ライフサイエンスコーパス: cholesterol content

1 mechanistically linked to increased platelet cholesterol content.

2 lipidemia associated with increased platelet cholesterol content.

3 are sensitive to alterations in the membrane cholesterol content.

4 yperreactivity induced by increased platelet cholesterol content.

5 e in membranes with physiologically relevant cholesterol content.

6 at particle uptake has on the cell's overall cholesterol content.

7 -Gal A was less effective in normalizing the cholesterol content.

8 ol and increased hepatic free fatty acid and cholesterol content.

9 nificant increases in renal triglyceride and cholesterol content.

10 wed decreased extractability with increasing cholesterol content.

11 ect correlation with increased cellular free cholesterol content.

12 sponse that correlates with vesicle membrane cholesterol content.

13 (brown, not white) due to a 91% reduction in cholesterol content.

14 nifest the functional importance of membrane cholesterol content.

15 lesterol molecules vary as a function of the cholesterol content.

16 erol efflux consequently decreasing cellular cholesterol content.

17 r membranes, in particular those with a high cholesterol content.

18 tic cholesterol levels to changes in dietary cholesterol content.

19 shown to be affected by changes in cellular cholesterol content.

20 low in plant sterols and moderate to low in cholesterol content.

21 heightened in response to increases in cell cholesterol content.

22 sterol domains despite significantly reduced cholesterol content.

23 ain and is retarded by an elevated endosomal cholesterol content.

24 ule injury first lowers, then raises, tubule cholesterol content.

25 udied as a function of lipid phase state and cholesterol content.

26 , whose activity has been linked to membrane cholesterol content.

27 reased in abundance as a function of bilayer cholesterol content.

28 idylcholine transfer with an increase in the cholesterol content.

29 rescence, irrespective of headgroup size and cholesterol content.

30 , which is the retinal layer with the lowest cholesterol content.

31 et, many people avoid it because of its high cholesterol content.

32 is very low in total fat, yet it has a high cholesterol content.

33 r responses to these agents are regulated by cholesterol content.

34 ses changes in glioma cells that have higher cholesterol content.

35 C toward lower temperatures with increasing cholesterol content.

36 e A reductase, and increased plasma membrane cholesterol content.

37 elis-Menten kinetics independent of membrane cholesterol content.

38 es for changes in polarity versus changes in cholesterol content.

39 changes in membrane fluidity from changes in cholesterol content.

40 ngial expansion, kidney weight, and cortical cholesterol content.

41 nctions some of which are independent of its cholesterol content.

42 cholesterol efflux and increase in cellular cholesterol content.

43 protein abundance and renal triglyceride and cholesterol contents.

44 differences in surface monolayer protein and cholesterol contents.

45 f total surface area, P=.89) and analysis of cholesterol content (236+/-203 nmol/mg, 9.1+/-7.8 microg

46 He had exceptionally high cholesterol content (760 mg/dL; to convert to millimoles

47 subjects revealed double the normal hepatic cholesterol content, a markedly deficient rate of bile a

48 However, at high cholesterol content, a switch toward the C-terminus is o

49 Direct measurement of cholesterol content after beta-methyl-cyclodextrin treat

50 The plasma membrane cholesterol content also was altered by various biochemi

51 Cholesterol content alters cell membrane stiffness, and

52 f9 insect cells that typically have very low cholesterol content and a different phospholipid profile

53 timibe is a novel approach to reduce biliary cholesterol content and a promising strategy for prevent

54 ified in a sucrose gradient and measured for cholesterol content and cholesterol/phospholipid mole ra

55 The membrane cholesterol content and cholesterol/phospholipid mole ra

56 in octapeptide-induced contraction, membrane cholesterol content and cholesterol/phospholipid ratio,

57 the cell membrane appears to be regulated by cholesterol content and cytoskeleton integrity.

58 e delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake.

59 e in membranes with physiologically relevant cholesterol content and in membranes without cholesterol

60 hat ATRA-mediated decrease in total cellular cholesterol content and increase in lysosomal acidificat

61 ration and hydrophobicity but decreases with cholesterol content and lower temperature.

62 urons tolerate only slight alteration in the cholesterol content and plasma membrane tension.

63 Aortic tissue cholesterol content and platelet aggregation were also m

64 om lysosomes leads to a decrease of parasite cholesterol content and proliferation.

