ライフサイエンスコーパス: chief

1 munity - that of Development's new Editor in Chief.

2 Blood's birthday authored by past Editors-in-Chief.

3 PIPKIgamma is the chief 5-kinase at nerve terminals, and here we show that

4 stimulation using cre recombinase-dependent ChIEF-AAV-DJ expressed in ARC TH neurons evoked postsyna

5 tation of Ile(170) of ChEF to Val (yielding "ChIEF") accelerates the rate of channel closure while re

6 G protein-coupled receptor 65 (GPR65) as the chief acid-sensing receptor expressed by eosinophils, as

7 Aerial agility thus may be the chief adaptive asset derived by lepidopterans from posse

8 The chief adducts were MDA-Lys and a Lys-MDA-Lys cross-link.

9 The chief advantage of this method is its simplicity and rel

10 A chief advantage of this method is that samples may be in

11 In naming population groups, we think a chief aim is to use terms that the group members use the

12 As the chief aim of this framework is to influence public polic

13 he BovineSNP50 genotypes, the frequencies of Chief alleles on his two haplotypes then were determined

14 identified 49 chromosomal segments in which Chief alleles showed strong evidence of selection.

15 ChEF and ChIEF allow more precise temporal control of depolarizat

16 Chief among such adaptations is the ability to detect in

17 Chief among the extrinsic factors are the environmental

18 Chief among the problems has been the very large size of

19 Chief among the uncertainties in risk assessment for NA

20 Relevant ADAMTS genes, chief among them Adamts5 and Adamts15, were expressed bo

21 Chief among them is ferroelectric functionality using pe

22 Chief among them is that physical laws, relationships am

23 Chief among these are infections involving the lower air

24 Chief among these are physiological and anatomical studi

25 Chief among these are soluble Flt1 proteins (sFlt1s) pro

26 Chief among these is how secreted effector proteins trav

27 Chief among these is iron deficiency, which is commonly

28 Chief among these is that biodiesel is derived from rene

29 Chief among these is the accumulating knowledge of how t

30 Chief among these is the heat shock response (HSR), whic

31 Chief among these is the hippocampus, an area which has

32 Chief among these issues was the remarkable stability an

33 Chief among these lineages are the recently described an

34 t]2-fold increase in expression of 17 genes, chief among which is Spp1, encoding the cytokine osteopo

35 en retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigat

36 en retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigat

37 lly differentiated squamous cells, parietal, chief and gastric endocrine cells from a pre-patterned g

38 9 Gbp ( approximately 13.5x coverage) of the Chief and Mark genomic sequences, respectively.

39 3 million high-quality SNPs were detected in Chief and Mark sequences.

40 The parathyroid chief and oxyphil cells produce parathyroid hormone (PTH

41 en retracted at the request of the Editor-in-Chief and the Corresponding Author, Muhammad Kamran.

42 cattle industry, Pawnee Farm Arlinda Chief ("Chief") and his son Walkway Chief Mark ("Mark"), each ac

43 h service registers, clinic records, village chiefs, and a door-to-door survey between June, 2012, an

44 G. G. Simpson, one of the chief architects of evolutionary biology's modern synthe

45 The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticl

46 ngerols, shogaols and other non-volatiles as chief bioactive constituents.

47 Dogs are the chief cause of animal bites in children and the largest

48 While metastasis is the chief cause of cancer mortality, there nonetheless remai

49 Metastatic breast cancer remains the chief cause of cancer-related death among women in the W

50 Here we find that the chief cause of nanosecond-only operation has been therma

51 taldehyde (CAA), a metabolite of IFO, is the chief cause of nephrotoxicity, and that agmatine (AGM),

52 Klebsiella pneumoniae, a chief cause of nosocomial pneumonia, is a versatile and

53 eading airborne biological pollutant and the chief cause of pollen allergy worldwide.

54 haride-induced lung inflammatory injury, the chief cause of the acute respiratory distress syndrome.

