ライフサイエンスコーパス: chloro

1 cursor 3-bromo-1-(tert-butyldimethylsilyl)-2-chloro-1,2-dihydro-1,2-azaborine (2) to furnish new 2,3-

2 gave 4-N-(2-phthalimidoethyl)-N-alkylamino-5-chloro-1,2-dithiol-3-thiones that quantitatively cycload

3 ) with N-bromosuccinimide and Palau'chlor (2-chloro-1,3-bis(methoxycarbonyl)guanidine) followed by hy

4 1.87 x 10(3) M(-1)) with the carbinolamine 2-chloro-1-(chloroamino)ethanol.

5 structure determination of (E)-1,2-bis{(E)-2-chloro-1-(chloroimino)-2,2-dinitroethyl}diazene) (10), N

6 lic organochalcogen compounds derived from 2-chloro-1-formyl-3-hydroxymethylenecyclohexene (16) are d

7 The reagent 3-chloro-1-lithiopropene (4) can be generated by treating

8 dimethylaminopropyl) carbodiimide (EDC) or 2-chloro-1-methylpyridinium iodide (CMPI), followed by ami

9 ethyl ester (BAPTA/AM) or N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide (W7) before evaluating ap

10 ancement by the biocatalyzed conversion of 4-chloro-1-naphthol to insoluble benzo-4-chlorocyclohexadi

11 te starting from enantiomerically pure (R)-2-chloro-1-phenylethanol, which was transformed into (18)O

12 s includes an asymmetric methallylation of 3-chloro-1-phenylpropan-1-one catalyzed by the highly effe

13 yield, starting from the readily available 3-chloro-1-phenylpropan-1-one.

14 xemplified by 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzo ic ac

15 Compound 16 (N-{2-[4-(5-chloro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]eth

16 recognition of substrates with 2'-azido, 2'-chloro, 2'-amino, or arabinose sugars.

17 wo candidate compounds-[(18)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranos

18 To assess the efficacy of cladribine (2-chloro-2'-deoxyadenosine) in the treatment of ECD.

19 The first borazaronaphthalene, 2-chloro-2,1-borazaronaphthalene, was reported in 1959; ho

20 d to the eventual identification of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methyliso

21 AM and its two brominated analogues (i.e., N-chloro-2,2-bromochloroacetamide and N-chloro-2,2-dibromo

22 .e., N-chloro-2,2-bromochloroacetamide and N-chloro-2,2-dibromoacetamide) was quantitatively determin

23 ad of DCAM, a previously unreported N-DBP, N-chloro-2,2-dichloroacetamide (N-Cl-DCAM), was confirmed

24 lecular mechanism of Sirtuin inhibition by 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (Ex

25 he novel inhibitor selisistat (selisistat; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) ca

26 ositive allosteric modulator PNU120596 [N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-u

27 ncer drugs is based on competition between 1-chloro-2,4-dinitrobenzene (CDNB) and the drugs for the G

28 H-pyrrole-2-one with dichloromethyl group, 3-chloro-2,5-pyrroledione).

29 Oral administration of 2-((4-chloro-2,6-difluorobenzyl)amino)-7-oxo-5-propyl-4,7-dihy

30 hlorophenoxy)butanoic16 acid (2,4-DB), and 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan)) were m

31 Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a syntheti

32 translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[

33 tor protein (TSPO) binding using SPECT and 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[

34 propanol showed deuterium incorporation in 5-chloro-2-(4-chlorophenoxy)phenol, providing strong evide

35 ((2,4-dichlorophenoxy)acetic acid (2,4-D), 4-chloro-2-15 methylphenoxy)acetic acid (MCPA), 4-(2,4-dic

36 However, one mGlu5 PAM, CPPHA (N-(4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl

37 nds), (2) a novel TGR5 antagonist (m-tolyl 5-chloro-2-[ethylsulfonyl] pyrimidine-4-carboxylate [SBI-1

38 olboranes that are excellent precursors to 1-chloro-2-arylpropyl radicals.

39 derivatives, it was possible to prepare B-(1-chloro-2-arylpropyl)catecholboranes that are excellent p

40 chemical shift difference for tricarbonyl(1-chloro-2-deuteriomethylbenzene) chromium(0) was computed

41 previously described kinase inhibitors-3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5

42 fficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described.

