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1 sidues are affected by interactions with the chemokine receptor.
2 nce for epigenetic regulation of an atypical chemokine receptor.
3 nts is enforced by the ordered expression of chemokine receptors.
4 ies and challenges to find novel ligands for chemokine receptors.
5 spleen and lung cells expressing CCR3/CCR10 chemokine receptors.
6 aves the way for future allosteric drugs for chemokine receptors.
7 at CCR9, but potentially extending to other chemokine receptors.
8 s the plaque progression and upregulation of chemokine receptors.
9 occupancy as a key parameter when targeting chemokine receptors.
14 p130, CCL4, TNFalpha, SH2D1B, CAV1, atypical chemokine receptor 1 [duffy blood group]) whose mRNA tra
17 membrane-bound psoriasis-associated atypical chemokine receptor 2 (ACKR2) binds, internalizes and deg
22 mation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endotheli
24 lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE
26 rapidly mobilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the nonclassi
28 ltrate by modulating the expression of C-X-C chemokine receptors 2 and 4 on peripheral blood neutroph
31 The G protein-coupled receptor (GPCR) C-X-C chemokine receptor 3 (CXCR3) is a potential drug target
32 tion to IL-17A, the chemokine receptor C-X-C chemokine receptor 3 (CXCR3) is also important to enable
33 d abolished their differentiation into C-X-C chemokine receptor 3 (CXCR3)(lo)CD43(lo) effector-like m
35 environment signals in cancer: (C-X-C motif) chemokine receptor 4 (CXCR4) and PTK2 (encoding for foca
37 C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine receptor 4 (CXCR4) in orthotopic murine CRC mo
39 The G protein-coupled protein receptor C-X-C chemokine receptor 4 (CXCR4) is an attractive target for
40 ve hypoxia-induced expression of C-X-C motif chemokine receptor 4 (CXCR4) on invading tumor cells, ma
41 hat three genes belonging to the C-X-C motif chemokine receptor 4 (CXCR4) pathway were downregulated
45 ns covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino aci
47 stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 axis, in the development of those l
48 the lungs to up-regulate CXCR4 (C-X-C motif chemokine receptor 4) before entering the bone marrow, w
50 immunodeficiency virus (HIV) and human C-X-C chemokine receptor-4 (CXCR4) facilitates migration of in
52 evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque H
53 dified unselected CD8 T cells to express CXC chemokine receptor 5 (CXCR5), the chemokine receptor imp
54 autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T
57 t, even when LN retention signals such as CC chemokine receptor 7 (CCR7) are down-regulated, T cell i
59 adipose tissue immune cells that express C-C chemokine receptor 7 (CCR7) in mice and humans, and that
60 vity induced by BRAFV600E inhibits C-C motif chemokine receptor 7 (CCR7)-mediated DC migration, trapp
61 chemoresistance by upregulating C-X-C motif chemokine receptor 7 (CXCR7) expression through signal t
63 -regulation of SDF-1, and its receptor C-X-C chemokine receptor 7, was documented on podocytes and PE
67 We further demonstrate that the atypical chemokine receptor ACKR2, which scavenges inflammatory C
73 xpression of immune-related pathways such as chemokine receptor activity, chemotaxis and cytokine bio
74 Dendritic cells (DCs) expressing the XCR1 chemokine receptor, also known as CD103(+) or CD8alpha(+
77 ty through the photoactivation of engineered chemokine receptors and calcium release-activated calciu
78 1alpha regulates the expression of important chemokine receptors and cell adhesion molecules that con
80 major Th-cell subsets using combinations of chemokine receptors and fluorescence-activated cell sort
81 lesterol on the organization and function of chemokine receptors and GPCRs in general include direct
83 clones expressed high levels of skin-homing chemokine receptors and migrated in the presence of the
84 rresponding to the elevated concentration of chemokine receptors and more importantly increased PET s
85 ppears to be present in a large number of CC chemokine receptors and thereby could play a more genera
86 ine mediators are found to bind to classical chemokine receptors and to elicit critical biological re
87 -associated surface markers, interleukin-10, chemokine receptors, and immunoglobulin heavy-chain isot
89 ified, but, to date, only two small molecule chemokine receptor antagonists have been approved by the
94 itiating cells (TICs), the tumor stroma, and chemokine receptors, as well as invasion and metastasis.
95 to its apparent inhibitory effects on CXCR4 chemokine receptor, autophagy, and cholesterol metabolis
96 s that is strongly affected by the chemokine-chemokine receptor axes regulating the trafficking of in
97 erapies and point to a multifaceted role for chemokine receptor binding in promoting HIV-1 entry.
99 Our analysis suggests two distinct roles for chemokine receptor binding, one to trigger formation of
100 els on target cells or eliminating competent chemokine receptor-binding sites on Env trimers resulted
101 s and models promote unique understanding of chemokine receptor biology, including the interpretation
102 udies showed that in addition to IL-17A, the chemokine receptor C-X-C chemokine receptor 3 (CXCR3) is
103 lar, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors for
104 lencing of a group of chemokine (CC/CXC) and chemokine receptor (CCR) mRNAs, thereby helping to resol
107 latory properties and high expression of the chemokine receptor CCR10 for localization into the skin.
