ライフサイエンスコーパス: chloroethyl

1 arrest in response to exposure to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) alone; however, 70-80%

2 e 5-day cycle (1omega) of low-dose 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and a second group rec

3 esponse to the chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and cis-diamminedichlo

4 al administration of radiation and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) chemotherapy in three

5 to inhibit MGMT and to potentiate 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a MGMT-positive hum

6 Low concentrations of diamide plus 1,3-bis(2 chloroethyl)-1-nitrosourea (BCNU) increased intracellula

7 tentiate the antitumor efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) is being tested in cli

8 The bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) is cytotoxic primarily

9 ion of eNOS, by exposure to either 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or glutathione reducta

10 tion of 30 mg/kg 6-BG and 10 mg/kg 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or with 40 mg/kg BCNU

11 onal cycles of chemotherapy using 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) resulted in similar in

12 ter resistance to cell killing by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) than overexpression of

13 ured with buthionine sulfoximine and 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) to inhibit glutathione

14 th adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) would lead to an incre

15 stance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used f

16 study, we examined the effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a commonly used CNU,

17 rly hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, an

18 agenic effects of temozolomide and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and no further sensit

19 -disulfide oxidoreductase enzymes (1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), arsenite, and phenyla

20 The chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), carboplatin, and camp

21 ucts and compromise its integrity (1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), cisplatin, H(2)O(2) a

22 In combination with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), the prodrugs were not

23 and to the chloroethylating agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), with and without AGT

24 in of safety than the nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

25 re > 10-fold resistant to the CENU 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

26 ncluding melphalan, cisplatin, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

27 sferase (AGT) and are sensitive to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

28 ctive in enhancing cell killing by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

29 ro, 2,4-dinitrobenzene (CDNB); or 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU).

30 mbucil, melphalan, and carmustine [1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)] weakly induced lucife

31 -benzylguanine (O6-BG, 20 microM) or 1,3-bis(chloroethyl)-1-nitrosourea (BCNU, 100 microM), resulted

32 roencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biode

33 transduction and O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea (BG/BCNU) treatment has been

34 n animals treated with carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea 20 mg/kg/week, i.v. x 2; diff

35 effects of chemotherapy [25 mg/kg 1,3-bis(2-chloroethyl)-1-nitrosourea administered with a single i.

36 iving IL-2-transduced cells or 10% 1,3-bis(2-chloroethyl)-1-nitrosourea alone.

37 also protected HeLa cells against 1,3-bis(2-chloroethyl)-1-nitrosourea and methyl methanesulfonate c

38 e toxic and clastogenic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and mitomycin C (MMC), as mea

39 rapeutic alkylating agents, namely 1,3-bis(2-chloroethyl)-1-nitrosourea and mitomycin C, indicating t

40 cells and polymers containing 10% 1,3-bis(2-chloroethyl)-1-nitrosourea had significantly improved su

41 reatine:Pi and ATP:Pi ratios after 1,3-bis(2-chloroethyl)-1-nitrosourea treatment indicate improved b

42 oximine) or glutathione reductase (1,3-bis(2-chloroethyl)-1-nitrosourea) in the presence or absence o

43 ozolomide, N-methyl-N-nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea, 9-aminocamptothecin, topotec

44 ne in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to c

45 of BLMVECs with the GR inhibitor, 1,3 bis-(2 chloroethyl)-1-nitrosourea, abolished the inhibitory eff

46 had been treated with carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea, or BCNU).

47 0 degrees C and after addition of 1,3-bis-(2-chloroethyl)-1-nitrosourea, there was effective S-thiola

48 -mediated tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea, we performed a novel dose es

49 ze human tumor cells to killing by 1,3-bis(2-chloroethyl)-1-nitrosourea, with O6-benzyl-3'-O-(gamma-f

50 lling by the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea.

51 tance to the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea.

