ライフサイエンスコーパス: cholesterol

1 s examples of trans-mediators (TAGAP for LDL cholesterol).

2 lyceridemia and low high-density lipoprotein cholesterol.

3 and involved in intracellular trafficking of cholesterol.

4 e F-derived peptides and conjugating them to cholesterol.

5 cted QT interval or high-density lipoprotein-cholesterol.

6 known to be associated with increased serum cholesterol.

7 ompartment (ERC) are both highly enriched in cholesterol.

8 volving nucleophilic attack by a molecule of cholesterol.

9 . smegmatis, which mediates the transport of cholesterol.

10 o a greater effect on HbA1c, weight, and LDL cholesterol.

11 egy to help manage total cholesterol and LDL cholesterol.

12 synthesis and intracellular accumulation of cholesterol.

13 2-2.17), MI (OR 1.58, 95% CI 1.06-2.35), LDL-cholesterol (0.21 standard deviations, 95% CI 0.01-0.4),

14 standard deviations, 95% CI 0.01-0.4), total cholesterol (0.21 standard deviations, 95% CI 0.03-0.38)

15 arotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple compari

16 'western diet' (WD) high in fat (45% kcal), cholesterol (1% w/w) and sucrose (15% kcal).

17 lycerides (reductions of 33.2 to 63.1%), LDL cholesterol (1.3 to 32.9%), very-low-density lipoprotein

18 and borderline low high-density lipoprotein cholesterol (1.4 [1.0-1.8]) remained significant predict

19 1.6 [1.2-2.2]), high low-density lipoprotein cholesterol (1.6 [1.1-2.1]), and borderline low high-den

20 0]), borderline high low-density lipoprotein cholesterol (1.6 [1.2-2.2]), high low-density lipoprotei

21 27.9 to 60.0%), non-high-density lipoprotein cholesterol (10.0 to 36.6%), apolipoprotein B (3.4 to 25

22 vated blood pressure, 40.98% for reduced HDL-cholesterol, 23.33% for elevated triglycerides, 18.95% f

23 ighest increase (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.

24 Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in respon

25 (1.3 to 32.9%), very-low-density lipoprotein cholesterol (27.9 to 60.0%), non-high-density lipoprotei

26 vels of bile acid synthesis genes, including cholesterol 7alpha-hydroxylase (Cyp7a1).

27 ced by PX20606 was independent of changes in cholesterol absorption.

28 n induces a paradoxical response, increasing cholesterol accumulation (but not lipofuscin) via upregu

29 holesterol challenges induce massive hepatic cholesterol accumulation and damage, which is rescued by

30 capacity of glucolipotoxicity to induce free cholesterol accumulation in human pancreatic islets and

31 y providing an inhibitor that overrides this cholesterol activation.

32 Using cholesterol analogues with a diazirine in either the 7 p

33 nteractions between an exchangeable mimic of cholesterol and an exchangeable mimic of a low-melting p

34 ssessed changes in HbA1c, triglycerides, HDL cholesterol and BMI in a mixed effects longitudinal anal

35 ee fatty acid (FFA) content and release, and cholesterol and cholesterol esters increased linearly up

36 (chol) and HSV(des) were similar, suggesting cholesterol and desmosterol in the HSV envelope support

37 protein Rv3723/LucA, functions to integrate cholesterol and fatty acid uptake in Mtb.

38 inside its host cell is heavily dependent on cholesterol and fatty acids.

39 simple dietary strategy to help manage total cholesterol and LDL cholesterol.

40 s extracellular virions (HSV(des)) that lack cholesterol and likely contain desmosterol.

41 e available through day 210, and data on LDL cholesterol and proprotein convertase subtilisin-kexin t

42 The balance between cholesterol and sphingolipids within the plasma membrane

43 The serum and liver cholesterol and TAG levels in rats fed with 1,3-DAG-rich

44 d the effect of free sugars on total and LDL cholesterol and triacylglycerols.

45 Further analyses revealed that cholesterol and triglyceride levels had decreased by 37%

46 etes) and an unfavorable profile (higher LDL cholesterol and triglycerides).Choline and its metabolit

47 ced CSLC only were found to target genes for cholesterol and unsaturated fatty acid synthesis.

48 score and lower serum total cholesterol, LDL cholesterol, and albumin concentrations.

