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1 ilA (transformation pseudopilus) and chiA-1 (chitinase).
2 tial mixotrophic goal (i.e. exoproteases and chitinases).
3 ding 12 proteases, two phospholipases, and a chitinase.
4 pendent of the chitinolytic activity of this chitinase.
5 can be negatively regulated by a vertebrate chitinase.
6 rming the type II dependency of the secreted chitinase.
7 sidase and to that of mouse acidic mammalian chitinase.
8 nel of strains where each expresses a single chitinase.
9 erences in processivity of the S. marcescens chitinases.
10 to degrade chitin analogs and produce active chitinases.
11 hin a sequence that is conserved in class IV chitinases.
12 and transgenic expression of plant class IV chitinases.
13 recycled by ubiquitous bacterial and fungal chitinases.
14 olutionary paths for human and monkey acidic chitinases.
15 x1 in infection and in protection from wheat chitinases.
16 unusual among the other class I plant basic chitinases.
17 efense response, namely the effects of wheat chitinases.
18 tion of pathogenesis-related genes including chitinases.
21 ificant reduction in the expression level of chitinase 1 and caused abortive molting in the insects.
22 ons in the genes CG6479, separation anxiety, chitinase 11, CG6364 (Uck2), CG6543 (Echs1), withered (w
24 egression protein-39 (BRP-39), also known as chitinase 3-like 1 (CHI3L1) and encoded by the Chi3l1 ge
26 ingle nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) promoter, the gene encoding
29 d by genetic variation in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patien
30 A promoter SNP (-131C-->G) in CHI3L1, the chitinase 3-like 1 gene encoding YKL-40, was associated
31 in Brp-39, the murine protein product of the chitinase 3-like 1 gene, as a critical component of this
34 uman cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the seru
35 e wound tissue expressed high levels of Ym1 (chitinase 3-like 3), an established marker of the IL-4-i
37 eta and TNFalpha caused increased release of chitinase 3-like protein 1 (CHI3L1), CHI3L2, complement
46 rils via the TGF-beta1 signaling pathway and chitinase 3-like-1 activity in fibroblasts in lymphoid t
49 indicated by increases in the expression of Chitinase 3-Like-1, and the colorectal cancer metastasis
50 s that comprised matrix metalloproteinase 9, chitinase 3-like-1, S100 calcium binding protein A8 (S10
51 teomic analysis revealed decreased levels of chitinase-3-like 3 and accumulation of the receptor for
52 rease 2.53), agouti-related protein; (1.48), chitinase-3-like protein 1 (1.35), C-C motif chemokine 2
55 secretion of matrix metalloproteinase 9 and chitinase-3-like-1 protein but differentially affected t
57 nes and helped identify genes (e.g. Tomosyn, Chitinase 5, Adar, Innexin 2, Transferrin 1, Sick, Oatp2
58 that might function with dyl and identified Chitinase 6 (Cht6) as a strong candidate, as knocking do
59 ontrols the expression of the promoter for a chitinase, a type VI secretion-related gene, a transcrip
60 creted proteins were predicted to encode two chitinases, a chitin binding protein, a protease (PepO),
61 Instead, the new cuticle is protected from chitinase action by the T. castaneum Knickkopf (TcKnk) p
64 molecular basis to explain the differential chitinase activities observed among the species and subp
65 bacteria compared with nonpathogenic E coli; chitinase activities were measured using the colloidal c
66 gher gene regulation and beta-1,3-glucanase, chitinase activities were observed in cv. Ryan compared
70 iae sprE resulted in decreased extracellular chitinase activity and decreased secretion of the cell s
71 tics, asthmatic children exhibited increased chitinase activity and increased YKL-40 levels in BALF.
72 Transformants expressing tri5 displayed low chitinase activity and induced expression of Botrytis ci
73 uences in two regions that are essential for chitinase activity and that were previously thought to b
75 h this analysis, we found that low levels of chitinase activity are sufficient for natural transforma
77 which is ameliorated by restoration of lung chitinase activity by genetic or therapeutic approaches.
78 Our data also indicate that an enzyme with chitinase activity can promote infection of a mammalian
80 ave shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and al
83 ssociated with whole-cell lysates, while the chitinase activity of F. novicida localized to the cultu
85 Denaturation experiments indicate that the chitinase activity on RNase B is not dependent on the te
90 itionally, we assessed factors that regulate chitinase activity within the lungs of patients with CF.
