ライフサイエンスコーパス: chlorpromazine

1 using low-dose neuroleptics (haloperidol or chlorpromazine).

2 by the antipsychotic drugs thioridazine and chlorpromazine.

3 high doses of epinephrine, dexamethasone, or chlorpromazine.

4 rom baseline to day 2 for patients receiving chlorpromazine.

5 luoperazine and approximately 120 microM for chlorpromazine.

6 ed pit-mediated trafficking was blocked with chlorpromazine.

7 tamidine, and a phenothiazine antipsychotic, chlorpromazine.

8 by using the clathrin endocytosis inhibitor chlorpromazine.

9 itrophenol and 20 mV for 100 microM cationic chlorpromazine.

10 ibitors, which included the compounds W7 and chlorpromazine.

11 ly, hypoxia blunted the inhibitory action of chlorpromazine.

12 gen, dopamine, ascorbic acid, Fe(3+/2+), and chlorpromazine.

13 K+ and histamine uptake was antagonized with chlorpromazine.

14 ed pesticides, polychlorinated biphenyls and chlorpromazine.

15 total n=949, amisulpride=20, aripiprazole=8, chlorpromazine=13, haloperidol=316, intramuscular olanza

16 ted the kinase activity, but the addition of chlorpromazine, a calmodulin antagonist, blocked its sti

17 -geminin was inhibited at 4 degrees C and by chlorpromazine, a compound that induces misassembly of c

18 Intracellular MDP uptake was inhibited by chlorpromazine, a drug that disrupts clathrin-dependent

19 d discovery of the antipsychotic activity of chlorpromazine, a variety of therapeutic agents have bee

20 6(3+/2+), IrCl6(2-/3-), methyl viologen, and chlorpromazine all involve electron transfer that is ins

21 more effectively than either pentamidine or chlorpromazine alone.

22 W-7 and chlorpromazine also lowered levels of phosphatidylinosit

23 ed temperature or the fusion promoting agent chlorpromazine), an additional set of bands at >150 kDa,

24 e 243 to tyrosine [D243Y]) or by exposure to chlorpromazine, an agent that induces fusion pores in he

25 The cationic amphiphilic drug chlorpromazine, an inhibitor of clathrin-dependent, rece

26 Chlorpromazine, an inhibitor of clathrin-mediated endocy

27 rus entry into beta1+/+ cells was blocked by chlorpromazine, an inhibitor of clathrin-mediated endocy

28 This effect is blocked by chlorpromazine, an inhibitor of the clathrin-mediated en

29 ned the effect of amphipathic ions, cationic chlorpromazine and anionic trinitrophenol, which are tho

30 able antiprion potencies similar to those of chlorpromazine and emphasized the importance of the side

31 Finally, studies using chlorpromazine and endosomal acidification inhibitors re

32 Treatment with chlorpromazine and filipin had opposing effects on HPV31

33 Cholesterol efflux was partially blocked by chlorpromazine and hypertonic media, two inhibitors of c

34 rs of the clathrin-mediated pathway, such as chlorpromazine and hypertonic sucrose medium.

35 Both chlorpromazine and knockdown of clathrin expression by R

36 y by an excess of unlabeled histamine and by chlorpromazine and phenoxybenzamine.

37 l treatments that block endocytosis, namely, chlorpromazine and potassium depletion.

38 s, as shown by use of the clathrin inhibitor chlorpromazine and the dynamin inhibitor Dynasore.

39 ow potency antipsychotic drugs drugs such as chlorpromazine and thioridazine were more strongly assoc

40 The inhibitory effects of chlorpromazine and trans-dominant-negative forms of dyna

41 HF-HP and HF-LP received alpha-blockers (chlorpromazine and/or prazosin).

42 ministration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs.

43 ee xenobiotic compounds: phenobarbital (PB), chlorpromazine, and caffeine.

44 s-flupenthixol, (+)-butaclamol, haloperidol, chlorpromazine, and fluphenazine inhibited constitutive

45 he efficacy and side effects of haloperidol, chlorpromazine, and lorazepam for the treatment of the s

46 ion was markedly reduced by trifluoperazine, chlorpromazine, and naphthalene sulfonamide (W7).

