ライフサイエンスコーパス: chimaera

1 vices used in cardiac surgery (Mycobacterium chimaera).

2 ed species (such as M. intracellulare and M. chimaera).

3 cidia sequence is a basidiomycete/heterokont chimaera).

4 rosslinking and activation of a CD69-CD3zeta chimaera.

5 al and histopathologic ocular findings of M. chimaera.

6 cell (ESC) inoculum contributes to the adult chimaera.

7 18% were M. intracellulare, and 28% were M. chimaera.

8 criteria for infection than patients with M. chimaera.

9 obacterium intracellulare, and Mycobacterium chimaera.

10 tracellulare and 4 (7.4%) were Mycobacterium chimaera.

11 cter, including multilineage contribution to chimaeras.

12 ation epiblast and efficiently contribute to chimaeras.

13 from a field population readily mix to form chimaeras.

14 ral T cells are present in all older FADD-/- chimaeras.

15 opulations were apparently normal in newborn chimaeras.

16 gase, followed by sequencing to identify the chimaeras.

17 modules are described for the paired fins of chimaeras.

18 ,041 chondrichthyan fishes-sharks, rays, and chimaeras.

19 uting to traditional germline and tetraploid chimaeras.

20 e competent for multilineage colonisation of chimaeras.

21 erentiated progeny to all foetal lineages of chimaeras.

22 tribute to somatic tissues and germ cells in chimaeras.

23 e full development when combined together in chimaeras.

24 eage differentiation both in fetal and adult chimaeras.

25 how compromised development when combined in chimaeras.

26 st, 30 (73%) household water samples were M. chimaera, 8 (20%) were other MAC X species (i.e., isolat

27 th disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (N

28 In the chimaeras, activation resembled that of mu1, fast inacti

29 nse, M. mucogenicum and M. phocaicum, and M. chimaera and M. intracellulare.

30 Mycobacterium chimaera and other pathogens were recovered from water a

31 Many methods for generating both chimaeras and a range of markers for tracing their linea

32 Rs by the creation of retroviral bone marrow chimaeras and a TCR transgenic line revealed that microb

33 rtoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding

34 ter, these iPSC clones contributed poorly to chimaeras and failed to support the development of entir

35 They efficiently produced adult chimaeras and gave germline transmission.

36 Dlk1-Dio3 cluster contributed to high-grade chimaeras and generated viable all-iPSC mice.

37 paralogues, the potential for unidentifiable chimaeras and priming across taxa.

38 gynandromorph birds are genuine male:female chimaeras, and indicated that male and female avian soma

39 avium (AOR, 5.64; 95% CI, 1.51-21.10) and M. chimaera (AOR, 4.47; 95% CI, 1.08-18.53) were more likel

40 Chimaeras are both monsters of the ancient imagination a

41 In modern terms, chimaeras are composite animals consisting of geneticall

42 Using genetically mixed blastocyst and BM chimaeras as well as in vivo T cell transfer systems, we

43 roper and to the trophectoderm lineages in a chimaera assay.

44 INTERPRETATION: HCU contamination with M chimaera at the LivaNova factory seems a likely source f

45 transfected with complementary DNAs encoding chimaeras bearing appropriate localization signals.

46 igher viral loads while variants such as the chimaeras bearing the B14 and B28 Envs grew less well.

47 First, we made aggregation chimaeras between transgenic Dct-lacZ and non-transgenic

48 cing more than their fair share of spores in chimaeras, but cooperating normally when clonal.

49 rived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can gener

50 inst intravenous or mucosal SHIV (an HIV/SIV chimaera) challenge and topically applied antibodies can

51 endent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle ha

52 Sharks, rays, and chimaeras (Class Chondrichthyes; herein 'sharks') are th

53 Chimaera competition is therefore a sensitive, quantitat

54 Interestingly, an LMP1/ CD40 chimaera comprising of the N-terminus and transmembrane

55 Chimaera containing the S1-S6 transmembrane region of HE

56 Finally, in mouse bone marrow chimaeras containing both wild-type and Tp53(+/-) haemat

57 derably shorter than either authentic ARF or chimaeras containing the entire coding domain, both of w

