ライフサイエンスコーパス: chimaeric

1 Further, correctly folded chimaeric 2S albumin proteins containing structural epit

2 By constructing chimaeric 5-HT3A and 5-HT3B subunits we identified a reg

3 In contrast to previous data, chimaeric and mosaic embryonic melanoblast patterns sugg

4 Chimaeric antigen receptors (CARs) are a class of synthe

5 insic kinases, including, as we demonstrate, chimaeric antigen receptors being developed for cancer i

6 kinetics of exogenously expressed mRNA from chimaeric Arc constructs (Arc/MS2 mRNA) in the dendrites

7 ion embryo and fail to resume development in chimaeric assays.

8 vivo competition assay in which we prepared chimaeric blastocysts, composed of a mixture of wild-typ

9 ryos were incubated to either E7 or E10 when chimaeric brains were removed.

10 One chimaeric capsid composed of five different parental AAV

11 iruses (MLV) followed by selection yielded a chimaeric clone with a completely new tropism for Chines

12 Using chimaeric constructs from mcm sensitive and mcm insensit

13 The chimaeric developmental origin of this model of modulari

14 We use chimaeric domains to demonstrate that this internal fric

15 These chimaeric elements are called Pack-MULEs in this study.

16 ed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmis

17 Chimaeric embryos derived from several independent mutan

18 esentation in different cell lineages as the chimaeric embryos developed.

19 s to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of ea

20 Examination of chimaeric embryos revealed that c-myb(-/-) donor-derived

21 tion of Stella(+) cells in vitro and PGCs in chimaeric embryos, and is associated with human germ-cel

22 of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GP

23 ent contradiction, and here we show that two chimaeric enhancers, constructed by swapping the 5' and

24 Western blot demonstrated that chimaeric envelope proteins were incorporated into retro

25 n and provides a framework for the design of chimaeric enzymes with altered specificities.

26 misalignment or ambiguity, misclustering or chimaeric EST sequences, assessing data such as raw chro

27 Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein

28 rn-3a but not Brn-3b interacts in vitro with chimaeric EWS/Fli-1, EWS/ATF-1 and EWS/ERG proteins.

29 We have made a chimaeric fusion between the prion domains of two specie

30 Remarkably chimaeric fusions of sin1 with chicken sin1 sequences re

31 However, in some chimaeric fusions that comprised the amino and carboxy t

32 This is the first vertebrate example of a chimaeric gene generated by this mechanism of exon shuff

33 A chimaeric gene was constructed comprising a wheat high m

34 barley plants containing the antisense SnRK1 chimaeric gene were produced by particle bombardment of

35 Libraries of chimaeric genes can be generated by random fragmentation

36 The resulting chimaeric genes express SYT-SSX1 or SYT-SSX2 fusion prot

37 A set of chimaeric genes was constructed containing different pro

38 s to generate embryos containing male:female chimaeric gonads.

39 es lost through transfer to the nucleus, and chimaeric, half-monocot, half-dicot genes.

40 erstanding of these discrepancies, we used a chimaeric human-murine liver model to compare directly t

41 es resembles that of cancer patients who are chimaeric individuals carrying a small number of mutated

42 tively large number of YAC clones containing chimaeric inserts.

43 tion of the YAC clones were found to contain chimaeric inserts.

44 The features of these two chimaeric IS elements are discussed in terms of possible

45 otility of wild-type KIF3A/B heterodimer and chimaeric KIF3A/A and KIF3B/B homodimers made by splicin

46 in clinical studies, we used the same murine chimaeric liver model to perform serial selection using

47 Chimaeric messages spliced over the breakpoint fuse the

48 Observations on chimaeric mice argue that there must be considerable dis

49 Previous studies of adult chimaeric mice carrying different coat colour markers ha

50 Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hype

51 s, we devised protocols to generate germline chimaeric mice from embryonic stem (ES) cells heavily mu

52 Analysis of chimaeric mice generated from these cells allows us to s

53 erated tissue using Y chromosome painting in chimaeric mice indicates that once differentiated to exp

54 This was corrected in chimaeric mice reconstituted with bone marrow from wild-

55 Experiments in bone marrow chimaeric mice revealed that IFN-I must act on both haem

56 capable of generating germline-transmitting chimaeric mice using only Oct4 (also known as Pou5f1) an

57 Chimaeric mice were made by aggregating Pax6(-/-) and wi

58 Chimaeric mice with a high level of mutant germ cells we

59 d EG cells contribute extensively to healthy chimaeric mice, including to the germline.