47 increase but could fuse upon the addition of chlorpromazine; and 3) at the point of the intermediate,

48 mbination of domperidone, dexamethasona, and chlorpromazine at night controlled toxicity in most pati

49 ative of chlorpromazine, we demonstrate that chlorpromazine binding at the beta8-beta9 loop is respon

50 , we determine the molecular determinants of chlorpromazine binding in the Erwinia ligand-gated ion c

51 bition of clathrin-mediated endocytosis with chlorpromazine blunted NKCC2 endocytosis by 54 +/- 6%, w

52 promazine, which is structurally similar to chlorpromazine but lacking both D2-effects and antipsych

53 ll gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and r

54 s half-maximally inhibited by 0.1 millimolar chlorpromazine, by 35 nanomolar K-252a and by 7 nanomola

55 ological and functional effects of four APs: chlorpromazine (CLP), haloperidol (HAL), risperidone (RI

56 ntagonist to full agonist by the addition of chlorpromazine (CPZ) and other cationic membrane-active

57 em using the well-known peroxidase substrate chlorpromazine (CPZ) and the hydrazine derivative isonia

58 novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RG

59 ) in 1 M KCl, Fe(CN)6(3-/4-) in 1 M KCl, and chlorpromazine (CPZ) in 10 mM HClO4.

60 stem was used to characterize the effects of chlorpromazine (CPZ) on the mechanical properties of the

61 Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years

62 Chlorpromazine (CPZ), a potent nicotinic acetylcholine r

63 cs and thermodynamics for the interaction of chlorpromazine (CPZ), an antipsychotic drug used in the

64 amphipathic compounds including salicylate, chlorpromazine (CPZ), and trinitrophenol (TNP).

65 We show that chlorpromazine (CPZ)-induced repression of pol III trans

66 Finally, chlorpromazine, dibucaine, and trifluoperazine, agents t

67 pramine treatment and the antipsychotic drug chlorpromazine does not alter Gsalpha.

68 between studies with low compared with high chlorpromazine equivalent daily dose.

69 IQ difference from comparison subjects, and chlorpromazine equivalent daily dose.

70 uding publication year; severity of illness; chlorpromazine equivalent daily dose; and mean IQ, mean

71 as a trend-level predicter, with each 100-mg chlorpromazine equivalent unit increase in dose associat

72 The patients' median dose was 68.4 mg/day of chlorpromazine equivalent.

73 They were compared in terms of total chlorpromazine-equivalent daily dose, changes in total d

74 The total discharge dose in chlorpromazine equivalents for the 349 patients for whom

75 daily neuroleptic dose higher than 200 mg of chlorpromazine equivalents.

76 differential network analyses on cerulenin, chlorpromazine, ethionamide, ofloxacin, thiolactomycin a

77 In general, the conventional drugs, such as chlorpromazine, fluphenazine and pimozide, were more tox

78 For Ru(NH3)6(3+/2+), Fe(CN)6(3-/4-), and chlorpromazine, fresh PPF surfaces show electron-transfe

79 B activity is inhibited by trifluoperazine > chlorpromazine > clozapine.

80 affinity, with a rank order of haloperidol > chlorpromazine > domperidone > (+)-butaclamol > (-)-sulp

81 A combination of valproate and chlorpromazine had proven effective in managing most of

82 enzhexol, tetrabenazine, pimozide, baclofen, chlorpromazine, haloperidol, carbamazepine and acetozola

83 their antipsychotic treatment (thioridazine, chlorpromazine, haloperidol, trifluoperazine, or risperi

84 Because quinacrine and chlorpromazine have been used in humans for many years a

85 V-8 open reading frame 73 gene expression by chlorpromazine HCl, bafilomycin A, and NH(4)Cl demonstra

86 tly inhibited by preincubation of cells with chlorpromazine HCl, which blocks endocytosis via clathri

87 onventional antipsychotics (eg, haloperidol, chlorpromazine hydrochloride), with the use of a retrosp

88 o-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition approximately 40-fold

89 a model where dual action of pentamidine and chlorpromazine in mitosis results in synergistic antitum