55 Aggressive metastasis is the chief cause of the high morbidity and mortality associat

56 As the chief cause of this result, we assume that the rigidity

57 ropathogenic Escherichia coli (UPEC) are the chief cause of urinary tract infections.

58 Brain metastasis is one of the chief causes of mortality in breast cancer patients, but

59 The PLS-DA model built to discriminate chief cell adenoma from oxyphil cell adenoma allowed us

60 of various types with the exception of rare chief cell carcinoma ( approximately 1%).

61 onfirm MIST1 expression is restricted to the chief cell compartment in normal oxyntic mucosa, rare in

62 a in humans arises at least in part from the chief cell lineage.

63 5), epithelial differentiation to mucous and chief cell lineages was rudimentary, with no expression

64 munoreactive for TFF2 and the differentiated chief cell markers, Mist1 and intrinsic factor, suggesti

65 moesin participate in parietal cell acid and chief cell pepsinogen secretion, respectively.

66 Taking advantage of the chief cell-restricted expression of Mist1-Cre-ER(T2), we

67 of the digestive enzyme secreting zymogenic (chief) cell (ZC).

68 COX defects than the mitochondria-poor clear chief cells (P < 0.001).

69 ferentiation of fundic cell types, including chief cells and functional parietal cells.

70 Moreover, the parathyroid adenoma subtypes (chief cells and oxyphil cells) were characterized by the

71 associated with preservation of parietal and chief cells and protection from the development of gastr

72 rise in part through transdifferentiation of chief cells as opposed to expansion of mucus neck or pro

73 Thus, mature gastric chief cells have the ability to act as cryptic progenito

74 mine whether SPEM lineages were derived from chief cells in 3 independent models of induction by DMP-

75 ted in an overlapping fashion in parathyroid chief cells in adenoma and hyperplastic glands, and also

76 rrectly predict 100% of oxyphil and 99.8% of chief cells in the external validation data set.

77 ls or differentiated, post-mitotic zymogenic chief cells in the gland base.

78 been recognized that the secretion of PTH by chief cells in the parathyroid gland is regulated by ext

79 tion of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that

80 sion of the activated form of Ras in gastric chief cells of mice leads to the development of SPEM, as

81 Expression of activated Ras in chief cells of Mist1-Kras mice led to the full range of

82 ce, which express the active form of Kras in chief cells on tamoxifen exposure.

83 olves through either transdifferentiation of chief cells or activation of a basal cryptic progenitor.

84 /+ (Mist1-Kras-mTmG) mice to examine whether chief cells that express active Kras give rise to SPEM a

85 th adenocarcinoma, we found normal zymogenic chief cells that were transitioning into SPEM cells only

86 osure of monolayers of renal collecting duct chief cells to orbital shaking and quantified the forces

87 to mature chief cells, is down-regulated as chief cells undergo experimentally induced metaplasia.

88 etal cells (PCs) and metaplasia of zymogenic chief cells within 3 days.

89 resence of functionally distinct oxyphil and chief cells within parathyroid primary adenomas and prov

90 Compared with normal chief cells, 858 genes were differentially expressed in

91 t tumors, preparatively isolated oxyphil and chief cells, and laser-captured microdissected PA specim

92 IST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that meta

93 s, giving rise to parietal, mucous neck, and chief cells, but not to enterochromaffin-like-cell.

94 factor MIST1, normally restricted to mature chief cells, is down-regulated as chief cells undergo ex

95 d glands, we have isolated and characterized chief cells, oxyphil cells, and tumor-infiltrating lymph

96 sion of myofibroblasts, loss of parietal and chief cells, spasmolytic polypeptide expressing metaplas

97 s produce approximately 50% more PTH than do chief cells, yet display significantly greater PTH suppr

98 racing that SPEM evolves from differentiated chief cells.

99 least in part, from transdifferentiation of chief cells.

100 xpression is also a specific marker of human chief cells.

101 ct reprogramming of existing cells-mainly of chief cells.

102 of SPEM derived from transdifferentiation of chief cells.

