ライフサイエンスコーパス: chiefly

1 sed many individuals to radioactive iodines, chiefly (131)I, the effects of which on benign thyroid d

2 Impaired IMF was chiefly a loss of sustained muscle contraction secondary

3 Helicobacter pylori is chiefly acquired in childhood, but the exact timing of a

4 2 weeks after vaccination and were directed chiefly against Mycobacterium tuberculosis-secreted prot

5 The antibodies are directed chiefly against the adhesive domain, a 25-amino-acid rep

6 Chiefly among them is the pseudogap phase, which sets in

7 may be responsible for its thermostability, chiefly an increase in ion pair number and the considera

8 short, our data expose early auditory cortex chiefly as a frequency analyzer, and spectral frequency,

9 Thus, env can accelerate cell death chiefly as an entry function, but one or more viral func

10 in has been used widely in clinical medicine chiefly as an indicator of iron stores and inflammation.

11 with rheumatoid arthritis (RA) and manifests chiefly as neutropenia and recurrent infections.

12 ) have historically been viewed as important chiefly as the major indication for hysterectomy.

13 ex hypercellular fully demyelinated plaques, chiefly associated with cases of intermediate duration.

14 between the SC and TA cell populations were chiefly associated with changes in nucleic acid conforma

15 Motor dysfunctions were chiefly associated with the anterior lobe and posterior

16 zeta expressed in transfected cells occurred chiefly at EETD downward arrowG and DGMD downward arrowG

17 ion on mammalian gene regulation is targeted chiefly at the level of trans-regulatory circuitry, enab

18 The transient arrhythmias were chiefly at the time of conversion and included appearanc

19 This progress is chiefly attributable to the introduction of the donor-ac

20 annual cycles has been highly controversial, chiefly because it is difficult to isolate the contribut

21 ors less effectively than cortical receptors chiefly because Mg(2+)(o) unbinds much more rapidly from

22 underlies channelopathies that are suspected chiefly because of a near-drowning or drowning.

23 brain and spinal cord is poorly understood, chiefly because of the inaccessibility and poor optical

24 Glycation of LDL occurs chiefly because of the nonenzymatic reaction of glucose

25 e rates of phenol unbinding remains obscure, chiefly because residues implicated in phenol exchange a

26 ections and potential drug interactions, but chiefly because there is so little published information

27 laxis in individuals with HIV infection, and chiefly benefited those who were tuberculin skin test po

28 e errors, cancer was the diagnosis involved, chiefly breast (44 claims [24%]) and colorectal (13 clai

29 Research has chiefly, but not exclusively, tackled (i) the spatial ep

30 ablished whether NusG enhances transcription chiefly by (1) increasing the rate of elongation between

31 results in a complex phenotype characterized chiefly by abnormalities in fibroblasts, connective tiss

32 It is produced chiefly by activated macrophages as a membrane or secret

33 eceptor binding site on ICOSL is constituted chiefly by aromatic/hydrophobic residues.

34 The inflammatory disease was characterized chiefly by arthralgia, skin rashes, and AA amyloidosis.

35 vation of the deafferented striatum occurred chiefly by axon terminals that formed asymmetric synapse

36 smic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death-domain interactions with the

37 ted that it severely affects FOXP2 function, chiefly by disrupting nuclear localization and DNA-bindi

38 Iron absorption is controlled chiefly by hepcidin, the iron-regulatory hormone.

39 t chemotherapeutical drugs kill cancer cells chiefly by inducing DNA damage, which unfortunately also

40 els hold that serum Ab titers are maintained chiefly by long-lived bone marrow (BM) plasma cells (PCs

41 netic code of DNA methylation is interpreted chiefly by methyl cytosine binding domain (MBD) proteins

42 x microbial stimulus, the tubercle bacillus, chiefly by other routes.

43 ly infection, when innate immunity expressed chiefly by skin macrophages is key, we investigated the

44 patterns of binocular VF loss were dominated chiefly by superior hemifield defects.