43 for 4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylme thyl)-2-oxo-1,2

44 rophenol, 2-chloro-4-phenylphenol, and bis(5-chloro-2-hydroxyphenyl)methane) antimicrobial agents fou

45 7 muM for triclocarban, 0.372 muM for bis-(5-chloro-2-hydroxyphenyl)methane, 4.89 muM for 2-chloro-4-

46 ared by in-situ grafting polymerization of 3-chloro-2-hydroxypropyl methacrylate (HPMA-Cl) and follow

47 omising candidate, Ru2(chp)4ONO2 (4, chp = 6-chloro-2-hydroxypyridinate), displays a set of signals c

48 the parent compound, were synthesized from 6-chloro-2-iodo-9-methyl-9H-purine (2) by selective C-C bo

49 ichloroisopropyl) phosphate (TDCIPP), tris(1-chloro-2-isopropyl) phosphate (TCIPP), triphenyl phospha

50 ular, the compound labeled NSC 130813 [4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piper

51 demonstrated with the lead compound 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimi

52 on isotope fractionation of MCPP ((R,S)-2-(4-chloro-2-methylphenoxy)-propionic acid), DCPP ((R,S)-2-(

53 teraction between the goethite surface and 4-chloro-2-methylphenoxyacetic acid (MCPA) herbicide was s

54 nd-specific isotope fractionation of MCPA (4-chloro-2-methylphenoxyacetic acid) and 2,4-D (2,4-dichlo

55 of isobutyraldehyde; cyclotrimerization of 2-chloro-2-methylpropanal; dehydochlorination of 2,4,6-tri

56 dichloro-2-propyl) phosphate (BDCIPP), bis(1-chloro-2-propyl) phosphate (BCIPP), diphenyl phosphate (

57 lphenyl phenyl phosphate (tb-PPP), and bis(1-chloro-2-propyl) phosphate (BCIPP)] using negative elect

58 temporal distribution are given for Tris-(1-chloro-2-propyl) phosphate (TCiPP), EHDPP, tri-n-butyl p

59 he pattern was generally dominated by tris(1-chloro-2-propyl) phosphate (TCPP), although tri-n-butyl

60 The most abundant chlorinated OPE was tris(1-chloro-2-propyl) phosphate (TCPP).

61 ,2',4,4'-tetrabromodiphenyl ether and tris(1-chloro-2-propyl) phosphate.

62 ng/L) followed in decreasing order by tris(1-chloro-2-propyl)phosphate (TCIPP; max: 14500 ng/L), bis(

63 2-propyl)phosphate (TDCPP or TDCIPP), tris(1-chloro-2-propyl)phosphate (TCPP or TCIPP), and tris(2-ch

64 Tris-(1-chloro-2-propyl)phosphate (TCPP) was the most abundant c

65 While tris-2-chloroethyl phosphate, tris(1-chloro-2-propyl)phosphate and tris-1,3-dichloropropylpho

66 sphate, tris(2-chloroethyl)phosphate, tris(1-chloro-2-propyl)phosphate, and triphenyl phosphate conce

67 yl-1,3-pentanediol diisobutyrate, and tris(1-chloro-2-propyl)phosphate, which stood out from other na

68 ntagonists capsazepine (CPZ) and BCTC ((4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-pi

69 2-Chloro-, 2-bromo-, and 2-iodothiophenes undergo photoche

70 demonstrated for 4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylme th

71 hydrochlorofluorocarbon HCFC-1233zd(E) (E-1-chloro-3,3,3-trifluoroprop-1-ene trans-CF3CH horizontal

72 ecular simulation revealed 2-chloro-N (1)-[4-chloro-3-(2-pyridinyl)phenyl]-N (4),N (4)-bis(2-pyridiny

73 identification of new Mtb ThyX inhibitors, 2-chloro-3-(4-methanesulfonylpiperazin-1-yl)-1,4-dihydrona

74 lted in the identification of compound (Z)-4-chloro-3-(5-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolid

75 ty acids and found that the analogue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadec

76 ll-molecule allosteric modulator Org27569 [5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperid

77 cannabinoid 1 (CB1) allosteric modulator, 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperid

78 5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole

79 Starting from commercially available 2-chloro-3-hydroxypyridine, a new route leading to the fir

80 annel (KATP channel) openers diazoxide and 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-di

81 chloroaniline, 2,3,5,6-tetrachloroaniline, 4-chloro-3-methylphenol, pentylbenzene, pyrene, and bromop