52 kyl N-nitrosourea-type drugs, e.g. 1,3-bis(2-chloroethyl)-1-nitrosourea.

53 ne or in combination with 13 mg/m2 1,3-bis(2-chloroethyl)-1-nitrosourea.

54 with 0.5, 1, or 2 x LD10 doses of 1,3-bis(2-chloroethyl)-1-nitrosourea.

55 therapeutic drugs temozolomide and 1,3-bis(2-chloroethyl)-1-nitrosourea.

56 lating agents, such as carmustine [1,3-bis(2-chloroethyl)-1-nitrosourea; BCNU], lomustine [1-(2-chlor

57 ere treated with the alkylator agent 1,3-bis-chloroethyl-1-nitrosourea.

58 of glutathione reductase (GR) with 1,3-bis[2-chloroethyl]-1-nitrosourea or transfection of macrophage

59 cells as compared with 19 exhibited by 4-[(2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl-l-glutamic ac

60 ity differential than the published N-[4-[(2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl]-l-glutamic a

61 of this class, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- 2(-)[[2-chloroethyl)-amino]carbonyl]hydraz

62 of this class, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M).

63 another agent, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-nitrobenzyloxy)carbonyl]hy drazine (P

64 ty to sensitize 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (laromus

65 f these agents, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carb onyl]hydra

66 cumulation of a liposome formulation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), an effec

67 r response to the chemotherapeutic drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in vitro.

68 ethyl)-1-nitrosourea; BCNU], lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; CCNU], and stre

69 and presence of sublethal nitrosourea ([1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea]; CCNU) concentr

70 -(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), an alkylating antitum

71 without affecting [3H](+)-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc

72 bis(2-chloroethyl)nitrosourea (BCNU)-induced chloroethyl adducts are fully converted into interstrand

73 ted esters provides CNTs functionalized with chloroethyl, allyl, and propargyl groups, which can furt

74 race impurities from the synthesis of tris(2-chloroethyl)amine (HN3) that point to the reagent and th

75 g PGP (N-p- inverted question markN,N-bis (2-chloroethyl)amino inverted question markphenoxycarbonyl-

76 higher than that of sarcolysin [(L-3-[bis(2-chloroethyl)amino]-L-phenylalanine] against all leukemia

77 ID50 and ID90 values for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester

78 a-glutamyl-alpha-amino-beta-[[[2-[[bis[bis(2-chloroethyl)amino]ph osp horyl]oxy]ethyl]sulfonyl]propio

79 [3,5-Difluoro-4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave

80 coupling of two key intermediates: 4-[bis(2-chloroethyl)-amino]-L-phenylalanine ethyl ester trifluor

81 s(methylsulfonyl)-1-(2-chloroethyl)- 2(-)[[2-chloroethyl)-amino]carbonyl]hydrazine, was further evalu

82 ompounds consist of 4-(3-aminopropyl)-N,N-(2-chloroethyl)-aniline linked to 2-(4'-hydroxyphenyl)-3-me

83 is (chloromethyl)-propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate (V6)).

84 -bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate, known as V6, is a flame retar

85 this N-substituent could be cleaved using 1-chloroethyl chloroformate.

86 -32 by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)cysteine, in peptides 1-24 and 45-58, was si

87 N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydron

88 Dichloroborane adducts of monoglyme and beta-chloroethyl ether also showed high reactivity, even at r

89 Dioxane, ethyl acetate, and beta-chloroethyl ether form relatively stable boron trichlori

90 Monoglyme and beta-chloroethyl ether give stable dichloroborane adducts req

91 ether, dioxane, anisole, ethyl acetate, beta-chloroethyl ether, and monoglyme, were examined as prosp

92 Mass spectra for xenon, 2-chloroethyl ethyl sulfide (CEES), and octane were acquir

93 r the oxidation of a mustard gas analogue, 2-chloroethyl ethyl sulfide (CEES), in the presence of an

94 photooxidation of a mustard-gas simulant, 2-chloroethyl ethyl sulfide (CEES), is studied using a por

95 oxidation of the sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES).

