ライフサイエンスコーパス: cholesterol acyltransferase

1 DGAT1 gene family (i.e. related to acyl-CoA:cholesterol acyltransferases).

2 ribute to the optimum activation of lecithin:cholesterol acyltransferase.

3 he intracellular esterifying enzyme acyl-CoA:cholesterol acyltransferase.

4 viously characterized antagonist of acyl-CoA cholesterol acyltransferase.

5 aining particles by incubation with lecithin:cholesterol acyltransferase.

6 f cholesterol 7alpha-hydroxylase or acyl-CoA:cholesterol acyltransferase.

7 Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein

8 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular

9 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endo

10 Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a resident enzy

11 The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol es

12 Human acyl-coenzyme A:cholesterol acyltransferase 1 (hACAT1) esterifies choles

13 Acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2) co

14 pression of Niemann Pick C1 Like 1, Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceri

15 ecimens and cell lines, mediated by acyl-CoA cholesterol acyltransferase-1 (ACAT-1) enzyme.

16 In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), an enzyme in the

17 idic acid acyltransferase (LAT), or acyl-CoA cholesterol acyltransferase 2 (ACAT-2).

18 Targeted deletion of acyl-CoA:cholesterol acyltransferase 2 (ACAT2) (A2), especially i

19 Deficiency of acyl CoA:cholesterol acyltransferase 2 (ACAT2) in mice results in

20 The role of liver acyl-CoA:cholesterol acyltransferase 2 (ACAT2), earlier shown to

21 ryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase 2 in infected cells.

22 is 32% identical to the vertebrate lecithin:cholesterol acyltransferase, a secreted phospholipase.

23 Acyl coenzyme A:cholesterol acyltransferase (ACAT) (EC 2.3.1.26) is an e

24 Acyl CoA:cholesterol acyltransferase (ACAT) 2 is the major choles

25 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in the intes

26 efflux to apoA-I was independent of acyl-CoA:cholesterol acyltransferase (ACAT) activity.

27 r cholesterol esterification enzyme acyl-CoA:cholesterol acyltransferase (ACAT) are present in the no

28 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes intracellul

29 Acyl-COA:cholesterol acyltransferase (ACAT) converts cholesterol

30 e of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal

31 The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholestero

32 thophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much at

33 Inhibitors of acyl CoA:cholesterol acyltransferase (ACAT) have attracted consid

34 The rationale was that the acyl-coenzyme A:cholesterol acyltransferase (ACAT) in homogenates should

35 s LDL cholesterol from lysosomes to acyl-CoA/cholesterol acyltransferase (ACAT) in the endoplasmic re

36 derived cholesterol is catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic re

37 e have found previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition led to imp

38 Although originally designed as acyl CoA: cholesterol acyltransferase (ACAT) inhibitors, compariso

39 Esterification of cholesterol by acyl-CoA:cholesterol acyltransferase (ACAT) is a key element in m

40 Acyl-CoA:cholesterol acyltransferase (ACAT) is a key enzyme in ce

41 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is a membrane protein

42 Acyl-CoA:cholesterol acyltransferase (ACAT) is a membrane-bound e

43 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an enzyme involved

44 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an integral membra

45 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular e

46 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) plays important roles

47 Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles

48 Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles

49 Cholesterol trafficking to acyl-coenzyme A:cholesterol acyltransferase (ACAT) was also defective in

50 used our studies on the activity of acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme for mai

51 ) synthase, squalene epoxidase, and acyl-CoA:cholesterol acyltransferase (ACAT), ACAT2, small heterod

52 ous studies have identified acyl-coenzyme A: cholesterol acyltransferase (ACAT), an enzyme that regul

53 as activator for the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT), by monitoring the ac

54 terification reaction, catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT), competes for the inc

55 sterol esterification, catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT), plays a central role

56 The inhibition of macrophage acyl coenzyme A:cholesterol acyltransferase (ACAT), which catalyzes the

57 he sterol esterifying enzyme acyl-coenzyme A-cholesterol acyltransferase (ACAT), which likely occurs

58 teraction of the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related enzyme (Are)2

59 olesteryl ester synthesis by acyl coenzyme A:cholesterol acyltransferase (ACAT).

