ライフサイエンスコーパス: chemoselective

1 ese TMP salts were demonstrated to be highly chemoselective.

2 te experimental data showing that it is less chemoselective.

3 al environments and then undergo a rapid and chemoselective 1,4-Michael addition with the pKa-perturb

4 Additionally, the chemoselective 1,4-reduction of the enone products provi

5 Furthermore, this allows for a chemoselective 1,5-HAT over competing direct cyclization

6 This has enabled a chemoselective 1,6-HAT over a competing 1,5-HAT.

7 oxazolidinone-substituted oxyallyl undergoes chemoselective (3 + 2) cycloaddition onto the carbonyl g

8 n with photoredox catalysis allows for mild, chemoselective access to a wide array of related structu

9 Driven by the unmet need to develop chemoselective access to boron chemotypes, we report her

10 The chemoselective acetoxylation of the epsilon-C-H bond was

11 Especially, the BDG-aided chemoselective acetoxylation of the remote epsilon-C(sp(

12 -catalyzed, bidentate directing group-aided, chemoselective acetoxylation/substitution of remote epsi

13 Chemoselective acidic hydrolysis of sulfonamides with tr

14 The chemoselective activation and coupling of C-terminal pep

15 Chemoselective activation of amide carbonyl functionalit

16 ysis has emerged as a powerful technique for chemoselective activation of chemical bonds under mild r

17 -amino acid selenoesters which are effective chemoselective acylating reagents.

18 etic derivatization of starting material via chemoselective acylation of the l-ornithine alpha-amino

19 th microscopic investigation that probes the chemoselective addition of Ag to Pt-Fe3O4 heterodimer se

20 The chemoselective addition of arenes and 1,3-diketones to a

21 a'-haloketones has been achieved through the chemoselective addition of halomethyllithium carbenoids

22 The chemoselective addition of N-heterocycle 1a onto alkyne

23 inert atmospheres in toxic organic solvents, chemoselective addition of organolithium reagents to non

24 Highly chemoselective addition of Schwartz's reagent to widely

25 An efficient organocatalytic method for chemoselective aerobic oxidation of secondary benzylic a

26 The method is chemoselective against secondary and primary alcohols, t

27 a non-natural amino acid (NNAA) followed by chemoselective albumin conjugation to prolong therapeuti

28 tion that normally poses major challenges in chemoselective, aliphatic C-H functionalization.

29 es by a pyridinium dichromate (PDC)-mediated chemoselective allylic oxidation.

30 amily of iron catalysts capable of promoting chemoselective alpha-oxidation of a range of ethers with

31 Notably, chemoselective amidation of aliphatic amines takes place

32 (Asa) side chain can be easily prepared by a chemoselective amide-forming ligation that results in th

33 We show that chemoselective amide-forming ligations of potassium acyl

34 talysts capable of promoting predictable and chemoselective aminations solely through reagent control

35 Herein, we report remarkable chemoselective aminations that employ a single metal (Ag

36 C, and D, through a route fueled by several chemoselective and carefully orchestrated steps.

37 y Z-selective alkene cross-metathesis, and a chemoselective and diastereoselective dichlorination of

38 lar nitrene transfer reactions that are both chemoselective and flexible for aziridination or C-H ins

39 s fast, operationally simple, high yielding, chemoselective and functional group tolerant method.

40 The reactions are chemoselective and high yielding.

41 h repeat unit, which is enabled by perfectly chemoselective and highly syndiospecific coordination po

42 e-reduction methods, this reaction is highly chemoselective and is compatible with alcohols, phenols,

43 Multiple chemoselective and redox-economic functional group inter

44 proach outlined in this protocol enables the chemoselective and regioselective late-stage silylation

45 udo-single-atom structures as highly active, chemoselective and reusable catalysts for hydrogenation

46 that peptide fragments can be exchanged by a chemoselective and reversible native chemical ligation (

47 yne substrates are found to undergo a highly chemoselective and stereoselective domino Pauson-Khand a

48 ty of this catalyst system is evident in the chemoselective and stereospecific oxidation of the polyo

