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4 ion structure-activity relationship study of chimeric agouti-related protein (AGRP)/[Nle4,DPhe7]alpha
5 nized alphaCD154, n = 9), 5C8H1 (mouse-human chimeric alphaCD154, n = 5), or 2C10R4 (mouse-rhesus chi
6 alphaCD154, n = 5), or 2C10R4 (mouse-rhesus chimeric alphaCD40, n = 6) monotherapy using a consisten
8 importance in cotton, but through pioneering chimeric and morphometric studies, it has contributed to
12 deficient in both TNF receptors p55 and p75, chimeric animals and anti-TNFalpha antibody blockade we
15 tus; using cellular-based therapies, such as chimeric antigen and high-affinity T-cell receptors to d
16 study, we have engineered an FVIII-specific chimeric antigen receptor (ANS8 CAR) using a FVIII-speci
17 antitumor properties, making them attractive chimeric antigen receptor (CAR) carriers for redirected
18 of T cells to SLAMF7 through expression of a chimeric antigen receptor (CAR) derived from the huLuc63
20 nation, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T-cell-based adoptiv
21 CD30 with T cells expressing a CD30-specific chimeric antigen receptor (CAR) may reduce the side effe
23 has been re-energized by the application of chimeric antigen receptor (CAR) T cell therapy in cancer
30 nt antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical h
31 ducted the first-in-humans clinical trial of chimeric antigen receptor (CAR) T cells targeting BCMA.
35 -TRBC immunotherapy, we developed anti-TRBC1 chimeric antigen receptor (CAR) T cells, which recognize
38 iloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, showed e
39 reported with the use of T cells modified by chimeric antigen receptor (CAR) that target CD19 in B-ce
41 mentation by highlighting the application of chimeric antigen receptor (CAR)-modified T cells in canc
42 the systemic administration of HER2-specific chimeric antigen receptor (CAR)-modified virus-specific
43 antigen receptor T cells redirected to CD19 (chimeric antigen receptor [CAR19]) show great promise in
44 ddressed these questions using a NKG2D-based chimeric antigen receptor construct (chNKG2D) in fully i
45 L survival and increased the efficacy of the chimeric antigen receptor T cell transfer and PD-1 inhib
49 nt's own T cells with a transgene encoding a chimeric antigen receptor to identify and eliminate CD19
50 strated therapeutic utility as components of chimeric antigen receptor-engineered T cells, further co
51 herapy followed by infusion of CD19-specific chimeric antigen receptor-modified (CAR) T cells has pro
52 ated the safety and feasibility of anti-CD19 chimeric antigen receptor-modified T (CAR-T) cell therap
53 phodepletion chemotherapy with CD19-targeted chimeric antigen receptor-modified T (CAR-T)-cell immuno
55 ry acute lymphoblastic leukemia treated with chimeric antigen receptor-modified T cell therapy on a p
59 using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently pr
66 an be re-directed to kill cancer cells using chimeric antigen receptors (CARs) or T cell receptors (T
68 ariable, and early reports of BCMA targeting chimeric antigen receptors (CARs) suggest antigen downre
69 pose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19
70 T cells with genes encoding disease-specific chimeric antigen receptors (CARs), so that they can comb
72 antibodies or T cells engineered to express chimeric antigen receptors or T-cell receptors (TCRs) ha
73 lass I-restricted T-cell receptors (TCRs) or chimeric antigen receptors to genetically modify CD8(+)
74 or example, through genetic engineering with chimeric antigen receptors.This meeting report puts pres
75 ing cancer antigens through highly activated chimeric antigen T cells (CAR-Ts) and second, re-animati
76 y from Abeta-dependent effects, we created a chimeric APP in which the Abeta domain is exchanged for
77 rbcs mutants expressing 'pyrenoid-competent' chimeric Arabidopsis SSUs containing the SSU alpha-helic
83 t iTMA was limited to the larger human-mouse chimeric blood vessels, which are located between the mu
84 a laminin polymerization-competent, designer chimeric BM protein in vivo to restore function of a pol
89 of either the endogenous fusion protein or a chimeric cDNA leads to the formation of indolent liver t
90 ecular biology techniques including making a chimeric channel between protease-sensitive hERG and ins
96 ting the PDX1 gene, which when combined with chimeric-competent human pluriopotent stem cells may ser
98 erformed radioligand-based uptake studies at chimeric constructs between BGT1 and GAT3, experiments w
104 ly, a single mouse EPS cell shows widespread chimeric contribution to both embryonic and extraembryon
105 dissociation of amyloids formed by covalent chimeric dimers of aS (syn-syn) and by the aS deletion m
106 the design and synthesis of an ITPA-specific chimeric dinucleotide (DIAL) that replaces the pyrophosp
109 condary structures and melting points of the chimeric DNA fragment and its complexes with perfect-mat
114 ts upon differentiation, failing to generate chimeric embryos and preferentially adopting an ectoderm
115 miR-142-3p, locally in EAE brain and in a MS chimeric ex vivo model, recovered glutamatergic synaptic
116 ed internal mammary artery osteomyocutaneous chimeric flap (PIMOC) for salvage head and neck reconstr
117 In total, 145 522 mapped full-length non-chimeric (FLNC) reads were analyzed, resulting in the co
119 as a full-length protein or as an engineered chimeric form in which its transmembrane and cytoplasmic
