ライフサイエンスコーパス: chinchilla

1 FP mutant to colonize the nasopharynx of the chinchilla.

2 th the nasopharynx and the middle ear of the chinchilla.

3 to the left and right middle ear cavities of chinchillas.

4 otitis media, to inoculate the middle ear of chinchillas.

5 pathogenesis of experimental otitis media in chinchillas.

6 tem efferent neurons were performed in young chinchillas.

7 BDNF transcripts were found in the untreated chinchillas.

8 auditory nerve response properties in adult chinchillas.

9 cells were recorded in the same cochleae in chinchillas.

10 s would protect against NTHi otitis media in chinchillas.

11 f type 6A-, 19A-, and 19F-challenged placebo chinchillas.

12 fection following transbullar inoculation of chinchillas.

13 ing of luciferase-producing NTHI in infected chinchillas.

14 esis were inoculated into the middle ears of chinchillas.

15 t to both colonize and cause otitis media in chinchillas.

16 Although the chinchilla 3D aVOR gain changed with both frequency and

17 cantly compared to untreated chinchillas and chinchillas 4 weeks after treatment.

18 neurons in the lateral lemniscus (LL) of the chinchilla, a species with pronounced low-frequency sens

19 th nerve input, ADN cells were recorded from chinchillas after bilateral semicircular canal occlusion

20 rynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.

21 f NTHi-specific bactericidal antibody in the chinchilla and also affords a reduction in the incidence

22 histochemical studies were done in the adult chinchilla and rat vestibular brainstem; diaphorase hist

23 elevated significantly compared to untreated chinchillas and chinchillas 4 weeks after treatment.

24 of sound localization in auditory neurons of chinchillas and guinea pigs of both sexes, and show how

25 esent in the vestibular ganglia of untreated chinchillas and trkB mRNA levels did not change followin

26 ishes that cochlear frequency selectivity in chinchillas (and probably in mammals in general) is full

27 The V(BM) simulation results for gerbil and chinchilla are consistent with in vivo cochlea measureme

28 al ILD sensitivity (in single neurons of the chinchilla auditory midbrain) remain robust under stimul

29 m-identification (Wiener kernel) analyses of chinchilla auditory nerve fiber responses to Gaussian no

30 re computed from existing records of cat and chinchilla auditory-nerve fibers on the basis of their c

31 align with each other, we predicted that the chinchilla aVOR would be relatively low in gain and isot

32 Here, we demonstrated that recombinant chinchilla beta defensin-1 specifically interacted with

33 the parent strain to killing by recombinant chinchilla beta-defensin 1.

34 homolog of human beta-defensin 3, designated chinchilla beta-defensin-1 (cBD-1), and found by Norther

35 d protocols to induce the differentiation of chinchilla bone marrow precursor cells into DCs, which r

36 Depleting complement in chinchillas by use of cobra venom factor (CoVF) rendered

37 chlear fluid model was developed for gerbil, chinchilla, cat, and human, featuring an active "push-pu

38 curred in 38%, 62%, 0, and 78% of vaccinated chinchillas challenged with types 6B, 6A, 19F, and 19A,

39 voviridae) in the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon d

40 genic PCho transferase (licD) mutant using a chinchilla (Chinchilla lanigera) model of otitis media.

41 responses to noise-vocoded tone complexes in chinchillas (Chinchilla laniger) using a stimulus genera

42 Chinchillas (Chinchilla laniger) were trained to discrim

43 In the chinchilla, co-administration of GM and EA can produce h

44 air cell (IHC) depolarization throughout the chinchilla cochlea were inferred from responses of audit

45 er responses to tones at a basal site of the chinchilla cochlea with characteristic frequency approxi

46 Chinchillas colonized by strains with the ChoP(+) phenot

47 19 per milliliter of nasal lavage fluid than chinchillas colonized with predominantly the ChoP(-) var

48 eustachian tube and inducing otitis media in chinchillas compromised by an ongoing viral upper respir

49 The chinchilla crista ampullaris was studied in 10 samples,

50 ceptor subunit, NR-1 was investigated in the chinchilla cristae ampullaris and utricular maculae at t

51 These data are the first to characterize chinchilla DCs and their functional properties.

52 As chinchilla DCs have not been described, we adapted well-

53 thermore, they suggest an important role for chinchilla DCs in the development of protective immunity

54 In vitro, chinchilla DCs readily internalized LB1, upregulated exp

55 We found that SNHL in chinchillas degraded peripheral temporal coding in backg

56 Chinchillas discriminated either a harmonic tone complex

57 ntral nucleus of the inferior colliculus (of chinchilla) effectively encode ILDs despite complete dec

58 ns were evaluated on the cell surface in the chinchilla eustachian tube (ET) lumen of a cohort challe

59 As chinchillas' eyes are afoveate and never align with each

60 In contrast, the lateral-eyed chinchilla faces different adaptive demands and thus enl

61 in the vestibular end organs and ganglia of chinchillas following gentamicin ototoxicity.