58 tic nuclear clones, they are in fact genetic chimaeras, containing somatic cell-derived nuclear DNA b

59 ragment of a mouse IgG1 antibody to create a chimaera CR2-Ig containing the major ligand binding doma

60 Mouse lymphoid chimaeras deficient in XBP-1 possessed normal numbers of

61 Chimaeras define the N terminus, and a segment of the pr

62 Chimaeras derived from ES cells treated with EMS transmi

63 ell autonomous, because wild-type cells in a chimaera do not rescue development of the autophagy muta

64 The slow inactivation phenotype in the chimaeras (domains denoted by subscripts) mu1(1)hH1(2,3,

65 In mixed bone marrow chimaeras, EBI2-deficient B cells phenocopied germinal c

66 Chimaeras, fanciful beasts that drew their force from be

67 rally assumed that PGCs do not contribute to chimaeras following injection into the early mouse embry

68 elopmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicat

69 Here we report that this chimaera forms alternate prion strains in vivo when init

70 evidence for the airborne transmission of M. chimaera from contaminated heater-cooler unit water tank

71 We were able also to culture M. chimaera from water circuits of heater-cooler units conn

72 dly out-competed in the bone marrow of mouse chimaeras generated with Gfi-1-/- embryonic stem cells.

73 technologies, and compared with published M chimaera genomes.

74 uencing of 250 isolates revealed two major M chimaera groups.

75 Such a chimaera has therapeutic potential as a complement inhib

76 Phosphomimetics and inter-species chimaeras have shown that negative charge in the RACK1 l

77 -alanine), in the form of a ligand-inducible chimaera HER-1/2, was co-transfected into HEK-293 fibrob

78 Analysis with chimaeras, however, shows that Arkadia functions within

79 could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis.

80 ted FADD-/- embryonic stem cells and FADD-/- chimaeras in a background devoid of the recombination ac

81 re reports of cultured cell contributions to chimaeras in golden hamster, rat and pig, definitive ES

82 ession of green fluorescent protein (GFP) GK chimaeras in MIN6 beta-cells to study the phenotype defe

83 en mouse and chick in generating mouse-chick chimaeras in ovo.

84 Using chimaeras in which premigratory chick neural crest had b

85 trast to the outcome for mammalian mixed-sex chimaeras, in chicken mixed-sex chimaeras the donor cell

86 ntified low but escalating risk of severe M. chimaera infection associated with heater-coolers with c

87 tinitis died of systemic complications of M. chimaera infection despite long-term targeted antimicrob

88 hed to assess risk of invasive Mycobacterium chimaera infection in cardiothoracic surgery and a possi

89 M. chimaera infection subsequent to cardiothoracic surgery

90 tion of cardiopulmonary bypass-associated M. chimaera infection through national laboratory and hospi

91 ases of cardiopulmonary bypass-associated M. chimaera infection were identified; all except one occur

92 findings, of patients with a disseminated M. chimaera infection.

93 The global outbreak of Mycobacterium chimaera infections associated with heater-cooler device

94 for cardiothoracic surgery-related severe M chimaera infections diagnosed in Switzerland, Germany, t

95 Invasive Mycobacterium chimaera infections were diagnosed in 2012 in 2 heart su

96 We included 24 M chimaera isolates from 21 cardiac surgery-related patien

97 Germany, the Netherlands, and the UK, 218 M chimaera isolates from various types of HCUs in hospital

98 ed on archived histopathology samples and M. chimaera isolates since 2006, and the patient population

99 Chimaeras made entirely of these equatorially or oblique

100 Chimaeras made from a 1:1 mix of targeted and wild-type

101 By contrast, chimaeras made from four-cell stage blastomeres from ear

102 The developmental defects of chimaeras made from the most vegetal blastomeres that re

103 However, the chimaera mu1(1)hH1(2,3,4) was more like wild-type hH1, w

104 ,3,4) was more like wild-type hH1, while the chimaeras mu1(1,2)hH1(3,4) and mu1(1,2,3)hH1(4) were mor

105 The fusion protein, a chimaera of glutathione S-transferase and BLT 801, has b

106 A chimaera of human Hook3 and Hok1 rescues the hok1 mutant

107 sed in Escherichia coli, gonococcal NarQ and chimaeras of E. coli and gonococcal NarQ are ligand-inse

108 Here, we tested chimaeras of rat Kv1.2 with the hERG channel for functio

109 Using cell-specific markers and chimaeras of wild-type and rzpA- cells, we show that rZI

110 did the human 'book of life' evolve to be a chimaera, part animal and part bacterium?