65 on was associated with a reduction in aortic cholesterol content and reduced platelet aggregability a

66 terol homeostasis, the combination of higher cholesterol content and reduced receptor activation asso

67 cholesterol restored granule morphology and cholesterol content and rescued insulin secretion in ABC

68 maintained elevated Src and plasma membrane cholesterol content and showed increased phosphorylation

69 B-100 dual transgenic mice and increased HDL cholesterol content and size comparable to torcetrapib (

70 s, accompanied with decreased pulmonary free cholesterol content and suppressed tumor cell proliferat

71 Both the cholesterol content and the cholesterol/phospholipid rat

72 -deficient mice with such a robust change in cholesterol content and the expression of cholesterol me

73 ating cholesterol in SCID mice increased the cholesterol content and the extent of protein tyrosine p

74 Cs - are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1).

75 fferent properties such as water content and cholesterol content and thus perform a more comprehensiv

76 size is associated with a linear increase in cholesterol content and with accumulation of amorphous c

77 lation of HA depends on cellular or membrane cholesterol content and, potentially, intact cholesterol

78 onditions of pH, temperature, lipid content, cholesterol content, and buffer dimethylsulfoxide concen

79 decreased bile acid pool, increased hepatic cholesterol content, and lowered serum cholesterol in mi

80 investigate the influence of electrostatics, cholesterol content, and peptide palmitoylation, we also

81 th cholesterol or variations in unesterified cholesterol content appear to have little effect on the

82 erimental data we find that measures of cell cholesterol content are important in differentiating bet

83 of up to 25 and 60% reduction in chylomicron cholesterol content are seen with a 10-mg dose.

84 s, the parameter tau depends linearly on the cholesterol content at 310 K and allows us to determine

85 c variation, as large as 50%, with liposomal cholesterol content at the theoretically predicted C(r),

86 fied, CE droplets accumulate and microdomain cholesterol content becomes poorly regulated.

87 hypothesized that the natural difference in cholesterol content between erythrocytes and leukocytes

88 utants p.E297G and p.R432T increased at high cholesterol content but did not reach the capacity of no

89 pools was unaffected by raising the cellular cholesterol content, but the size of the fast pool incre

90 s occurs through the maintenance of caveolae cholesterol content by cholesterol ester uptake from HDL

91 membrane, 8 mm in diameter, were assayed for cholesterol content by enzymatic fluorometry (n = 10, >7

92 After increasing the membrane cholesterol content by treatment of water-soluble choles

93 P, an antivascular drug, to demonstrate that cholesterol content can actually modulate the release an

94 otoxicity generated by lowering the membrane cholesterol content can be reversed by AbetaP calcium ch

95 hat these functions may be related; membrane cholesterol content can regulate receptor-mediated signa

96 of the membrane that do not change the total cholesterol content, can significantly affect how choles

97 among known organellar membranes in terms of cholesterol content, cholesterol dynamics, and response

98 s found to decrease by six times for 50 mol% cholesterol content compared with cholesterol-free lipos

99 A1(-A/-A) mice had a 2-fold increase in free cholesterol content compared with wild-type mice and fai

100 Increasing the SUV cholesterol content, concomitant with the presence of ne

101 t, saturated fat, protein, carbohydrate, and cholesterol content, consistent with former American Hea

102 GUVs of high cholesterol content containing the breakdown products of

103 A-I)-containing particles, and adrenal gland cholesterol content decreased by 42% and 72%, respective

104 ity directly depends on canalicular membrane cholesterol content, decreased BSEP presence in rafts ma

105 under ischemic conditions astrocyte membrane cholesterol content decreases, which could increase AQP4

106 have different phospholipid composition and cholesterol content, displaying a profile of fluidity th

107 Manipulations of membrane cholesterol content dramatically altered the diffusion p

108 L) did not substantially increase macrophage cholesterol content during in-vitro incubations, investi

109 be dramatically affected by changes in their cholesterol content during the development of atheroscle

110 sed mice to excrete up to 60% of their total cholesterol content each day.

111 of sPLA2 shows an alternating variation with cholesterol content, exhibiting a minimum at the critica

112 drating the head groups and as a function of cholesterol content for a fixed hydration level.