62 f the animals in each group, and all treated chinchillas had sterile MEF at 24 h.

63 Here we reveal that NTHI P5 binds to the chinchilla homologue of CEACAM1 and that rabbit anti-hum

64 wecA, lsgB, and siaA mutants survived in the chinchilla, inducing culture-positive middle ear effusio

65 these strains had persistence defects in the chinchilla infection model for otitis media, as well as

66 y potential glutamatergic connections of the chinchilla inferior colliculus (IC).

67 noise-vocoded tone complexes in chinchillas (Chinchilla laniger) using a stimulus generalization para

68 Chinchillas (Chinchilla laniger) were trained to discriminate IIRN[+]

69 n the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon degus).

70 ransferase (licD) mutant using a chinchilla (Chinchilla lanigera) model of otitis media.

71 the aVOR of a lateral-eyed, afoveate mammal (Chinchilla lanigera).

72 course of efferent fiber and SGN loss in the chinchilla may make it a practical model for studying me

73 y expressed Gly-Gly peptide-encoding gene in chinchilla middle ear effusions.

74 thickness and biomass for biofilms grown on chinchilla middle ear epithelial cells.

75 ast, LPS of ex vivo organisms recovered from chinchilla middle ear exudates was sialylated.

76 moniae caused a significant attenuation in a chinchilla middle ear infection model and a minor attenu

77 ot arcT, of an OM isolate is required during chinchilla middle ear infection.

78 ae (NTHI) can form biofilms during human and chinchilla middle ear infections.

79 f rbsB impaired bacterial persistence in the chinchilla middle ear, similar to our previous results w

80 HI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation

81 Furthermore, chinchilla middle ears challenged with the sapA mutant d

82 nal pathway, increases NTHI virulence in the chinchilla model for otitis media infections.

83 siaB mutants, show attenuated virulence in a chinchilla model of experimental otitis media (EOM).

84 an ex vivo middle ear (ME) aspirate from the chinchilla model of experimental otitis media is insuffi

85 on on pathogenesis and disease severity in a chinchilla model of experimental otitis media.

86 Studies in the chinchilla model of middle ear infection demonstrated th

87 cts various aspects of NTHI virulence in the chinchilla model of nasopharyngeal colonization and otit

88 Furthermore, these data indicate that the chinchilla model of nasopharyngeal colonization provides

89 ession is upregulated in the middle ear in a chinchilla model of nontypeable Haemophilus influenzae (

90 In the chinchilla model of NTHi infection, we observed consiste

91 ession in one specific anatomical niche of a chinchilla model of NTHI-induced otitis media.

92 e bactericidal antibody or protection in the chinchilla model of OM.

93 The nuclease mutant formed a biofilm in the chinchilla model of otitis media and demonstrated a prop

94 ly attenuated in its ability to survive in a chinchilla model of otitis media compared with the paren

95 infection with Haemophilus influenzae in the chinchilla model of otitis media results in the formatio

96 Analyses of a modA2 strain in the chinchilla model of otitis media show a clear selection

97 In vivo infection studies using the chinchilla model of otitis media showed a direct correla

98 In vitro and in vivo studies using the chinchilla model of otitis media were performed using a

99 We used a chinchilla model of otitis media, which has previously b

100 The chinchilla model will likely be extremely useful to test

101 nasopharynx and invade the middle ear in the chinchilla model.

102 enge of the middle ear were evaluated in the chinchilla model.

103 transbullar inoculation was evaluated in the chinchilla model.

104 -di-GMP), flagella, and quorum sensing--in a chinchilla model.

105 eduction in pneumococcal colonization in the chinchilla model.

106 es for their relative protective efficacy in chinchilla models of otitis media.

107 Herein, we describe mouse and chinchilla models of RSV infection of the nasopharynx an

108 y of immunogens derived from this adhesin in chinchilla models support the continued development of P

109 vivo, LB1-activated DCs trafficked from the chinchilla nasal cavity primarily to the nasal-associate

110 or P5), is essential for colonization of the chinchilla nasopharynx and infection of the middle ear.

111 ability of M. catarrhalis to survive in the chinchilla nasopharynx over a 3-day period.