45 erma serum-induced EPC apoptosis is mediated chiefly by the Akt-FOXO3a-Bim pathway, which may account

46 ties in continental landscapes is determined chiefly by the autecology of species, interspecific comp

47 autophagy are known that are distinguishable chiefly by the mode in which cargo is delivered to the l

48 umans are those of the urinary tract, caused chiefly by uropathogenic Escherichia coli (UPEC).

49 tial fusion of sediments, but must be caused chiefly by volcanism-plutonism and contraction.

50 Hydroxylamine-cleaved fragments were chiefly C3b and iC3b; 70% of hydroxylamine-sensitive C3b

51 This suggests that sqh mutant phenotypes are chiefly caused by sequestration of myosin into inactive

52 atterns are nutrient specific and not or not chiefly caused by stochastic fluctuations.

53 nges of vessels between highland and lowland chiefly centers were reciprocal, or two-way.

54 misphere axonal injury in cardiac arrest and chiefly central myelin injury in TBI.

55 AGS is chiefly characterized by a paucity of intrahepatic bile

56 uantity and quality of its photosensitizers, chiefly chromophoric dissolved organic matter (CDOM) and

57 Caspase-3, -6, -7, and -8 chiefly cleaved human PKCzeta at EETD downward arrowG, a

58 is, the commensal Neisseria lactamica, which chiefly colonizes infants not adults.

59 ractions as these change in the emergence of chiefly communities.

60 ly, suggesting that the assembled fibers are chiefly composed of nucleosomes.

61 unyaviridae is a large family of RNA viruses chiefly comprised of vertebrate and plant pathogens.

62 urcumin and its analog demethoxycurcumin are chiefly concentrated in the pith rather than the other p

63 tem is also an episodic memory for an animal chiefly concerned with locations.

64 control; (2) the left insular cortex may be chiefly concerned with parasympathetic cardiac regulatio

65 he presence of extracellular amyloid plaques chiefly consisting of amyloid-beta (Abeta) peptides in t

66 (27.6% of the ipsilateral projection), which chiefly contacts relay cell dendrites (84.6%) but also G

67 and, ion transfer at lower concentrations is chiefly controlled by diffusional mass transport from th

68 archaic states emphasize the independence of chiefly controlled territories (ahupua'a) based on an ag

69 r than their glaucoma care costs; these were chiefly costs for cataract surgery and treatment of reti

70 ocalization reveals that the Gal6 protein is chiefly cytoplasmic and thus may be involved in binding

71 While these events chiefly depend upon the type III protein secretion syste

72 currently available thrombolytic regimens is chiefly dependent on choice of thrombolytic regimen, bod

73 cations of the MHC-I receptor repertoire are chiefly dependent on cis binding, which provides additio

74 The exogenous 'contaminant' DNA, chiefly derived from microorganisms, presents significan

75 Antimalarial drugs have thus far been chiefly derived from two sources-natural products and sy

76 The functions of plant PRC2 have been chiefly described in Arabidopsis, but specific functions

77 Red and yellow peel color was chiefly determined by the presence and absence of anthoc

78 o have been organized into a series of small chiefly districts within which ceremonial activities wer

79 e, clustered mostly in DNA metabolism genes, chiefly DNA polymerase.

80 New approaches, chiefly dose escalation strategies, have shown promise i

81 nges in gamma diversity in the Cambrian were chiefly driven by changes in beta diversity.

82 Mitotic chromosome condensation is chiefly driven by the condensin complex.

83 The difference in affinity is chiefly due to a slower dissociation rate for the 3A1f s

84 most frequent among Asian/Pacific Islanders, chiefly due to hepatitis B vertical transmission, but ot

85 and/or potential for radiation dose savings, chiefly due to image noise suppression, the magnitude of

86 rimer that has remained poorly characterized chiefly due to inability to obtain the complete primary

87 it size variation, with increased fruit size chiefly due to increased carpel ovary cell number.