113 le for development-associated differences in cholesterol content for the differential responses of th

114 The dynamics are independent of cholesterol content from 10 to 35%.

115 the ultrastructure of the MVB by perturbing cholesterol content genetically through the use of a del

116 cells, we found that changes in the overall cholesterol content have a limited effect on the average

117 Changes in membrane cholesterol content have potent effects on cell signalli

118 is that DRMs of vastly different protein and cholesterol contents have been isolated from erythrocyte

119 Regardless of cholesterol content, high fat diets induced mineralizati

120 xamine how lipid phase, packing density, and cholesterol content impact SERM-membrane interactions.

121 ic activity of sPLA2 is found to change with cholesterol content in an alternating manner.

122 However, CsA treatment decreased cholesterol content in caveolae and displaced eNOS from

123 These data suggest that decreasing cholesterol content in caveolae by CsA is a potentially

124 ndothelial dysfunction is related to reduced cholesterol content in caveolae.

125 tivation in endothelial cells via decreasing cholesterol content in caveolae.

126 reatment with TO901317 resulted in increased cholesterol content in Dhcr7(-/-) embryos.

127 eta-(1-42) would differentially modify Golgi cholesterol content in DINTC1 astrocytes and that the ef

128 Cholesterol content in each well was measured using a fl

129 ance, fatty acid content and composition and cholesterol content in egg yolk has been evaluated durin

130 ll be very useful for the quality control of cholesterol content in food matrices and can be easily a

131 stone dissolution in mice and reduce biliary cholesterol content in human beings.

132 eased cholesteryl ester levels and decreased cholesterol content in MA-10 cells.

133 Given that cholesterol content in plasma membranes varies with cell

134 zymatic product of CYP27A1, reduced cellular cholesterol content in prostate cancer cell lines by inh

135 nsfer by PLTP decreases with increasing free cholesterol content in rHDL and with decreasing HDL size

136 Increasing cholesterol content in target vesicles increased lipid-

137 rich domains is constant, independent of the cholesterol content in the bilayer.

138 otaxis to an SDF-1 gradient was dependent on cholesterol content in the cell membrane and on the inco

139 be nonhorizontal, indicating a difference in cholesterol content in the coexisting phases.

140 that aged Abeta-(1-42) significantly reduced cholesterol content in the Golgi complex.

141 mitochondria with a significantly increased cholesterol content in the inner mitochondrial membrane.

142 he water permeability of AQP4 depends on the cholesterol content in the lipid bilayer, but it was not

143 embrane surface independently of the overall cholesterol content in the membrane.

144 Increasing cholesterol content in the membranes resulted in a reduc

145 ddition of linseed oil did not influence the cholesterol content in yolks (P=0.5200) while the only f

146 tion rates could be observed with increasing cholesterol contents in the vesicle membranes.

147 First, the total cellular cholesterol content increase was 2-3-fold and 3-5-fold i

148 However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats t

149 ce also exhibited higher plasma LDL and VLDL cholesterol content, increased circulating apolipoprotei

150 repulsive to attractive to repulsive as the cholesterol content increases.

151 xpression attenuated the increase in hepatic cholesterol content induced by consumption of a high cho

152 correlation between atherosclerosis, plasma cholesterol content, inflammation, and alpha1-AT rate of

153 holesterol synthesis inhibitor, lowered raft cholesterol content, inhibited Akt1 serine-threonine kin

154 also disrupted LRs, reduced plasma membrane cholesterol content, inhibited NADPH oxidase 4 transloca

155 The increase in cholesterol content is associated with 1) increased expr

156 ty reaches a local minimum when the membrane cholesterol content is at or near the critical cholester

157 Since membrane cholesterol content is disturbed in the development of c

158 Increasing macrophage cholesterol content is sufficient to trigger IL-1beta re

159 d in the inner mitochondrial membrane, where cholesterol content is very low.

160 because gPr80gag-negative M-MuLV has a lower cholesterol content, is less sensitive to inhibition of

161 Instead by considering the intracellular cholesterol content it is found that internalisation of

162 counterstained with filipin, an indicator of cholesterol content, MNV NS3 displayed a greater associa

163 Hence, changing membrane cholesterol content modulates BSEP and MRP2 transport ki

164 ity consistent with the increase in membrane cholesterol content observed after 4 h of DCA treatment

165 Fatty acid composition and cholesterol content of caveolae/lipid rafts before and a

166 tion that was preceded by an increase in the cholesterol content of cell membranes and increased acti

167 synthase inhibitor squalestatin reduced the cholesterol content of cells and prevented the accumulat

168 ression analysis of the relation between the cholesterol content of each DGUC fraction as the depende

169 sphocholine (POPC)), and the average GM1 and cholesterol content of each ND were determined.