49 The reaction is both chemoselective and syn-selective, making it complementar

50 The method is chemoselective and tolerates a wide range of reducible f

51 igosaccharide synthesis including selective, chemoselective, and orthogonal strategies is demonstrate

52 The reaction is efficient, chemoselective, and pH/redox neutral.

53 mer-polymer click reaction, achieving rapid, chemoselective, and quantitative coupling at room temper

54 This mild, operationally simple, chemoselective, and scalable difluoromethylation method

55 Discovery of this broadly applicable, chemoselective, and solvent-versatile reagent should all

56 gy involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of function

57 techol-boronate binding mechanism provides a chemoselective approach for controlling the release of B

58 A chemoselective approach was developed for the synthesis

59 d, among them the most recent strategies for chemoselective arene metalation on peptides.

60 useful toolkit of Cu-based catalysts for the chemoselective arylation of a wide-range of nucleophiles

61 clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cysteine in ribosomally prod

62 Notably, chemoselective arylation of diazo compounds over other e

63 The method is highly chemoselective as a vast array of functional groups are

64 Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations,

65 The procedure is chemoselective, avoids the use of precious metals, and c

66 al C-H abstraction/rebound, as observed with chemoselective base metals such as iron.

67 lignin degradation strategy consisting of a chemoselective benzylic oxidation with a recyclable oxid

68 er as a mechanism towards enabling site- and chemoselective bioconjugation.

69 further method development in the context of chemoselective, bioorthogonal labeling.

70 The identification of fast, chemoselective bond-forming reactions is one of the majo

71 for a range of organic reactions, including chemoselective borylation, silylation and amination of b

72 Also, Ag-mediated, completely chemoselective Br displacement from 2S leads to a range

73 This reaction allows the chemoselective C-C bond formation between the pyrrole C3

74 Highly chemoselective C-S cross-coupling was achieved versus co

75 el gold surface in regards to NO2 reduction, chemoselective C=O bond hydrogenation, ether formation,

76 f an entropic chemical ligation consist of a chemoselective capture step merging the N and C termini

77 This chemoselective carbene insertion into -NH bond over -COO

78 Relying on these factors, highly regio- and chemoselective carbene insertion reaction of C-H bonds i

79 to Dha, promoted by zinc and copper, enables chemoselective carbon-carbon bond formation.

80 trate the application of these catalysts for chemoselective carbon-halogen bond activation to achieve

81 Palladium-catalyzed chemoselective carbonylation of aminophenols with iodoar

82 Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C-H bond

83 A chemoselective catalytic fluorination of alkyl triflates

84 Chemoselective catalytic oxidation of beta-O-4 linkages

85 The reaction provides a chemoselective catalytic synthesis of 2H-indazoles, 2H-b

86 The reaction provides a chemoselective catalytic synthesis of alpha-acyloxy este

87 Here we report a highly chemoselective catalytic system for the indole oxidation

88 and stable cell-cell contacts in 3D through chemoselective cell-surface engineering based on liposom

89 ere labeled or immobilized by application of chemoselective chemistry at the anomeric center.

90 by chlorotrimethysilane is described for the chemoselective chlorination of polyprenoids.

91 Chemoselective cleavage of the Phen group was performed

92 A stepwise chemoselective click reaction was performed on nucleosid

93 for the synthesis of alkylated arenes by the chemoselective combination of two electrophilic carbons.

94 g molecules is also affected by geometry and chemoselective confinement via matrix binding.

95 issue assemblies through chemistry involving chemoselective conjugation and release.

96 licylate as a novel molecular switch for the chemoselective construction of the macrodiolide.