88 inding of multiple yeast in a macrophage was chiefly due to intracellular replication rather than mul

89 The restriction of V genes is not chiefly due to oligoclonal expansion but reflects recurr

90 o identify those subjects whose amblyopia is chiefly due to one or more of the following deficits: ab

91 collagen loss in isolated, compensated MR is chiefly due to posttranslational processing and degradat

92 mune complex deposition could be shown to be chiefly due to the combined contributions of MIP-2 (39%)

93 K differences, therefore, are expected to be chiefly due to the different charge-charge interactions.

94 n injury have produced inconsistent results, chiefly due to the use of relatively small samples from

95 stream activation of EGFR, JNK activation is chiefly EGFR-independent.

96 ine regimens using DNA, fowlpox or MVA, have chiefly elicited T-cell responses that have promisingly

97 s have been prepared by short syntheses that chiefly employed alkyne trimerization, palladium-catalyz

98 ical techniques revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C-terminal domai

99 MGL is chiefly expressed at presynaptic terminals, optimally po

100 In this tutorial review we will chiefly focus on the impact of the morphology and compos

101 Studies of c-di-GMP signaling have chiefly focused on Gram-negative bacteria.

102 This article chiefly focuses on the second question.

103 kebe National Park (MNP), Gabon, was created chiefly for its reputation of harboring a large elephant

104 2-hr cell cycle duration and are responsible chiefly for providing myonuclei to growing fibers.

105 e mother to offspring dependence was derived chiefly from anti-LANA antibodies.

106 variant are younger and usually symptomatic, chiefly from back or abdominal pain.

107 e in delta(13) Corg during the bloom results chiefly from decreasing ambient CO2 concentration (which

108 previously deduced (napA, BngNAP1, and gNa), chiefly from DNA sequences.

109 nly due to natural selection, but originates chiefly from in-built genetic properties of pathogens, w

110 er-hardness palladium-silver alloy fractured chiefly from occlusal surface damage.

111 doped YBa(2)Cu(3)O((6)+x) are shown to arise chiefly from oscillations in the chemical potential.

112 The evidence comes chiefly from retrospective data on earlier events, obtai

113 Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their

114 ively small expenditure of energy, resulting chiefly from the low half-saturation constant for Rubisc

115 e systematic error, Hubble's velocities come chiefly from Vesto Melvin Slipher, and the interpretatio

116 nes throughout the genome appears to result, chiefly, from random insertions with the numbers on each

117 this assembly depends more on host biology (chiefly gestational age at birth) than identifiable exog

118 e evolution of cytochrome b in Peromyscus is chiefly governed by purifying selection.

119 ads to the conclusion that surface charge is chiefly governed by the effect of osmolytes on the surfa

120 Fused cells were chiefly Gr-1(+), a myeloid cell marker, and found predom

121 fection induces pathology, as opposed to the chiefly immune-mediated pathology observed in nonsuscept

122 mately P to block ComE-driven transcription, chiefly impacting sigma(X) production.

123 Leptin is produced chiefly in adipose cells, but in humans, mRNA encoding l

124 d FANCG colocalize in cytoplasm and nucleus, chiefly in chromatin.

125 with EPP may overproduce protoporphyrin IX, chiefly in developing erythrocytes.

126 hMSH2 x hMSH3 complex (hMutSbeta) functions chiefly in repair of heteroduplexes containing two to fo

127 30 adult D. variabilis Say ticks, collected chiefly in southern California, were negative.

128 ex, immunoglobulin-like immunoreactivity was chiefly in subplate neurons, marginal zone neuropil, and

129 thalamus, strong IRS-2 staining was detected chiefly in the arcuate (ARC), ventromedial (VMN) nucleus

130 MyD88-5/GFP was detected chiefly in the brain, where it associated with punctate

131 3), and the phosphorylated protein was found chiefly in the cytoplasm.

132 subjects, showed elevated plasma LPS levels chiefly in the first 3 days after injury.

