ライフサイエンスコーパス: cholesterol-rich

1 holesterolemia characterized by unesterified cholesterol-rich abnormal lipoproteins (lamellar/vesicul

2 Although plasma membrane (PM) cholesterol-rich and -poor domains have been isolated by

3 l phase separation in the outer leaf between cholesterol-rich and -poor liquids causes a similar, but

4 omponents (DR5, FADD, and procaspase-8) into cholesterol-rich and ceramide-rich domains known as cave

5 The coexistence between cholesterol-rich and cholesterol-poor domains is univers

6 Both cholesterol-rich and triglyceride-rich lipoproteins corr

7 tive at promoting lateral domains, which are cholesterol-rich and unsaturation-rich, respectively.

8 Lipid rafts are highly ordered, cholesterol-rich, and detergent-resistant microdomains f

9 The PV membrane is cholesterol-rich, and inhibition of host cholesterol met

10 excess lipids derived from the ingestion of cholesterol-rich apoptotic corpses.

11 sclerosis is the subendothelial retention of cholesterol-rich, atherogenic lipoproteins.

12 ) mediate the binding of the CDC monomers to cholesterol-rich cell membranes.

13 mediates the interaction of the CDCs with a cholesterol-rich cell surface.

14 aged with mobile ligand coalesce into large, cholesterol-rich clusters that occupy the central portio

15 ining HDL formed intrahepatically are likely cholesterol-rich compared to the smaller intracellular l

16 -2, and NPC1, but not CI-MPR, similar to the cholesterol-rich compartment in NPC mutant cells.

17 ts, mature nicastrin, APH-1, and PEN-2, with cholesterol-rich detergent insoluble membrane (DIM) doma

18 ins from bovine neutrophils co-isolates with cholesterol-rich, detergent-resistant membrane fragments

19 tion between Talpha and caveolin-1 occurs in cholesterol-rich, detergent-resistant membranes and is l

20 exclusively resides in low-buoyant-density, cholesterol-rich, detergent-resistant membranes that can

21 uencing of different organs of both WHHL and cholesterol-rich diet (Chol)-fed NZW rabbits.

22 ol (HDL-C) compared with those of rats fed a cholesterol-rich diet (HCD).

23 We conclude that a cholesterol-rich diet affects learning speed and perform

24 olling the TFH-germinal center response to a cholesterol-rich diet and uncover a PDL1-dependent mecha

25 Excessive alcohol consumption and cholesterol-rich diet are associated with a high risk of

26 e show that lesions from diabetic pigs fed a cholesterol-rich diet contain abundant insulin-like grow

27 nces in the plasma lipoprotein response to a cholesterol-rich diet observed in the transgenic rabbits

28 esent study was to determine the effect of a cholesterol-rich diet on learning performance and monito

29 c rabbits (18 +/- 4 mg/dl) were similar, the cholesterol-rich diet raised the non-HDL cholesterol con

30 LDL receptor-deficient mice that were fed a cholesterol-rich diet showed increased cholesterol level

31 After 4 weeks of cholesterol-rich diet, a switch to a control diet for 4

32 en fluorescent protein were fed a control or cholesterol-rich diet, and green fluorescent protein-pos

33 ects on cholesterol metabolism in mice fed a cholesterol-rich diet, including complete resistance to

34 We show that diabetic animals fed a cholesterol-rich diet, like humans, develop severe lesio

35 9 embryos are substantially ameliorated by a cholesterol-rich diet.

36 ere divided into 3 groups (n=8) and fed with cholesterol-rich diets supplemented with cellulose (CC,

37 When diabetic mice are fed cholesterol-rich diets, on the other hand, they develop

38 cholesterol mixtures suggest that a separate cholesterol rich domain coexists with the DMPC rich doma

39 15% cholesterol content, suggesting that the cholesterol rich domain has a definite stoichiometry and

40 lay a role in sequestering this protein to a cholesterol-rich domain in the membrane.

