ライフサイエンスコーパス: chief cell

1 developed directly from Kras (G12D)-induced chief cells.

2 essed in the gastric pepsinogen-synthesizing chief cells.

3 racing that SPEM evolves from differentiated chief cells.

4 least in part, from transdifferentiation of chief cells.

5 xpression is also a specific marker of human chief cells.

6 ct reprogramming of existing cells-mainly of chief cells.

7 of SPEM derived from transdifferentiation of chief cells.

8 or cell or by transdifferentiation of mature chief cells.

9 at SPEM derived from transdifferentiation of chief cells.

10 cally localized to the secretory granules in chief cells.

11 ed potentiation of cAMP levels in guinea pig chief cells.

12 tion of cAMP levels in cholera toxin-treated chief cells.

13 5'-triphosphate-binding protein, in gastric chief cells.

14 Compared with normal chief cells, 858 genes were differentially expressed in

15 The PLS-DA model built to discriminate chief cell adenoma from oxyphil cell adenoma allowed us

16 6 mouse showed a marked loss of parietal and chief cells, along with a marked expansion of an aberran

17 c factor expression is both predetermined in chief cells and can be expressed in parietal cells in re

18 ferentiation of fundic cell types, including chief cells and functional parietal cells.

19 Moreover, the parathyroid adenoma subtypes (chief cells and oxyphil cells) were characterized by the

20 associated with preservation of parietal and chief cells and protection from the development of gastr

21 t tumors, preparatively isolated oxyphil and chief cells, and laser-captured microdissected PA specim

22 IST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that meta

23 s of FK-506 on cholera toxin-treated gastric chief cells are caused by its inhibitory actions on calc

24 rise in part through transdifferentiation of chief cells as opposed to expansion of mucus neck or pro

25 irmed rab3D immunoreactivity localization to chief cells but not acid-secreting parietal cells.

26 s, giving rise to parietal, mucous neck, and chief cells, but not to enterochromaffin-like-cell.

27 We conclude that, in gastric chief cells, calcineurin mediates cross-talk between the

28 of various types with the exception of rare chief cell carcinoma ( approximately 1%).

29 onfirm MIST1 expression is restricted to the chief cell compartment in normal oxyntic mucosa, rare in

30 Atp4a(-/-) stomachs revealed the presence of chief cells, demonstrating that the lack of acid secreti

31 rs not to perturb parietal cell viability or chief cell differentiation.

32 sia and oxyntic atrophy were sustained while chief cell, enterochromaffin-like cell, and somatostatin

33 e, including a profound loss of parietal and chief cells, focal de novo production of acidic mucins,

34 Thus, mature gastric chief cells have the ability to act as cryptic progenito

35 mine whether SPEM lineages were derived from chief cells in 3 independent models of induction by DMP-

36 ted in an overlapping fashion in parathyroid chief cells in adenoma and hyperplastic glands, and also

37 Intrinsic factor is produced primarily by chief cells in rat and mouse, but 4 to 11% of isolated r

38 sulted in a loss of specialized parietal and chief cells in the corpus and the appearance of a metapl

39 rrectly predict 100% of oxyphil and 99.8% of chief cells in the external validation data set.

40 ls or differentiated, post-mitotic zymogenic chief cells in the gland base.

41 been recognized that the secretion of PTH by chief cells in the parathyroid gland is regulated by ext

42 numbers of parietal cells, a loss of mature chief cells, increased numbers of mucous and undifferent

43 In cholera toxin-treated gastric chief cells, incubation with a cholinergic agonist (carb

44 tion of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that

45 factor MIST1, normally restricted to mature chief cells, is down-regulated as chief cells undergo ex

46 a in humans arises at least in part from the chief cell lineage.

47 5), epithelial differentiation to mucous and chief cell lineages was rudimentary, with no expression

48 -4 scale to score inflammation, parietal and chief cell loss, mucus metaplasia, and helicobacter colo

49 munoreactive for TFF2 and the differentiated chief cell markers, Mist1 and intrinsic factor, suggesti

50 sion of the activated form of Ras in gastric chief cells of mice leads to the development of SPEM, as

51 Expression of activated Ras in chief cells of Mist1-Kras mice led to the full range of

52 issues such as acinar cells of the pancreas, chief cells of the stomach, and parotid and lacrimal sec

53 ce, which express the active form of Kras in chief cells on tamoxifen exposure.

54 olves through either transdifferentiation of chief cells or activation of a basal cryptic progenitor.

55 d glands, we have isolated and characterized chief cells, oxyphil cells, and tumor-infiltrating lymph

56 COX defects than the mitochondria-poor clear chief cells (P < 0.001).

57 moesin participate in parietal cell acid and chief cell pepsinogen secretion, respectively.

58 gen-mediated apoptosis depletes parietal and chief cell populations, leading to architectural distort

59 mitochondrial energy generation, whereas the chief cell predominantly expresses digestive enzymes and

60 Pepsinogen secretion from gastric chief cells requires a series of intracellular vesicle i

61 Taking advantage of the chief cell-restricted expression of Mist1-Cre-ER(T2), we

62 sion of myofibroblasts, loss of parietal and chief cells, spasmolytic polypeptide expressing metaplas

63 istribution of the rab3D-like protein in the chief cell suggests that it may play an important role i

64 /+ (Mist1-Kras-mTmG) mice to examine whether chief cells that express active Kras give rise to SPEM a

65 th adenocarcinoma, we found normal zymogenic chief cells that were transitioning into SPEM cells only

66 osure of monolayers of renal collecting duct chief cells to orbital shaking and quantified the forces

67 to mature chief cells, is down-regulated as chief cells undergo experimentally induced metaplasia.

68 e stomach-the parietal, mucus-producing, and chief cells-were harvested from cryosections of infected

69 etal cells (PCs) and metaplasia of zymogenic chief cells within 3 days.

70 Chief cells within bovine parathyroid glands exhibit a s

71 resence of functionally distinct oxyphil and chief cells within parathyroid primary adenomas and prov

72 s produce approximately 50% more PTH than do chief cells, yet display significantly greater PTH suppr

73 of the digestive enzyme secreting zymogenic (chief) cell (ZC).

74 zed secretory vesicles in gastric zymogenic (chief) cells (ZCs) as they differentiate from their muco