103 or cell or by transdifferentiation of mature chief cells.

104 at SPEM derived from transdifferentiation of chief cells.

105 developed directly from Kras (G12D)-induced chief cells.

106 essed in the gastric pepsinogen-synthesizing chief cells.

107 zed secretory vesicles in gastric zymogenic (chief) cells (ZCs) as they differentiate from their muco

108 o personalized diet interventions remain the chief challenges.

109 e dairy cattle industry, Pawnee Farm Arlinda Chief ("Chief") and his son Walkway Chief Mark ("Mark"),

110 Its chief circulating metabolite, 25-hydroxyvitamin D, is co

111 gical disparity of basal dinosaurs and their chief "competitors," the crurotarsan archosaurs, shows t

112 , and less likely to enroll into care with a chief complaint (AOR, 0.08; 95% CI, .05-.12).

113 92.9% versus 70.3% for surveillance with the chief complaint field (difference, 22.6%; P < 0.001).

114 the whole encounter note was superior to the chief complaint field alone.

115 true case of influenza was 2.3 by using the chief complaint field model.

116 ore accurate than a model that uses only the chief complaint field.

117 olics Anonymous meeting location, having the chief complaint of bizarre behavior (i.e., grossly inapp

118 ce of highly active anti-retroviral therapy, chief complaint of fever, low serum sodium and low hemog

119 with a diagnosis of tuberous sclerosis and a chief complaint of gingival enlargement affecting mastic

120 man presented to an outside facility with a chief complaint of headache and pain behind his right ey

121 with metastatic melanoma presented with the chief complaint of pulmonary infiltrates.

122 A 61-year-old white man presented with the chief complaint of wanting to replace his posterior mand

123 Her chief complaint pertained to the unesthetic appearance o

124 t incorporate other clinical factors such as chief complaint that may inform necessity for ED care.

125 The chief complaint was vomiting after intake of cow' milk f

126 ormality, renal insufficiency, arrival mode, chief complaint, admission diagnosis, and abnormal vital

127 Eye symptoms may be the chief complaint, so MC should be considered in any patie

128 as primary care treatable, we identified the chief complaint.

129 es in terms of caring for patients with this chief complaint.

130 on rehabilitation were asked, "What are your chief complaints about your vision?" before their appoin

131 By the end of the study period, top chief complaints among those undergoing CT included head

132 By the end of the study period, the top chief complaints among those who underwent CT were abdom

133 Disease Control and Prevention, incorporates chief complaints but not data from the whole encounter n

134 To determine whether these chief complaints correspond to nonemergency ED visits, w

135 visits associated with CT for all evaluated chief complaints increased-most substantially among thos

136 d, she was admitted to our hospital with the chief complaints of vomiting and diarrhea.

137 acteristics, and disposition associated with chief complaints related to nonemergency ED visits.

138 eatable ED discharge diagnoses were the same chief complaints reported for 88.7% (95% CI, 88.1%-89.4%

139 s and our modification of the algorithm, the chief complaints reported for these ED visits with prima

140 amined all ED visits with this same group of chief complaints to ascertain the ED course, final dispo

141 The most common chief complaints were gastroenterological (17%) and abno

142 The chief complaints were poor feeding and weight loss.

143 The top three chief complaints were related to pain, respiratory distr

144 andinka, and Soninke) presented with various chief complaints.

145 It is the chief component of the mammalian Hippo pathway and promo

146 GE ligands to their cell surface receptor, a chief consequence of which is Rac-1 and Cdc42 activation

147 ILCs localized in the meninges and acted as chief coordinators of meningeal inflammation by inducing

148 The chief criterion for neglecting such fluctuations is that

149 ximum conversion toward 4CaO.3Al2O3.SO3, the chief CSA clinker component, was the largest for MB and

150 me linearity stems from the existence of two chief dangers: inappropriate DNA damage response (DDR) r

151 lon, and zetazeta signaling subunits, is the chief determinant for specific CD4(+) and CD8(+) T cell

152 annular septal-lateral (SL) diameter is the chief determinant of "Alfieri stitch" tension, but hemod

153 The CaSR carboxyl terminus is the chief determinant of intracellular retention of a signif

154 nd not breast MR imaging BI-RADS scores were chief determinants in decisions regarding CPM.

