ライフサイエンスコーパス: chemoselectivity

1 lsulfoxide (DMSO) ligand in controlling this chemoselectivity.

2 tep as well as obtain the correct regio- and chemoselectivity.

3 hanges in reaction conditions markedly alter chemoselectivity.

4 to the desired vicinal dichlorides with high chemoselectivity.

5 cts with high levels of stereo-, regio-, and chemoselectivity.

6 40-60% conversion with excellent tryptophan chemoselectivity.

7 ere labeled with OND electrophiles with high chemoselectivity.

8 -based catalyst systems displayed orthogonal chemoselectivity.

9 mechanism and the rationale for this unusual chemoselectivity.

10 nto the controlling features of the observed chemoselectivity.

11 the corresponding aldehydes with remarkable chemoselectivity.

12 c coupling of the 2-naphthol with remarkable chemoselectivity.

13 inoalcohols had lower rate constants or less chemoselectivity.

14 TMS(2)NLi) displays highly solvent-dependent chemoselectivity.

15 group efficiency (OMe vs OPh) modulates the chemoselectivity.

16 up of ascorbic acid with complete regio- and chemoselectivity.

17 osed to play a role in the solvent-dependent chemoselectivity.

18 ding opportunities to increase both rate and chemoselectivity.

19 fice the high claim to stereoselectivity and chemoselectivity.

20 trate scope, operational simplicity and high chemoselectivity.

21 yields with essentially complete regio- and chemoselectivity.

22 lymerization processes and the origin of the chemoselectivity.

23 with good efficiency and complete regio- and chemoselectivity.

24 l of regio-, stereo-, and, where applicable, chemoselectivity.

25 ium catalyst produces kinetically controlled chemoselectivity.

26 00 h(-1), a 99:1 enantiomeric ratio and 100% chemoselectivity.

27 ssential in terms of reaction efficiency and chemoselectivity.

28 up to 99% enantiomeric excess) and excellent chemoselectivity.

29 substituents determine the overall reaction chemoselectivity.

30 sions, high preparative yields and excellent chemoselectivity.

31 splaying fast kinetics, high yield, and good chemoselectivity.

32 vicinal diamines in a single step, with high chemoselectivity.

33 l reaction that proceeds with high yield and chemoselectivity.

34 The system shows moderate chemoselectivity.

35 excellent enantio-, diastereo-, regio-, and chemoselectivities.

36 h a process raises the problem of regio- and chemoselectivity, a challenging goal even more difficult

37 Investigations on scope, limitations, chemoselectivities and stereoselectivities regarding an

38 discovered cascade reaction showed excellent chemoselectivity and a wide substrate scope for both oxy

39 se under-utilized amino acids with excellent chemoselectivity and affords good-to-high yields using l

40 The reactions exhibit high levels of chemoselectivity and broad functional-group tolerance, a

41 quantitative chemical yield with remarkable chemoselectivity and diastereoselectivity.

42 ligand, solvent, and temperature on both the chemoselectivity and ee value were explored.

43 s under ambient conditions exhibits complete chemoselectivity and high stereoselectivity, thus produc

44 on of allylic alcohols is effected with high chemoselectivity and is tolerant of a wide range of func

45 of the PCO/POC-isomers proceeds with a high chemoselectivity and leads to the formation of P(IV)-dio

46 However, the combination of high substrate chemoselectivity and low substrate stereoselectivity is

47 wide array of substrates, demonstrating the chemoselectivity and mildness of this simple reaction.

48 s and drug molecules demonstrates remarkable chemoselectivity and predictable regioselectivity.

49 izations, which proceed with noteworthy high chemoselectivity and provide an overall access to struct

50 The observed chemoselectivity and regioselectivity are explained via

51 ored in a mechanistic study to ascertain the chemoselectivity and stereospecificity.

52 The boron influences both the chemoselectivity and the regioselectivity of this reacti

53 ones generally in high yields with excellent chemoselectivity and very good functional group toleranc

54 tion), the ratio of 3 to the sum of (4 + 5) (chemoselectivity), and the ratio of 4 to 5 (diastereosel

55 to commercial availability of reagents, high chemoselectivity, and a pressure on delivery.

56 applied to address challenges of reactivity, chemoselectivity, and enantioselectivity.