41 We show that the selective localization of cholesterol-rich domains and associated ganglioside rece

42 tition into submicroscopic sphingolipid- and cholesterol-rich domains called lipid rafts, but the det

43 and integral membrane proteins that organize cholesterol-rich domains called lipid rafts.

44 NAP-22 also protects the cholesterol-rich domains during extraction by methyl-bet

45 The present studies explored the role of cholesterol-rich domains in maintaining this functional

46 the previously described affinity of SCR for cholesterol-rich domains in membranes.

47 sion as well as localization of the virus to cholesterol-rich domains in membranes.

48 in the PM, consistent with the existence of cholesterol-rich domains in the plasma membrane of livin

49 also suggest that Gag assembly must occur in cholesterol-rich domains in the plasma membrane.

50 cluster, we find that the composition of the cholesterol-rich domains is constant, independent of the

51 This study demonstrated that cholesterol-rich domains mediate the actions of early up

52 id components, particularly the formation of cholesterol-rich domains that are thought to be importan

53 conclude that adenylyl cyclase must occur in cholesterol-rich domains to be susceptible to regulation

54 phospholipid monolayers and the tendency of cholesterol-rich domains to form in cholesterol-lipid bi

55 iation of IgE-Fc epsilon RI with specialized cholesterol-rich domains within approximately 4-nm proxi

56 pid rafts enriched in glycosphingolipids and cholesterol-rich domains, but selectively lacking glycos

57 ndent manner, leading to the hypothesis that cholesterol-rich domains, or "lipid rafts," may act as f

58 prefer to partition within the more ordered, cholesterol-rich/DOPC-poor/GM1-rich micrometer-scale pha

59 A cholesterol-rich environment also induces processing of

60 hains in gel-fluid bilayers, fluid bilayers, cholesterol-rich fluid bilayers, and gel-fluid bilayers

61 et, and particularly from the consumption of cholesterol-rich foods.

62 axons is increased by myelin, a specialized, cholesterol-rich glial cell membrane that tightly wraps

63 own AMD risk factors: advanced age, high fat cholesterol-rich (HF-C) diet, and apolipoprotein E (apoE

64 B1), found in lipid rafts, is a receptor for cholesterol-rich high-density lipoproteins (HDL).

65 Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characte

66 Caveolae, cholesterol-rich invaginations of the plasma membrane, h

67 glycolipid rafts and in caveolae, noncoated, cholesterol-rich invaginations on the plasma membrane.

68 directly supported LB monolayers containing cholesterol-rich l(o) phases are inherently unstable whe

69 le concentration, accumulates heavily inside cholesterol-rich late endosomes in Npc1(-/-) cells.

70 the well recognized role and contribution of cholesterol-rich LDL or lipoprotein B particles to the p

71 By contrast, the larger cholesterol-rich LDL particles and all high-density lipo

72 version of triglyceride-rich VLDL to smaller cholesterol-rich LDL, arginine-3,500 interacts with the

73 tein function, contributing, for example, to cholesterol-rich lesions associated with age-related mac

74 LDLR is involved in uptake of cholesterol rich lipid particles from bloodstream.

75 ture of transbilayer couplings in asymmetric cholesterol-rich lipid bilayers, the effects on the lipi

76 F. tularensis live vaccine strain recruits cholesterol-rich lipid domains ("lipid rafts") with cave

77 within lipid rafts; ordered sphingolipid and cholesterol-rich lipid domains believed to exist within

78 that the formation of glycosphingolipid- and cholesterol-rich lipid domains can be driven solely by c

79 f the lipid raft concept is the formation of cholesterol-rich lipid domains.

80 l nitric oxide synthase (eNOS), localizes to cholesterol-rich lipid raft domains of the plasma membra

81 alization is mediated by caveolae, which are cholesterol-rich lipid raft domains.

82 lity, we identified an Akt1 subpopulation in cholesterol-rich lipid raft fractions prepared from LNCa

83 rters, especially EAAT2, are associated with cholesterol-rich lipid raft microdomains of the plasma m

84 associates in a Ca(2+) dependent manner with cholesterol-rich lipid raft microdomains.