120 PIV1 vector as a full-length protein or as a chimeric form with its TMCT domain derived from HPIV1 F.
121 ficity of all three TbOST isoforms and their chimeric forms in the heterologous expression host S. ce
122 n human is Metnase (also known as SETMAR), a chimeric fusion protein consisting of a su(var)3-9, enha
124 as novel genes arising from non-coding DNA, chimeric fusions, and lateral gene transfers from other
126 decades to be the translational product of a chimeric gene created by the stable chromosome transloca
127 However, these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 containing a small dis
130 ion of ferrets with viral vectors expressing chimeric HA, aimed at boosting Ab reactivity against the
131 nted into naive mice, the recipient mice (UV-chimeric) had reduced accumulation of elicited monocytes
133 A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergr
134 roadly protective vaccine candidate based on chimeric hemagglutinins, consisting of globular head dom
136 on levels indicated that Gag proteins with a chimeric HIV-1 CA NTD/HTLV-1 CA CTD did not result in Ga
138 te models, humanized mouse models containing chimeric human livers offer a valuable alternative as sm
140 at is induced by type II IFN, and the use of chimeric IFN-gamma-sensitive/resistant viruses indicates
141 ur proof-of-concept studies of a mouse/human chimeric IgE antibody (MOv18 IgE), which is specific for
142 ercome these limitations, we created a novel chimeric IL2-IL2Rbeta fusion protein of IL2 and its rece
143 ombining antigenic motifs in a single-domain chimeric immunoglobulin-like fold generated a vaccine th
144 iated signaling mechanism(s), we constructed chimeric Kv1.3-Kv1.5 channels and point-mutant Kv1.3 cha
146 Analyses of Notch signal activation by using chimeric ligands with swapped intracellular domains (ICD
148 in this regard, as the human hepatocytes in chimeric livers generate human metabolites, but the rema
150 spicilin with d-desosamine, a quick entry to chimeric macrolides with potential antibiotic activity.
151 +) = 200 mM), as also seen with peptide-silk chimeric materials, whereas CaP(S) was most effective wh
157 o accumulated in the peritoneal cavity of UV-chimeric mice (ie, mice transplanted with BM from UV-irr
158 acrophages differentiating from the BM of UV-chimeric mice also had an inherent reduced ability to mi
160 for preclinical drug development.Human liver chimeric mice are increasingly used for drug testing in
162 TLR2 knockout (TLR2KO)-->TLR2KO bone marrow chimeric mice exhibited increased bacterial burden, diso
163 er injury, and rapidly generated human liver chimeric mice in a reproducible and scalable fashion.
164 rial burden and pulmonary immunopathology of chimeric mice lacking TLR2 in the hematopoietic compartm
165 Second, transplantable tumors developing in chimeric mice reconstituted with bone marrow cells from
166 showed greater atheroprotective activity in chimeric mice reconstituted with TET2-deficient cells th
170 type, Emc10-deficient, and Emc10 bone marrow-chimeric mice subjected to transient coronary artery lig
171 n left ventricular tissue sections of IL10KO chimeric mice suggests that myofibroblasts were derived
172 s, gammadeltaT17 cells emerge in bone marrow chimeric mice upon induction of skin inflammation by top
173 ur approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produc
177 inferior vena cava, APP-KO mice, as well as chimeric mice with selective deficiency of APP in blood
178 henotype was reproduced by mixed bone marrow chimeric mice with Sema4C deficient only in B cells, ind
179 in bone marrow-depleted IL10KO mice (IL10KO chimeric mice) reduced transverse aortic constriction-in
180 nfected humanized livers compared to control chimeric mice, irrespective of the human hepatocyte dono
195 ion at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stabl
197 llergic airway inflammation in a human/mouse chimeric model of respiratory allergy independently of A
199 extracellular domains to produce a panel of chimeric molecules that held the target epitope at diffe
201 to investigate the interaction between CD23, chimeric monoclonal human IgE, and the corresponding bir
204 occurred after introduction of cetuximab, a chimeric mouse-human antibody, for cancer treatment.
