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1 complementation assay to screen against this chimeric receptor.
2 e specificities not directly targeted by the chimeric receptor.
3 in the sustained signaling activity of this chimeric receptor.
4 sts demonstrated greater EC50 values for the chimeric receptor.
5 to compete for (33)P-relaxin binding to the chimeric receptor.
6 tations of signaling exclusively through the chimeric receptor.
7 the activation of PLCgamma mediated by this chimeric receptor.
8 tracytoplasmic portion of the IL-2R via this chimeric receptor.
9 yrosines contributed to the function of this chimeric receptor.
10 toreactive T cells by a MBP89-101-IA(s)-zeta chimeric receptor.
11 ell receptor and tumor targets through their chimeric receptors.
12 domain is critical for proliferation of the chimeric receptors.
13 based reporter assay employing LXRalpha-GAL4 chimeric receptors.
14 nic receptors was evaluated at wild-type and chimeric receptors.
15 stimulating hormone to bind or activate the chimeric receptors.
16 necessary to impart full BZD potentiation to chimeric receptors.
17 nd antitumor activity mediated through their chimeric receptors.
18 CCR5 inhibitor binding site using CCR5/CCR2b chimeric receptors.
19 R/syntrophin interaction was confirmed using chimeric receptors.
20 ce expression and abrogated signaling of the chimeric receptors.
21 t1 fibroblasts transfected with EGFR or HER2 chimeric receptors activated by synthetic ligands withou
23 he melatonin-related receptor, the resultant chimeric receptors all displayed specific 2-[(125)I]iodo
24 isulfide-mediated oligomerization of another chimeric receptor, alpha zetazeta, enhances signaling.
28 D8(+) T cells were engineered to express the chimeric receptor and were costimulated ex vivo with bea
29 se differences was investigated by preparing chimeric receptors and by site-directed mutagenesis.
30 18 inhibition of cells expressing CXCR4/CCR5 chimeric receptors and CCR5 with a truncated N terminus
31 esponsible for this selectivity, a series of chimeric receptors and mutant receptors was constructed
32 its ligand-selective activation, we assayed chimeric receptors and receptor variants containing subs
33 d this dichotomy through the construction of chimeric receptors and site-directed mutagenesis in orde
35 eptor is tyrosine phosphorylated through the chimeric receptors and the endogenous IL-6 and OSM recep
36 gastrin-releasing peptide (GRPR), we used a chimeric receptor approach and a site-directed mutagenes
37 n and therefore validated the utility of the chimeric receptor approach for signaling pathway identif
40 To investigate the basis for this, we used a chimeric receptor approach to make both GRPR loss of aff
45 specifically validate humanized MBP-DR2-zeta chimeric receptors as a potential therapeutic in MS.
46 scence microscopy revealed that internalized chimeric receptors, as identified with fluorescent ligan
47 binding specificity of alpha(L)beta(2), the chimeric receptor became competent to support cell migra
52 tion induces tyrosine phosphorylation of the chimeric receptor but does not enhance its binding to SH
55 demonstrate activation of a TREM-2A/CD3zeta chimeric receptor by both bacteria and dextran sulfate.
56 ty of a constitutively active RARgamma-VP-16 chimeric receptor by the inverse agonist AGN193109 requi
58 l domain of SV2A or SV2B alone, expressed in chimeric receptors by replacing the extracellular domain
60 B cell lines expressing the human CD40-LMP1 chimeric receptor, CD40- and LMP1-mediated NF-kappaB and
62 rm of DEP-1 formed a stable complex with the chimeric receptor colony stimulating factor 1 (CSF)-Met
63 t effective of these interventions created a chimeric receptor combining the ligand-binding domain of
64 myoblast proliferation in situ, we created a chimeric receptor composed of a modified FK506-binding p
66 ith the AChBP, Torpedo californica nAChR and chimeric receptor composed of the alpha7 nAChR extracell
68 e first, or regulatory, cassette comprises a chimeric receptor composed of the hinge and ligand bindi
71 y of PC12 cell lines stably transfected with chimeric receptors composed of the extracellular domain
72 C12 cell lines expressing similar amounts of chimeric receptors composed of the extracellular domain
73 hypothesis, we created ligand-regulated TLR chimeric receptors composed of the extracellular region
77 M1 failed to induce autophosphorylation of a chimeric receptor consisting of the extracellular domain
78 -15Ralpha cytoplasmic domain, we generated a chimeric receptor consisting of the extracellular domain
79 dimer peptide, but not IL-5, can activate a chimeric receptor consisting of the IL-5Ralpha extracell
85 in and p75(NTR), we analyzed binding between chimeric receptor constructs and truncated p75(NTR) vari
86 ansmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1
87 both receptors, we engineered a series of 14 chimeric receptor constructs, allowing us to determine t
88 these receptors using LRP minireceptors, its chimeric receptor constructs, and full-length VLDLR and