85 e factor at the cell surface is localized in cholesterol-rich lipid rafts and extensively colocalized

86 he possibility that microvesicles arise from cholesterol-rich lipid rafts and found that both TF and

87 udy, we show that E-selectin is localized in cholesterol-rich lipid rafts at the cell surface, and th

88 tracellular cysteines, partitioning CD2 into cholesterol-rich lipid rafts constitutively, human CD2 h

89 in the lipid raft fractions suggesting that cholesterol-rich lipid rafts mediate PKC-triggered NET i

90 human prostate cancer (LNCaP) cells contain cholesterol-rich lipid rafts that mediate epidermal grow

91 Numerous enveloped viruses utilize cholesterol-rich lipid rafts to bud from the host cell m

92 P2X7 receptors associate with cholesterol-rich lipid rafts, but it is unclear how this

93 irus, which is associated with controversial cholesterol-rich lipid rafts.

94 ETEC vesicle endocytosis depended on cholesterol-rich lipid rafts.

95 dicating that the channels are targeted into cholesterol-rich lipid rafts.

96 of SNAP-23 is associated with non-caveolar, cholesterol-rich lipid rafts.

97 nces or the organization of sphingolipid and cholesterol-rich lipid rafts.

98 ferrin receptor and often were juxtaposed to cholesterol-rich lipid rafts.

99 n-mediated bacterial internalization through cholesterol-rich lipid rafts.

100 yn kinase, was dependent on the integrity of cholesterol-rich lipid rafts.

101 esis and is known to be tightly regulated by cholesterol-rich "lipid rafts." Collectively, these data

102 Recent studies have implicated cholesterol-rich, lipid raft microdomains in survival si

103 late in atherosclerotic plaques, internalize cholesterol-rich lipoprotein particles, and evolve into

104 o prepare an apoE peptide that bound to both cholesterol-rich lipoproteins and lipoprotein receptors,

105 re, this peptide selectively associated with cholesterol-rich lipoproteins and mediated their acute c

106 ran sulfate participates in the clearance of cholesterol-rich lipoproteins as well.

107 nding and clearance of both triglyceride and cholesterol-rich lipoproteins from the circulation.

108 atherogenic because of their ability to trap cholesterol-rich lipoproteins in vitro.

109 cellular cholesterol homeostasis by binding cholesterol-rich lipoproteins through their apoB and apo

110 e into the subendothelial space, internalize cholesterol-rich lipoproteins, and become foam cells by

111 erforming "receptor-mediated endocytosis" of cholesterol-rich lipoproteins.

112 solated from both cells and sphingolipid and cholesterol-rich liposomes (SCRLs) in association with d

113 Similar cholesterol-rich liposomes are found in early developing

114 Inoculation of mice with cholesterol-rich liposomes containing the adjuvant monop

115 with cholesterol esterase converts LDL into cholesterol-rich liposomes having >90% cholesterol in un

116 esterase-mediated transformation of LDL into cholesterol-rich liposomes is an LDL modification that:

117 We now show that cholesterol-rich liposomes produced from cholesterol est

118 arly, binding of anti-cholesterol A to small cholesterol-rich liposomes resulted in the appearance of

119 effect on SLO-mediated poration of synthetic cholesterol-rich liposomes.

120 oglycan complex formation, and conversion to cholesterol-rich liposomes.

121 Sphingolipid- and cholesterol-rich liquid-ordered (Lo) lipid domains (raft

122 ne of the main properties distinguishing the cholesterol-rich liquid-ordered (Lo) phase from the liqu

123 We showed previously that cholesterol-rich liquid-ordered domains with lipid compo

124 ximately 2, consistent with the zone being a cholesterol-rich liquid-ordered phase.