96 for binding the sulfur mustard surrogate, 2-chloroethyl ethyl sulfide (CEES).

97 The hydrolysis of 2-chloroethyl ethyl sulfide has been examined in an effort

98 dditional products in the disappearance of 2-chloroethyl ethyl sulfide with k3 in particular causing

99 nethiol) and one S-type vesicant simulant (2-chloroethyl ethyl sulfide) were found in each case (samp

100 xidation (O(2) oxidation of the thioether, 2-chloroethyl ethyl sulfide, CEES) led to the discovery th

101 Detection of the CWA simulants 2-chloroethyl ethyl sulfide, triethyl phosphate, and dimet

102 CEES to the comparatively nontoxic product 2-chloroethyl ethyl sulfoxide (CEESO) without formation of

103 ES was transformed selectively to nontoxic 2-chloroethyl ethyl sulfoxide and vinyl ethyl sulfoxide us

104 A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alk

105 by thioredoxins alkylated at Cys-32 by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)cysteine, i

106 mutations seen in other organisms with S-(2-chloroethyl)glutathione or ethylene dibromide.

107 The synthetic analog S-(2-chloroethyl)glutathione was used to produce DNA damage;

108 -based assays accompanied replacement of the chloroethyl group with unhalogenated substituents.

109 (aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydr azi nes were synthesized and primarily

110 ylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) after bioreductive activati

111 yloxycarbonyl)-1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines (4, 6, and 7) were synthesized an

112 The 2-chloroethyl moiety on selected dithiazoles was also modi

113 ell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced ac

114 wley rats were administered 50 mg/kg i.p. N-(chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) or were

115 NE in the spinal cord dorsal horn with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

116 inistered the noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

117 males with the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

118 by cortical NA denervation with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] a

119 rats and in rats pretreated with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine], a neurotoxin t

120 tau transgenic mice with the neurotoxin N-(2-chloroethyl)-N-ethyl-bromobenzylamine (DSP-4) starting a

121 both O6-benzylguanine (O6BG) and N,N'-bis(2-chloroethyl)-N-nitroso-urea (BCNU) stably increased the

122 en a single dose of 35 mg/m(2) of N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), which was otherwise i

123 and are sensitive to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea (BCNU).

124 synthesis, complicates the use of N,N-bis(2-chloroethyl)-N-nitrosourea as a GR inhibitor.

125 (DBT-FG) sensitized the tumors to N,N'-bis(2-chloroethyl)-N-nitrosourea chemotherapy, as measured by

126 reports of various GR inhibitors, N,N-bis(2-chloroethyl)-N-nitrosourea, an anticancer drug with IC(5

127 olar range, it is more potent than N,N-bis(2-chloroethyl)-N-nitrosourea, which is currently the most

128 such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered

129 nes and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).

130 MT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic signifi

131 on induced by alkylating agents, including 2-chloroethyl-N-nitrosourea-based antitumor drugs.

132 in (SAP) +/- intraperitoneal injection of N-[chloroethyl]-N-ethyl-2-bromobenzylamine (DSP-4) (noradre

133 -nitrobenzyl ester (9) and carbamic acid, (2-chloroethyl)nitroso-2,3,4, 6-tetra-O-acetyl-1-alpha,beta

134 One compound, carbamic acid, (2-chloroethyl)nitroso-4-acetoxybenzyl ester (3), was selec

135 rementioned compound, both carbamic acid, (2-chloroethyl)nitroso-4-nitrobenzyl ester (9) and carbamic

136 Seven new (2-chloroethyl)nitrosocarbamates have been synthesized as p

137 er treatment, a time interval in which bis(2-chloroethyl)nitrosourea (BCNU)-induced chloroethyl adduc

138 ic effects of the antitumor agents 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) and temozolomide were st

139 ismatched-BALB/c model followed by N,N-bis(2-chloroethyl)-nitrosourea (BCNU) treatment to enhance don

140 rstrand cross-linking reaction of N,N'-bis(2-chloroethyl)-nitrosourea (BCNU) were investigated using

141 link induction and cytotoxicity of 1,3-bis(2-chloroethyl)-nitrosourea (BCNU).