89 nsulin receptor and a mutated version of the chimeric receptor containing a 12-amino acid deletion of
90 ary CD4+ T cells expressing a CD8 alpha/CD28 chimeric receptor containing a mutation at tyrosine 200
91 essed, in bone marrow-derived macrophages, a chimeric receptor containing a range of tyrosine to phen
92 ammaRII(b)(-/-) mice or upon clustering of a chimeric receptor containing CD8 and the immunoreceptor
93 ensitizes signaling mediated by a transduced chimeric receptor containing extracellular domains of pl
94 ionally significant, we transduced EC with a chimeric receptor containing extracellular domains of pl
95 GP Ibalpha was inhibited by co-expressing a chimeric receptor containing interleukin 2 receptor alph
96 in the receptors, individual exoloops of the chimeric receptor containing the ectodomain of the LH re
97 uate potential ligand activators of SmRK1, a chimeric receptor containing the extracellular domain of
99 cient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of
100 s proliferation in vitro and activation of a chimeric receptor containing the TACI intracellular doma
104 in the V3 crown had fusogenic activity with chimeric receptors containing either the N terminus or l
106 oped a functional assay utilizing a panel of chimeric receptors containing the extracellular and tran
108 stoma cells when compared with expression of chimeric receptors containing wild-type gp130 cytoplasmi
111 loss of transactivation seen with the mutant chimeric receptor correlated with a decrease in Vav tyro
113 characterize this survival pathway we used a chimeric receptor (CSF1R/IR) consisting of the ligand-bi
116 s expressing the dileucine-mutated CD28-zeta chimeric receptor demonstrated enhanced proliferation, c
117 compounds for as little as 15 s resulted in chimeric receptor dimerization detectable as beta-gal en
118 tance by transducing CD56+CD3- NK cells with chimeric receptors directed against CD19, a molecule wid
120 eta4 signaling, however, dimerization of the chimeric receptor does not activate either Akt or Erk1/2
121 d neutralization by engineered antibodies or chimeric receptors, downregulation of its expression wit
122 two receptors intact, we, recently developed chimeric receptors (EGDR and EGLT) in which the extracel
125 behind these divergent responses, we made a chimeric receptor (ErbB1/2) composed of the extracellula
126 nstitution experiments demonstrated that the chimeric receptor, even in the phosphorylated state, exi
132 differences, we constructed two Flag-tagged chimeric receptors, Flag-h/rkor and Flag-r/hkor, in whic
134 ion, a method for tailoring spacer length of chimeric receptors for optimal function, and a functiona
136 we first studied four loss-of-affinity GRPR chimeric receptors formed by exchanging the four extrace
137 ignaling in a cellular context, a c-fms-Tie1 chimeric receptor (fTie1) was expressed in NIH 3T3 cells
138 ate that inactivation of this motif enhances chimeric receptor function, and illustrate a potential n
140 er ex vivo expansion and transduction with a chimeric receptor gene (CD4/CD3-zeta) between identical
142 mary) T cells transduced with tumor-specific chimeric receptor genes can be expanded and maintained l
149 ne receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based, high-thro
152 ther than CD28 could be included in a single chimeric receptor in series with TCRzeta to mediate the
153 ptor (TfR/SR-A) resulted in retention of the chimeric receptor in the endoplasmic reticulum suggestin
156 nities are similar to those for binding to a chimeric receptor in which the ECD1 of CRFR2beta replace
157 gain insight into this mechanism, we used a chimeric receptor in which the ligand binding domain of
158 emonstrated by its weakened antagonism for a chimeric receptor in which the membrane-spanning domains
161 e homology and equivalent expression by both chimeric receptors in the ventral prostate gland, only F
162 s pharmacological difference, we constructed chimeric receptors in which individual extracellular loo
164 CH-8 cells were transfected with CXCR1/CXCR2 chimeric receptors in which the 40-amino acid C-terminal
169 ; site-directed mutagenesis in wild-type and chimeric receptors indicated that the threonine residue
171 Upon arginine vasopressin stimulation, this chimeric receptor induced robust calcium mobilization an
187 for the IFN-gamma-like response through the chimeric receptors, nor does it mediate an IFN-gamma-lik
188 Using a series of deletion mutations and chimeric receptors of p75(NTR) and the related Fas recep
189 en coupled to the green fluorescent protein, chimeric receptors offer a powerful new tool to 1) study
191 rated cell lines that express either EGFR-H2 chimeric receptor or HER2 and HER3 receptors in an EGFR-
193 imulating factor receptor (GCSFR)-gp130(133) chimeric receptor, overexpression of Stat3 induced gamma
195 with their PTH1R counterparts resulted in a chimeric receptor, PEC, which had normal CRFR1 functiona