170 Moves to reduce the cholesterol content of formula feeds below those of brea

171 henotypic differences in either the relative cholesterol content of gallbladder bile, bile acid pool

172 significant reduction in the lesion area and cholesterol content of high-fat, high-cholesterol diet-i

173 suggested that endo-CHOL contributes to the cholesterol content of late endosomes and controls its m

174 and size of LDL particles in addition to the cholesterol content of LDL.

175 s study, we tested whether alteration of the cholesterol content of lipid rafts in prostate cancer (P

176 asma membrane, likely through regulating the cholesterol content of lipid rafts.

177 ly lower, but no significant decrease in the cholesterol content of major lipoprotein fractions was m

178 goal of this experiment was to diminish the cholesterol content of Manchego, the most popular Spanis

179 ompares favourably with the fat, energy, and cholesterol content of many other meats and poultry.

180 ctions as a molecular machine to control the cholesterol content of membranes in mammalian cells.

181 While the cholesterol content of most tissues is normal in PEX2(-/

182 Increasing cholesterol content of PS liposomes also suppresses Abet

183 lity of RBC cholesterol was unrelated to the cholesterol content of RBCs or plasma, but was associate

184 Treatment with glucosamine-PI increased the cholesterol content of ScGT1 cell membranes and reduced

185 ibute significantly to the saturated fat and cholesterol content of the American diet.

186 When the cholesterol content of the diet was raised to 1.0%, hepa

187 in apoAI-Tg mice, independent of the fat or cholesterol content of the diet.

188 terol transfer was greatly influenced by the cholesterol content of the donor vesicles.

189 The cholesterol content of the endoplasmic reticulum (ER) an

190 However, the high cholesterol content of the envelope (ca. 40 to 50 mol%)

191 reduces the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane.

192 est hydrophobic characteristics; and (4) the cholesterol content of the membrane bilayer.

193 ted with low fluidity, low polarity, or high cholesterol content of the membranes, and a low GP is th

194 lts in increased chemotaxis dependent on the cholesterol content of the plasma membrane and receptor

195 Doubling the unesterified cholesterol content of the plasma membrane by incubation

196 In addition, results indicate that as the cholesterol content of the plasma membrane is increased,

197 The effect of the cholesterol content of the plasma membrane on the intrac

198 n TCR reorganization and is sensitive to the cholesterol content of the T cell membrane.

199 ly overlooked therapeutic consideration: the cholesterol content of the treated cell determines which

200 Although the cholesterol content of the treated cells increased after

201 ains, two properties that depend on the high cholesterol content of the viral membrane.

202 inhibited by EGTA, and is independent of the cholesterol content of these membranes.

203 Aortic lesions in D-HL swine had double the cholesterol content of those in N-HL swine, and incorpor

204 This implies that elevated cholesterol content of triglyceride-rich lipoprotein par

205 es in lipid composition, particularly in the cholesterol content of very-low-density lipoproteinparti

206 n inducing a 3-5-fold increase in macrophage cholesterol content of which >60% is esterified.

207 gressively broadens and is not detectable at cholesterol contents of >40 mol%.

208 The cholesterol contents of major tissues were not altered.

209 Cell-type-specific effects of cholesterol content on function of human Pgp were detect

210 The influence of calcium and disc membrane cholesterol content on fusion between ROS membrane speci

211 The affects of cholesterol content on fusion were investigated by incre

212 We also examined the effect of varying cholesterol content on the cold Triton X-100 solubility

213 d a detailed study of the effect of membrane cholesterol content on the initial hydrolytic activity o

214 etion of ABCA1 and ABCG1 causes an increased cholesterol content on the inner leaflet of the PM, asso

215 d in vitro, but it had no effect on cellular cholesterol content or efflux.