60 enerated in a reaction catalyzed by acyl CoA:cholesterol acyltransferase (ACAT).

61 ity to a human cDNA encoding acyl-coenzyme A:cholesterol acyltransferase (ACAT).

62 L)-receptor, HMG CoA reductase, and acyl-CoA:cholesterol acyltransferase (ACAT).

63 ery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT).

64 to a deficiency in the activity of acyl-CoA:cholesterol acyltransferase (ACAT).

65 synthesis of cholesterol esters by acyl-CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) is an im

66 The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyze

67 o be catalyzed by the enzyme acyl-coenzyme A:cholesterol acyltransferase, ACAT, the neutral cholester

68 olesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-ch

69 Acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) are two e

70 glycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) provided

71 A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified.

72 id binding, cholesterol efflux, and lecithin-cholesterol acyltransferase activities of the lipoprotei

73 SRBI cells was not due to increased acyl-coA:cholesterol acyltransferase activity and was observed ev

74 a-helicity, cholesterol efflux, and lecithin-cholesterol acyltransferase activity of the recombinant

75 ctivity and approximately 90% lower lecithin-cholesterol acyltransferase activity relative to circula

76 espite an increase in hepatic mRNA; lecithin:cholesterol acyltransferase activity toward endogenous E

77 orm with 88.1 +/- 8.5% reduction in lecithin-cholesterol acyltransferase activity, a finding corrobor

78 flux, and also had markedly reduced lecithin cholesterol acyltransferase activity.

79 t shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fa

80 Lecithin:cholesterol acyltransferase analysis, using reconstitute

81 Only in the absence of both lecithin cholesterol acyltransferase and apolipoprotein E is para

82 he presence of normal activities of acyl-CoA:cholesterol acyltransferase and glycerol phosphate acylt

83 There were no significant lecithin:cholesterol acyltransferase and lysophospholipase activi

84 gests the possible interaction with lecithin-cholesterol acyltransferase and may shed light on the mo

85 ression on the microsomal levels of acyl-CoA:cholesterol acyltransferase and neutral cholesterol este

86 LDL-cholesterol to be esterified by acyl-CoA:cholesterol acyltransferase and stored in lipid droplets

87 logous to enzymes called glycerophospholipid-cholesterol acyltransferases and, following translocatio

88 nriched in apoM, cholesteryl ester, lecithin:cholesterol acyltransferase, and S1P.

89 e chemoattractant protein-1, acyl coenzyme A:cholesterol acyltransferase, and tissue factor, in lesio

90 s of diacylglycerol acyltransferase and acyl cholesterol acyltransferase are expressed in the lumen o

91 r-activated receptor modulators and lecithin-cholesterol acyltransferase-based therapy, hold great pr

92 associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I.

93 ., paraoxonase, apolipoprotein A-I, lecithin:cholesterol acyltransferase, cholesterol ester transfer

94 ce and the roles of plasma factors (lecithin-cholesterol acyltransferase, cholesterol ester transfer

95 l particles reminiscent of those in lecithin/cholesterol acyltransferase deficiency and cholestasis).

96 Patients with lecithin: cholesterol acyltransferase deficiency have both prebeta

97 (adrenocortical lipid depletion in acyl-CoA:cholesterol acyltransferase-deficient (Acact-/-) mice an

98 sc-associated apoA-I that binds the lecithin-cholesterol acyltransferase enzyme is well structured an

99 Cholesteryl ester synthesis by the acyl-CoA:cholesterol acyltransferase enzymes ACAT1 and ACAT2 is,

100 spholipases A (PLAs) and glycerophospholipid:cholesterol acyltransferases (GCATs), may target host ce

101 ted DGAT1), which is related to the acyl CoA:cholesterol acyltransferase gene family, or to any other

102 ment-binding proteins and activated acyl-CoA:cholesterol acyltransferase in a normal fashion.

