), cytokines (IL1B, I

43 In addition, the chemokines CXCL1, CXCL5, CXCL6, and complement C3, known

44 Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13

45 differentially elicited a further downstream chemokine (CXCL1/CXCL8) autocrine loop, with the two loo

46 were expressed at adult levels, whereas the chemokines CXCL1, CXCL9, and CCL2 remained at baseline l

47 onuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2).

48 al colony forming units, and by elevation of chemokine CXCL1, cytokine IL-6, and endogenous G-CSF pro

49 okines, as well as a prolonged half-life for chemokine CXCL1-encoding mRNA after treatment with IL-17

50 instead reduced secretion of the angiogenic chemokine CXCL1 from head and neck cancer cells in vitro

51 ncer Genome Atlas showed that the neutrophil chemokine CXCL1 gene was highly upregulated in colon tum

52 , HNP 1-3, elafin, and LL-37) and neutrophil chemokines (CXCL1/GRO-alpha, CXCL2/GRO-beta, CXCL5/ENA-7

53 and correspondingly had lower levels of the chemokine CXCL1 in bronchoalveolar lavage fluid and lung

54 The functional role of the ELR(+) chemokine CXCL1 in host defense and disease following in

55 anoma cells, the basal expression of the CXC chemokine, CXCL1, is constitutively up-regulated.

56 previous studies have revealed that the CXC chemokine, CXCL1, is overexpressed in human malignant me

57 Using the mouse chemokine CXCL1 (KC) gene as a model, we have examined t

58 f intron content on the rate of decay of the chemokine CXCL1 (KC) mRNA.

59 i) DC produced elevated levels of the murine chemokine CXCL1 (KC), interleukin 12p40, and RANTES in r

60 appin-2-treated PA01 up-regulated the murine chemokine CXCL1/KC after 2 hours with a corresponding in

61 cytes but with elevated levels of the ELR(+) chemokines (CXCL1/keratinocyte-derived chemokine and CXC

62 In humans, the chemokine CXCL1/MGSA (hCXCL1) plays fundamental and dive

63 The chemokine CXCL1/MGSA plays a pivotal role in the host im

64 Levels of the angiogenic chemokine CXCL1 (mouse functional homologue of human IL-

65 ow here that IL-17 enhanced the stability of chemokine CXCL1 mRNA and other mRNAs through a pathway t

66 The ELR-CXC chemokine, CXCL1 or MGSA/GROalpha, is traditionally cons

67 The CXC chemokine CXCL1, or MGSA/GROalpha, is traditionally cons

68 on E-selectin (slowly) or by exposure to the chemokine CXCL1 (rapidly).

69 r alpha (TNF-alpha), IL-10, and IL-6 and the chemokine CXCL1 were upregulated in cocultured HT-29 cel

70 and VCAM-1), and enhanced the release of CXC chemokine CXCL1 when incubated with primary cultures of

71 lso had higher levels of the proinflammatory chemokine CXCL1, which CD T cells produce, in the kidney