82 ar affinity cannabinoid CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S

83 One of the antagonists, 2-(4-chloro-3-methylphenyl)-2-oxoethyl thiocyanate (CMOT), ha

84 The reactions of (Z)- and (E)-ethyl 2-chloro-3-octenoate (4a and 17) and (E)- and (Z)-diethyl

85 rile (1) in the presence of HCl to produce 2-chloro-3-phenyl-4(3H)-quinazoliniminium chloride (Qz) in

86 thyl 3-formylindol-2-ylacetate and N-tosyl-4-chloro-3-piperidone oxime have been used to construct th

87 ic synthetic strategy for the synthesis of 2-chloro-3-substituted benzo[b]thiophenes is developed via

88 ne derivative (11)C-GMOM ((11)C-labeled N-(2-chloro-3-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methy

89 2-yl 27 (0.6), thien-2-yl 32 (0.6) and its 5-chloro 33, MRS5980 (0.7) and 5-bromo 34 (0.4) equivalent

90 With 3'-chloro-4'-(alpha-d-mannopyranosyloxy)biphenyl-4-carbonit

91 liferative than CA-4, indicating that the 3'-chloro-4'-ethoxyphenyl moiety was a good surrogate for t

92 4-ylethynyl]pyridine (basimglurant, 2) and 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1

93 onitrile (NEU-924, 83) for T. cruzi and N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4-((4-methyl-1,

94 inhibitors for each pathogen, such as 4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-(4-((4-met

95 henyl)benzamide dihydrochloride] and 2 [N-(3-chloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-4-

96 tructure of PPARgamma bound to 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(

97 n of a series of mGlu1 PAMs based on an N-(3-chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran

98 antiretroviral medication efavirenz ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-

99 glutamate-evoked response was observed for 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiad

100 From this library, we identified 7-chloro-4-(4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)qu

101 Of these compounds, N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-2-pi

102 MX (3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) is a

103 rination, such as the highly mutagenic MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) or h

104 ich led to the discovery of (2R)-1-[4-(4-{[5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]ami

105 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methy

106 selective S1P1 receptor agonists (Z,Z)-5-(3-chloro-4-[(2R)-2,3-dihydroxy-propoxy]-benzylidene)-2-pro

107 hit 1 to the potent and selective compounds chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-

108 sly described "GPR39-selective" agonist N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4- pyrimidin

109 In addition, TTA-Q4 [(S)-4-(6-chloro-4-cyclopropyl-3-(2,2-difluoroethyl)-2-oxo-1,2,3,4

110 active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadi

111 The GluN2A-selective antagonist, 3-chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbo

112 pharmacological inhibition of GluN2A with 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbo

113 ridinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicating these as optimized 6-

114 s with the prolyl hydroxylase inhibitor 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetate enha

115 o a small molecule PHD inhibitor (PHI) (2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid)

116 to grow by organohalide respiration using 3-chloro-4-hydroxyphenyl acetate (Cl-OHPA) as an electron

117 lic acid (85, EC50 12.1 nM) and 6-bromo-8-(2-chloro-4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxyli

118 Among them, compound 6c, 2-acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b]

119 henol (2), 2-chloro-4-nitrophenol (3), and 3-chloro-4-methoxyphenol (4), in chemical yields of 69.2%,

120 N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxa mide (PF-048023

121 Irradiation (lambda > 330 nm) of 2-chloro-4-nitroanisole (1) at 25 degrees C in aqueous NaO

122 nuclear Pd(atz,ur) complex at 457nm by the 2-chloro-4-nitrophenol (2-CNP) which produced from the rea

123 hotoproducts: 2-methoxy-5-nitrophenol (2), 2-chloro-4-nitrophenol (3), and 3-chloro-4-methoxyphenol (

124 five variant NDP acceptors and six variant 2-chloro-4-nitrophenyl glycoside donors to produce 30 dist

125 duced from the reaction of the enzyme with 2-chloro-4-nitrophenyl-alpha-d-maltotrioside (CNPG3) subst

126 used to follow the enzymatic hydrolysis of 2-chloro-4-nitrophenyl-beta-D-galactopyranoside using UV-v

127 nalog as well as the kynurenic acid analog 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid (7-chlorokyn

