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1 filing after inducing signalling through our chimeric protein.
2 i and examined the function of the resulting chimeric protein.
3 r, and provide approaches for targeting this chimeric protein.
4 latively weak costimulatory delivered by the chimeric protein.
5 led-coil motifs in the NH(2) terminus of the chimeric protein.
6 when part of it was fused with LBP to form a chimeric protein.
7 eer human red blood cells that express these chimeric proteins.
8 ttempted to generate ectopic eyes with these chimeric proteins.
9 tem, rapamycin is used to heterodimerize two chimeric proteins.
10 d-type RARalpha/RXRalpha or other X-RARalpha chimeric proteins.
11 phrinB2 and EphB4 and did not respond to the chimeric proteins.
12 v, and nef to encode a series of novel HIV-1 chimeric proteins.
13 by the identity of the N-terminal arm in the chimeric proteins.
14 human Src tyrosine kinase to create inactive chimeric proteins.
23 the high-affinity binding of VCAM-1/CD106 Fc chimeric protein and promoted VCAM-1-dependent arrest to
24 part, for the higher affinity of the native chimeric protein and the lower affinity of the denatured
26 ation were investigated by preparing various chimeric proteins and mutants, using CD8 as a reporter m
27 in vitro Ub binding assays using domain swap chimeric proteins and mutated domains in isolation as we
28 we have constructed a collection of C92/P98 chimeric proteins and tested their abilities, both in th
29 derstand the biochemical properties of these chimeric proteins and to establish a system to study the
30 metal ions modulate assembly kinetics of the chimeric proteins, and the extent of modulation is highl
36 -124 of PrP, Chi3 Tg mice, which express the chimeric protein at a very low level, start developing a
37 Abrogation of Axl activation by soluble Axl chimeric protein (Axl-Fc) or small interfering RNA (siRN
40 subfamily members to Klotho family proteins, chimeric proteins between FGF19 subfamily members or chi
42 proteins between FGF19 subfamily members or chimeric proteins between Klotho family members were con
43 ivity of OATP1B3, we constructed a series of chimeric proteins between OATP1B3 and 1B1, expressed the
44 s that did not interact with S(3)-RNase, and chimeric proteins between Pi SLF(1) and Pi SLF(2) to add
45 cific regions, and used truncated Pi SLF(2), chimeric proteins between Pi SLF(2) and one of the Pi SL
46 n heat-induced desensitization, we generated chimeric proteins between TRPV1 and TRPV3, a heat-gated
49 re we developed a soluble NUDT9H model using chimeric proteins built from complementary polypeptide f
50 ally homologous when expressed as individual chimeric proteins but not when expressed in the context
51 ch allostery can evolve, we have generated a chimeric protein by joining the catalytic domain of an u
52 lar and structural domains so that the final chimeric protein can be utilized to create novel bioacti
54 This simple but powerful approach, employing chimeric proteins, can reinvigorate studies of 14-3-3/ph
55 ace, and its successful use in the design of chimeric proteins capable of targeting genomic regions o
59 cture-function relationships by constructing chimeric proteins combining sequences from CerS2, which
66 re we demonstrate that FIST15, a recombinant chimeric protein composed of the T-cell-stimulatory cyto
71 50 partner genes and result in production of chimeric proteins composed of the ALL1 N terminus and th
72 ts leading to GDP release, we have created a chimeric protein comprised of Escherichia coli NFeoB and
76 ns of the rod has been addressed by making a chimeric protein consisting of the subfragment 2 (S2) re
78 85beta differ in their N-terminal sequences, chimeric proteins consisting of amino or carboxy-termina
79 steps, we performed an unbiased screen using chimeric proteins consisting of CD4 fused to the muscle
82 the branching and cyclobutanation reactions, chimeric proteins constructed from farnesyl diphosphate
84 mation reactions are promiscuous in that the chimeric protein containing 14 repeats can readily cross
85 ocumented Pex15p traffic from the ER using a chimeric protein containing a C-terminal glycosylation a
90 teins of Newcastle disease virus (NDV) and a chimeric protein containing the cytoplasmic and transmem
91 verexpressing in vivo a transgene encoding a chimeric protein containing the cytoplasmic domain of GP
92 could be transferred to PRMT1 by creating a chimeric protein containing the N terminus of PRMT8 fuse
94 and undetectable at the cell surface, (ii) a chimeric protein containing the TM of ABCG1 and the cyto
96 noic acid, was decreased in cells expressing chimeric proteins containing at least one ABCD2 moiety.