60 Accordingly, in chimaeric mice, NMDA receptor-initiated signals are not

61 ifferentiation assays and formation of adult chimaeric mice.

62 udied its function during spermatogenesis in chimaeric mice.

63 Half of the chimaeric mixtures show a clear cheater and victim.

64 rrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive

65 Here we develop a novel chimaeric mouse model of mCRPC to efficiently test combi

66 was validated in vivo using an HCV-infected chimaeric mouse model.

67 The translocation produces an invariant chimaeric NUP98/HOXA9 transcript containing the amino te

68 lication of methylphosphonate:phosphodiester chimaeric oligonucleotides to U937 cells reduced mRNA le

69 fusion protein E2A-HLF, indicating that the chimaeric oncoprotein probably affects cell survival rat

70 Using a chimaeric p53 fusion protein with the oestrogen receptor

71 s subsequently prepared from these mouse-rat chimaeric pancreata were transplanted into mice with str

72 Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexe

73 To enable siRNA binding, a chimaeric peptide was synthesized by adding nonamer argi

74 m genomic segments to create a repertoire of chimaeric polypeptides displayed on filamentous bacterio

75 ial relationship between sister cells in non-chimaeric postimplantation epiblast by ionophoretic inje

76 Notably the generation of the chimaeric PRCC-TFE3 gene appears to be accompanied by co

77 y generating a transgenic mouse expressing a chimaeric protein in which the oxygen-dependent degradat

78 A chimaeric protein is synthesized from one of the derivat

79 Through the use of a chimaeric protein microarray system together with sera f

80 combinase or a tamoxifen-inducible MerCreMer chimaeric protein was targeted to the Kit locus in mice

81 inding), resulting in a rapidly destabilized chimaeric protein.

82 In conclusion, the combination of chimaeric proteins and protein microarrays will greatly

83 sarcomas, which also express characteristic chimaeric proteins as a consequence of fusion of the TET

84 Zinc-finger recombinases (ZFRs) are chimaeric proteins comprising a serine recombinase catal

85 d-type SYT and SSX proteins, and the SYT-SSX chimaeric proteins, can modulate transcription in gene r

86 HVR-chimaeric rAd5 vectors expressing simian immunodeficienc

87 We constructed novel chimaeric rAd5 vectors in which the seven short hypervar

88 anti-Ad5 immunity, the immunogenicity of HVR-chimaeric rAd5 vectors was not detectably suppressed, wh

89 These HVR-chimaeric rAd5 vectors were produced at high titres and

90 By using chimaeric receptor constructs, we have identified a regi

91 we report that the association of these two chimaeric receptors with the histone deacetylase (HDAC)

92 rchitecture of the synapse, we constructed a chimaeric recombination site (resF) which allows Hbsu to

93 The existence of such chimaeric RNAs has far-reaching implications for the pot

94 the fungal cellulosome is an evolutionarily chimaeric structure-an independently evolved fungal comp

95 the doubly enhanced CaMV 35S promoter or the chimaeric 'Super-Promoter'.

96 y in vitro, we found that the ArtB/PltA/CdtB chimaeric toxin exhibits reduced lethality in an animal

97 ranslocations resulting in the expression of chimaeric transcription factors are frequently observed

98 Apparently chimaeric transcripts (from oncogenic fusion genes gener

99 y validated, novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours.

100 Our approach involves generating chimaeric transcripts of viral RNAs (MS2 and PP7) and si

101 9-HERVH drives hESC-specific alternative and chimaeric transcripts, including pluripotency-modulating

102 ading frames, some of which are expressed as chimaeric transcripts.

103 Some of these 'chimaeric' transcripts are formed by genetic rearrangeme

104 Such chimaeric viral vectors may have important practical imp

105 challenge with HIV or simian/human (SIV/HIV) chimaeric viruses (SHIVs) respectively, the long-term ef

106 Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call th

107 We isolated and mapped a single non-chimaeric YAC (17IA12, 260-280 kb) containing D6S193 and