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1 roups of samples, enabling counterfeit drug "chemotyping".
2 of Thymus zygis, subspecies gracilis, thymol chemotype).
3 a mGlu5 positive allosteric modulator (PAM) chemotype.
4 d based on our lead acyclic phenyl imidazole chemotype.
5 llent starting point for optimization of the chemotype.
6 e C-H bonds but by the individual structural chemotype.
7 s, which are based on the indenoisoquinoline chemotype.
8 creening platform for fingerprinting of wood chemotype.
9 nd could differentiate compounds of the same chemotype.
10 ctural changes within ER ligands of the same chemotype.
11 mising hit in the 4-aminopyrazolylpyrimidine chemotype.
12 gical and cardiovascular liabilities of this chemotype.
13 ide which were presented only in the carvone-chemotype.
14 ess that has been made in this promising new chemotype.
15 ration of the 3,4-dihydropyrimidin-2(1H)-one chemotype.
16 with gene clusters known to encode distinct chemotypes.
17 on, and in breeding S. sclarea for desirable chemotypes.
18 ucture-based design and the discovery of new chemotypes.
19 s and biological evaluations of 13 different chemotypes.
20 igands on the basis of previously identified chemotypes.
21 less herbivory than individuals of differing chemotypes.
22 three major class I deacetylases using these chemotypes.
23 ion chemistry to produce complex, polycyclic chemotypes.
24 selectivity in the clinical Hsp90 inhibitor chemotypes.
25 d substantial activity and 8 represented new chemotypes.
26 phenomenon, widely observed across different chemotypes.
27 hop in chemical space to substantially novel chemotypes.
28 model built with reported mGlu2 receptor PAM chemotypes.
29 distinct features for binding these diverse chemotypes.
30 strates for reactions generating several new chemotypes.
31 ctivity relationships (SAR) across different chemotypes.
32 ealing cryptic homologies across targets and chemotypes.
33 F-dependent signaling in response to all LPS chemotypes.
34 ative levels of simultaneously expressed LOS chemotypes.
35 ese structures have high similarity to known chemotypes.
36 ted common allosteric inhibition by distinct chemotypes.
37 igations exist for other hemozoin inhibiting chemotypes.
38 culosis and discovered several novel binding chemotypes.
39 ses of CXCR3 antagonists and to identify new chemotypes.
40 ontent of A. annua varieties sorted into two chemotypes.
41 d differences between species based on their chemotypes.
42 vel, yet synthetically accessible, bioactive chemotypes.
43 e method for the discrimination of the three chemotypes.
44 y accelerate the discovery of new antibiotic chemotypes.
45 A new histamine H3 receptor (H3R) antagonist chemotype 1 was designed by combining key pharmacophoric
46 ere we describe a modular synthesis of a new chemotype 1, simulation of its solution-state conformati
48 it thizolopyrimidin-dione 7, we obtained two chemotypes, 8 and 9, using computer-aided drug design (C
49 So far, efforts made in the discovery of chemotypes able to target G-quadruplexes mainly succeede
51 right-hand side of the template for diverse chemotypes accompanied by favorable effects on weight lo
52 el N-acyl-triazolopiperazine NK3R antagonist chemotype achieved through bioisosteric lead change from
54 yrazolobenzothiazine scaffold as a promising chemotype against hepatitis C virus (HCV) NS5B polymeras
55 ndole, 2-phenyl benzimidazole and pyridinium chemotypes allow for specific recognition of RNA motifs.