100 teractions, the oligomeric state of purified chimeric proteins containing the Staphylococcal nuclease
101 r basis of transport inhibition, a series of chimeric proteins containing transmembrane and cytosolic
103 2-OB(Stn1) chimeras indicates that whether a chimeric protein contains the Rpa2 or Stn1 version of th
104 induced nuclear export, the human TCF4/POP-1 chimeric protein continues to function as a repressor fo
105 iption of KSHV lytic genes, and a Rad21-CTCF chimeric protein converted CTCF into an efficient transc
106 neutralized only by homologous antisera, the chimeric proteins could be neutralized by both BTV-1 and
112 l basis for receptor selectivity by studying chimeric proteins developed by interchanging loops betwe
115 lecules were covalently fused, the resulting chimeric protein efficiently promoted proliferation.
118 ter transfer function can be maintained in a chimeric protein even when over 40% of the sequence is f
119 ine whose oncogenic potential is driven by a chimeric protein EWS-ATF1 (Ewing's sarcoma protein-activ
120 reatment reduced the levels of each of these chimeric proteins except for one containing mutations in
125 g chemical cross-linking, we showed that the chimeric protein exists predominantly as a tetramer, med
126 munosorbent assay, the resulting recombinant chimeric proteins expressed epitopes from all three vari
129 core proteins, NP and M, and containing two chimeric proteins, F/F and H/G, composed of respiratory
130 -derived cell line (HEK 293-C3) to express a chimeric protein (F9CH) comprising the Gla domain of fac
132 rehensive series of IL-36 agonist/antagonist chimeric proteins for which we measured binding to the I
137 and betac were expressed in Phoenix cells as chimeric proteins fused to enhanced cyan or yellow fluor
139 er of chromosomal translocations that create chimeric proteins, fusing the N terminus of MLL to sever
141 We have catalyzed the four reactions with chimeric proteins generated by replacing segments of a c
143 e.g., from nucleases or integrases, to form chimeric proteins, genomes could be manipulated or modif
146 ic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detai
147 d C termini of NMDA receptor subunits, these chimeric proteins have been used as a model for studying
148 hannesburg/1/66 HEF full-length protein or a chimeric protein HEF-Ecto, which consists of the HEF ect
149 yt1Aa to Ls's BinA yielding a broad-spectrum chimeric protein highly mosquitocidal to important vecto
151 omains and expressed each independently as a chimeric protein in a heterologous expression system.
153 o overcome this bottleneck, we constructed a chimeric protein in the cyanobacterium Synechococcus elo
154 yelocytic leukemia (PML) to produce PAX5-PML chimeric protein in two patients with B-cell acute lymph
157 he TCR constant regions and/or creation of a chimeric protein in which the human constant regions wer
161 xy)-2-propylamine (ATB-BMPA) labeling of the chimeric proteins in low density microsome fractions iso
162 e examined the cleavage-secretion of ACE-CD4 chimeric proteins in mammalian cells and Pichia pastoris
163 hus potential for the production of abnormal chimeric proteins in the brains of translocation carrier
164 vely active anaplastic lymphoma kinase (ALK) chimeric proteins in the pathogenesis of anaplastic larg
172 f on each protein, we constructed a panel of chimeric proteins in which the extracellular and transme
176 ever, several studies have demonstrated that chimeric proteins in which the nucleocapsid domain of Ga
177 ed in Cep164-depleted cells by expression of chimeric proteins in which TTBK2 is fused to the C-termi
178 foreign domain, we found that the resulting chimeric protein, in a concentration-dependent manner, t
179 ytosis and post-endocytic sorting of EGFR, a chimeric protein, in which the K63 linkage-specific deub
180 wo immunological properties: 1) it encodes a chimeric protein including peptides that may be targets
184 rane targeting and surface expression of the chimeric protein, indicating that the BST-2 GPI anchor s
185 protein, led to nuclear accumulation of this chimeric protein, indicating that this sequence was suff
188 and Western blot analyses confirmed that the chimeric protein is expressed in tumor tissue, and a cel
190 ular basis for the oncogenic activity of MLL chimeric proteins is incompletely understood, it seems t
191 n to create fusion genes and their resulting chimeric proteins is supported, including inter-chromoso
192 res delivery to the PVC of either Kex2p or a chimeric protein (K-V), in which the Vps10p cytosolic ta
193 -expressing lymphoid cells stimulated with a chimeric protein linking IL-2 to the ectodomain of TGF-b
194 the LacI/GalR homologues, we have created a chimeric protein (LLhP), which comprises the LacI DNA-bi
196 ried out with single islet cells adherent to chimeric proteins made of functional E-, N-, or P-cadher
201 PiSLF-like protein), and expressed GFP-fused chimeric proteins, named b-2-b and 2-b-2, in S(2) S(3) t
204 l translocation induces the formation of the chimeric protein nucleophosmin-anaplastic lymphoma kinas
208 howed no requirement for LTP, we constructed chimeric proteins of the two excitatory neuroligin subty
209 the surface of red blood cells by expressing chimeric proteins of VHHs with Glycophorin A or Kell.