133 rhino (rhi) is expressed only in females and chiefly in the germline, thus providing a new tool to di

134 secondary lymphoid tissues from normal mice, chiefly in the gut-associated lymphoid tissue.

135 ade and orthograde labeling in the thalamus, chiefly in the lateral geniculate nucleus and lateral po

136 in layers I, III-IV, and VI that originated chiefly in the medial division and had the lowest densit

137 bands are associated with membrane fractions chiefly in the outer medulla.

138 infected macaques, in which it was localized chiefly in the PA-SMCs.

139 In these larger complexes, PML was found chiefly in the rims of the spheres, while the known ND10

140 nd surrounded by an Fe-C network, and differ chiefly in the stacking sequence of these layers.

141 ns of the colony, and KinC and KinD function chiefly in the younger, outer regions.

142 ing pattern of sequence similarity localized chiefly in their proximal 5'-flanking regions.

143 wise, HCV infection prevalence declined, but chiefly in younger IDUs.

144 ar delivery of poly I:C (complexed poly I:C) chiefly induced expression of IFN-beta and IL-6.

145 These interactions appear to be chiefly influenced by sex and ethnicity.

146 driven by voltage and controlled by anions, chiefly intracellular chloride.

147 This gain chiefly involved carotid territory ischaemic strokes (2.

148 and suggests that the paralemniscal route is chiefly involved in modulatory functions rather than sim

149 Postnatal growth of the heart chiefly involves nonproliferative cardiomyocyte enlargem

150 vasculitis in adults, is a panarteritis that chiefly involves the extracranial branches of the caroti

151 adolescents exposed to radioactive iodines, chiefly iodine-131 ((131)I), after the 1986 Chornobyl (U

152 Several arenaviruses, chiefly Lassa virus (LASV) and Junin virus in West Afric

153 Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF)

154 Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF)

155 Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever dise

156 hogens and include several causative agents, chiefly Lassa virus (LASV), of hemorrhagic fever disease

157 al marae (associated with the highest-ranked chiefly lineages) and 19 marae in the inland 'Opunohu Va

158 ,IFNgamma+ T lymphocytes in RA synovium were chiefly localized within clusters containing CD68+, CD16

159 by neurotoxicity of mutant spastin proteins, chiefly M1.

160 perty of both type I BMPRs, axon guidance is chiefly mediated by only one of the type I BMPRs, BMPRIB

161 These factors, chiefly members of the fibroblast growth factor (FGF) ge

162 extend and retract cytoskeletal structures, chiefly microtubules and filopodia, to process informati

163 the MIC-regulated phosphorylation sites were chiefly modified by mTOR, as well as multiple isoforms o

164 The oxides of nitrogen (chiefly NO, NO3(-), NO2(-) and N2O) are key components o

165 Neurons are chiefly nonrenewable; thus, cytolytic immune strategies

166 RG1 bound and stabilized methyltransferases, chiefly O(6)-methylguanine-DNA methyltransferase (MGMT),

167 ported that both FRs and ripples (80-200 Hz) chiefly occur during non-rapid eye movement sleep (NREM)

168 on of vascular and cerebral plaques composed chiefly of amyloid beta-peptide (A beta) derived from cl

169 We observed that CD8+ T cells in BM consist chiefly of CCR7+ L-selectin+ central memory cells (TCMs)

170 ials in the JCT were confirmed to be made up chiefly of collagen type IV, laminin, and fibronectin.

171 Intriguingly, these mutations consist chiefly of deletions in nonexpressed genes.

172 51 were WNV specific, and the remaining 86, chiefly of E, NS3, and NS5, shared an identity of nine o

173 cruited in IST-3, despite the early hazards (chiefly of fatal intracerebral hemorrhage), thrombolysis

174 tail of a BALB/c nu/nu mouse, were comprised chiefly of host x tumor hybrids.