97 hydroxy ketone to a diketone was followed by chemoselective conversion of the methyl ketone in this s

98 alized cyclopentenones can be generated by a chemoselective copper(II)-mediated Nazarov/Wagner-Meerwe

99 the less reactive allylphenyl carbonates as chemoselective copper-hydride elimination is faster with

100 antero- and retrograde tracers in rats, and chemoselective, Cre-dependent viral constructs in parval

101 riazolium salts are shown to catalyze highly chemoselective cross-benzoin reactions between aliphatic

102 n iridium-catalyzed Krische allylation and a chemoselective cross-coupling approach toward the macroc

103 alpha,beta-unsaturated carbonyl compound by chemoselective cross-coupling of propargyl alcohols with

104 SCl, and a mild reductant can participate in chemoselective cross-coupling with aryl iodides using a

105 neous electrophile control allows sequential chemoselective cross-couplings in a single operation in

106 An efficient protocol for stereo- and chemoselective crystallization of (S)-1,2-dodecanediol a

107 on of primary alcohols to aldehydes, using a chemoselective Cu(I)/TEMPO (TEMPO = 2,2,6,6-tetramethyl-

108 systems and provides a unifying strategy for chemoselective CuAAC ligations in multialkyne/azide syst

109 ional design of carbonylacrylic reagents for chemoselective cysteine bioconjugation.

110 offer the greatest potential for regio- and chemoselective dehydrogenation of alkyl groups and alkan

111 ex catalyzes oxidant-free, acceptorless, and chemoselective dehydrogenation of primary and secondary

112 By using the highly chemoselective depolymerization to prepare new ultra low

113 A new, fast, mild and chemoselective deprotection method to cleave p-methoxybe

114 -irciniastatin A intermediate to implement a chemoselective deprotection/oxidation sequence to access

115 We have synthesized chemoselective derivatives of the tarantula toxin guangx

116 n of interest in the first step, followed by chemoselective derivatization with a tetrazine-fluoropho

117 Highly chemoselective direct reduction of primary, secondary, a

118 f an activating Weinreb carboxamide, further chemoselective elaboration leads to the efficient format

119 Ps, the PRO-functionalized Pt NPs are highly chemoselective even at 100% conversion.

120 uinolinones, and quinolinols in a regio- and chemoselective fashion.

121 azole rings were formed in both a regio- and chemoselective fashion.

122 (OTf)2), N-fluoro-2-methylbenzamides undergo chemoselective fluorine transfer to provide the correspo

123 The polymerization by 1 is perfectly chemoselective for all four polar divinyl monomers, proc

124 The reaction is fully chemoselective for amides even in the presence of esters

125 This reaction is chemoselective for aromatic aldehydes, as an aliphatic a

126 port a new iridium catalyst that is strictly chemoselective for C-H borylation of terminal alkynes.

127 The method was shown to be highly chemoselective for cysteine over other potentially nucle

128 s onto diblock-copolymer-coated surfaces are chemoselective for the placement of thiol and alcohol nu

129 The key sequence features a highly chemoselective formamide activation that triggered a Vil

130 e Hg complex that drives the reaction to the chemoselective formation of 2,5-dihydrofurans.

131 Rhodium(I) and a new SDP ligand promote chemoselective formation of a cyclohex-3-enecarbaldehyde

132 inetic effects of DMSO provide the basis for chemoselective formation of cyclohexenones.

133 e addition and transmetalation, this enables chemoselective formation of two C-C bonds in a single op

134 to the assay is the utilization of a highly chemoselective Friedlander reaction that captures and si

135 Cell surface tailoring of chemoselective functional groups was achieved by a lipos

136 ron products is demonstrated through several chemoselective functionalizations.

137 ive functional group, the reaction is highly chemoselective giving the dichloromethyl derivative.

138 Applications of 2S include chemoselective Grignard coupling, enabling the very shor

139 Chemoselective GxTX mutants conjugated to dendrimeric be

140 Exceedingly facile (23 degrees C) and chemoselective H-CF3 activation with [(dppp)Pd(Ph)(OH)]

141 The stability of the borate unit allows chemoselective halogenation of the heteroaromatic ring,

142 A highly chemoselective heteroannulation protocol for the synthes

143 ][HBPh3], act as efficient catalysts for the chemoselective hydroboration of a wide range of aldehyde

144 r work up, 1 degrees and 2 degrees alcohols; chemoselective hydroboration of aldehydes over ketones i

145 droboration of styrenes as well as excellent chemoselective hydroboration of ketones over alkenes wer

146 Chemoselective hydroboration of nitriles over esters is

147 e consists of a C3 extension (allylation), a chemoselective hydroboration, an alkyne reduction, and a

148 ization/proto-desilylation sequence; and the chemoselective hydrogenation of a fully substituted dien

149 rity affords a flexible means to control the chemoselective hydrogenation of aromatic aldehydes.