103 ting enzyme inhibitor, or an acyl coenzyme A-cholesterol acyltransferase inhibitor.

104 Plasma lecithin:cholesterol acyltransferase is unchanged despite an incr

105 storage form by the enzyme acyl-coenzyme A: cholesterol acyltransferase, is a critical component of

106 residues and domains implicated in lecithin:cholesterol acyltransferase (LCAT) activation or lipid b

107 Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results co

108 f responsible for lipid binding and lecithin:cholesterol acyltransferase (LCAT) activation.

109 holipid transfer protein (PLTP) and lecithin cholesterol acyltransferase (LCAT) activities were decre

110 Lecithin:cholesterol acyltransferase (LCAT) activity was measured

111 Total endogenous plasma lecithin:cholesterol acyltransferase (LCAT) activity was reduced

112 ltered secondary structure affected lecithin:cholesterol acyltransferase (LCAT) activity.

113 than other acyltransferases such as lecithin cholesterol acyltransferase (LCAT) and acyl CoA acyltran

114 laboratory previously reported that lecithin:cholesterol acyltransferase (LCAT) and LDL receptor doub

115 lesterol binding, esterification by lecithin/cholesterol acyltransferase (LCAT) and transfer by chole

116 pacity and 37% capacity to activate lecithin:cholesterol acyltransferase (LCAT) as compared to the WT

117 osomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structura

118 on dramatically reduces the rate of lecithin:cholesterol acyltransferase (LCAT) catalyzed cholesterol

119 Lecithin-cholesterol acyltransferase (LCAT) catalyzes the formati

120 Lecithin:cholesterol acyltransferase (LCAT) catalyzes the formati

121 revious studies have indicated that lecithin-cholesterol acyltransferase (LCAT) contributes significa

122 udy was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would acce

123 e been made in our understanding of lecithin-cholesterol acyltransferase (LCAT) function.

124 ng cassette transfer protein A1 and lecithin cholesterol acyltransferase (LCAT) gene loci.

125 Expression of human lecithin cholesterol acyltransferase (LCAT) in mice (LCAT-Tg) lea

126 had diminished capacity to activate lecithin/cholesterol acyltransferase (LCAT) in vitro.

127 Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzym

128 and interfacial binding activity of lecithin-cholesterol acyltransferase (LCAT) is affected different

129 Lecithin cholesterol acyltransferase (LCAT) is an enzyme involved

130 Although the major function of lecithin-cholesterol acyltransferase (LCAT) is cholesterol esteri

131 fied cholesterol (UC) by the enzyme lecithin:cholesterol acyltransferase (LCAT) is cholesteryl ester

132 Lecithin:cholesterol acyltransferase (LCAT) is the major determin

133 We recently reported that lecithin:cholesterol acyltransferase (LCAT) knock-out mice, parti

134 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in r

135 Because lecithin:cholesterol acyltransferase (LCAT) possesses intrinsic P

136 be a physiological inhibitor of the lecithin-cholesterol acyltransferase (LCAT) reaction.

137 Further, plasma lecithin:cholesterol acyltransferase (LCAT) substrate reactivity

138 or protein-protein interaction with lecithin-cholesterol acyltransferase (LCAT) the enzyme for which

139 Lecithin:cholesterol acyltransferase (LCAT) then drives the conve

140 Binding of lecithin cholesterol acyltransferase (LCAT) to lipoprotein surfac

141 asma but reduces atherosclerosis in lecithin cholesterol acyltransferase (LCAT) transgenic (Tg) mice,

142 on in blood is closely regulated by lecithin-cholesterol acyltransferase (LCAT) which is produced in

143 The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A

144 pear to show that the reactivity of lecithin:cholesterol acyltransferase (LCAT) with the mutant is sl