91 ead, we show that an rpoS mutant has reduced chitinase activity, which is required to liberate the so
97 e, we provide evidence that acidic mammalian chitinase (AMCase) can function as a major digestive enz
105 g an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse
106 ng epithelial cells secrete acidic mammalian chitinase (AMCase), which is required for airway chitina
107 with the IL-4- and IL-13-inducible mammalian chitinase, AMCase, or if the chitin was injected into mi
108 a potent and specific inhibitor of filarial chitinases, an activity not previously reported for this
109 s significantly suppressed for activities of chitinase and beta-1,3-glucanase at pH 5 and 7, consiste
110 notype and repressed the expression of Basic Chitinase and beta-1,3-Glucanase, the GCC-box-containing
111 regulated PATHOGENESIS-RELATED genes, Basic Chitinase and beta-1,3-Glucanase, was upregulated in 35S
116 It is becoming increasingly apparent that chitinases and chilectins play an important role in infl
117 he absence of endogenous chitin, a number of chitinases and chitinase-like proteins (C/CLPs) have bee
118 d 18-glycosyl-hydrolase family contains true chitinases and chitinase-like proteins that lack enzymat
120 e created a strain that lacks all 7 putative chitinases and from this strain, generated a panel of st
121 sing evidence highlights the contribution of chitinases and fungal infection to the development of as
124 , and not CHIA, is a gene encoding an acidic chitinase, and cloned it, using the sequence of human CH
125 ng motility apparatus and for secretion of a chitinase, and the P. gingivalis PorSS is involved in se
126 hrough the airway epithelium inhibits mucus, chitinases, and eosinophilia, independent of Th2 cell ac
127 ium-binding site not previously seen in GH18 chitinases, and, importantly, a displaced catalytic acid
128 duction of rhizoxin analogs, orfamide A, and chitinase are required for full oral toxicity of Pf-5 ag
132 face component of parasites and insects, and chitinases are induced in lower life forms during infect
136 nt, including aminopeptidases, an RNase, and chitinase, as well as proteins with no homology to known
137 e phylogenetically related to the Salmonella chitinase, as well as unrelated chitinases from Listeria
140 sion of the ethylene-responsive genes E4 and chitinase B was upregulated in transgenic plants, but et
141 ed activity of defence related enzymes, i.e. chitinase, beta-1,3-glucanase and PAL, and higher conten
143 ide hydrolases along with numerous authentic chitinases, but the proteins have novel consensus sequen
144 ned the binding affinities of the Salmonella chitinase by carbohydrate microarray screening and found
145 I-4 [cyclo-(L-Arg-D-Pro)] inhibits family 18 chitinases by mimicking the structure of the proposed re
146 , whereas those of aryl acylamidase (AA) and chitinase (CHI) increased during the initial period and
151 cular dynamics simulations of two processive chitinases (ChiA and ChiB), the ChiC catalytic module, a
152 olific secretor of proteins, including three chitinases (ChiA, ChiB, and ChiC) and a chitin binding p
153 that cdGMP stimulated the transcription of a chitinase (ChiB) known to contribute to biofilm formatio
155 g these carbohydrate-active enzymes, such as chitinases, chitobiases, and lytic polysaccharide monoox
156 that the T2SS releases chitinolytic enzymes (chitinase, chitosanase) and chitin-binding proteins.
168 ndoS confirmed the previous predictions of a chitinase domain and leucine-rich repeat but also reveal
175 he purpose of this study was to characterize chitinase expression and serological markers of fungal i
178 icate functional specialization among insect chitinase family genes, primarily during the molting pro
180 e glycoprotein YKL-40 (CHI3L1) is a secreted chitinase family protein that induces angiogenesis, cell
183 wn that both the human chitotriosidase and a chitinase from Salmonella enterica serovar Typhimurium h
186 e Salmonella chitinase, as well as unrelated chitinases from Listeria monocytogenes using the fluores
187 he hydrolytic specificity of this enzyme and chitinases from Sodalis glossinidius and Polysphondylium
191 ized the structure of a single copy LmexCht1-chitinase gene from the primitive trypanosomatid pathoge
192 gCHT2 as the orthologue of the P. falciparum chitinase gene PfCHT1, a malaria transmission-blocking t
194 ence has suggested the existence of a second chitinase gene, PgCHT2, in the avian malaria parasite Pl
195 ormatic analyses identified two new putative chitinase genes (chiC and chiD), as well as the previous
199 he expression of both beta-1,3-glucanase and chitinase genes in naturally infected fruit of both cult
200 However, defense-related proteins such as chitinases, glucanases, myrosinases, and others showed e
203 the three-dimensional structure of a barley chitinase) had changes in the catalytic site that are li