125 Cholesterol-rich, liquid-ordered (L(o)) domains are beli

126 ecognition is barely detectable in analogous cholesterol-rich, liquid-ordered (l0) bilayers.

127 e consistent with condensed complex-rich and cholesterol-rich liquids.

128 ein receptor (LDLR) is involved in uptake of cholesterol rich low-density lipoprotein (LDL) particles

129 esis and through receptor-mediated uptake of cholesterol-rich low density lipoprotein (LDL).

130 s DA efflux and enhances DAT localization in cholesterol rich membrane microdomains.

131 ation of the small GTPase p21Ras to GM1- and cholesterol-rich membrane areas.

132 Disruption of cholesterol-rich membrane domains by filipin inhibits Pl

133 ndings demonstrate that Francisella requires cholesterol-rich membrane domains for entry into and pro

134 at specific localization of the F protein in cholesterol-rich membrane domains is not required for ce

135 disease virus (NDV) fusion (F) protein with cholesterol-rich membrane domains, its localization in d

136 d by CD81 oligomerization, partitioning into cholesterol-rich membrane domains, or other, lateral pro

137 cal for the trafficking of these proteins to cholesterol-rich membrane domains, which leads to cleava

138 anifestations of receptor co-localization in cholesterol-rich membrane domains.

139 st in part because it directs the protein to cholesterol-rich membrane domains.

140 actin and myosin II filament organization at cholesterol-rich membrane domains.

141 active as long as GPI-ACE was sequestered in cholesterol-rich membrane domains.

142 for the formation of signaling platforms in cholesterol-rich membrane domains.

143 T adopts an outward facing conformation in a cholesterol-rich membrane environment, suggesting a nove

144 naptosomes and transfected cells, DAT was in cholesterol-rich membrane fractions after mild detergent

145 lex of Toxoplasma is immobilized within this cholesterol-rich membrane likely extends to closely rela

146 cells, suggesting that it may partition into cholesterol-rich membrane microdomains (lipid rafts), it

147 Disruption of cholesterol-rich membrane microdomains by acute exposure

148 graphy and remain intact after disruption of cholesterol-rich membrane microdomains by methyl-beta-cy

149 Exosome uptake depends on cholesterol-rich membrane microdomains called lipid raft

150 The targeting of ion channels to cholesterol-rich membrane microdomains has emerged as a

151 Detection of cholesterol-rich membrane microdomains is confirmed by o

152 nding, TrkA translocates and concentrates in cholesterol-rich membrane microdomains or lipid rafts, f

153 Our results indicate that cholesterol-rich membrane microdomains play a role in tr

154 Neither luminal acidification nor cholesterol-rich membrane microdomains play essential ro

155 ex to stabilize the BCR in sphingolipid- and cholesterol-rich membrane microdomains termed lipid raft

156 Lipid rafts are cholesterol-rich membrane microdomains that are thought

157 t well characterized, and the involvement of cholesterol-rich membrane microdomains, or lipid rafts,

158 A subset of BACE1 localizes to cholesterol-rich membrane microdomains, termed lipid raf

159 Disruption of cholesterol-rich membrane microdomains, the localization

160 hannel function by regulating trafficking to cholesterol-rich membrane microdomains.

161 ne-targeted form of the protein to reside in cholesterol-rich membrane microdomains.

162 interactions in vivo with sphingolipid- and cholesterol-rich membrane microdomains.

163 esynaptic termini is dependent on sorting to cholesterol-rich membrane microdomains.

164 mine efflux and enhances DAT localization in cholesterol-rich membrane microdomains.

165 ies have suggested that prestin localizes in cholesterol-rich membrane microdomains.

166 endodomain for an efficient interaction with cholesterol-rich membrane patches.

167 and NP have been shown to be concentrated in cholesterol-rich membrane raft domains, whereas M2, alth

168 seudomonas aeruginosa, which is initiated by cholesterol-rich membrane rafts and is dependent on Lyn,

169 Here we show that this platform is a cholesterol-rich membrane structure.

170 the interaction of a bacterial toxin with a cholesterol-rich membrane.