145 ue T. gondii homologue of mammalian lecithin:cholesterol acyltransferase (LCAT), a key enzyme that pr

146 Lecithin:cholesterol acyltransferase (LCAT), an important enzyme

147 G esters (PE) by the plasma enzyme lecithin: cholesterol acyltransferase (LCAT), and by other enzyme(

148 ol acyltransferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from h

149 apoA-I) activates the plasma enzyme lecithin:cholesterol acyltransferase (LCAT), catalyzing the rapid

150 ns, and had minimal reactivity with lecithin-cholesterol acyltransferase (LCAT), compared with rHDL p

151 l ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT), on chromosome 16q; a

152 hydroxylase, Scavenger receptor B1, lecithin:cholesterol acyltransferase (LCAT), or apoA-I in the liv

153 aturally occurring mutants of human lecithin-cholesterol acyltransferase (LCAT), T123I and N228K, wer

154 f cholesterol-containing r-HDL with lecithin-cholesterol acyltransferase (LCAT), to form cholesteryl

155 Human lecithin-cholesterol acyltransferase (LCAT), which is normally sp

156 pathway is critically dependent on lecithin:cholesterol acyltransferase (LCAT), which rapidly conver

157 oA-I structure, and reactivity with lecithin:cholesterol acyltransferase (LCAT).

158 poprotein particles is catalyzed by lecithin:cholesterol acyltransferase (LCAT).

159 tect the esterification activity of lecithin:cholesterol acyltransferase (LCAT).

160 and agonizing a circulating enzyme lecithin cholesterol acyltransferase (LCAT).

161 ger receptor B-1 (SRB-1) and plasma lecithin-cholesterol acyltransferase (LCAT).

162 erol esterifying enzymes, ACAT1 and lecithin:cholesterol acyltransferase (LCAT).

163 quences identical to those of human lecithin:cholesterol acyltransferase-like lysophospholipase (LLPL

164 es, due primarily to an increase in lecithin:cholesterol acyltransferase-mediated (LCAT-mediated) cho

165 ates LDL uptake and degradation and acyl-CoA:cholesterol acyltransferase-mediated esterification of L

166 lesteryl ester transfer protein and lecithin:cholesterol acyltransferase only function optimally in h

167 lesteryl ester transfer protein and lecithin-cholesterol acyltransferase (phosphatidylcholine-sterol

168 cholesteryl ester transfer protein, lecithin:cholesterol acyltransferase (phosphatidylcholine-sterol

169 he first molecular probe of acyl-coenzyme A: cholesterol acyltransferase provided a key to understand

170 e of similar size, composition, and lecithin:cholesterol acyltransferase reactivity when compared to

171 apoA-I(-/-) HDL in the presence of lecithin cholesterol acyltransferase reorganized the large hetero

172 long-chain acyl-CoA synthetase and acyl-CoA:cholesterol acyltransferase, respectively.

173 types toward a major plasma enzyme, lecithin:cholesterol acyltransferase responsible for the HDL matu

174 eletion of LRO1, a homolog of human lecithin cholesterol acyltransferase, resulted in a dramatic redu

175 phimurium translocates a glycerophospholipid:cholesterol acyltransferase (SseJ) into the host cytosol

176 mation, apoA-I activates the enzyme lecithin:cholesterol acyltransferase stimulating the formation of

177 nzymes that esterify cholesterol (lecithin : cholesterol acyltransferase), transfer cholesterol (chol

178 Lecithin cholesterol acyltransferase treatment alone or addition

179 ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and 2 (ACAT1 and ACA

180 a cholesterol esterification enzyme lecithin:cholesterol acyltransferase was also compared.

181 Lecithin-cholesterol acyltransferase was unaffected by psyllium i

182 ver, apoA-V was a poor activator of lecithin:cholesterol acyltransferase where the activity was 8.5 +

183 parameters of the lipophilic enzyme lecithin:cholesterol acyltransferase, which binds to phosphatidyl