155 lted in unclear or high risk of bias for the chief dimensions of trial quality.

156 Neuropathy is the chief dose-limiting side effect associated with the majo

157 e chemotherapy for multiple myeloma with the chief dose-limiting side effect of painful peripheral ne

158 Tyr216)), leading to loss of beta-catenin, a chief downstream transcriptional effector.

159 Metastasis to distant tissues is the chief driver of breast cancer-related mortality, but lit

160 In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of pa

161 Blind for the Use of Those Who Can See," the chief editor of the French Encyclopedie was arrested and

162 ographic structures, we demonstrate that the chief effect of NNRTIs is to constrain a key rigid-body

163 Platelets are chief effector cells in hemostasis.

164 Platelets are the chief effector cells in hemostasis.

165 rol of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE).

166 IL-10 is considered a chief effector molecule that promotes the vitamin D-indu

167 city by up-regulating expression of XCL1 and chief effector molecules of Treg function.

168 The chief effects of age on the rate of progression are seen

169 nd future plans of dental journal editors in chief (EICs) on RGs.

170 Whether BDNF is a chief element in appetite control in the mature brain re

171 robust numbers of surface pit, mucous neck, chief, endocrine and parietal cells.

172 robust numbers of surface pit, mucous neck, chief, endocrine and parietal cells.

173 Protein disulfide isomerase (PDI), the chief endoplasmic reticulum (ER) resident oxidoreductase

174 Glucose, a chief energy source in cellular metabolism, has a signif

175 In 1949, Alexander Langmuir became the first chief epidemiologist at the Communicable Disease Center

176 Questionnaires were completed by the chief executive officer of each grantee.

177 rmth, "envied" professions included lawyers, chief executive officers, engineers, accountants, scient

178 operties and amount of released payloads are chief factors determining the overall ADC potency and by

179 resent in the genomes of RNA viruses are the chief feature of RIG-I recognition and immune triggering

180 One of the chief findings in this investigation was that PKR and eu

181 ess the question of size when applied to the chief flagellar protein flagellin and the flagellar fila

182 of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data that were

183 of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data that were

184 en retracted at the request of the Editor-in-Chief following concerns raised by a reader.

185 ity of the heart to utilize fatty acids, the chief fuel, is diminished.

186 ibrillar peptide amyloid-beta (A beta) has a chief function in the pathogenesis of Alzheimer's diseas

187 proving that capping enzyme recruitment is a chief function of the Ser5-PO(4) mark.

188 This, in fact, may be one of the chief functions of the self.

189 microtubule-severing protein spastin, is the chief gene mutated in hereditary spastic paraplegia.

190 ated for mean number of cases per graduating chief general surgery resident (GSR) and vascular surger

191 ed the evidence on the mortality benefit and chief harms of mammography screening and what is known a

192 Fourteen editors-in-chiefs have steered Gastroenterologyto success since its

193 cts, public health warnings, an order by the chief health officer under the Victorian Food Act 1984,

194 Gordon Tomaselli as the next editor in chief, I pass on the editorial duties for the JCI to him

195 ic era, a contrary view: that microbiology's chief idol has feet of clay.

196 ogenetic origin and tissue localization, the chief immunoglobulins of all mucosa-associated lymphoid

197 ators and show that background photons are a chief impediment to voltage sensing.

198 I joined Langmuir as assistant chief in 1955 and was appointed chief of the Surveillanc

199 irus to express the light-gated ion channel, ChIEF, in layer VI neurons.

200 tical spectra spanning several octaves are a chief ingredient in the emerging field of attoscience.

201 on of cancerous inhibitor of PP2A (CIP2A), a chief inhibitor of PP2A activity.

