ライフサイエンスコーパス: chicoric acid

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1 nge was sufficient to confer resistance to L-chicoric acid.

2 atalysis in vitro, and cross-resistance to l-chicoric acid.

3 ed neutral, nonhydrolyzable analogues of the chicoric acids.

4 dertaken to examine structural features of L-chicoric acid (3) which are important for potency agains

5 analogues, it was shown that enantiomeric D-chicoric acid (4) retains inhibitory potency against pur

6 All mutant HIVs were resistant to l-chicoric acid, a dicaffeoyltartaric acid IN inhibitor, b

7 In this study, 17 analogues of L-chicoric acid, a potent inhibitor of HIV integrase, were

8 structed from energy-minimized structures of chicoric acid and dicaffeoylquinic acid.

9 In CEM cells, for both the parent chicoric acid and selected analogues, antiviral activity

10 st HIV-1- and HIV-2-infected MT-4 cells, the chicoric acids and their tetraacetylated esters exhibite

11 potent compounds were D-chicoric acid, meso-chicoric acid, bis(3,4-dihydroxydihydrocinnamoyl)-L-tart

12 ications but no such differences observed in chicoric acid content or PAL activity.

13 The charged nature of the chicoric acids contributes to poor cellular uptake, and

14 y related IN inhibitor, the tetra-acetylated-chicoric acid derivative (2R,3R)-2,3-bis[[(2E)-3-[3,4-bi

15 , potent antiviral IN inhibitors such as the chicoric acids do not act upon the intended enzymatic ta

16 ted in target and cell-based assays that the chicoric acids do not significantly inhibit other target

17 e presence of increasing concentrations of L-chicoric acid, HIV-1 was completely resistant to the com

18 inacea, exemplified by the natural product d-chicoric acid (I1) is disclosed.

19 thoxyoxalyl-3,5-dicaffeoylquinic acid, and L-chicoric acid, inhibit HIV-1 integrase in biochemical as

20 previous biochemical studies showing that L-chicoric acid inhibits integrase and that the drug is li

21 L-Chicoric acid is an inhibitor of human immunodeficiency

22 d derivates and one digalloylderivative of L-chicoric acid (L-CA) showed improved selectivity over L-

23 of the anti-HIV-1 integrase (IN) inhibitor L-chicoric acid (L-CA) were prepared.

24 The most potent compounds were D-chicoric acid, meso-chicoric acid, bis(3,4-dihydroxydihy

25 A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the

26 id change at position 140 into the native, L-chicoric acid-sensitive virus demonstrated that this cha

27 study also examined the reported ability of chicoric acid to exert cytoprotective effects in HIV-inf

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