142 he 5-member exocyclic ring and are formed by chloroethyl nitrosoureas, which are used in cancer thera

143 ide] into the homobenzylic C-Cl bond of 4-(2-chloroethyl)phenol 1.

144 nt (e.g., t(1/2) (HD) approximately 18 s, (2-chloroethyl phenyl sulfide, C(6)H(5)SCH(2)CH(2)Cl) appro

145 Reactions of alpha-chloroethyl phenyl sulfone (14) and ethyl 2-chloropropio

146 Fmoc-4-(1-chloroethyl)-phenylalanine (5) was synthesized in four s

147 While tris-2-chloroethyl phosphate, tris(1-chloro-2-propyl)phosphate

148 loro-isopropyl) phosphate (TDCIPP) and bis(2-chloroethyl) phosphate (BCEP)-tris(2-chloroethyl) phosph

149 Furthermore, tris (2-chloroethyl) phosphate (TCEP), a known carcinogen, was f

150 ris(2-butoxyethyl) phosphate (TBOEP), tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

151 e analyzed for three halogenated OPs (tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

152 These OPEs include tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

153 or exposure pathway for SigmaTCPP and tris(2-chloroethyl) phosphate (TCEP), while participants had hi

154 d bis(2-chloroethyl) phosphate (BCEP)-tris(2-chloroethyl) phosphate (TCEP).

155 loroisopropyl) phosphate (TCIPP), and tris(2-chloroethyl) phosphate (TCEP).

156 hloro-2-propyl)phosphate (TDCIPP) and tris(2-chloroethyl)phosphate (TCEP).

157 propyl)phosphate (TCPP or TCIPP), and tris(2-chloroethyl)phosphate (TCEP).

158 hosphate (TDCIPP; max: 3150 ng/L) and tris(2-chloroethyl)phosphate (TCEP; max: 8450 ng/L).

159 to 150 pg/m3, and tributyl phosphate, tris(2-chloroethyl)phosphate, tris(1-chloro-2-propyl)phosphate,

160 pha-amino-beta(2-ethyl-N,N,N', N'-tetrakis(2-chloroethyl)phosphorodiamidate)-sulfonyl-propionyl-( R)-

161 ct with DABCO in hot PhCl to give N-{4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene

162 )methanes with DABCO failed to give {4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene

163 n-retrocycloaddition strategies from 4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazole-5-thione

164 gallamine (M2), and 4-4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (4-DAMP mustard; M

165 ) receptor inhibitor, 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (4-DAMP; 10(-5) M)

166 3 receptor antagonist 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride had no effect.

167 Six (2-chloroethyl)porphyrins were synthesized from a common di

168 gave 5-substituted 3-(chloromethyl)- or 3-(2-chloroethyl)pyrazoles.

169 D, bis(2-chlororethyl) sulfide) and a range (chloroethyl) sulfide simulants of variable lipophilicity

170 exposure to the DNA-damaging compound bis-(2-chloroethyl) sulfide.

171 toxic chemical warfare agent mustard (bis(2-chloroethyl)sulfide) in the environment and during its d

172 face or within the droplet core, a range of (chloroethyl) sulfides, including HD, spanning some 7 ord

173 he A1/A2 purinergic receptor blocker 7-(beta-chloroethyl) theophylline (CET; given at 5 x 10-6 M and

174 receptor affinity-enhancing effects of 7-(2-chloroethyl) vs 7-methyl were comparable to the known en

175 ance affinity over hydrogen, except for 7-(2-chloroethyl), which enhanced the affinity of theophyllin