112 ability of M. catarrhalis to persist in the chinchilla nasopharynx were upregulated in the mesR muta

113 onic antigen blocks NTHI colonization of the chinchilla nasopharynx, providing the first demonstratio

114 exhibit a reduced ability to survive in the chinchilla nasopharynx.

115 s and theta cells) were identified in intact chinchillas, no direction-specific activity was seen aft

116 Using a chinchilla OM infection model, we demonstrated that H. p

117 tC of NTHI strain 2019 were evaluated in the chinchilla OM model.

118 otypes within serogroups was measured in the chinchilla otitis media (OM) model because several serot

119 arcD and arcT are potentially essential in a chinchilla otitis media (OM) model.

120 zed middle ear inflammatory responses in the chinchilla otitis media model after injecting a very sma

121 of H. influenzae attenuated virulence in the chinchilla otitis media model of noninvasive disease.

122 We conclude from these studies that a chinchilla otitis media model provides a means to evalua

123 LOS purified from chinchilla-passed NTHi 86-028NP had increased PCho conte

124 m; diaphorase histochemistry was done in the chinchilla periphery.

125 or LPD-LB1(f)2,1,3 to adenovirus-compromised chinchillas, prior to intranasal challenge with nontypea

126 following intranasal challenge; however, the chinchilla proved to be more permissive than the mouse.

127 l clusters in the cochlear nerve root of the chinchilla provide the simplest example of this structur

128 r otolithic organs, and Scarpa's ganglia) in chinchilla, rat, and guinea pig were examined for immuno

129 Chinchillas received three monthly subcutaneous injectio

130 Fifty-eight chinchillas received three subcutaneous or intramuscular

131 8 and 51%, respectively, in the P6-immunized chinchillas relative to the sham-immunized cohort.

132 ory epithelial cells, in colonization of the chinchilla respiratory tract as well as a requirement fo

133 ances into the endolymph or perilymph of the chinchilla's cochlea and then used scanning laser interf

134 reactivity of a panel of high-titered immune chinchilla sera to the 8- to 10-mer peptides representin

135 ly sensitive to the bactericidal activity of chinchilla serum and thus did not survive.

136 IRN[-] test stimuli were more variable among chinchillas, suggesting that IIRN[-] did not evoke simil

137 ithelium with morphophysiological studies in chinchilla suggests that the labeled population consists

138 te outer-face ribbons being more numerous in chinchilla than in squirrel monkey, afferent discharge p

139 pithelium lining the uppermost airway of the chinchilla, the established rodent host for the study of

140 In the vestibular ganglia of untreated chinchillas, the level of expression of BDNF mRNA is low

141 d in a sensitized background provided by the chinchilla (Tyrc-ch) mutation, which uncovers a phenotyp

142 ession of the sap operon within sites of the chinchilla upper airway upon infection.

143 ease in children and experimental disease in chinchillas, we found a hierarchical pattern of immunodo

144 In 11 normal chinchillas, we recorded binocular 3D eye movements in d

145 A total of 48 research-grade, young adult chinchillas weighing 500 g were used for 2 series of ani

146 Young adult chinchillas were atraumatically inoculated with Moraxell

147 Chinchillas were challenged with NTHI variant population

148 Chinchillas were exposed to an impulse noise at 155 dB p

149 Chinchillas were given tetravalent vaccine composed of p

150 Chinchillas were immunized subcutaneously with either th

151 Data from a second study, wherein chinchillas were immunized with LB1 or lipoprotein D, ea

152 Chinchillas were immunized with P6 and challenged 10 day

153 When chinchillas were immunized with recombinant P1 (rP1) obt

154 To test this hypothesis, the middle ears of chinchillas were infected with either a strain of GAS ca

155 Chinchillas were infected with nontypeable Haemophilus i

156 Chinchillas were infected with S. pneumoniae TIGR4 and e

157 time course of efferent fiber and SGN loss, chinchillas were injected with GM (125 mg/kg IM) followe

158 Both middle ears of chinchillas were inoculated with one of the three pneumo

159 Chinchillas were passively immunized here with serum spe

160 Chinchillas were psychophysically trained and tested bef

161 dle ear fluids sequentially recovered from a chinchilla with an ongoing NTHI-induced otitis media (OM

162 media (OM) after intranasal immunization of chinchillas with an NTHI P5-derived synthetic peptide im

163 ingle auditory nerve fibers were measured in chinchillas with complete cochlear de-efferentation prod

164 ys post-transbullar challenge, the number of chinchillas with middle ear fluid and the incidence of N

165 Chinchillas with psychophysical evidence of chronic tinn