216 We find that alteration of membrane cholesterol content or perturbation of lipid rafts regul

217 SCVD and all-cause mortality, and that their cholesterol content or remnant cholesterol likewise are

218 Partial restoration of membrane cholesterol content partially restored shear-induced pla

219 to approximately 2 x 10(-9) cm(2)/s in high-cholesterol-content phases, to approximately 2 x 10(-10)

220 he flip-flop rate is independent of membrane cholesterol content, phospholipid acyl saturation, and l

221 Cellular cholesterol content reflects a balance of lipid influx b

222 ld, respectively, whereas plasma and hepatic cholesterol content remained unchanged.

223 ophilic BS eliminated or increased vesicular cholesterol content, respectively.

224 ell CD36 receptors and by depleting caveolae cholesterol content, resulting in the disruption of eNOS

225 Temperature variation at constant cholesterol content revealed three of the eight combinat

226 High cholesterol content shifted E17betaG to Michaelis-Menten

227 indicate that a reduction in neuron-derived cholesterol content, similar to that observed in diabeti

228 thods produced 20-31% reductions in cellular cholesterol content, similar to the decrease in choleste

229 on oligomer size is independent of membrane cholesterol content, so one interpretation of the data i

230 As a regulator of plasma membrane cholesterol content, SR-B1 promotes the uptake of lipid

231 nduction of hepatic Abcg5/g8 and gallbladder cholesterol content, suggesting a role of FXR in the reg

232 minished and eventually disappeared over 15% cholesterol content, suggesting that the cholesterol ric

233 rs are reported as a function of the bilayer cholesterol content, temperature, and incubation time.

234 ces in mineral content, fatty acid profiles, cholesterol content, texture parameters and sensory acce

235 nes made from the same cells showed a higher cholesterol content than nondetergent lipid rafts but we

236 via small vesicles having lower GP and lower cholesterol content than the surface membrane.

237 abolism is a 46% increase in plasma membrane cholesterol content, the implications of which are discu

238 pecimens were analyzed for the percentage of cholesterol content, the percentage of calcium bilirubin

239 urrent studies show that cells control their cholesterol content through receptor-ligand interactions

240 ne transcription by increasing intracellular cholesterol content through the hydrolysis of cellular s

241 adrenocortical cells increases mitochondrial cholesterol content under conditions in which StAR is in

242 d by increasing and decreasing disc membrane cholesterol content using well established lipid exchang

243 In particular, membrane cholesterol content varies with aging and consequently w

244 ne out of four types of phospholipids plus a cholesterol content varying from 0 to 50 mol %.

245 Cellular cholesterol content was altered by incubating cells with

246 The activity variation with cholesterol content was correlated well with the area of

247 Liver TG content was unchanged, whereas cholesterol content was decreased.

248 The increase in biliary cholesterol content was dependent on expression of G5 an

249 Cellular cholesterol content was depleted by exposing the cells t

250 Liver cholesterol content was elevated in Sr-bI ko only (P < 0

251 l diets, whole liver and isolated hepatocyte cholesterol content was higher in the apoE knockout mice

252 efold in livers of the -/- mice, and hepatic cholesterol content was increased by 50%.

253 ore IAF and were more insulin resistant, the cholesterol content was increased in VLDL, intermediate-

254 e of lipid polarity, membrane curvature, and cholesterol content was investigated.

255 e mass spectroscopy revealed that esterified cholesterol content was markedly reduced.

256 the labeling studies; a decrease in cellular cholesterol content was observed in the 8-Br-cAMP-treate

257 Total and free cholesterol content was significantly higher in 25 RA CH

258 Lysosome cholesterol content was significantly lower after treatm

259 =0.5200) while the only factor affecting the cholesterol content was the hens age (P<0.0001).

260 The highest losses of cholesterol content were found during thermal processing

261 Intracellular triacylglycerol and cholesterol contents were also decreased.

262 esis rate and the aortic free and esterified cholesterol contents were also higher in the LDLR:(-/-)A

263 nical properties of the cells with different cholesterol contents were compared by measuring the degr

264 and acetate increase the total intracellular cholesterol content, which is attenuated with lovastatin

265 We hypothesized that cholesterol content will modulate the recruitment of mon

266 tent at 310 K and allows us to determine the cholesterol content with an accuracy of at least 5%.

267 Elevated cholesterol content within pancreatic beta-cells has bee

268 d at 4 degrees C vs. 60 degrees C; increased cholesterol content yielded more PDH and SSHH at 60 degr