150 remarkably prohibited the hydrogenolysis in chemoselective hydrogenation of C=C bonds, leading to an

151 nanoclusters were utilized as a catalyst for chemoselective hydrogenation of nitrobenzaldehyde to nit

152 C-enabled tunable heterogeneous catalyst for chemoselective hydrogenation.

153 Chemoselective hydrolysis of the resulting 5,6-dihydro-1

154 A copper-catalyzed, chemoselective hydrometalation process enables the use o

155 mbination was explored to achieve regio- and chemoselective hydroxylation.

156 Using these probes, chemoselective imaging of either H(2)O(2) or caspase 8 a

157 ulfamidate 17 and alcohol 4 and a remarkably chemoselective, improved palladium(II)-mediated Corey-Yu

158 Chemoselective interaction of aromatic enynes with Bu3Sn

159 A transprotection tactic by a chemoselective intramolecular 6-exo-trig iodoetherificat

160 Highly chemoselective intramolecular amination of propargylic C

161 odides in the presence of Mn2(CO)10 leads to chemoselective iodine atom abstraction and radical addit

162 ble indole-linked delta-lactams via a highly chemoselective iridium(I)-catalyzed reduction.

163 dendralene) and a new method for stereo- and chemoselective isocyanation.

164 hanced resolution and sensitivity offered by chemoselective isotope tags have enabled new and enhance

165 ess the pendant cyclopentenone, and a highly chemoselective lactam reduction delivered the natural pr

166 h native chemical ligation (NCL) and related chemoselective ligation approaches provide an elegant me

167 Diversification of existing chemoselective ligations is required to efficiently acce

168 Key steps include the chemoselective lithiation of a 1-iodo-2-bromoolefin, the

169 midazolidinone, which is followed first by a chemoselective malonate PMB ester removal and then a Cur

170 gnized as valuable synthetic handles for the chemoselective manipulation of peptides and proteins.

171 ion, the functionalized end groups allow for chemoselective manipulations and further elongation of t

172 cyclopropenes occur in a regioselective and chemoselective manner to produce either vinyl thioethers

173 amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditio

174 onalize the aromatic aminobenzoic acids in a chemoselective manner without implementing protection an

175 achieve patterned bioconjugation in a highly chemoselective manner.

176 The mechanism of a recently reported, highly chemoselective metal-free protocol of wide general appli

177 kyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonatio

178 Here, we report a strategy for chemoselective methionine bioconjugation through redox r

179 This highly chemoselective method can tolerate labile and reactive c

180 proach takes advantage of a nonenzymatic and chemoselective method to rapidly generate A2AR embedded

181 A non-enzymatic and chemoselective method to spontaneously generate phosphol

182 he present methodology provides an efficient chemoselective method to synthesize a variety of (Z)-ena

183 Here, we report a non-enzymatic and chemoselective methodology capable of autocatalytically

184 ires the development of a regioselective and chemoselective methodology.

185 acilitated greatly by recent developments in chemoselective methods for biomolecular modification.

186 A suite of flexible and chemoselective methods for the transition-metal-free oxi

187 Non-enzymatic and chemoselective methods to generate phospholipid membrane

188 A novel, organobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is

189 catechols with aniline functional groups is chemoselective, mild, and rapid; however, the oxidativel

190 e soft-N-donors as effective complexants for chemoselective minor actinide extraction from used nucle

191 stic orthogonal recoding of translation with chemoselective modification (SORT-M) to address this cha

192 ting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that

193 Chemoselective modification of complex biomolecules has

194 However, chemoselective modification of the identical functional

195 ilability of a suitable functional group for chemoselective modification.

196 face syn to the ammonium moiety exclusively; chemoselective N-benzylation then provided either (1RS,2

197 d decarbonylative Heck reaction of amides by chemoselective N-C activation using N-acylsaccharins as

198 eck reaction of amides proceeding via highly chemoselective N-CO cleavage catalyzed by Pd(0) utilizin

199 Subsequent chemoselective N2'-functionalization and O3'-phosphityla

200 Chemoselective nanoporous membranes: tunably porous memb

201 ted peptide segments using site-specific and chemoselective native peptide ligation methods.