211 have been developed to reengineer promising chimeric proteins one at a time through targeted point m
217 determine whether the Nmnat1 portion of the chimeric protein provides axonal and somatic protection
218 s lowering the critical concentration of the chimeric protein required for a nucleation reaction.
220 enterocolitica strains expressing a Ysp-CyaA chimeric protein resulted in Ysa T3S system-dependent in
221 a role for TANGO1 and TANGO1-like (TALI), a chimeric protein resulting from fusion of MIA2 and cTAGE
223 y of mass spectrometry to identify oncogenic chimeric proteins resulting from chromosomal rearrangeme
228 In the case of the F protein, analysis of chimeric proteins revealed that the signal peptide of th
231 espite being transactivation-competent, this chimeric protein shows selectivity in p53 effector funct
232 h the major or minor fimbriae to the TLR4-Fc chimeric protein, signaling through TLR4 for both protei
235 te that mice expressing a soluble B7-2 Ig Fc chimeric protein spontaneously develop colitis that is d
236 simple procedure for the production of such chimeric proteins, starting from correctly folded protei
237 describe how the use of this newly developed chimeric protein strategy has allowed us to test the fun
242 , the adapters LAT and SLP-76, visualized as chimeric proteins tagged with yellow fluorescent protein
243 f the quadruple mutant of strain 4243 with a chimeric protein that comprised human fH domains 6 and 7
244 d this idea by creating PAS-DHFR, a designed chimeric protein that connects a light-sensing signaling
245 d(s) mutation results in the production of a chimeric protein that contains the full-length coding se
246 these transcription factors creates a unique chimeric protein that controls a key cell-cycle and -dif
247 h the bacterial hemolysin ClyA resulted in a chimeric protein that elicited strong anti-GFP antibody
248 esponding residues from HCMV US6 generates a chimeric protein that inhibits human TAP and provides fu
249 entation by using IL-15 preassociated with a chimeric protein that is comprised of the extracellular
250 parasitic nematode, Ascaris suum, revealed a chimeric protein that is similar to a Phe-Met-Arg-Phe-am
251 c expression of alphaLNNd, a laminin/nidogen chimeric protein that provides a missing polymerization
253 rom Ciona intestinalis, Ci-VSP, we generated chimeric proteins that are voltage-sensitive and display
254 ce of BRD-NUT fusion oncogenes, which encode chimeric proteins that block differentiation and maintai
255 he Mixed Lineage Leukemia (MLL) gene produce chimeric proteins that cause abnormal expression of a su
258 everal other non-NKCC1 homologues results in chimeric proteins that form homodimers but show little o
260 ve residues (HGEKL) in the ACE region of the chimeric proteins that were essential for their cleavage
261 further show, by using an allele encoding a chimeric protein, that this difference maps primarily to
262 ort that activity of nucleophosmin (NPM)/ALK chimeric protein, the dominant form of ALK expressed in
266 wth was corrected with an inability of these chimeric proteins to form stable PD-localized complexes.
273 lting green fluorescent protein (GFP)-tagged chimeric proteins was examined by fluorescence imaging,
274 ing a beta-lactamase (betaLa) reporter/NiV-M chimeric protein, we produced NiVLPs expressing NiV-G an
275 sed GFP reporter system and a recombinant Fc chimeric protein, we show that human FCRL6, a receptor s
276 yAsf1 C-terminal truncations and yeast-human chimeric proteins, we found that truncations at residue
279 Recombinant SIN viruses encoding nsP2/GFP chimeric protein were capable of growth in tissue cultur
280 ken up by mannose-6-phosphate receptors, all chimeric proteins were additionally endocytosed via mann
282 he cytoplasmic tail of PC7 were deleted, and chimeric proteins were constructed consisting of the lum
285 ng of the role of gL in EBV-mediated fusion, chimeric proteins were made using rhesus lymphocryptovir
286 ies of monomeric and dimeric ebvIL-10.hIL-10 chimeric proteins were produced and characterized for re
287 wapped; NIH3T3 cells overexpressing the four chimeric proteins were tested for transformation activit
292 parental genes PIP5K1A and PSMD4, forming a chimeric protein with a distinct cellular localization a
293 and minor fimbriae bound to a human TLR2:Fc chimeric protein with an observed K(d) of 28.9 nM and 61
294 position as the full-length protein or as a chimeric protein with its transmembrane and cytoplasmic
297 ve been seen for single transmembrane domain chimeric proteins with appended C termini of NMDA recept
298 de, PhrA, was analyzed in part by generating chimeric proteins with RapC, which targets the DNA-bindi
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