128 loro-2-hydroxyphenyl)methane, 4.89 muM for 2-chloro-4-phenyl phenol, 45.7 muM for 2-benzyl-4-chorophe

129 trichlorophenol, 2-benzyl-4-chlorophenol, 2-chloro-4-phenylphenol, and bis(5-chloro-2-hydroxyphenyl)

130 (1) GABA(A) receptors was observed for the 5-chloro, 5-bromo, and 5-methyl substituted analogues of 2

131 ed conversion of the non-native substrate 5'-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deo

132 We studied the structure of 2-chloro-5-((Z)-((E)-5-((5-(4,5-dimethyl-2-nitrophenyl)fur

133 sodium hydrogen carbonate in acetonitrile, 7-chloro-5-(4-fluorophenyl)-1,3-dihydro-2,3,4-benzothiadia

134 rifluoromethyl) pyridine-2-acetic acid and 3-chloro-5-(trifluoromethyl) picolinic acid was elucidated

135 thyl benzamide and subsequent formation of 3-chloro-5-(trifluoromethyl) pyridine-2-acetic acid and 3-

136 lying matrix-matched calibration and using 2-chloro-5-bromoanisole as surrogate standard.

137 nitrogenous heterocyclic compounds (e.g., 3-chloro-5-hydroxy-1H-pyrrole-2-one with dichloromethyl gr

138 cumbens administration of (R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid sodium salt (CHPG) an

139 (11)C-CNS5161 (N-(2-chloro-5-methylthiophenyl)-N'-(3-methylthiophenyl)-N'-(1

140 the following: (1) how ROSI and/or GW9662 (2-chloro-5-nitro-N-phenylbenzamide; PPARgamma antagonist)

141 The reaction also works with 4-chloro-5H-1,2,3-dithiazol-5-one and -thione, giving the

142 Reacting (Z)-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines

143 Furthermore, thermolysis of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines

144 -pyrazol-5-amines 2 gives main products N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines

145 N-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)anilines react with

146 While the reaction of several (4-chloro-5H-1,2,3-dithiazol-5-ylidene)methanes with DABCO

147 fter bezafibrate ( approximately 18-fold), 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (

148 o induction of CYP3A4 mRNA and protein by [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (W

149 liferator-activated receptor (PPAR) alpha [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY

150 eridine class, also known as VUF11211 [(S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpi

151 ists of distinct chemotypes: VUF11211 [(S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpi

152 BT2, its analog 3-chloro-6-fluorobenzo[ b]thiophene-2-carboxylic acid (BT2

153 A comparison of the effects of the 6-(2-chloro-6-fluorobenzyl)-2-(alkylthio)pyrimidin-4(3H)-ones

154 se with (1) either a 2,6-difluorostyryl or 2-chloro-6-fluorostyryl subunit, (2) either an N-methylami

155 the substitution pattern (4,6-dimethyl vs 5-chloro-6-methoxy-4-methyl) had a significant effect on b

156 For example, LY2033298 (3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carbox

157 One such compound (MLS1547; 5-chloro-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-

158 nerate a set of compounds with the general 6-chloro-7-methoxy-2-methyl-4(1H)-quinolone scaffold which

159 acids in the samples were derivatized with 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) prior to CE

160 We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one

161 C-(2-ethyl-2H-tetrazol-5-yl)-adenosine and 2-chloro-adenosine derivatives was synthesized as novel, h

162 , or n-octyl3Al, with triphenylalane or aryl(chloro)alanes is reported.

163 ce of the rationally designed MALDI matrix 4-chloro-alpha-cyanocinnamic acid (ClCCA) in comparison to

164 n treated with a strong base, forms an alpha-chloro-alpha-fluorocarbanion that adds to nitroarenes at

165 onalized ketones such as alpha-bromo-, alpha-chloro-, alpha-mesyloxy-, alpha-tosyloxy-, and alpha-hyd

166 the potentially genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resulting in compounds

167 6,6'-phenyl BTPhen derivatives (including 4-chloro and 4-bromo) in five simple steps.

168 elies on facile reactions performed on the 9-chloro and 9-bromomethyl precursors.

169 lfonyl-substituted carbanions carrying alpha-chloro and alpha-bromo substituents (1a-e) with quinone

170 rties were optimized by introducing the para-chloro and aminopyrrolidine groups.