49 imester serum levels of triglycerides, total cholesterol, and C-reactive protein (CRP).

50 f high-density lipoprotein (HDL) and non-HDL cholesterol, and extended to stroke and myocardial infar

51 and catabolism of lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cell

52 n ages 6 and 24 years) of systolic BP, total-cholesterol, and smoking associated inversely with midli

53 olic blood pressure, MCM6 and DARS for total cholesterol, and TRIB1 for triglycerides) that were caus

54 e to lower levels of low-density lipoprotein cholesterol are not associated with neurocognitive effec

55 le C57BL/6J mice were fed with either a high-cholesterol atherogenic diet (HCD) or matching normal di

56 SIDT1 and SIDT2 share identity and conserved cholesterol binding (CRAC) domains with C. elegans ChUP-

57 t domains, whereas M2, although containing a cholesterol binding motif, is not raft associated.

58 it has been unclear whether PFO* and related cholesterol-binding proteins bind uniformly to the plasm

59 e cell membrane to alter the localization of cholesterol-binding proteins, and prevented the associat

60 Cataloguing cholesterol-binding sites is a vital step in the effort

61 used to identify two, to our knowledge, new cholesterol-binding sites on the A2A adenosine receptor,

62 y secondary to inappropriate derepression of cholesterol biosynthesis.

63 l proliferation, leukocyte extravasation and cholesterol biosynthesis.

64 ion (but not lipofuscin) via upregulation of cholesterol biosynthesis.

65 etic deletion, potentiates the expression of cholesterol biosynthetic genes and increases cholesterol

66 roduction of isoprenoid intermediates in the cholesterol biosynthetic pathway, the post-translational

67 ate existing clinical practice guidelines on cholesterol, blood pressure, and overweight/obesity.

68 oprotein, and high-density lipoprotein (HDL) cholesterol, but not in the total-to-HDL cholesterol rat

69 espond rapidly to small declines in cellular cholesterol by activating SREBPs, increasing cholesterol

70 alyzed under the combined effect of SP-C and cholesterol by deuterium NMR and phosphorus NMR and by e

71 Cholesterol can be deleterious for LS function, a condit

72 High hepatic cholesterol causes non-alcoholic steatohepatitis (NASH)

73 In Nrf1 deficiency, in vivo cholesterol challenges induce massive hepatic cholestero

74 Pravastatin lowered low-density lipoprotein cholesterol (change in SD units [95% confidence interval

75 ce interval]: -1.01 [-1.14, -0.88]), remnant cholesterol (change in SD units [95% confidence interval

76 presence of acidic lipids and is enhanced by cholesterol (Chol).

77 transporter that have been shown to bind to cholesterol/CHS in Drosophila melanogaster dopamine tran

78 l clearance in macrophages, identify reduced cholesterol clearance as the primary macrophage defect d

79 ults demonstrate that GM-CSF is required for cholesterol clearance in macrophages, identify reduced c

80 sma total cholesterol, triglycerides and LDL cholesterol comparable to oral ATV.

81 ime-weighted average low-density lipoprotein cholesterol compared with placebo/simvastatin, irrespect

82 This M2-cholesterol complex structure, together with previously

83 The main differences in composition (higher cholesterol concentration and increased tail unsaturatio

84 s, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering the

85 relationship between progressively lower LDL-cholesterol concentrations achieved at 4 weeks and clini

86 LDL-cholesterol concentrations after the cheese diet were lo

87 del, and (iii) agreement of predictions with cholesterol concentrations in high- and low-density lipo

88 rdiovascular risk factors, and fasting total cholesterol concentrations of 6.5 mmol/L or lower, and w

89 re were no safety concerns with very low LDL-cholesterol concentrations over a median of 2.2 years.

90 se (CVD) context and low density lipoprotein-cholesterol concentrations within a saturated fat and CV

91 ted with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary athero

92 patocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together res

93 nockdown also resulted in increased cellular cholesterol, consistent with APOE's role in regulating c

94 f CYP2E1 in promoting liver fibrosis by high cholesterol-containing fast-food (FF).