57 igh concentrations of ammonium ion, the high chemoselectivity, and the high enantioselectivity (99.5%

58 A primary reason for this imperfect chemoselectivity appears to be the slow chain extension

59 polyfunctional substrate, unique profiles in chemoselectivity are exhibited by the metal-free approac

60 is reaction is that it exhibits a remarkable chemoselectivity, as acid and ketone functionalities are

61 NaB(OAc)3H that not only achieves excellent chemoselectivity but also avoids formation of the undesi

62 tric constraint to iORC substrates, both the chemoselectivity (C7 vs N1 cyclization) and the stereose

63 f such stabilizing interactions, established chemoselectivities can be overthrown.

64 High chemoselectivity can be achieved with epichlorohydrin an

65 g reagent or method of addition of reagents, chemoselectivity can be controlled toward either oxazole

66 The chemoselectivity can be easily switched by the selection

67 This high chemoselectivity can be governed by the use of different

68 ty, including substrate, stereo-, regio- and chemoselectivity, can be markedly affected, and sometime

69 A fundamental chemoselectivity challenge that remains intrinsically un

70 The method allows good chemoselectivity control and shows good functional group

71 The chemoselectivity could not be improved through kinetic c

72 Enzymatic chemoselectivity (Cys vs Ser cyclization rates) was asse

73 he mechanisms and origins of this switchable chemoselectivity, density functional theory (DFT) calcul

74 ond functionalization at a single site, with chemoselectivity derived from the properties of the cata

75 to an allyl group have been investigated for chemoselectivity, diastereoselectivity, and enantioselec

76 This chemoselectivity difference is explored by means of mole

77 observe a protecting group dependency in the chemoselectivity displayed by the dioxirane 1b.

78 This observed bimetallic chemoselectivity effect follows the same general trend a

79 ty, substrate selectivity, regioselectivity, chemoselectivity, enantioselectivity and catalysis at am

80 Catalytic antibodies have been shown to have chemoselectivity, enantioselectivity, large rate acceler

81 Common problems of regio- and chemoselectivity encountered in the kalihinol class are

82 The reaction demonstrates extraordinary chemoselectivity-even di- and trisubstituted alkenes suc

83 meric (exo/endo) photoproducts with complete chemoselectivity (exclusive [2 + 2] photoproduct).

84 e method was discovered by comparison of the chemoselectivities exhibited by complexes 1a, 1b, 2, and

85 tuted aldehydes, giving high conversions and chemoselectivities for a wide variety of substrates.

86 The observed experimental chemoselectivity for ArCl was found to be inconsistent w

87 nantiomeric 3 degrees centers, displays high chemoselectivity for benzylic oxidation, and enables the

88 proved crucial for achieving high rates and chemoselectivity for C-C bond formation over beta-H elim

89 The chemoselectivity for C-H bond amination is greater than

90 These reactions occur with chemoselectivity for insertion of the nitrene units into

91 ~52%, turnover numbers of 100, and improved chemoselectivity for monoborylated versus diborylated me

92 The possibility of enhanced chemoselectivity for simultaneous separation of ephedrin

93 using aryl halides, strategies that provide chemoselectivity for systems bearing multiple carbon-hal

94 es a rapid and straightforward prediction of chemoselectivity for systems involved in halofunctionali

95 of these reactions have been limited by low chemoselectivity for the amination of C-H bonds over com

96 Pd(DMSO)2(TFA)2 is unique in its high chemoselectivity for the conversion of cyclohexanones to

97 cid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product

98 The chemoselectivity for the formation of carboxylic acid ra

99 enzylidene functionality, but there was poor chemoselectivity for the reduction of the thioacetal in

100 nal propeptide of substrate 88mer, and (2) a chemoselectivity for thiazole over oxazole formation.

101 h the regioselectivity from C5 to C4 and the chemoselectivity from hydroxylation to chlorination.

102 This transformation represents different chemoselectivity from previous reports that demonstrated

103 mplex substrates and exhibits high levels of chemoselectivity (functional group tolerability), regios

104 This excellent chemoselectivity gives zinc- and magnesium-organometalli

105 A key role played by ammonium acetate in chemoselectivity has been examined.

106 Moreover, a very interesting chemoselectivity has been observed depending on the natu

107 in insight into the factors that control the chemoselectivity (i.e., acylation vs alpha-arylation rea

108 Computation has also revealed the origin of chemoselectivity in (5 + 2) cycloadditions with allene-y

109 ver, this methodology demonstrated excellent chemoselectivity in formation of only the corresponding

110 ionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivi

111 owing achievement of complete control of the chemoselectivity in reactions of the beta-arylmethyl der

112 rium-mediated redistribution at silicon, and chemoselectivity in sigma-bond metathesis reactions, are

113 d spectroscopic analysis of alkyne-dependent chemoselectivity in the copper-catalyzed azide-alkyne cl

114 alcohol was required to provide the desired chemoselectivity in the elimination of HX.