90 Treatment with either haloperidol or chlorpromazine in relatively low doses resulted in signi

91 antipsychotic drugs, such as haloperidol and chlorpromazine, increase synthesis of the neuropeptide n

92 Chlorpromazine inhibition of DOP-4 in the nervous system

93 Chlorpromazine initiated effective pharmacotherapy for s

94 Chlorpromazine is a potent and specific inhibitor of the

95 The antipsychotic compound chlorpromazine is a widely used tool to probe the ion ch

96 Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Sl

97 Dynamin inhibitors, chlorpromazine, methyl-beta-cyclodextrin, chloroquine, a

98 Unexpectedly, we do not find a chlorpromazine molecule in the channel pore of ELIC, but

99 gned to treatment with haloperidol (N = 11), chlorpromazine (N = 13), or lorazepam (N = 6).

100 ective cumulative doses (gram equivalents of chlorpromazine) of more than 5 g, 5 to 99 g, and 100 g o

101 ion is restored by the lipophilic amphiphile chlorpromazine or by the phospholipase C inhibitor U7312

102 y crystal structures of ELIC in complex with chlorpromazine or its brominated derivative bromopromazi

103 he same effect was observed upon addition of chlorpromazine or sodium deoxycholate at concentrations

104 , 12-myristate 13-acetate phorbol (PMA), W7, chlorpromazine, or the intracellular Ca+2 chelator BAPTA

105 ibody to integrin alphaVbeta3 (P=0.027), and chlorpromazine (P=0.027).

106 The pharmacologic inhibitors chlorpromazine, phorbol 12-myristate 13-acetate, and cyt

107 mg/day of olanzapine alone or 1200 mg/day of chlorpromazine plus 4 mg/day of benztropine mesylate.

108 pare the efficacy of olanzapine with that of chlorpromazine plus benztropine in patients with treatme

109 C for 1 h) with phenothiazine neuroleptics (chlorpromazine & promethazine) as additive neuroprotecta

110 luding haloperidol, clozapine, aripiprazole, chlorpromazine, quetiapine, olanzapine, risperidone, and

111 d cells with the membrane-destabilizing drug chlorpromazine rescued the hemifusion block and allowed

112 1-naphthalenesulfonamide, phenothiazine, and chlorpromazine, resulted in rapid apoptotic cell death i

113 Olanzapine and chlorpromazine showed similar efficacy, and the total am

114 -5-chloro-1-naphthalenesulfonamide (W-7) and chlorpromazine significantly lowered all higher inositol

115 ic effects are inhibited by nystatin but not chlorpromazine, suggesting an involvement of caveolar-me

116 Pharmacologic therapy with chlorpromazine terminated the respiratory flutter and pe

117 l (to mimic cell swelling) or the cup former chlorpromazine (to mimic cell shrinkage) caused robust a

118 responded according to a priori criteria; no chlorpromazine-treated patients responded.

119 tor and cardiovascular side effects than the chlorpromazine-treated patients.

120 treated patients had fewer side effects than chlorpromazine-treated patients.

121 ve found that the commonly used neuroleptics chlorpromazine, trifluoperazine and clozapine inhibit PP

122 ion of certain cationic amphiphiles, such as chlorpromazine, trifluoperazine, and imipramine, which m

123 d higher incidence of tardive dyskinesia for chlorpromazine versus clozapine (risk differences, 5% an

124 idence showed no difference in mortality for chlorpromazine verus clozapine or haloperidol versus ari

125 The EC(50) for chlorpromazine was 3 microM, whereas quinacrine was 10 t

126 Treatment with haloperidol or chlorpromazine was associated with an extremely low prev

127 tory tests were performed in a rodent model, chlorpromazine was found to reduce the progression of ca

128 e mutants and a thiol-reactive derivative of chlorpromazine, we demonstrate that chlorpromazine bindi

129 o detect a short-lived radical metabolite of chlorpromazine which is too unstable to be detected usin

130 e effect of hypotonic stress was mimicked by chlorpromazine, which is known to cause membrane deforma

131 showed concentration-dependent inhibition by chlorpromazine, which, among other actions, blocks clath