171 , thienylation occurs with modest yield from chloro and bromo derivatives (via photogenerated triplet

172 Effects of chloro and bromo substitution at the 4-position of the p

173 A chloro and ethoxy group at the meta- and para-positions,

174 lic bromonium ions; however, in the cases of chloro and fluoro derivatives, open forms are more prefe

175 Aromatic cyano, chloro, and bromo functionalities are tolerated by the t

176 Comparison of the dynamics of the chloro- and bromo-complexes shows that inertial effects

177 Chloro- and bromo-substituted benzo[b]naphtho[2,1-d]thio

178 We identify p-chloro- and fluoronitrobenzenes and dichlorotriazines as

179 Sixteen analogues including the chloro- and nitro-substituted 1, 3, 5, 6, 7, 11, 12, and

180 o-Chloro- and o-bromophenylmethylidenefuranones also affor

181 identify both polyhalogenated (mixed bromo-/chloro- and polybromo-) dibenzo-p-dioxins and dibenzofur

182 mical properties of the (poly)fluoro-, (poly)chloro-, and (poly)bromobenzenes, including standard ent

183 al profiles of the yet-unsynthesized bromo-, chloro-, and fluoro- analogues show a progressive loweri

184 vel one-step synthesis of anthraquinones and chloro anthraquinones from simple ketone precursors and

185 hydrate (165% [161-176]) > 2,2-dichloro- > 2-chloro approximately 2,2,2-trifluoroethanol > ethanol.

186 Two chemically very similar chloro-aromatic fragments differ strongly in their poten

187 h small-molecule organic surface modifier, 4-chloro-benzoic acid (CBA), via a simple spin-coating met

188 le (or 5,6-dimethyl-1H-benzotriazole), and 5-chloro-benzotriazole, and the target benzothiazoles were

189 -carbonyl)-2-methyl-azetidine-2-carbonyl]-(3-chloro -benzyl)-amino]-butyric acid 99 (GLPG0974), is ab

190 The alpha-chloro-beta-aminoketone intermediates featuring a chlori

191 on, are used to produce the respective alpha-chloro-beta-fluoroalkylcarbonyl products in excellent yi

192 The chloro-bridged heterodinuclear ansa-zirconocenium cation

193 Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura r

194 tners with sensitive functionalities such as chloro, bromo, hydroxy, and cyano were also amenable to

195 Fluoro, chloro, bromo, iodo, and gem-dihaloalkenes are viable su

196 al, and replacement of the 5-iodo group with chloro, bromo, or fluoro groups led to losses in potency

197 while controlling the formation of regulated chloro-bromo-DBPs (Cl-/Br-DBPs).

198 ee, photoinduced, dual C-H/C-X borylation of chloro-, bromo-, and iodoarenes.

199 <10 to 3830 ng/L (gemfibrozil), and those of chloro/bromo byproducts ranged from <4 to 370 ng/L (dibr

200 ulas, corresponding to chlorinated and mixed chloro/bromo compounds.

201 rane species (C18H13Cl11), and a novel mixed chloro/bromo-carbazole (C12H5NCl2Br2) in a number of sed

202 kenes to form chloro, difluoromethylated and chloro, carbomethoxydifluoromethylated products.

203 The resulting Ru(II) chloro complex was converted into the catalytically acti

204 Au seeds in aqueous solutions containing Pd-chloro complexes.

205 with salinity, consistent with transport by chloro-complexes and confirming the importance of brines

206 however, these readily convert into neutral chloro-complexes.

207 educe itself and to form mixed Pt(II)-Sn(II) chloro-complexes.

208 for syn versus anti oxidative addition of 3-chloro-cyclopentene to Pd(0)L(n) was investigated using

209 The chloro derivative reacts with N2O with loss of N2 to for

210 itions (ATRA) to unactivated alkenes to form chloro, difluoromethylated and chloro, carbomethoxydiflu

211 f 3-hydroxyanthranilate 3,4-dioxygenase by 6-chloro-dl-tryptophan prevented both increased lactate pr

212 )-N,N'-1,2-ethanediylidenebis(2, 2-dinitro-2-chloro-ethanamine) (12) was helpful in their characteriz

213 on conversion of the vinyl ether to an alpha-chloro ether prior to cyanide addition in a pathway that

214 Furthermore, chloro, fluoro, or cyano substitutions on the 4- and 6-p

215 ing opening of a cis-dialkyl substituted syn-chloro-gem-chlorofluorocyclopropane, in violation of the

216 The chloro group was substituted with a chiral amine, allowi

217 the positions bearing the amino, ethyl, and chloro groups.