95 zymatic product of CYP27A1, reduced cellular cholesterol content in prostate cancer cell lines by inh

96 ly overlooked therapeutic consideration: the cholesterol content of the treated cell determines which

97 es in lipid composition, particularly in the cholesterol content of very-low-density lipoproteinparti

98 Elevated cholesterol content within pancreatic beta-cells has bee

99 ) fibroblasts, which lack the desmosterol-to-cholesterol conversion enzyme, resulted in the generatio

100 MI, HDL cholesterol, low-density lipoprotein cholesterol, coronary artery disease, C-reactive protein

101 insulin-like growth factor I, triglycerides, cholesterol, cortisol, and leptin, were measured after a

102 Cholesterol crystals (CC) are abundant in atheroscleroti

103 sponses in total and low-density lipoprotein cholesterol (decreased in LFHC group only), and high-den

104 Cholesterol-dependent cytolysins (CDCs) represent a fami

105 is a vital step in the effort to understand cholesterol-dependent function of membrane proteins.

106 nel but also mediates membrane scission in a cholesterol-dependent manner to cause virus budding and

107 Ch25h deficiency results in cholesterol-dependent reduced mitochondrial respiratory

108 In cholesterol depleted membranes, PmB forms clusters on th

109 We propose a mechanism in which cholesterol depletion triggers a signaling cascade, culm

110 5-HT2C agonist, (-)-enduracididine and azido-cholesterol derivatives demonstrate broad applications o

111 membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoprote

112 fat diet (HFD) and moderately high fat plus cholesterol diet (HFC)-on wildtype (WT) and liver-specif

113 duced in response to LXR activation and high-cholesterol diet feeding.

114 Here we show that in rats on a high-cholesterol diet, cholesterol levels in hippocampal neur

115 arkedly increased the susceptibility to high cholesterol diet-induced liver injury and abolished the

116 B5 binding to GM1 in vesicles, suggests that cholesterol does not "mask" GM1, at least not in NDs.

117 addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene ex

118 (4D Study), we investigated whether the HDL cholesterol efflux capacity is predictive for cardiovasc

119 h, we also revealed that M2 polarization and cholesterol efflux do not necessarily represent inter-de

120 and function, vascular tone in aortic rings, cholesterol efflux from macrophages, and expression of S

121 In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely as

122 PE cells that TSPO specific ligands promoted cholesterol efflux to acceptor (apo)lipoprotein and huma

123 l, consistent with APOE's role in regulating cholesterol efflux.

124 rum, while loss of TSPO resulted in impaired cholesterol efflux.

125 phage-like SMCs in the lesions, and impaired cholesterol efflux.

126 The cholesterol efflux/apoA-1 ratio was inversely associated

127 oreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher

128 the APOE4 allele associated with greater LDL-cholesterol elevation in response to saturated fatty aci

129 We show that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC

130 ditis elegans encodes an ortholog of neutral cholesterol ester hydrolase 1 (NCEH-1), an IIS downstrea

131 The cholesterol esterification fraction is a valid biomarker

132 erlapping cases)].Baseline concentrations of cholesterol esters (CEs) were inversely associated with

133 FA) content and release, and cholesterol and cholesterol esters increased linearly up to 25 mm glucos

134 athway, to which biliary and transintestinal cholesterol excretion (TICE) contribute.

135 t has been shown to bind to NPC1 and inhibit cholesterol export.

136 plexes also support transport of LDL-derived cholesterol from endosomes to the endoplasmic reticulum,

137 However, in contrast to cholesterol functions, little is still known about the r

138 t smoking, hypertension, diabetes, and total cholesterol >/=200 mg/dL) were evaluated in multivariabl

139 esterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were either directly measured or cal

140 l cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol

141 h triglycerides and high-density lipoprotein cholesterol (HDL-C; cg27243685; P=8.1E-26 and 9.3E-19) w

142 riglycerides [TGs], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol

143 re on the postintervention values of TC, LDL cholesterol, HDL cholesterol, TC:HDL cholesterol, trigly

144 , systolic and diastolic blood pressure, LDL cholesterol, HDL cholesterol, total cholesterol, triglyc

145 at least 1 of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol,

146 rofile [lower high-density lipoprotein (HDL) cholesterol, higher total homocysteine, and higher body

147 role of the intestine in the maintenance of cholesterol homeostasis increasingly is recognized.

148 ctions, including autophagosome degradation, cholesterol homeostasis, antigen presentation, and cell

149 accumulation defects in cells with disrupted cholesterol homeostasis.