115 A distinct chemoselectivity in the gold-catalyzed oxidative cycliza

116 An exploration into the origin of chemoselectivity in the NHC-catalyzed cross-benzoin reac

117 Additionally, the DCCP exhibits remarkable chemoselectivity in the presence of aryl chloride substr

118 ulfenate anion arylation exhibited excellent chemoselectivity in the presence of functional groups, s

119 intramolecularly, while displaying excellent chemoselectivity in the presence of pi functionality.

120 Additionally, the DCCP exhibits remarkable chemoselectivity in the presence of substrates that are

121 NH/HSi cross-dehydrocoupling, with excellent chemoselectivity in the reaction of (di)amines with (di)

122 ut to be important in order to ensure a high chemoselectivity in the reaction.

123 This process allows unprecedented chemoselectivity in the reduction of cyclic esters using

124 n state palladium chemistry, we examined the chemoselectivity in the reductive elimination of a dinuc

125 esented as a strategy to achieve nucleophile chemoselectivity in the Suzuki-Miyaura reaction.

126 iverse demonstration of synthetically useful chemoselectivity in the synthesis of di-, tri-, and tetr

127 ant cells may be an example of gene deletion chemoselectivity, in which genetic deletions that occur

128 ligation/migratory insertion event allowing chemoselectivity independent of overall rate.

129 Chemoselectivity is a cornerstone of catalysis, permitti

130 The altered chemoselectivity is attributed to a prior enyne cyclizat

131 the ones obtained with heme enzymes, but the chemoselectivity is lesser affected by external perturba

132 controlled conditions reveal that this high chemoselectivity is not accompanied by a loss of catalyt

133 Chemoselectivity is observed, whereby Zr(IV) and Hf(IV)

134 id, and lysine demonstrated that significant chemoselectivity is present in this reaction.

135 A mechanistic rationale for the observed chemoselectivity is provided.

136 The chemoselectivity is reversed for [4 + 2]-cycloadditions,

137 A critical requirement for the high chemoselectivity is the use of donor/acceptor-substitute

138 upport provides a mechanism to alleviate the chemoselectivity issues and provide products in high pur

139 on for the preparation of polyynes; however, chemoselectivity issues have precluded its widespread ut

140 Alkylidenecarbene insertion chemoselectivity issues were explored en route to the fi

141 The key problems are a lack of chemoselectivity-namely, the preponderance of side react

142 C-H bonds with the pi-bond would explain the chemoselectivity observed for cyclic substrates.

143 The high chemoselectivity observed is a result of greater electro

144 The reactivities and chemoselectivities of sodium diisopropylamide (NaDA) in

145 e reaction takes advantage of the pronounced chemoselectivity of a recently reported ruthenium-based

146 tuning of reaction conditions to control the chemoselectivity of Ar-Ar' coupling.

147 these reactions and provide insight into the chemoselectivity of cross-benzoin reactions.

148 The chemoselectivity of diazo and alkynyl groups enables dua

149 s have been reduced, highlighting the unique chemoselectivity of diimide as a reduction system.

150 By studying the regio- and chemoselectivity of fluoro-substituted thienothiophene a

151 In addition, these studies shed light on the chemoselectivity of insertion, suggesting that the alken

152 In particular, the ability to control the chemoselectivity of intermolecular reactions in the pres

153 plore the mechanism for the observed unusual chemoselectivity of pnGFP toward peroxynitrite over hydr

154 The practicality and chemoselectivity of radical reactions enable rapid acces

155 Another indication is obtained from the chemoselectivity of the catalyses.

156 hindrance of the enyne greatly affected the chemoselectivity of the cycloaddition of enynes and alde

157 tional analyses to provide insights into the chemoselectivity of the diazo group in 1,3-dipolar cyclo

158 OH) ratio, which is determined by the unique chemoselectivity of the La-X (X = OR, NR2, R) group.

159 The excellent chemoselectivity of the process, where only monoalkylati

160 The wide substrate scope highlights the chemoselectivity of the process.

161 These conditions retain the high chemoselectivity of the reaction and do not lead to a su

162 Exceptionally high chemoselectivity of the reactions (no side-formation of

163 eC bond and at the iminic carbon atom on the chemoselectivity of the reduction was studied.

164 (pLys)-containing peptides by employing the chemoselectivity of the Staudinger-phosphite reaction.