202 theory (DFT) was used to explore the highly chemoselective nature of the catalytic hydrogenation of

203 The predictable and chemoselective nature of these transformations has led t

204 mino ketones with an aza-glycine equivalent, chemoselective nitrogen functionalization, and ring clos

205 Mild and chemoselective opening of lactones with sodium trimethyl

206 ectroscopic and kinetic studies suggest that chemoselective organic transformations occur on site-iso

207 The highly regio- and chemoselective oxidation of activated C-H bonds has been

208 Unusual regio- and chemoselective oxidation of aromatic amines hindered wit

209 ion conditions employed here is suitable for chemoselective oxidation of secondary alcohol in the pre

210 RuCl3-NaIO4 reagent system were crucial for chemoselective oxidation of sulfide in the presence of a

211 The regio- and chemoselective oxidation of unprotected vicinal polyols

212 sopropenyllithium TMEDA complex and a facile chemoselective oxidation with selenium dioxide.

213 The chemoselective oxidations of akuammicine leading up to t

214 lectively produces the heterocycles based on chemoselective oxidative addition.

215 ble bonds have been exploited to demonstrate chemoselective oxidative cleavage in substrates containi

216 A chemoselective oxidative cleavage of synthetic gracilioe

217 The reaction is chemoselective, oxidizing one alkene in the presence of

218 ross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling

219 Here, we describe the chemoselective partial reduction of silyl-protected C6O6

220 The chiral dienediynes undergo highly chemoselective Pauson-Khand (PK) cycloaddition in benzal

221 odified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether

222 In this Communication, we develope a chemoselective photoacoustic sensor (LP-hCy7) composed o

223 In the present study, we used a unique chemoselective photoaffinity labeling strategy, the meth

224 A novel chemoselective polymerization control yields predictable

225 An efficient chemoselective practical route to fully substituted thia

226 ronically challenging substrates in a highly chemoselective, practical, and rapid manner.

227 boron atom of the boronic acids, leading to chemoselective primary amination.

228 c reactive handle on the NP is targeted by a chemoselective probe to enable its detection by mass spe

229 obtained from readily available amides via a chemoselective process involving Tf2O-mediated amide cyc

230 itroso compounds has been transformed into a chemoselective process that converts sulfinic acid into

231 tryptophan residue was shown to allow rapid, chemoselective protein modification using the azo-coupli

232 e recent progress made in the development of chemoselective protocols for amide reduction and gives a

233 allography and mass spectrometry confirmed a chemoselective reaction between the sulfonyl fluoride an

234 The results suggest that this chemoselective reaction can occur in the presence of exc

235 The chemoselective reaction of donor/acceptor (D/A) and acce

236 We report the facile and chemoselective reaction of tyrosine-containing G-protein

237 to a given protein and then undergo a rapid chemoselective reaction to form a covalent conjugate hav

238 In addition, chemoselective reactions are possible when there are phe

239 Here, we show that reversible chemoselective reactions can be harnessed to achieve non

240 Chemoselective reactions for amide bond formation have t

241 of our group's recent advances in exploring chemoselective reactions for stitching together lipid fr

242 e various functional groups, allowing highly chemoselective reactions in the presence of halide, este

243 Combining chemoselective reactions with encoded amino acids has fa

244 of the past two decades, the demand for new chemoselective reactions with unique abilities, and thos

245 ehyde capture ligation that parlays the high chemoselective reactivity of aldehydes and amines to enf

246 y dramatic spectral shifts by leveraging the chemoselective reactivity of novel functional groups ins

247 aryl fluorosulfates studied thus far exhibit chemoselective reactivity toward Lys and, particularly,

248 fold to produce protein-like structures with chemoselective reactivity.

249 ast reaction rate with stable, nontoxic, and chemoselective reagents.