175 xed cellular populations in vivo, consisting chiefly of neuronal (N)-type and substrate (S)-type cell

176 e benign, tumor-like proliferations composed chiefly of plasma cells that manifest primarily in the l

177 time of flight mass spectrometry to consist chiefly of proteins ranging in mass from 5200 to 6700 Da

178 These goals consisted chiefly of reduced intake of saturated fat and cholester

179 ic exercise stimulates amino acid oxidation, chiefly of the branched-chain amino acids, and ammonia p

180 ow an organized hexameric lattice consisting chiefly of the capsid (CA) domain, with periodic stalk-l

181 n IX may accumulate, with resultant toxicity chiefly of the marrow, skin, nervous system, and liver.

182 to emerge as a cause of serious infections, chiefly of the skin and soft tissues.

183 l appeal, with a mechanistic rationale based chiefly on abrogation of gemcitabine-induced G2-M checkp

184 This review has concentrated chiefly on contributions to this field of inquiry made b

185 Simulations performed here focus chiefly on reproducing findings of in vitro experiments

186 potheses that seek to explain them are based chiefly on terrestrial data.

187 ing DNA sequences exerted selective pressure chiefly on the central stretch of the nucleosomal DNA.

188 n 400 and 600 species distributed worldwide, chiefly on the continents but also on oceanic islands.

189 sening life satisfaction in China has fallen chiefly on the lowest socioeconomic groups.

190 Bacterial motility relies chiefly on the rotation of a molecular propeller, the fl

191 and consequent cell fate progression) relies chiefly on three let-7 family microRNAs, whereas after q

192 antimicrobial agents, but they have focused chiefly on vaccines, and vaccinology is thriving.

193 ell-differentiated adenocarcinomas comprised chiefly or entirely of glands lined by tall columnar cel

194 ported to bind to FANCC, we showed that cdc2 chiefly phosphorylated a 14-kDa fragment of the C-termin

195 cled between expansionist states and smaller chiefly polities, and (iii) that U-shaped structures wer

196 onal sporangia confirmed that pro-sigmaE was chiefly present in the membrane fraction and that sigmaE

197 ption PCR analyses show that these mRNAs are chiefly produced by the aggregate gland.

198 macrophages (MAMs), rather than tumor cells, chiefly produced V1-VCAN, the precursor to versikine, wh

199 ed for activation of select client proteins, chiefly protein kinases and transcription activators and

200 t studies on the protein folding problem are chiefly pursued by two approaches; one statistically inv

201 percentage loss of freely diffusing thiols (chiefly reduced glutathione) that have been derivatized

202 irthweight and subsequent blood pressure may chiefly reflect the impact of random error, selective em

203 ulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin releas

204 ng as a post-translational modification that chiefly regulates protein function.

205 new information regarding drug interactions, chiefly related to rifamycins and antiretroviral drugs;

206 number of barriers to team formation exist, chiefly related to the challenges of human relationships

207 o indicate that platelet-derived IL-1beta is chiefly released in microparticles through mechanisms de

208 r to be highly conserved, with novel aspects chiefly represented by addition of lineage-specific core

209 cillus anthracis is a zinc hydrolase that is chiefly responsible for anthrax-related cell death.

210 -Per-Arnt-Sim (bHLH-PAS) superfamily and are chiefly responsible for cellular adaptation to oxygen de

211 s lacking the isopentenyl-transferase enzyme chiefly responsible for cytokinin synthesis are defectiv

212 ionine gamma-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesi

213 Muscle stem cells (satellite cells) are chiefly responsible for providing new muscle during post

214 ld-type cells, the V-ATPase-driven Vcx1p was chiefly responsible for restoring cytosolic Ca(2+) conce

215 y (tpm) cells and propose that tpm cells are chiefly responsible for the global surveillance of non-l

216 To identify the viral gene(s) chiefly responsible for the high virulence of the 1918 v

217 lls during transmission and persistence--are chiefly responsible for the observed sequence diversity

218 Tyr4 downward arrow bonds, respectively, are chiefly responsible for the preference of human chymase

219 -iron metalloenzymes, and that the enzyme is chiefly responsible for the proximal signal events in IN

220 Advances chiefly rest on the ability to manipulate biological sys

221 evidence that conventional transmission was chiefly restricted to monosynaptic actions.