165 The chemoselectivity of these complicated transformations ca

166 Additives have a profound impact on the chemoselectivity of these reductive elimination reaction

167 The high chemoselectivity of this process was demonstrated and as

168 ds could be achieved, demonstrating the high chemoselectivity of this process.

169 The unique chemoselectivity of this reaction is attributed to the c

170 The regio- and chemoselectivity of this reaction is discussed and evide

171 The chemoselectivity of unsymmetrical diaryliodonium salts h

172 electivity, modification yield, and reaction chemoselectivity of vinyl sulfonamide 4 are good enough

173 The high reactivities and chemoselectivities often complement those of LDA-THF.

174 i then C-Si, or C-H then C-H auration); this chemoselectivity originates from differences in the prod

175 esis--including site-selectivity, regio- and chemoselectivity, orthogonal reactivity, coupling reacti

176 ith excellent functional-group tolerance and chemoselectivity over aryl and vinyl C-X bonds.

177 of cyclic alpha-diazocarbonyl compounds with chemoselectivity over beta-hydride elimination are descr

178 ted 3,4-dihydroisoquinolines (DHIQs) in high chemoselectivity over competing annulation processes, ex

179 with high to excellent yields and with good chemoselectivities (over N-alkylation).

180 ates under mild conditions with an excellent chemoselectivity profile and a divergent syn/anti select

181 arkable selectivity pattern and an excellent chemoselectivity profile using air-, moisture-insensitiv

182 arrangement shows a wide substrate scope and chemoselectivity profile while exhibiting an excellent [

183 high enantioselectivities and possess unique chemoselectivity profiles.

184 Chemoselectivity, scalability, and recyclability of reag

185 scussed, highlighting factors such as yield, chemoselectivity, stereoselectivity, or the importance o

186 xin substrate but displays distinct and dual chemoselectivity, suggesting this E. coli pertussis-like

187 ition reaction is characterized by excellent chemoselectivity, taking place only at conjugated and un

188 The reaction displays different chemoselectivity than conventional cross-coupling reacti

189 Streptomyces hygroscopicus, shows a broader chemoselectivity than the corresponding amide synthase p

190 his design yields QD platforms with distinct chemoselectivities that are greatly promising for use as

191 aliphatic C(sp(3))-H bonds while displaying chemoselectivity (that is, tolerance of more oxidizable

192 he reactants also end up in the product) and chemoselectivity (the use of reactions that take place o

193 itial steps in the catalytic cycle, reaction chemoselectivity, the nature of the active oxidant, and

194 In addition to excellent chemoselectivity, the reaction is stereospecific.

195 Because of high chemoselectivity, this approach is useful for the organi

196 Now, this work reverses this conventional chemoselectivity to enable the first ring-opening polyme

197 suspensions proceed with high efficiency and chemoselectivity to generate 4,4'-dimethoxy-dicumene 2OM

198 ethod described is relatively mild, exhibits chemoselectivity to other electrophiles present, avoids

199 dehyde carbon-hydrogen (C-H) bonds with high chemoselectivity to trigger carbon-carbon (C-C) bond cle

200 Very high chemoselectivity toward addition of primary and secondar

201 e readily available Shvo catalyst, excellent chemoselectivity toward alpha- and beta-protons with res

202 (3) and with TMSI generally gave the highest chemoselectivity toward ArN(3) and ArI formation.

203 e catalytic method showed exceptionally high chemoselectivity toward the carbonyl reduction over alke

204 tioselectivities (K(R)/K(S)) of up to 550:1, chemoselectivity up to 11,000:1, and sensitivities in th

205 The N-oxide exerted complete chemoselectivity via chelation in directing the Grignard

206 zed for the polymerization of LA, remarkable chemoselectivity was observed.

207 In all cases, complete chemoselectivity was observed; only dihydropyrans where

208 a number of positive attributes such as good chemoselectivity, water compatibility, high-yield under

209 chanism and origins of stereospecificity and chemoselectivity were explored with density functional t

210 us metal catalysts, however, suffer from low chemoselectivity when one or more reducible groups are p

211 or-substituted carbenoids display remarkable chemoselectivity, which allows for highly regioselective

212 functionalities and displays a high level of chemoselectivity, which is not generally explained by th

213 The chemoselectivity with bidentate phosphine ligands can be

214 achieved by combining kinetic or mechanistic chemoselectivity with click reactions between the monome

215 f sodium iodide to the reaction improved the chemoselectivity with the electron-deficient aryl bromid