196 An epidermal growth factor receptor/gp130 chimeric receptor previously shown by us to transactivat
197 elium is rescued by an exogenously expressed chimeric receptor (prl-EpoR) containing the PrlR extrace
198 rly, TCR transgenic CD8 cells expressing the chimeric receptor produced higher effector numbers durin
201 s using the EIAV SU gp90 protein and various chimeric receptor proteins derived from exchanges betwee
203 ng T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic cap
205 constitutively activated RARalpha or RARbeta chimeric receptors (RARVP16) in branching airways of tra
206 lar loop (E3) in the rat BRS-3 resulted in a chimeric receptor (RB3-E3) that behaved almost identical
207 reporter cells expressing a CD3zeta-NKR-P1A chimeric receptor; reciprocally, reporter cells with a C
208 modification of alloreactive T cells with a chimeric receptor recognizing folate-binding protein, an
215 eceptor cocapping studies indicate that this chimeric receptor signals T cells independently of the r
221 g a set of alpha7-5-hydroxytryptamine type 3 chimeric receptor subunit cDNAs, we expressed these cons
223 replaced with the I domain of alpha(M), the chimeric receptor supported cell migration to Fg; howeve
225 ly, we used an erythropoietin (EPO) receptor chimeric receptor system in which IL-2-dependent HT-2 T
226 h these two receptors intact, we developed a chimeric receptor system in which the N terminus of the
227 T-cell precursors transduced to express a chimeric receptor targeting hCD19 resulted in significan
230 xpression of transgenic wild-type IL-7R or a chimeric receptor that consisted of the extracytoplasmic
231 s of IL-2 from PBT than a similar transduced chimeric receptor that contains a wild-type CD28 CYT.
233 nically expressed on T cells a heterodimeric chimeric receptor that genetically links an autoantigeni
234 m and TMB-8 had much higher affinity for the chimeric receptor that included the M(2) second outer lo
235 The cells are engineered with a cell-surface chimeric receptor that presents the nonmammalian enzyme
236 with that of the rP2Y(4) receptor yielded a chimeric receptor that was activated fully by UTP and ne
237 quirement for Wnt ligand can be abrogated by chimeric receptors that allow formation of Frizzled-LRP
238 embrane domains 4 or 6, however, resulted in chimeric receptors that displayed no detectable 2-[(125)
239 ocket was obtained in signaling studies with chimeric receptors that exhibited improved responses to
241 ors, we constructed a series of single-chain chimeric receptors that incorporate extracellular human
242 atory cells are transgenically modified with chimeric receptors that link antigen-major histocompatib
244 When coexpressed with dIRS in COS-7 cells, a chimeric receptor (the extracellular domain of human IR
245 ons of TM4 and TM5 than for any of the other chimeric receptors (the affinities of which remained sim
247 one of the alphav subunit did not enable the chimeric receptor to bind alphaIIbbeta3-specific ligands
250 developed a cellular immunotherapy that uses chimeric receptors to selectively redirect therapeutic T
254 IA was exacerbated in IL-2R beta/IL-4R alpha chimeric receptor transgenic mice, with increased diseas
255 us, CD8 and CD4 T cells transduced with this chimeric receptor underwent an enhanced proliferative re
258 rosine was efficiently phosphorylated in the chimeric receptor upon treating the cells with pervanada
266 for the ALV-J receptor activity, a series of chimeric receptors was created by exchanging the extrace
271 interleukin-3-dependent cell line Ba/F3, the chimeric receptors were appropriately expressed on the c
273 eptor (and to further study the mGluRs), two chimeric receptors were constructed in which the large E
276 ical residues, site-directed mutagenesis and chimeric receptors were evaluated in functional calcium
278 hese three ligands for the two related LGRs, chimeric receptors were generated to elucidate the mecha
281 virus receptor interaction on infection, two chimeric receptors were prepared which contained antibod
285 ally, proline recognition was conferred to a chimeric receptor when TM regions associated with the pu
286 so conferred potent alphaBgtx sensitivity to chimeric receptors when co-expressed with the beta4 subu
288 Modulating the signaling characteristics of chimeric receptors will be important for their applicati
290 Long-term treatment of cells expressing the chimeric receptor with agonists, antagonists, and invers
291 ation of neurons transfected with a Met-Robo chimeric receptor with Hepatocyte growth factor leads to
292 created by engineering T cells to express a chimeric receptor with high affinity for human mesotheli
293 in parallel sets of mice as IgM, IgG1, or a chimeric receptor with IgM extracellular domains and tra
296 ptor subunit to Stat recruitment we employed chimeric receptors with the extracellular domain of eith
300 FcR vs NKG2D-DAP10) or ectopically expressed chimeric receptors (with ITAM-containing cytoplasmic tai
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