56 ent molecule, the discovery of unprecedented chemotypes among the new inhibitors, and the apparent bi
57 2,3-c]pyridines render this hitherto unknown chemotype an attractive class of compounds which are exp
58 ias of commercial libraries toward GPCR-like chemotypes, an issue that we attempt to investigate quan
59 These steroid derivatives represent a novel chemotype and provide a new scaffold for developing smal
60 the value of quinolin-4(1H)-imines as a new chemotype and their suitable properties for further drug
62 esis of innovative and diverse scaffolds and chemotypes and allows access to previously unexplored "c
63 rmal shift assay is applicable to a range of chemotypes and can be useful in evaluating both potent (
65 tely the binding affinity of all major Hsp90 chemotypes and has a testing range that spans low nanomo
67 very to identify new ligands with unexplored chemotypes and physical properties, leading to new biolo
69 We report here the de novo generation of chemotypes and scaffolds for the estrogen receptor, with
70 d biological activity with the current Hsp90 chemotypes and set the ground for the development of par
74 essential oil of Thymbra capitata, carvacrol chemotype); and thymol (basal diet with 500mgg(-1) of es
75 lead follow-up confirmed the activity of the chemotype, and a structure-based design approach using p
77 the fragments are completely new bromodomain chemotypes, and three have never before been crystallize
79 zyme kinetics studies that analogues of this chemotype are noncompetitive inhibitors, and by using a
83 ined properties show that covalently-binding chemotypes are not the unique arbiters of cytotoxicity a
84 hat many more chemotypes and combinations of chemotypes are present among fragments than are availabl
86 rences in trichothecene metabolite profiles (chemotypes) are not well correlated with the Fg complex
87 n SIRT1/2/3 inhibitors, representing a novel chemotype, are significantly more potent than currently
88 n, we report our efforts to identify a novel chemotype as one strategy to potentially circumvent safe
89 hput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial
90 -R1 competitive binding assay, and six novel chemotypes as low micromolar affinity antagonist "hits"
92 (Q54L) in NS5A conferred resistance to this chemotype, as did a single substitution of tyrosine to h
93 noncompetitive antagonists of widely diverse chemotypes assayed at 1 or 10 microM inhibited [(14)C]TE
97 s new scaffold, we sought a broader range of chemotypes by docking 2.2 million fragments, which revea
100 virus (HIV) drug discovery generally entails chemotypes capable of chelating two divalent metal ions
101 igh-throughput screen yielded two attractive chemotypes capable of inhibiting S1P formation in cells.
102 is an urgent need for identifying innovative chemotypes capable of modulating unexploited drug target
104 that TRPV1 antagonists representing various chemotypes cause an increase in body temperature (hypert
105 at BnREF1-suppressing seeds produced a novel chemotype characterized by reduced levels of sinapate es
107 wever, we found that individuals of the same chemotype communicated more effectively and experienced
108 chemical similarity networks for large-scale chemotype (consensus chemical pattern) recognition and d
109 cantly, the 6-alkylamino variant of this new chemotype consistently conferred low nanomolar inhibitor
110 arylmethyl HID analogues, previously unknown chemotypes, consistently inhibited HIV RT-associated RNa
111 construction, we show that different JG cell chemotypes contribute to distinct microcircuits within o
112 diketo-acid moiety, we speculated that this chemotype could serve to develop dual inhibitors of both
113 relationships across multiple inhibitors and chemotypes, coupled with mechanistic studies and biochem
114 technique can be used to exploit the better chemotype coverage that exists at the fragment level.
115 properties of the parent bis-phenylimidazole chemotype, culminating in the identification of the high
117 erse agonist activity by some full mGlu5 NAM chemotypes demonstrated adverse effects, including psych
119 commercially available substrates and novel chemotypes designed to address recent developments in th
122 ucture of MAL3-101 generated a collection of chemotypes, each modulating Hsp70 function, but exhibiti
126 sm for modulating the amount of multiple LOS chemotypes expressed in a single cell is not understood.
127 report herein a critical redesign of the HPD chemotype featuring an additional wing at the C5 positio
129 reen to identify compound 1 (ML351), a novel chemotype for 12/15-LOX inhibition that has nanomolar po
130 This screen led to the discovery of a novel chemotype for 15-hLO-1 inhibition, which displays nM pot
132 n effort to explore this novel cannabinergic chemotype for CB receptor binding affinity, in vitro and
138 r affinity, indicating the potential of this chemotype for the development of further promising PET r
139 al high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) o
140 high-throughput campaigns to identify novel chemotypes for combination therapies to treat multidrug-
141 ets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported.
142 ibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis.
143 Together, we present indirubins as novel chemotypes for the development of 5-LO inhibitors, the i
144 ies that led to the discovery of 1 and other chemotypes for which resistance maps to the NS5A protein
148 ese nodes, and quickly distinguish promising chemotypes from less interesting or problematic ones.