205 od ependymoma samples identified SEC61G-EGFR chimeric mRNAs in one infratentorial ependymoma WHO III,
208 terminants, we engineered viruses to contain chimeric NSP2 genes in which specific regions of AU-1 se
212 protein-coding exons and encode truncated or chimeric ORFs translated into products with predicted ab
214 wever, when mice were challenged with double chimeric P. berghei-P. falciparum parasites expressing b
215 vivo Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (P
216 parasitemia across mouse strains and against chimeric parasites expressing PfUIS3 as well as wild-typ
217 nd presented tumor-associated antigen with a chimeric PD-1:28 receptor increases effector function to
220 like inhibitor binding profiles, makes these chimeric PI3Kalpha proteins valuable model systems for s
221 bility was further investigated by measuring chimeric polymerase activity and growth of selected reas
223 The resulting fusions give rise to a novel chimeric prion, [SPS(+)], exhibiting [PSI(+)]-like nonse
224 ction with the SPR technique and neutralized chimeric probe DNA can be realized for the SNP genotypin
225 nic strength and high temperature allows the chimeric probe DNA distinguishing perfect-matched and si
227 ization and discrimination efficiency of the chimeric probe DNA for the SNP genotyping were verified
228 e were aggregated, and spinal cords of adult chimeric progeny were examined for motor neurons with cy
229 yt1Aa to Ls's BinA yielding a broad-spectrum chimeric protein highly mosquitocidal to important vecto
231 c expression of alphaLNNd, a laminin/nidogen chimeric protein that provides a missing polymerization
232 position as the full-length protein or as a chimeric protein with its transmembrane and cytoplasmic
240 the surface of red blood cells by expressing chimeric proteins of VHHs with Glycophorin A or Kell.
242 This simple but powerful approach, employing chimeric proteins, can reinvigorate studies of 14-3-3/ph
245 A FMF-knock-in mouse strain that expresses chimeric pyrin protein with a V726A mutation (Mefv(V726A
246 assing >10 billion independent antibodies in chimeric rabbit/human Fab format and validated it by nex
247 we used phage display to produce a panel of chimeric rabbit/human monoclonal antibody fragments (bot
254 for the ALV-J receptor activity, a series of chimeric receptors was created by exchanging the extrace
255 tivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoprote
257 his AD is required for transcription of both chimeric reporter genes and authentic chromosomal Rap1 e
258 ion that can be achieved in vitro or through chimeric research, as well as fundamental ethical consid
260 T4 RNA Ligase 2 to efficiently join adjacent chimeric RNA-DNA probe pairs hybridized in situ on fixed
266 Together with binding studies of mutant and chimeric SCs, which revealed domain contributions to sec
268 ences by proximity ligation, forming RNA-DNA chimeric sequences, which are converted to a sequencing
271 al form (Thermosynechococcus vulcanus) and a chimeric spinach-like form of photosystem II allows us t
275 ivity to allosteric modulators, we generated chimeric subunits that combined segments from NMDA and k
276 the number and position of the incorporated chimeric subunits, we expressed chimeric constructs with
279 A-binding domain fusion proteins to serve as chimeric transcriptional activators challenge use of thi
283 strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV
284 emic, we used an EILV cDNA clone to design a chimeric virus containing the chikungunya virus (CHIKV)
285 HCV, we established an infectious clone and chimeric virus of hepatotropic and lymphotropic HCV stra
287 whole-inactivated virus, live-attenuated or chimeric virus, and protein or viruslike particle vaccin
288 o-incorporated with influenza HA-antigens in chimeric virus-like particles (cVLPs), in boosting stron
289 nuated DENV-2 virus strain (TDV-2) and three chimeric viruses containing the premembrane and envelope
293 inant vesicular stomatitis virus (VSV)-based chimeric viruses that include genes from other viruses s
296 ined the long-lasting protective efficacy of chimeric VLPs (cVLPs) containing influenza HA and GPI-an
298 elta cells with yeast, human, truncated, and chimeric yeast/human TOP1 constructs and of assessing th
299 he Fab HM14c10 light chain CDRs.IMPORTANCE A chimeric yellow fever-dengue live-attenuated tetravalent
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