202 ted that gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter, is co-released by dop

203 des the major subunit of TCP, the organism's chief intestinal colonization factor.

204 a single copy of the gene encoding ClpP, the chief intracellular protease responsible for tolerance t

205 re aware of the treatment allocated, but the chief investigator and analysts were masked.

206 ar incident late AMD cases were confirmed by chief investigators of the Beaver Dam Eye Study, BMES, a

207 phone-based interviewers, statisticians, and chief investigators were masked to group allocation.

208 nical history of the 27th president and 10th chief justice of the Supreme Court offers a unique oppor

209 between the chemokine receptor CXCR4 and its chief ligand CXCL12 plays a critical role in the retenti

210 However, the chief limitation of current approaches is that the growt

211 therapy-induced cardiotoxicity, which is the chief limiting factor in delivering optimal chemotherapy

212 Arlinda Chief ("Chief") and his son Walkway Chief Mark ("Mark"), each accounting for approximately 7

213 um release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in imm

214 A chief mechanism of Ca2+ entry in lymphocytes is through

215 hesis (TLS) by Y-family DNA polymerases is a chief mechanism of DNA damage tolerance.

216 Our findings identify a chief mechanism that underlies the important role of IL-

217 gh bursting bubbles have been considered the chief mechanisms of environmental aerosol dispersion.

218 ansduction and the ion channel Piezo2 as the chief mechanotransducer.

219 reasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressiv

220 CsA resistance, indicating that CyPA is the chief mediator of the observed CsA resistance.

221 investigated by the New York City Office of Chief Medical Examiner.

222 ntion group was sent a letter from England's Chief Medical Officer and a leaflet on antibiotics for u

223 The investigation was ordered by the chief medical officer of health in accordance with the Q

224 he authors, the AASLD, the journal Editor in Chief, Michael H. Nathanson, and Wiley Periodicals, Inc.

225 The chief mobilizer of the DSB response is the ATM protein k

226 The chief molecular networks identified in primary and passa

227 Deletion of Mdm2, the chief negative regulator of p53, induced an aging phenot

228 The chief novelties of our method are that it is able to inf

229 an Hospital Association data and a survey of chief nursing officers.

230 The chief objective of this paper is to provide guidance to

231 ears exhibited robust OAE activity, and our chief observation was that SFOAE phase accumulation betw

232 HIV latency is the chief obstacle to eradicating HIV but is widely believed

233 protective immunity against Plasmodia is the chief obstacle to malaria control, and inadequate T-cell

234 I encountered in moving from being Editor-in-Chief of a basic science journal to the same position at

235 l of Bacteriology for a decade, as editor-in-chief of Applied and Environmental Microbiology for a de

236 2013, a site visit consisting of a National Chief of Catheterization Laboratory Managers, a cardiac

237 personal reflections on serving as editor-in-chief of Gastroenterology.

238 ere flagged for administrative review by the chief of surgery (or designee) before the scheduled oper

239 th from 1956 to 2007 and served as editor-in-chief of the American Journal of Epidemiology from 1979

240 d that effort, the king tapped Samir Khleif, chief of the cancer vaccine section at the US National C

241 Karl Professor and Chief of the Division of Endocrinology, Metabolism and L

242 ently learned that Dr. Peter D. Olch, Deputy Chief of the History of Medicine Division, National Libr

243 John was the Founder and first Editor-in-Chief of the Journal of Molecular Biology, Deputy Chairm

244 as assistant chief in 1955 and was appointed chief of the Surveillance Section in 1961.

245 es, practices, and opinions, conducted among chiefs of cardiology and program directors, which demons

246 Flagella are the chief organelles of motility in bacteria.

247 t that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating

248 epithelial cells lining the intestine is the chief point of entry for these organisms, little is know

249 in high endothelial venules (HEVs) that are chief portals for the entry of blood-borne lymphocytes i

250 In human cells, cytosolic citrate is a chief precursor for the synthesis of fatty acids, triacy

251 cularly the presence of LOMT orders, was the chief predictor of hospital survival.