150 e (AUC8-72) values, an indicator of neuronal cholesterol homoeostasis, were significantly higher than

151 o results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active

152 In conclusion, LAT1 is modulated by cholesterol impacting on its stability and transporter a

153 e with an ion trap mass spectrometer, native cholesterol in its free alcohol form is readily detected

154 We blocked intestinal absorption of cholesterol in milk fed to newborn mice by supplementing

155 al disorder, hypertension, obesity, and high cholesterol in parents and those same conditions in thei

156 e (0-5 mM, 2.72 x 10(-6) A.mM(-1)) and total cholesterol in serum from 0 to 9 mM (1.34 x 10(-8) A.mM(

157 Spectral titrations with cholesterol, in the presence of EFV or l-Glu, suggest th

158 HC group only), and high-density lipoprotein cholesterol (increased in VHFLC group only).

159 ng the intermolecular forces in the way that cholesterol interacts with sphingolipids promotes the sy

160 We propose cholesterol interacts with the conserved regions in the

161 ile salt pool stimulated robust secretion of cholesterol into the intestinal lumen via the sterol-exp

162 Some genetic evidence suggests that HDL-cholesterol is a causal risk factor for AMD risk and tha

163 DMPC/Cholesterol samples with 13 and 25 mol% cholesterol is a linear function of the heat capacity me

164 Cholesterol is an important risk factor of atheroscleros

165 Furthermore, when mTORC1 activity is low, cholesterol is delivered to lysosomes through two membra

166 cholesterol reduction, suggesting that cell cholesterol is important for the HSV-1 replicative cycle

167 Fecal excretion of cholesterol is the last step in the atheroprotective rev

168 In resting T cells cholesterol keeps TCRs in the resting conformation that

169 Serum low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholest

170 ersistently elevated low-density lipoprotein cholesterol (LDL-C) levels despite use of statins.

171 TP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascul

172 of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events.

173 ificant reduction in low density lipoprotein-cholesterol (LDL-C), an increase in CEC and beneficial c

174 cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG).

175 sterol, particularly low-density lipoprotein cholesterol (LDL-C), is frequently seen in obese women.

176 the levels of plasma low-density lipoprotein cholesterol (LDL-C).

177 cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC]) were studie

178 Low-density lipoprotein cholesterol(LDL-C) is a well established metabolic marke

179 lobal assessment score and lower serum total cholesterol, LDL cholesterol, and albumin concentrations

180 nd point was the change from baseline in LDL cholesterol level at 180 days.

181 shows a significant spillover effect of the cholesterol level check on the blood pressure check and

182 not vary by patient low-density lipoprotein cholesterol level nor statin use.

183 er protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotei

184 ed in significant reductions in plasma total cholesterol levels and suppression of diet-induced weigh

185 Pcsk9 is reduced to undetectable levels, and cholesterol levels are significantly lowered about 35% t

186 cholesterol biosynthetic genes and increases cholesterol levels both in liver and plasma.

187 how that in rats on a high-cholesterol diet, cholesterol levels in hippocampal neurons are increased.

188 t PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.

189 n a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0

190 80, the least-squares mean reductions in LDL cholesterol levels were 27.9 to 41.9% after a single dos

191 ty index, fasting insulin, triglycerides and cholesterol levels were all significantly higher in LG-I

192 transport allows ER to constantly monitor PM cholesterol levels, and respond rapidly to small decline

193 identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), hi

194 d dose-dependent reductions in PCSK9 and LDL cholesterol levels.

195 or, weight gain, and higher triglyceride and cholesterol levels.

196 and increases high-density lipoprotein (HDL) cholesterol levels.

197 significantly attenuated the lowering of LDL cholesterol levels.

198 cardiovascular disease who had elevated LDL cholesterol levels.

199 levels correlated directly with circulating cholesterol levels.

200 erol without altering PM or overall cellular cholesterol levels; (2) demonstrate that LDL-derived cho

201 s reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected an

202 and abolished the protective effect against cholesterol lipotoxicity in Sort1 knock-out mice.

203 es and polygenic profile scores for BMI, HDL cholesterol, low-density lipoprotein cholesterol, corona

204 diometabolic risk-factor profile (higher HDL cholesterol, lower BMI, lower C-reactive protein, lower

205 nd 6 months after treatment with probucol, a cholesterol-lowering agent.