149 activity and assist in the generation of new chemotypes from these intermediates, several iminium eth
151 crocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop i
152 criptase (NNRTIs) representing eight diverse chemotypes have been correlated with their anti-HIV acti
153 headgroup and lipophilic tail, a variety of chemotypes have been found to show S1P1 receptor agonism
154 ree novel PPAR scaffolds displaying distinct chemotypes have been identified, namely, 5-(4-(benzyloxy
155 Unfortunately, compounds containing these chemotypes have been published as screening actives in r
157 mall-molecule inhibitors of Hsp90 of diverse chemotypes have shown potent antitumor activity in a wid
160 s enzymatic inhibition for several prominent chemotypes identified by this HTS, including some pan-as
162 es of polar extracts of carvone and linalool chemotypes, identified by GC-MS analyses of the essentia
163 t associations between p16 mutant status and chemotypes implicated in cell cycle control, and extende
164 or aromatic groups attached to the thioether chemotype in TFKs, can be developed for use in in vivo e
165 ve compounds and efficiently discovers novel chemotypes in comparison with commonly used diversity-si
166 et prediction with respect to representative chemotypes in large (>200) compound sets, in comparison
167 udy of degraders with divergent BRD9-binding chemotypes in models of acute myeloid leukemia resolves
169 ment of BRD4 inhibitors by focusing on their chemotypes, in vitro and in vivo activity, selectivity,
170 number of tandem processes leading to novel chemotypes including aza-Prins/intramolecular Friedel-Cr
172 roperties profiling of 4c and show that this chemotype inhibits the T. cruzi CYP51 enzyme, an observa
174 reviously reported that the 6-aminoquinolone chemotype is a privileged scaffold to obtain antibacteri
176 ry, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude
178 tographic profile pointed to three different chemotypes: linalool/eugenol, neral/geranial, and estrag
182 al exploration of the sulfonyl acrylonitrile chemotype may result in useful inhibitors for other memb
185 l structures, our SAR analysis of the common chemotype of AT-076 suggests rational approaches to modu
187 nstrated that derivative 19 represents a new chemotype of FXR modulator, whereas alcohol 6, with a si
189 lamino-thiazolo[5,4-d]pyrimidines as a novel chemotype of non-nucleoside partial agonists for the A2A
190 reverse transcriptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic wa
191 In conclusion, our approach has led to a new chemotype of promising antiproliferative compounds with
192 inoline-6-carboxamide derivatives as a novel chemotype of selective cannabinoid CB(2) receptor agonis
194 inhibitors for ATX have resembled the lipid chemotype of the native ligand; however, a small number
199 the rapid discovery and optimization of new chemotypes of EthR ligands starting from a fragment.
201 for both indications, raising demand for new chemotypes of KOR antagonists as well as G-protein-biase
205 study tested the hypothesis that hydrophilic chemotypes of the medicinal vine Uncaria tomentosa (UT)
206 docking campaigns can find ligands with new chemotypes, often revealing the new biology that may be
209 tro ADME assays demonstrated that this novel chemotype possesses largely favorable physicochemical pr
210 tane)carboxamide [(+)-KF4, (+)-5] as a novel chemotype possessing potent antagonist activity at the d
211 ly disclosed in the patent literature into a chemotype previously used for the preparation of muscari
212 d has successfully identified novel distinct chemotypes primed for development as new agents against
216 and metabolite profiles of eight opium poppy chemotypes revealed four cytochrome P-450s, three from t
217 lyl acetate; the second was characterized by chemotypes rich in cymyl-compounds, mainly carvacrol, th
219 on and identification of such thiol-reactive chemotypes should accelerate triage of nuisance compound
221 t DCs, synthetic MLA of the Escherichia coli chemotype (sMLA) showed the same activity as its diphosp
222 tive binding mode is augmented by unexpected chemotype-specific contacts with amino acid residues Asn
225 entially novel mode of action and a distinct chemotype support the clinical development of SC83288, a
226 mental results validate this use of ROCS for chemotype switching or "lead hopping" and suggest that i
227 ing studies suggested that this piperazinone chemotype targets the HCV nonstructural protein NS4B.
229 may be amenable to modulation using generic chemotypes, termed "proteomimetics", which can be assemb
231 the identification of a new monophosphonate chemotype that bind in an allosteric pocket of hFPPS.