252 edical services medical directors and trauma chiefs, preferably those based at the main trauma center

253 Hepatic CD4(+) lymphocytes were chief producers of IL-17A in patients with progressive d

254 s chlorosugar, yielding alpha anomers as the chief products.

255 orinated in apolipoprotein A-I (apoA-I), the chief protein in HDL, and that chlorinated apoA-I loses

256 mparison with commercial "Annurca" and "Gold Chief(R) Gold Pink *" cultivars.

257 consumed cultivars like "Annurca" and "Gold Chief(R) Gold Pink *".

258 and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gu

259 (constitutive photomorphogenic 1), is not a chief regulator of the early response to darkness, in co

260 sing activity against quorum sensing (QS), a chief regulatory and communication system in bacteria co

261 Heme oxygenase-1 (HO-1) is the chief regulatory enzyme in the oxidative degradation of

262 The chief resident (CR) year is a pivotal experience in surg

263 Chief resident cases are crucial in surgical training an

264 Chief resident cases contribute less to overall experien

265 ment of Surgery at Duke University, called a chief residents' meeting to ask for suggestions regardin

266 The chief risk factors for late death included older age and

267 The gut microbiota plays a chief role in vitamin production.

268 We demonstrate a chief role of alpha2delta-1, a calcium channel subunit a

269 e RyR1 channel activity, indicating that the chief role of CSQ1 in this tissue is as an intra-SR Ca(2

270 Vaccine candidates based on a chief RSV neutralization antigen, the fusion (F) glycopr

271 pulation then were identified by referencing Chief's DNA sequence within these selected chromosome bl

272 ity of Wisconsin, he served for two years as Chief Scientist of the Competitive Grants Program of the

273 British Heart Foundation and Chief Scientist Office (Scotland).

274 Chief Scientist Office (Scottish Government), Breast Can

275 he MRC and NIHR, with contributions from the Chief Scientist Office in Scotland and National Institut

276 Chief Scientist Office of the Scottish Government Health

277 UK Medical Research Council, Chief Scientist Office of the Scottish Government, and U

278 UK Medical Research Council, Chief Scientist Office of the Scottish Government, and U

279 Chief Scientist Office of the Scottish Government.

280 Cancer Research UK and Chief Scientist Office of the Scottish Government.

281 Chief Scientist Office Scotland and British Heart Founda

282 ealth Research, Guys and St Thomas' Charity, Chief Scientist Office Scotland, Tommy's Charity.

283 , Department of Health for England, Scottish Chief Scientist Office, Department for Work and Pensions

284 , Department of Health for England, Scottish Chief Scientist Office, Department for Work and Pensions

285 , Department of Health for England, Scottish Chief Scientist Office, Department for Work and Pensions

286 Chief Scientist Office, Scotland; GE Healthcare.

287 Anushka Patel is the Chief Scientist, The George Institute for Global Health,

288 UK Medical Research Council, UK Chief Scientists Office.

289 niacin, along with progress in reducing the chief side effect of flushing, should enhance the use of

290 Via AGE interaction with their chief signaling receptor, RAGE, membrane translocation o

291 epifluorescence microscopy, and located the chief sites of insulin release to intercellular junction

292 on of iron-containing macromolecules, is the chief source of cellular iron.

293 imited range; in this area fisheries are the chief source of economic productivity.

294 Tregs were the chief source of IL-4 and IL-5 as well as IL-10.

295 an incurable disease state which remains the chief therapeutic challenge.

296 increased approximately 2.5-fold from clear chief to oxyphil cells.

297 Nausea and gastrointestinal symptoms are the chief tolerability issue, but they are usually self-limi

298 er, the development of caged versions of the chief vertebrate inhibitory neurotransmitter, gamma-amin

299 enome-wide haplotypes inherited by Mark from Chief were reconstructed using approximately 1 million i

300 e a mean of 252 cases by FB residents in the chief year, theoretically making 126 cases available for