108 cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance
111 monocyte-derived macrophages, which use the chemokine receptor CCR2 to gain entry to injured tissues
112 identified two novel biased ligands for the chemokine receptors CCR2 and CCR5 and characterized thei
115 d, CD18, CD11a, CD11b, L-selectin) or of the chemokine receptor CCR3, but decreased CD49d and CCR3 wa
117 In conclusion, our study suggested that chemokine receptor CCR4 promotes HCC malignancy and faci
119 ated T cell recruitment to the heart via the chemokine receptor CCR5 by inducing autocrine CCR5 ligan
122 show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome
125 icate that ABCs express higher levels of the chemokine receptor CCR7, have higher responsiveness to C
133 ecific small molecule antagonist of the CCR6 chemokine receptor, CCX2553, was efficacious in reducing
135 has obscured the contributions of individual chemokine receptor/chemokine pairs to this process.
137 oming involve chemokines (Ch) and lymphocyte chemokine receptors (ChR) for vascular wall arrest and d
138 okine and small molecule action, whereas the chemokine receptor conserved disulfide bridge between th
139 The metal ion Zn(2+) is anchored to the chemokine receptor-conserved Glu-283(VII:06/7.39) Both c
141 ligand discovery and design studies based on chemokine receptor crystal structures and homology model
142 ifferentially promoted the expression of the chemokine receptor CX3CR1 and the integrin alpha4beta7 o
144 ders had a significantly lower expression of chemokine receptor CX3CR1 on CD56(bright) NK cells and i
148 tment and activation are orchestrated by the chemokine receptors CX3CR1 and CCR2 and their cognate li
149 ted mice expressed lower levels of F4/80 and chemokine receptors CX3CR1 and CCR2 in the F4/80(+) rena
150 ne.IMPORTANCE RSV binds to the corresponding chemokine receptor, CX3CR1, through a CX3C chemokine mot
153 me cyclooxygenase-2, the IL-8 receptor C-X-C chemokine receptor (CXCR) 1, and the intracellular kinas
155 of CXCL4 or pharmacologic inhibition of the chemokine receptor CXCR2, significantly decreased cell v
156 es through non-cognate interactions with the chemokine receptors CXCR2 and CXCR4, in addition to acti
157 ment with Ag downregulates expression of the chemokine receptor CXCR3 and prevents diabetogenic Th1 c
158 ort that Tregs expressing the TH1-associated chemokine receptor CXCR3 are enriched in the kidneys of
160 ration is due to a reduction in inflammatory chemokine receptor CXCR3 surface expression and cellular
166 to porcine endothelium depends on particular chemokine receptors (CXCR3, CCR4) and integrins (CD18 an
167 lesions, and further, that the IFN-inducible chemokine receptor, CXCR3, is upregulated on alopecic ef
171 r effectors of BM extravasation, such as the chemokine receptor CXCR4 and the integrin dimer VLA-4, b
176 in infection and inflammatory processes, the chemokine receptor CXCR4 might be a potent target in ima
177 s that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mecha
178 tor S1PR5 on NK cells, and expression of the chemokine receptor CXCR4 were all required for NK cell l
179 n sites at the distal C-terminal tail of the chemokine receptor CXCR4, but were unable to determine w
182 ng integrins (CD11a/CD11c/CD29/CD49d/CD49e), chemokine receptors (CXCR4), and adhesion molecules (CD4
183 otoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell fol
193 ocal recruitment of lymph node-resident XCR1 chemokine receptor-expressing DCs via secretion of the X
194 ytes using flow cytometry revealed increased chemokine receptor expression and enhanced transendothel
195 cule 1 (ICAM-1) expression in the brain, and chemokine receptor expression by both myeloid and T cell
196 rculating fibrocytes and characterized their chemokine receptor expression in 54 patients with COPD e
197 rization of MR1T cell clones showed multiple chemokine receptor expression profiles and secretion of
198 MSN-deficient T cells also displayed poor chemokine receptor expression, increased adhesion molecu
200 rocytes highly expressed CXCR4 and CCR3, the chemokine receptors for CXCL12 and CCL11, respectively.