206 Purpose Cholesterol-lowering medication (CLM) has been reported

207 It has also been suggested that the cholesterol-lowering potential of KJM may be greater tha

208 dl, glycosylated hemoglobin <5.7%, and total cholesterol <200 mg/dl.

209 use, lipid control (low-density lipoprotein cholesterol <70 mg/dL or statin therapy), blood pressure

210 luding patients with low-density lipoprotein cholesterol <70 mg/dl.

211 The 2013 cholesterol management guidelines from the American Coll

212 The amount of the cholesterol measured by this paper-loaded DART mass spec

213 information from repeated blood pressure and cholesterol measurements to predict cardiovascular disea

214 alization at phase boundaries, suggests that cholesterol mediates M2 clustering to the neck of the bu

215 may offer a novel and safe means of managing cholesterol metabolism and diet induced dyslipidaemia, a

216 mechanistic connection between AIBP-mediated cholesterol metabolism and Notch signaling, implicating

217 enes and activation of genes associated with cholesterol metabolism and the p53 pathway in CDK19 knoc

218 AT activation and highlight the relevance of cholesterol metabolism by the host for diet-induced chan

219 ation studies (GWAS) as a novel regulator of cholesterol metabolism in humans.

220 o 27-hydroxycholesterol (27OHC), an oxidized cholesterol metabolite associated with neurodegeneration

221 quantities characterizing pure DMPC and DMPC/cholesterol mixtures, thus directly confirming the theor

222 zation of asymmetric, chemically stabilized, cholesterol-modified siRNAs (sd-rxRNAs((R))) that effici

223 l travels from lysosomes first to PM to meet cholesterol needs, and subsequently from PM to regulator

224 =3 wk that assessed the effect of KJM on LDL cholesterol, non-HDL cholesterol, or apolipoprotein B.

225 mic-resolution insight into the influence of cholesterol on oxygen diffusion across and within the me

226 When liposomes poor in sphingomyelin/cholesterol or mimicking the lipid composition of the mi

227 r between groups for changes in total or HDL cholesterol or triglycerides.

228 he effect of KJM on LDL cholesterol, non-HDL cholesterol, or apolipoprotein B.

229 ed by shielding its heptahelical domain from cholesterol, or by providing an inhibitor that overrides

230 ies but not with higher blood glucose, serum cholesterol, or serum homocysteine levels.

231 cholesterol, high-density lipoprotein (HDL) cholesterol, or triglycerides at a genome-wide level of

232 factor for AMD risk and that increasing HDL-cholesterol (particularly via CETP inhibition) will incr

233 Elevated cholesterol, particularly low-density lipoprotein choles

234 content of the treated cell determines which cholesterol pathways, either beneficial or harmful, are

235 of lipid nanodomains, which are enriched in cholesterol, phosphatidylinositol 4,5-bisphosphate, and

236 These findings establish that cholesterol plays a critical role in modulating GIRK act

237 Additionally, phospholipids and cholesterol preferentially accumulated in diseased skin

238 ering of non-HDL-C (high-density lipoprotein cholesterol), rather than increases in HDL-C.

239 heart rate, HbA1c, blood glucose, LDL-to-HDL cholesterol ratio, C-reactive protein, angiotensin II, a

240 ge from baseline in total cholesterol to HDL-cholesterol ratio.

241 DL) cholesterol, but not in the total-to-HDL cholesterol ratio.

242 LWYIK/R(683) sequence, proposed to embody a "cholesterol recognition/interaction amino acid consensus

243 er characterised by substantially raised LDL cholesterol, reduced LDL receptor function, xanthomas, a

244 In our simulations, cholesterol reduces the overall solubility of oxygen wit

245 statin treatment for low-density lipoprotein cholesterol reduction in children with HeFH.

246 the nuclear periphery was unaffected by the cholesterol reduction, suggesting that cell cholesterol

247 Moreover, 70% of the variation in cholesterol regulation was dependent on the hydrophobici

248 ad decreased lipogenesis mediated by hepatic cholesterol responsive element-binding protein and featu

249 activation by cholesterol through conserved cholesterol-responsive motifs.

250 olling the TFH-germinal center response to a cholesterol-rich diet and uncover a PDL1-dependent mecha

251 and NP have been shown to be concentrated in cholesterol-rich membrane raft domains, whereas M2, alth

252 ts increased affinity for, and retention in, cholesterol-rich membranes.