207 SS is involved in secretion of extracellular chitinase in addition to its role in secretion of SprB.
208 patients with asthma, in whom expression of chitinase in both compartments correlates with the sever
210 malian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune r
212 ssing constitutively active acidic mammalian chitinase in the lungs demonstrated a significant reduct
213 s are consistent with and suggest a role for chitinases in asthma pathogenesis among Bronx children a
216 rgic inflammation in the lung, and mammalian chitinases, including acidic mammalian chitinase, limit
217 ata, unexpected synergistic protonophore and chitinase inhibition activities have also been found to
219 increased, Arg1 expression was decreased by chitinase inhibition, suggesting that suppression of CHI
220 c activity that is sensitive to the specific chitinase inhibitor allosamidin and has the ability to b
225 d in phytoalexin synthesis, chitinaseb1-1, a chitinase involved in pathogen defense, and Glycine max
226 and microscopic investigations we found that chitinase is essential for bacteria to enter hyphae.
234 germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternat
235 are defined by the expression of Arginase 1, chitinase-like molecules, and resistin-like molecule (RE
236 mice, we identified the macrophage-secreted chitinase-like protein Brp-39, the murine protein produc
239 disc growth factor 2 (IDGF2) is a member of chitinase-like protein family (CLPs) able to induce the
244 se 3-like-1 (Chi3l1), a conserved prototypic chitinase-like protein, is induced by Streptococcus pneu
248 ndogenous chitin, a number of chitinases and chitinase-like proteins (C/CLPs) have been identified.
254 of individual members of the large family of chitinase-like proteins from the red flour beetle, Tribo
255 Our analysis revealed the presence of 18 chitinase-like proteins in the Drosophila protein databa
257 l homologues encoding catalytically inactive chitinase-like proteins or chilectins (all GH18 family p
258 ; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity.
259 ydrolase family contains true chitinases and chitinase-like proteins that lack enzymatic activity.
260 ity to study the structures and functions of chitinase-like proteins, and also to identify new member
261 r knockdown of transcripts for several other chitinase-like proteins, including imaginal disk growth
271 osed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target
273 the P. gallinaceum ortholog of P. falciparum chitinase PfCHT1) are both localized on the ookinete api
274 to evaluate the ookinete micronemal proteins chitinase (PgCHT1), circumsporozoite and TRAP-related pr
275 defenses by deposition of the plant-derived chitinases Pr4 and Endochitinase A is a unique way an in
278 t mutation in the AtCTL1 gene that encodes a chitinase-related protein, although molecular and bioche
279 ndicate that ChiA is a soluble extracellular chitinase required for chitin utilization and that it re
282 n of the entire chitinolytic machinery, with chitinase secretion being blocked at a late stage in the
283 a protein of 464 amino acids with a typical chitinase structure, including a signal peptide, a highl
284 tection against plant- and microbial-derived chitinases, suggesting a broader role beyond deregulatio
285 pecific knockdown of transcripts for another chitinase, TcCHT10, which has multiple catalytic domains
287 rate that mouse chitotriosidase is a typical chitinase that belongs to the mammalian chitinase gene f
288 ate-binding proteins) that crosslink chitin, chitinases that degrade chitin, and Jessie lectins that
289 rasite from digestive enzymes; production of chitinases that degrade the stomodeal valve of the sand
290 rived from antibodies specific to a parasite chitinase, the 25 kDa protein and the circumsporozoite p
291 e named the new enzyme MACase (Macaca Acidic Chitinase) to emphasize its differences from AMCase.
298 n binding domain (CBD) of Bacillus circulans chitinase, which binds to chitin matrices prepared from
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