218 ent of H2Q with the higher-potential EPTM, 2-chloro-H2Q, allows for faster O2 reduction rates at high

219 stable intermediate products, such as the N-chloro-haloacetamides (N-chloro-HAMs), may form during t

220 ped for the detection of a family of seven N-chloro-haloacetamides (N-Cl-HAMs).

221 ucts, such as the N-chloro-haloacetamides (N-chloro-HAMs), may form during the course of HAN chlorina

222 oss the dihalogenated HBQs: iodo- > bromo- > chloro-HBQs (P < 0.05).

223 PAd3 during Suzuki-Miyaura cross-coupling of chloro(hetero)arenes (40 examples) at low Pd loading, in

224 Whereas the related chloro-hydride complex, trans-H(Cl)Pt(P(t)Bu3)2, does no

225 ation and determination of aqueous gold(III)-chloro-hydroxyl, gold(III)-bromo-hydroxyl, gold(I)-thios

226 ess allowed the synthesis of 1.84 g of alpha-chloro ketone from the respective N-protected amino acid

227 of carboxylic acids, the synthesis of alpha-chloro ketones and pyrazoles, and palladium-catalyzed cy

228 sion by combined bath-application of NMDA (7-chloro-kynurenic acid) and AMPA (CNQX) receptor blockers

229 epared by stoichiometric substitution of one chloro ligand in the parent, neutral W-oxo-alkylidene-NH

230 In response to high [K(+)], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated

231 Both 4-chloro-m-cresol and halothane caused adenosine accumulat

232 d blood lymphocytes incubated with 0-10 mM 4-chloro-m-cresol or 0-10.7 mM halothane.

233 Similarly, at 1 mM 4-chloro-m-cresol or 0.96 mM halothane, adenosine levels w

234 acteristic analyses showed areas under the 4-chloro-m-cresol receiver-operating characteristic curves

235 Although 4-chloro-m-cresol receiver-operating characteristic curves

236 a-susceptible B cells treated with 0.75 mM 4-chloro-m-cresol relative to controls.

237 the ryanodine receptor Ca channels agonist 4-chloro-m-cresol was compared in blood lymphocytes from m

238 mework was applied and validated for PCMC (4-chloro-m-cresol), household derived antimicrobial agent

239 , ATP, and ryanodine but not for Ca(2+) or 4-chloro-m-cresol, although they all induced Ca(2+) releas

240 (p approximately 0.0001), suggesting that 4-chloro-m-cresol-induced adenosine could readily distingu

241 Two unnatural bromo-chloro-malbrancheamide analogues were generated through

242 bers, either a ryanodine receptor agonist (4-chloro-meta-cresol) or depolarizing pulses were used.

243 were reduced, and consequently, SOCE after 4-chloro-meta-cresol-induced store depletion was suppresse

244 H) caged in ZIF-8 is synthesized in steps of chloro-monomer impregnation, in situ polymerization, ami

245 followed by molecular simulation revealed 2-chloro-N (1)-[4-chloro-3-(2-pyridinyl)phenyl]-N (4),N (4

246 he last experiment compared the ability of 2-chloro-N(6)-cyclopentyladenosine (CCPA) (10 muM; selecti

247 h a selective A1 adenosine receptor agonist, chloro-N(6)-cyclopentyladenosine (CCPA), induced the exp

248 small-molecule agonist [JNJ-63533054, (S)-3-chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl) benzamide

249 cocrystal structure of PPARgamma bound to 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio

250 We also identified 5-chloro-N-(4-(dimethylamino)phenethyl)-3-hexyl-1H-indole-

251 A robust CB1 allosteric modulator 5-chloro-N-(4-(dimethylamino)phenethyl)-3-pentyl-1H-indole

252 A potent CB1 allosteric modulator 5-chloro-N-(4-(dimethylamino)phenethyl)-3-propyl-1H-indole

253 One of these compounds is 7-chloro-N-(4-ethoxyphenyl)-4-quinolinamine, an inhibitor

254 azolo[5,4-c]pyridin-3-ol hydrochloride and 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]]benza

255 modulator of the GABAA delta subunit, DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzam

256 ontaining delta subunits were sensitive to 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzam

257 cal characterization of LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-

258 or (mAChR) potentiator, LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-

259 A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2-

260 tituent on the 4-phenylimidazole, but a para-chloro or bromo substituent engendered a second closed c

261 In the absence of the halogen (chloro or fluoro), the apparent alkyl shift proceeds mor

262 cement of a polar pyrazole group by a simple chloro or trifluoromethyl group led to improved Caco-2 p

263 -directed functionalization took place and 3-chloro- or 3-bromobipyridine N-oxides were obtained in h

264 xcellent regioselectivities through either a chloro- or a bromocyclization, using Koser's reagent and

265 Using NCS or NBS (N-chloro- or N-bromosuccinimide) and 5 mol % Pd(OAc)2 in c

266 comparison to having electron withdrawing p-chloro (PClB) or p-cyanobenzyl ether (PCNB) protecting g

267 overall chlorination rate depending on the (chloro)phenol identity and chloride concentration.

268 The aqueous chlorination of (chloro)phenols is one of the best-studied reactions in t

269 2 and Cl2O, may play in the chlorination of (chloro)phenols.

270 zepine, while the herbicide MCPA (2-methyl-4-chloro-phenoxyacetic acid) and the drug 4-acetamidoantip

271 on with 3-(5-tert-butyl-isoxazol-3-yl)-2-[(3-chloro-phenyl)-hydrazono]-3-oxo-propionitril e, an EPAC-

272 ieved by N(6)-substitution with a 2-fluoro-4-chloro-phenyl- or a methyl- group.

273 show that the selective Epac activator 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3', 5-cyclic mon

274 low detection to 119 pg m(-3) for ethanol, 2-chloro-, phosphate (3:1) (TCEP).

275 activity, a variety of substitutions at the chloro position only increased its IC50 by 2-3-fold.

276 With azine-linked N2-COF photosensitizer, chloro(pyridine)cobaloxime co-catalyst, and TEOA donor,

277 sed to involve formation of a putative alpha-chloro pyridinium carbamate intermediate, which appeared

278 ) is obtained from the reaction of the alpha-chloro silyl functionalized heavier vinylidene analogue

279 the unprecedented hydroborylene-coordinated (chloro)(silyl)nickel(II) complex 3, {[cat((TMS) L)Si](Cl

280 on reduction affords a Lewis base stabilized chloro-stibinidene, whereas three-electron reduction giv

281 Facile nucleophilic replacement of the alpha-chloro substituent is shown to lead to further diverse f

282 Relative rates between nitro and chloro substituents indicate the nucleophilic addition s

283 When starting from 7-chloro-substituted 2,3,4-benzothiadiazepine 2,2-dioxide,

284 eted with the synthesis of the corresponding chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-benzothi

285 The 5-chloro-substituted analogs 9 and 10 with no substituent

286 ved between the product distributions of the chloro-substituted and the thiadiazolo-fused derivatives

287 receptor potentiator in vitro, whereas the 7-chloro-substituted compound 36c emerged as the most prom

288 gh-energy 2,4,6-triazidopyrimidine and its 5-chloro-substituted derivative, the detonation of which i

289 e group transfer of both P and Cl atoms from chloro-substituted dibenzo-7lambda(3) -phosphanorbornadi

290 alized quinolines by selective metalation of chloro-substituted quinolines with metal amides followed

291 nonpolar substituents approach or match the chloro-substituted vancomycin and were insensitive to th

292 Trp-248 was further confirmed by ZnClTerp, a chloro-substituted version of ZnTerp that showed no inhe

293 inylzinc bromide with an electrophilic alpha-chloro sulfide, and last by ring-closing metathesis reac

294 carbon-carbon bond formation using an alpha-chloro sulfide, regioselective hydrozirconation of an in

295 tion of an alkynylzinc reagent with an alpha-chloro sulfide.

296 d levetiracetam-huprine and levetiracetam-(6-chloro)tacrine hybrids to hit amyloid, tau, and choliner

297 anufacturing byproduct summation operator-3'-chloro-TCC C (r = 0.79), and summation operator-2'-hydro

298 ) as well as the manufacturing byproduct (3'-chloro-TCC) as total concentrations (Sigma-) after conju

299 When the ortho substituent is chloro, the compounds also exhibit stability to reductio

300 re not the most enthalpic binders; instead a chloro-thiophene fragment binds more enthalpically.