250 3-aminophenylboronic acid (FITC-APBA) as the chemoselective recognition probe of sialylation product,

251 ssing the power of high stereo-, regio-, and chemoselective redox biocatalysts and enabling reactions

252 Chemoselective reduction and functionalization of these

253 ical transformations were required to permit chemoselective reduction and oxidation reactions.

254 ned pendant hydroxyl group to facilitate the chemoselective reduction of an extremely unreactive lact

255 Chemoselective reduction of an intermediate enone requir

256 NHPtBu2] is the first efficient catalyst for chemoselective reduction of challenging unsaturated este

257 werful single electron donors for the highly chemoselective reduction of common functional groups.

258 Chemoselective reduction of nitro groups in the presence

259 The protocol exploits the mild and highly chemoselective reduction of the amide and lactam functio

260 Herein we report the chemoselective reduction of the carbonyl functionality v

261 Unprecedented chemoselective reductions of phosphine oxides to phosphi

262 Stannous chloride catalyzed chemoselective reductive amination of a variety of carbo

263 thus formed to react with enals in a highly chemoselective, regioselective, diastereoselective and e

264 This chemoselective relay cyclization strategy was utilized i

265 Reported herein is an exceptional chemoselective ring-opening/C(sp(3) )-C(sp(3) ) bond for

266 An eight-sensor array coupling a chemoselective room-temperature ionic liquid (RTIL) with

267 An efficient and chemoselective route for transforming BF2-BODIPYs to Et2

268 Herein, we demonstrate a chemoselective, salicylideneanilines-based COF (SA-COF),

269 tial of soft-Lewis basic complexants for the chemoselective separation of trivalent actinides from la

270 mponent catalytic process that begins with a chemoselective, site-selective and diastereoselective co

271 These chemoselective solutions should have value to other prob

272 approach relies on the use of two successive chemoselective steps: (i) phosphoramidite coupling, and

273 This contribution reports the first chemoselective, stereospecific, and living polymerizatio

274 We previously reported a chemoselective strategy for enrichment of hydroxyl-funct

275 Chemoselective Suzuki-Miyaura cross-coupling generally r

276 c substituent on the benzylic carbon atom, a chemoselective switch was observed, which preferred intr

277 An efficient, metal and base-free, chemoselective synthesis of aryl-, heteroaryl-, and alky

278 A highly chemoselective synthesis of beta-ketophosphonates from p

279 ation is presented as a new strategy for the chemoselective synthesis of boronic esters.

280 lished for [Pd(cinnamyl)Cl](2)/L1 toward the chemoselective synthesis of di-, tri-, and tetraamines w

281 An efficient tandem approach for the chemoselective synthesis of functionalized azido-pyranoq

282 This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic aci

283 y enolsilanes with dienes provide a mild and chemoselective synthetic route to seven-membered carbocy

284 s aim to provide site-specific approaches by chemoselective targeting of canonical and noncanonical a

285 hio)-4-functionalized thiazoles via one-step chemoselective thionation-cyclization of highly function

286 ect synthesis of beta-Mannich products via a chemoselective three-component coupling of aryl aldehyde

287 The chemoselective transformation into these functional grou

288 ed amines can easily be accessed in a highly chemoselective transformation.

289 New applications in highly regio- and chemoselective transformations in short reaction times a

290 or the development of a broad range of novel chemoselective transformations via open-shell electron p

291 A range of successful chemoselective transformations were investigated, which

292 ha-diimine nickel catalysts that promote the chemoselective triborylation of benzylic C(sp(3))-H bond

293 Our work establishes a unique chemoselective "unclickable" bioconjugation strategy to

294 In addition, the chemoselective use of C-C and C-O pi-bond functionality,

295 The latter was found to be chemoselective using platinum(IV) oxide as the catalyst

296 Reversible as well as stereo- and chemoselective: various proteases such as thermolysin an

297 and APC-2, a water-soluble congener) for the chemoselective visualization of Cu(II), a metal ion whic

298 s observed, including E/Z isomerizations and chemoselective Wagner-Meerwein shifts.

299 , which is less electrophilic and hence more chemoselective when reacting with nucleophiles.

300 This method is scalable and chemoselective with broad functional-group tolerance.