ライフサイエンスコーパス: chemotax

1 in-A1, and NP1 that impedes their ability to chemotax.

2 In chemotaxing ameboid cells, a complex leading-edge signal

3 defects, including a failure to polarize and chemotax, and abnormal morphogenesis.

4 on, a loss of the ability to phagocytose and chemotax, and decreased expression of chemokine mRNAs.

5 ved factor (SDF1)alpha, it triggers cells to chemotax, and in some cell types such as neurons, causes

6 rck1 null cells chemotax approximately 50% faster than wild-type cells,

7 Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal

8 y production/destruction of secreted cAMP in chemotaxing cells accounts for the observed oscillatory

9 GAP1, which localizes at the leading edge of chemotaxing cells and is activated by and essential for

10 ly, as the myosin II cap in the posterior of chemotaxing cells and myosin II assembly into cytoskelet

11 localizes at the leading edge and uropod of chemotaxing cells and the B domain of WASP is required f

12 tion and is localized to the leading edge of chemotaxing cells in vivo.

13 It relies on the ability of chemotaxing cells to prioritize their responses to diffe

14 ulation and localizes to the leading edge of chemotaxing cells via an F-actin-dependent pathway.

15 viding cells and the posterior of polarized, chemotaxing cells via its NH(2)-terminal domain.

16 anner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics an

17 Ras activation occurs at the leading edge of chemotaxing cells, and this local activation is independ

18 -actin in pseudopods at the front of motile, chemotaxing cells, but is not present in filopodia or at

19 dels have captured some of these features of chemotaxing cells, but no system has explained the compl

20 In chemotaxing cells, localization of phosphatidylinositol

21 ctant stimulation and to the leading edge in chemotaxing cells, PTEN, a negative regulator of PI3K pa

22 Chemotaxing cells, such as Dictyostelium and mammalian n

23 tructure of cells and is highly polarized in chemotaxing cells, with F-actin assembled predominantly

24 ts, including signals at the leading edge of chemotaxing cells.

25 re tightly controlled at the leading edge of chemotaxing cells.

26 , DockA and DockD, causes decreased speed of chemotaxing cells.

27 preferentially found at the leading edge of chemotaxing cells.

28 al activation of RacC at the leading edge of chemotaxing cells.

29 signaling is reminiscent of polarization in chemotaxing cells.

30 tral role in the polarization of neurons and chemotaxing cells.

31 in organizing polarized F-actin assembly in chemotaxing cells.

32 nslocate specifically to the leading edge of chemotaxing cells.

33 localization of WASP to the leading edge in chemotaxing cells.

34 ol and cortex, including the leading edge of chemotaxing cells.

35 spatiotemporal control of F-actin levels in chemotaxing cells.

36 n, and proper retraction of the posterior of chemotaxing cells.

37 ver, show that even when single cells do not chemotax, clusters of cells may, if their interactions a

38 d pathways interact to establish polarity in chemotaxing D. discoideum cells by localizing F-actin at

39 stigated WASP function and its regulation in chemotaxing Dictyostelium cells and demonstrated the spe

40 Previously, we found that chemotaxing Dictyostelium cells preferentially bleb from

41 sure the three-dimensional forces exerted by chemotaxing Dictyostelium cells, and examined wild-type

42 the mechanisms of leading edge formation in chemotaxing Dictyostelium cells.

43 Chemotaxing Dictyostelium discoideum cells adapt their m

44 rane at the front and back, respectively, of chemotaxing Dictyostelium discoideum cells.

45 Furthermore, cells can chemotax effectively to a secondary distant agonist afte

46 Mutant cells chemotax efficiently towards cAMP or folic acid and thei

47 ce to EGF stimulation, demonstrating that to chemotax efficiently, a cell must be able to respond to

48 Eukaryotic cells chemotax in a wide range of chemoattractant concentratio

49 , mature neutrophils from -/- mice failed to chemotax in vitro and failed to mobilize into peripheral

50 at 28 degrees C, they round up and cease to chemotax, move or cap ConA receptors.

51 Chemotaxing neutrophils and Dictyostelium amoebae produc

52 rogram, thereby promoting stable polarity in chemotaxing neutrophils.

53 ced aggregation, although individual amoebae chemotax normally.

54 ith only a single functional OSN are able to chemotax robustly, demonstrating that chemotaxis is poss

55 n of Dd-STATa null cells is delayed and they chemotax slowly to a cyclic AMP source, suggesting a rol

56 a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a

57 espite these defects, napA(-) cells move and chemotax surprisingly effectively.

58 Human polymorphonuclear neutrophils (PMN) chemotax to a foreign entity.

59 We demonstrate that C. elegans males chemotax to a source of hermaphrodite pheromones.

60 cAMP chemotactic signal, although the cells chemotax to cAMP.

61 The resulting sextuple mutant is able to chemotax to cyclic-AMP with near wild-type efficiency an

62 Whereas GC B cells do not chemotax to most chemokines and do not express the adhes

63 dr-2 mutants are defective in the ability to chemotax to odorants that are recognized by the two AWC

64 of cells at different developmental stages, chemotaxing to either folate or cyclic AMP and moving wi

65 starvation, individual Dictyostelium amoebae chemotax toward aggregation centers in tightly packed st

66 Instead, grk-2 mutant animals do not chemotax toward attractive olfactory stimuli or avoid av

67 r chemotaxis and phagocytosis; Dictyostelium chemotax toward bacteria and phagocytose them as food so

68 rophages competently phagocytose via FcR and chemotax toward CSF and CX3CL1.

69 nthetic catalytic rods have been reported to chemotax toward hydrogen peroxide fuel.

70 lassic back-of-the-wave problem is how cells chemotax toward the wave source, even though the spatial

71 n proteins, or active motor function did not chemotax toward tumor cylindroids, indicating that direc

72 oral dynamics of traction forces measured in chemotaxing unicellular amoeba, Dictyostelium discoideum

73 R knockouts could still spread, migrate, and chemotax using pseudopods driven by the Arp2/3 complex.

74 ed filamentous (F)-actin polymerization, and chemotax very slowly.