222 hts gleaned from studies of model organisms, chiefly rodents, will be considered in parallel with hum

223 ach modality dominates a circumscribed area, chiefly separate.

224 anthracis acts as a molecular sieve that is chiefly size-dependent, favoring catalytic domains over

225 ists or antagonists also altered eye growth, chiefly stimulating it.

226 eroid hormone-dependent transcription and is chiefly targeted to NRs via the LXXLL-containing MED1 su

227 Cellular immunity, chiefly the CD8(+) T-cell response, plays a critical rol

228 karyotypic evolution, rearrangements involve chiefly the centromere.

229 n of a wide variety of biological phenomena, chiefly the evolution of biological altruism as that fou

230 scribed by in vitro analysis of the process, chiefly the formation of large clusters of effector CD8(

231 LD-CBF increased 48 +/- 10%, ECoG shifted to chiefly the HVLF state, SEF(90) decreased approximately

232 cts of the system limit the generation time, chiefly the propensity of the substrate molecules to for

233 edge and data from behavioural interventions chiefly the randomized controlled trial (RCT) of a self-

234 ere identified in several deep-brain nuclei--chiefly the striatum and midbrain-and across motor, prem

235 GCPs but inhibits their differentiation and, chiefly, their intrinsic ability to migrate outside the

236 al setting of orbital cellulitis was absent; chiefly, there was no identified antecedent upper respir

237 Our results suggest that the 4E-BP pathway, chiefly thought of as a nutrient sensor, may represent a

238 mpact on health care use and indirect costs, chiefly through absenteeism.

239 Our data suggest that p63RhoGEF is regulated chiefly through allosteric control by Galpha(q), as oppo

240 trophils from AVCO2R-treated animals removed chiefly through apoptosis, but in the cases of HFPV and

241 ing itself induces changes in gel structure, chiefly through inhibition of fibril bundling.

242 Cultural change occurs chiefly through invention of new behavioral variants com

243 This regional homogenization occurs chiefly through modification of the magnitude and timing

244 This response to PGE(2) was mediated chiefly through the EP1 receptor and involved stimulatio

245 of large-scale public health interventions, chiefly through vaccination efforts, the disease continu

246 as revealed significant limitations relating chiefly to (a) practical problems implementing random as

247 lts indicate that the latter changes are due chiefly to changes in lifetime or fluorescence efficienc

248 ized to plasma membranes where they function chiefly to mediate water transport across cells.

249 expression was more restricted and localized chiefly to podocytes of developing glomeruli and develop

250 These patients responded chiefly to sequences within the N terminus and the 25-am

251 rphology, however, presents a challenge, due chiefly to the ease with which the "strings" can be brok

252 Their beneficial effects are owed chiefly to their abilities to home to sites of injury an

253 lithic artifacts associated with stone-faced chiefly tombs.

254 This protocol has been chiefly used for analyzing siRNAs and their chemical mod

255 accine efficacy appears to depend, may occur chiefly via a mechanism that involves antibody alone, as

256 adult mammalian brain, mediating its actions chiefly via a pentameric chloride ion channel, the GABAA

257 ng fibroblasts: (i) viral recognition occurs chiefly via a Toll-like receptor (TLR)-independent nucle

258 r and infragranular pyramidal cells mediated chiefly via excitatory chemical synaptic pathways, littl

259 closely packed segments that are associated chiefly with one of the heads.

260 nsporter overexpression (SM22-5HTT(+) mice), chiefly within PA-SMCs.

261 Type II NOS immunoreactivity was expressed chiefly within resident meningeal macrophages.

262 adenocarcinoma that has a tendency to spread chiefly within the confines of the lung by aerogenous an

263 oxidation), chelation of transition metals (chiefly Zn(2+), Mn(2+) and Cu(2+)) or S-nitrosylation [t