232 pyrazolopyridazinones as a novel, unrelated chemotype that binds to the prenyl-binding pocket of PDE
235 Alzheimer's disease (AD) utilizes an anilide chemotype that engages a key residue (Gly230) in the BAC
236 discovery of a highly potent biarylimidazole chemotype that established a potency benchmark in replic
237 unctional profiling of the 2-aminopyrimidine chemotype that has advanced to the clinic for allergy, a
238 ilot screen of 801 compounds yielded a novel chemotype that increased the release of sAPPalpha 2-fold
239 covery of a 2-(phenoxypyridine)-3-phenylurea chemotype that inhibited ADP-mediated platelet aggregati
240 ch has enabled the identification of a novel chemotype that selectively targets the HIV transactivati
241 series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6
242 wledge yielded a weakly potent but tractable chemotype that was rapidly progressed into a series with
244 rich core structures may be reorganized into chemotypes that are distinctly different from the parent
245 lting in the identification of several novel chemotypes that are potent and selective MCHR1 antagonis
246 ing, but there are surprisingly few distinct chemotypes that are specific for SUR1-containing KATP ch
247 l trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein
248 und collections and potentially identify new chemotypes that could deliver the same antiparasitic pro
249 ogs, and may also lead to discovery of novel chemotypes that exploit subtle differences in protein co
250 s revealed significant differences among the chemotypes that should be taken into account in the uses
251 ied approximately 100 hits and four distinct chemotypes, the most promising of which contained the qu
252 vation by ligands representing four distinct chemotypes: the peptide dynorphin A(1-17), the arylaceta
253 of this platform toward the discovery of new chemotypes through multidimensional reaction screening.
255 h that each ligand represents its own unique chemotype, thus ensuring that each similarity recognitio
256 ogues to demonstrate the amenability of this chemotype to achieving a suitable pharmacokinetic (PK) p
263 nd the synaptic inputs of identified JG cell chemotypes using mice expressing green fluorescent prote
264 hibition, determine the selectivity for this chemotype versus related reductase enzymes, and present
265 high-affinity CXCR3 antagonists of distinct chemotypes: VUF11211 [(S)-5-chloro-6-(4-(1-(4-chlorobenz
268 channel activity inherent within the initial chemotype was guided through modulation of physicochemic
271 tion of the core molecular structure of this chemotype, we define the essential pharmacophore, establ
272 g from the physicochemical properties of the chemotype, we undertook structure based molecular design
274 ed to develop chemoselective access to boron chemotypes, we report herein the synthesis of alpha- and
275 targets, representative members of the four chemotypes were added to aggregation reactions, where th
279 Several small molecule inhibitors with new chemotypes were identified, and compound 23 containing a
280 70 compounds that comprised the initial hit chemotypes were subsequently sourced from the full CSIRO
283 I-19), both derived from a thienopyrimidinyl chemotype, were selected to explore their antileukemic p
285 hesized using this reaction, yielded a novel chemotype which inhibited glycolytic ATP production by b
286 rb known as 'cidreira' that presents several chemotypes which exhibit different chemical profile and
287 his pocket to generate a novel low nanomolar chemotype, which did not interact with the catalytic res
288 und crystal structures and uncovered a novel chemotype with a unique and highly conserved mode of int
289 esulting tricyclic compounds are interesting chemotype with natural product resemblance and may find
290 data indicate that CC-5079 represents a new chemotype with novel mechanisms of action and that it ha
291 183240 designates the heterocyclic urea as a chemotype with potentially excessive protein reactivity
292 idazol-2-amines represent a novel, alternate chemotype with pure TLR8-agonistic activities and will l
293 rein, we report our efforts on a sulfonamide chemotype with the aim to generate liver selective GK ac
294 sisted of acyclic (linalool/linalyl acetate) chemotypes with a predominant presence of linalyl acetat
295 bilayers composed of LPSs from two bacterial chemotypes with different sensitivities to such antibiot
298 an effective tool for discovery of new lead chemotypes with therapeutically relevant functional prof
299 the BRPF1 bromodomain which resulted in six chemotypes with very favorable ligand efficiency (0.45-0
300 ctivity of 18 test compounds, with different chemotypes, with a root-mean-square error of 0.68 pKB un
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