111 lular or functional categories, but may be a chimaera partially supported by organelle robbery.

112 yoid and gill arches, whereas holocephalans (chimaeras) possess a single hyoid arch ray-supported ope

113 Since 2013, over 100 cases of Mycobacterium chimaera prosthetic valve endocarditis and disseminated

114 Mouse chimaeras reconstituted with wild-type, Nek7(-/-) or Nlr

115 This is the first report of M. chimaera recovery from household water.

116 The resulting chimaeras retain the respective functional hallmarks of

117 Assembly of FtsZ chimaeras revealed that the protofilaments assemble via

118 A chimaera S-peptide composed of the 10th beta-strand of G

119 tions dictate amyloid seeding specificity: a chimaera seeded by S. cerevisiae fibres efficiently cata

120 stribution of homozygous mutant cells in the chimaeras showed that the cell-autonomous removal of Pax

121 In mouse chimaeras, Sox9-/- cells are excluded from all cartilage

122 PCR demonstrated identical patterns among M. chimaera strains from heater-cooler unit water circuits

123 Mycobacterium chimaera strains were characterized by randomly amplifie

124 nses to acute infections by adopting a mixed chimaera strategy in which T cells lacking the high-affi

125 The resulting chimaeras survive and develop normally.

126 Conversely, a MEK1-MEK5 chimaera that phosphorylated ERK1/2 independently of Cu

127 A Sup35 chimaera that traverses the transmission barrier between

128 Moreover, beta-arrestin/arrestin chimaeras that are defective in either beta2AR or clathr

129 They produced high-contribution chimaeras that yielded germline transmission.

130 an mixed-sex chimaeras, in chicken mixed-sex chimaeras the donor cells were excluded from the functio

131 ansmit through the germ line via ES-cell rat chimaeras to create p53 gene knockout rats.

132 unctions of the organizer, using quail-chick chimaeras to distinguish graft- and host-derived cells,

133 ust pipeline for the discovery of novel gene chimaeras using high-throughput sequencing, opening up a

134 Mycobacterium chimaera was isolated from cardiac tissue specimens, blo

135 By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid o

136 Using this chimaera, we show that the influence of environment and

137 and protein engineering with a novel fusion chimaera, we solved the structure of the human OX2R boun

138 g chromatin assembled from histone H3/CENP-A chimaeras, we demonstrate that the conserved carboxy ter

139 ted biological activity of EGF receptor/CD45 chimaeras, we propose that dimerization and active-site

140 he microsurgical construction of quail-chick chimaeras, we show that the caudal boundary of the presu

141 Patients infected with M. chimaera were more likely to be prescribed an immunosupp

142 f Na+ channel slow inactivation, Na+ channel chimaeras were constructed with domains from hH1 and mu1

143 Germline chimaeras were derived from cultures that underwent a mu

144 Chimaeras were made by incorporating these ES cells into

145 nt stem cells that can contribute to primary chimaeras when introduced into pre-implantation embryos.

146 Similarly, in vitro the purified chimaera, when seeded with different species of Sup35 fi

147 Notably, ES cells robustly colonise chimaeras, whereas EpiSCs show little or no contribution

148 e synthesized stimuli that we call 'auditory chimaeras', which have the envelope of one sound and the

149 rditis or vascular graft infection due to M. chimaera, which became clinically manifest with a latenc

150 extracellular region of CD5, expressed as a chimaera with rat CD4 domains 3 and 4 (cCD5d1-3-CD4d3+4)

151 Examination of chimaeras with a high proportion of mutant cells showed

152 ak) mutant, which lacks all RGCs, we created chimaeras with eyes that contained single RGCs.

153 uripotency were confirmed by contribution to chimaeras with germline transmission.