ライフサイエンスコーパス: chlorzoxazone

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1 the CYP2E1 enzyme affinity for the substrate chlorzoxazone.

2 rat microsomes at varying concentrations of chlorzoxazone.

3 ed the ability to stimulate CYP2E1-catalyzed chlorzoxazone 6-hydroxylation.

4 rm-selective substrates and inhibitors, only chlorzoxazone, a cytochrome P-450 2E1 (CYP2E1) substrate

5 of 4-AP was comparable, and not additive, to chlorzoxazone, an activator of Ca(2+)-dependent K(+) cha

6 ndicated by the increased production of 6-OH-chlorzoxazone and by glutathione depletion after incubat

7 al NOS oxygenase domains cocrystallized with chlorzoxazone and four nitroindazoles: 5-nitroindazole,

8 Chlorzoxazone and mephenytoin metabolism correlated with

9 cs of a cytochrome P450 (CYP2E1) probe drug, chlorzoxazone, and to investigate the mechanism of these

10 ssessed using the oral clearance (CL(PO)) of chlorzoxazone (CHZ) in 20 NDN and 17 age, gender, and bo

11 d to measure the in vivo CYP3A activity, and chlorzoxazone (CHZ) oral clearance was used to assess in

12 f Ca(2+)-dependent K(+) channels, 1-EBIO and chlorzoxazone (CHZ).

13 Drug Administration (FDA)-approved compound, chlorzoxazone (CHZ).

14 ssessed by determination of the clearance of chlorzoxazone (CLZ), an in vivo CYP2E1-selective probe.

15 sing the probe drugs mephenytoin (CYP-2C19), chlorzoxazone (CYP-2E1), dapsone (multiple CYP enzymes),

16 In the case of chlorzoxazone, elimination was essentially unchanged.

17 was estimated by the fractional excretion of chlorzoxazone (fe(6-OH)) for 50 cases of BP and 50 contr

18 lot analysis, and rates of p-nitrophenol and chlorzoxazone hydroxylation were elevated 3- to 4-fold i

19 Rates of p-nitrophenol and chlorzoxazone hydroxylation were elevated approximately

20 a markedly reduces the systemic clearance of chlorzoxazone in cardiac arrest rats.

21 ncreased during postinjury recovery, whereas chlorzoxazone metabolism was suppressed to a lesser degr

22 The lowest energy docked configurations of chlorzoxazone, p-nitrophenol, and N-nitrosodimethylamine

23 Autodock was used to dock chlorzoxazone, p-nitrophenol, N-nitrosodimethylamine, ac

24 No changes in chlorzoxazone protein binding were observed at 37 degree

25 The binding of chlorzoxazone to iNOS and human and rat liver microsomal

26 Although the binding of chlorzoxazone to iNOS and its inhibition of iNOS activit

27 e (HCZ), the metabolite of the CYP2E1 probe, chlorzoxazone, under negative API.

28 Chlorzoxazone was administered as an intravenous bolus,

29 Chlorzoxazone was not a substrate for iNOS but was a pot

30 systemic clearance of the CYP2E1 substrate, chlorzoxazone, when compared with normothermia after car

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