253 olume expansion coefficient of DMPC and DMPC/Cholesterol samples with 13 and 25 mol% cholesterol is a

254 his conformational change helps transmit the cholesterol signal from loop 1 to loop 7, thereby allowi

255 Decreasing host cell cholesterol significantly reduced pathogen internalizati

256 ganelles, we determined that anionic lipids, cholesterol, sphingomyelin, and membrane fluidity play c

257 Perturbing the cholesterol/sphingomyelin balance was shown to induce na

258 features could be related to the respective cholesterol/sphingomyelin molar ratio in the three milk

259 Here, we show that cholesterol sulfate, a molecule present in relatively hi

260 3) ionoregulation and fluid balance, and (4) cholesterol synthesis and homeostasis.

261 mic reticulum membrane proteins that inhibit cholesterol synthesis by mediating sterol-induced ubiqui

262 As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood me

263 and facilitating the feedback inhibition of cholesterol synthesis.

264 fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (

265 nsity lipoprotein cholesterol [LDL-C], total cholesterol [TC]) were studied as continuous variables,

266 ervention values of TC, LDL cholesterol, HDL cholesterol, TC:HDL cholesterol, triglycerides, SBP, and

267 LC38A9, is required for mTORC1 activation by cholesterol through conserved cholesterol-responsive mot

268 Addition of excess cholesterol to a high-fat/high-sucrose diet produced gre

269 ipose tissue (BAT) and hepatic conversion of cholesterol to bile acids via the alternative synthesis

270 two groups in change from baseline in total cholesterol to HDL-cholesterol ratio.

271 d functions in transporting lipids including cholesterol to support neuronal homeostasis and synaptic

272 astolic blood pressure, LDL cholesterol, HDL cholesterol, total cholesterol, triglycerides, and fasti

273 ; and (3) determine that continuous PM-to-ER cholesterol transport allows ER to constantly monitor PM

274 To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting

275 ipoprotein E (apoE) plays a critical role in cholesterol transport in both peripheral circulation and

276 he last step in the atheroprotective reverse cholesterol transport pathway, to which biliary and tran

277 dentify a novel role for MC1-R in macrophage cholesterol transport.

278 not transport RNA, but they are involved in cholesterol transport.

279 associated with cis-expression of a reverse cholesterol transporter (ABCG1; P=7.2E-28) and incident

280 rol levels; (2) demonstrate that LDL-derived cholesterol travels from lysosomes first to PM to meet c

281 bited a significant decrease in plasma total cholesterol, triglycerides and LDL cholesterol comparabl

282 r directly measured or calculated from total cholesterol, triglycerides, and apoA-I.

283 ure, LDL cholesterol, HDL cholesterol, total cholesterol, triglycerides, and fasting blood glucose) a

284 pressure, low-density lipoprotein- and total cholesterol, triglycerides, fasting glucose, body mass i

285 TC, LDL cholesterol, HDL cholesterol, TC:HDL cholesterol, triglycerides, SBP, and DBP; calculated ove

286 stress causes significant increases in both cholesterol uptake and intracellular accumulation of the

287 cholesterol by activating SREBPs, increasing cholesterol uptake and synthesis.

288 ER to suppress activation of SREBPs, halting cholesterol uptake and synthesis; and (3) determine that

289 levels of albumin, calcium, iron, ferritin, cholesterol, vitamin B-6, and vitamin D (data collected

290 s (concentration of high-density lipoprotein cholesterol, vitamin D and C-reactive protein, and less

291 cibility of milk sphingomyelin (milk-SM) and cholesterol was investigated in this study.

292 When host cell cholesterol was substituted with various sterols, only d

293 ine (PC), phosphatidylethanolamine (PE), and cholesterol were created by extrusion.

294 Reductions in the levels of PCSK9 and LDL cholesterol were maintained at day 180 for doses of 300

295 ing, red meat consumption, saturated fat and cholesterol were significant risk factors across ethnic/

296 thesis (particularly FFA, triglycerides, and cholesterol), whereas glycogen production was comparativ

297 n ternary GUVs of dioleoyl-PC/dipalmitoyl-PC/cholesterol, whereas 16 carbons increase Tmix again.

298 crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre

299 The atomic interaction of cholesterol with M2, as with most eukaryotic membrane pr

300 Using ALOD4, we: (1) deplete ER cholesterol without altering PM or overall cellular chol