205 s to home to HSV lesions should elicit these chemokine receptors if possible to increase the homing o
206 xpress CXC chemokine receptor 5 (CXCR5), the chemokine receptor implicated in cellular entry into B-c
208 or sensitive and specific detection of these chemokine receptors in both a mouse vascular injury mode
210 novel difference between ATRA signaling and chemokine receptor induction in Treg versus Tconv and pr
211 he data identify similarities with classical chemokine-receptor interactions but also provide evidenc
214 rative analysis of ligand binding pockets in chemokine receptors is presented, including a detailed d
215 a indicate that CX3CR1, a microglia-specific chemokine receptor, is a novel therapeutic target for en
216 subsets to bacterial survival, we challenged chemokine receptor knockout mice and found that P. gingi
218 cilitates the prediction of the structure of chemokine receptor-ligand complexes that have not been c
219 n, greatly increased expression of the CXCR3 chemokine receptor ligands CXCL9 and CXCL10 in VV-infect
224 f antigen receptor-, cytokine receptor-, and chemokine receptor-mediated signaling was significantly
226 the metabolic pathway serves as a target for chemokine receptor-mediated T cell tolerance and suppres
228 Cells expressing the corresponding cognate chemokine receptors migrate against this gradient by cra
229 e construction and application of structural chemokine receptor models for the elucidation of molecul
230 the elucidation of molecular determinants of chemokine receptor modulation and the structure-based di
232 olipidemic recipients and those deficient in chemokine receptors necessary to recruit inflammatory Ly
233 ed high affinity synthetic agonists for this chemokine receptor, obtained by grafting the CXCL12 N-te
234 We emphasize the role of cholesterol in chemokine receptor oligomerization, thereby promoting th
235 g unselected CD8 T cells to express CXCR5, a chemokine receptor on TFH associated with B-cell follicl
238 f T cells from the blood involves the use of chemokine receptors on the T-cell surface and chemokines
240 but the identification of a single specific chemokine/receptor pathway that may constitute a suitabl
241 ificant differential regulation of chemokine/chemokine receptor pathways, antigen processing componen
243 s revealed that CD26(high) cells have a rich chemokine receptor profile (including CCR2 and CCR5), pr
244 inhibitory receptors, reduced expression of chemokine receptors, proliferated less, and produced les
245 tic deletion of CX3CR1, a microglia-specific chemokine receptor, promotes recovery after traumatic sp
246 along with associated signals from Notch and chemokine receptors, regulates the beta-selection checkp
248 ss CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required for homing to GCs) and expan
249 rsors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization fr
250 chestrating cell migration, it is vital that chemokine receptor signaling is tightly regulated to ens
251 a show an additional layer of complexity for chemokine receptor signaling that might be exploited to
253 terferon, M2 polarizing genes, and chemokine-chemokine receptor signaling were up-regulated in spleen
255 mmation and identify Rgs1, and inhibition of chemokine receptor signalling as potential therapeutic t
256 trated upregulation of specific integrin and chemokine receptor signature suggesting interaction with
257 ) T cells exhibited diminished expression of chemokine receptors, specifically CCR4 and CXCR3, and th
259 eceptor 2 (CCR2) is one of 19 members of the chemokine receptor subfamily of human class A G-protein-
260 to migrate to the periphery via a variety of chemokine receptors such as CCR4, CCR5, and CCR7 and to
262 e type of inflammation, making the chemokine/chemokine receptor system a key point of the immune resp
264 ymphocytes in the circulation and is the key chemokine receptor that enables these cells to target th
267 of BCL6 and BLIMP1 and unique expression of chemokine receptors that direct migration to inflamed si
268 lease promotes cross-talk between opioid and chemokine receptors that in part leads to reduced effica
269 form for sensitive and specific detection of chemokine receptors to assess plaque progression in mous
270 is linked with increased expression of other chemokine receptors to form Th1-, Th2-, and Th17-like Tf
271 recruits tumor cells expressing the cognate chemokine receptors to lymphatic vessels and LEC permeab
272 broad-spectrum peptide antagonist imaging 8 chemokine receptors together, the purpose of this study
273 -C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 1 (CCR1), which are the receptor
275 burned patients with a special focus on C-C chemokine receptor type 2 (CCR2) expressions on classica
277 c ablation or pharmacologic inhibition of CC chemokine receptor type 2 (CCR2) reduced macrophage (MP)
278 ether CCX140-B, a selective inhibitor of C-C chemokine receptor type 2 (CCR2), could further reduce a
282 ng factor 1 receptor blockade diminished C-C chemokine receptor type 2 [CCR2(neg) (Ly6C(lo))] monocyt
283 ajor histocompatibility complex II/C-C motif chemokine receptor type 2) macrophages expressed higher
284 ons were impaired by the inhibitors of C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine rece
285 in collagen and elastin staining, and C-X-C chemokine receptor type 4, nuclear factor kappa beta, an
286 udies demonstrated that ORM1 can bind to C-C chemokine receptor type 5 (CCR5) on muscle cells and del
287 t T-cell population is enriched with a C-X-C chemokine receptor type 5 (CXCR5)(+)CD4(+) TFH precursor
288 r of differentiation 4 (CD4) and coreceptors chemokine receptor type 5 and chemokine-related receptor
289 V)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required
291 that promote its interaction with one of the chemokine receptors, usually CCR5, ultimately leading to
294 of several candidate skin-homing-associated chemokine receptors was measured using flow cytometry.
295 detailed analysis of activation markers and chemokine receptors was performed on IgG4-expressing B c
297 Chemokine receptor 9 (CCR9), a cell surface chemokine receptor which belongs to the G protein-couple
298 cluding molecules such as ACKR2, an atypical chemokine receptor whose role in psoriasiform dermatitis
299 integration of new structural information on chemokine receptors with extensive structure-activity re
300 ation for modeling molecular interactions of chemokine receptors with small-molecule ligands, peptide
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