171 the situation in the bilayer regions of this cholesterol-rich membrane.

172 ing that oncogenic Akt is overrepresented in cholesterol-rich membranes compared with wild-type Akt.

173 Cs) assemble their giant beta-barrel pore in cholesterol-rich membranes has been the subject of inten

174 nificantly loosens both cholesterol-poor and cholesterol-rich membranes made from DPPC.

175 for membranes in general and preference for cholesterol-rich membranes may account for its great neu

176 hat the translocation of anionic NPs through cholesterol-rich membranes must be accompanied by format

177 essed the role of cPLA2 in the regulation of cholesterol-rich membranes that contain glycosylphosphat

178 Streptococcus intermedius, does not bind to cholesterol-rich membranes unless they contain the human

179 Treatment of cholesterol-rich membranes with a series of beta cyclode

180 ve Rac1 binds preferentially to low-density, cholesterol-rich membranes, and specificity is determine

181 PITP exhibits a preference for CerPCho- and cholesterol-rich membranes, we prepared unilamellar vesi

182 pendent on Src, reactive oxygen species, and cholesterol-rich membranes.

183 ts increased affinity for, and retention in, cholesterol-rich membranes.

184 o human CD59 (hCD59) rather than directly to cholesterol-rich membranes.

185 transduction when the protein is present in cholesterol-rich membranes.

186 ng the specific interaction of the CDCs with cholesterol-rich membranes.

187 ), and lipid rafts/caveolae (plasma membrane cholesterol-rich microdomain purified by a nondetergent

188 with flexible actin networks or sphingolipid-cholesterol rich microdomains in live cell membranes.

189 ked with anti-IgE, molecules associated with cholesterol-rich microdomains (e.g., saturated lipids (t

190 Cholesterol-rich microdomains (or "lipid rafts") within

191 nd tumor Ag were localized in membrane lipid cholesterol-rich microdomains and are thought to belong

192 These data suggest that (1) disruption of cholesterol-rich microdomains and caveolae by MCD leads

193 F-R transactivation by angiotensin II and 2) cholesterol-rich microdomains as well as focal adhesions

194 g hair cells was in keeping with the reduced cholesterol-rich microdomains in matured hair cells.

195 g domains in guinea pig endothelium and that cholesterol-rich microdomains in these cells can respond

196 MOG into TX-100-insoluble glycosphingolipid-cholesterol-rich microdomains initiates specific cellula

197 membrane and that the association with these cholesterol-rich microdomains is important for excitator

198 Alterations in plasma membrane lipids and cholesterol-rich microdomains might also contribute to a

199 entiation, and apoptosis is initiated in the cholesterol-rich microdomains of the plasma membrane kno

200 Additionally, Ply(WT) localized to cholesterol-rich microdomains on the HCEC surface, howev

201 ement, consistent with CFTR recruitment into cholesterol-rich microdomains with dimensions below the

202 e demonstrate that PI(4,5)P2 is localized to cholesterol-rich microdomains, lipid rafts, and the acti

203 aling are coordinated processes that require cholesterol-rich microdomains, whereas IC signaling is a

204 and Smoothened might also be found in these cholesterol-rich microdomains.

205 ns known to associate with sphingolipid- and cholesterol-rich microdomains.

206 cholesterol content and, potentially, intact cholesterol-rich microdomains.

207 1 cells reside in the low-density lipid (ie, cholesterol-rich) microdomains (lipid rafts).

208 Nanometer-scale domains in cholesterol-rich model membranes emulate lipid rafts in

209 Further, incubation in cholesterol-rich mouse serum resulted in the formation o

210 t strikingly different binding properties to cholesterol-rich natural and synthetic membranes.

211 other GPI-anchored proteins can be found in cholesterol-rich ordered domains within the plasma membr

212 n added to zwitterionic membranes containing cholesterol-rich ordered domains, PrP(106-126) oligomers

213 nts was hampered, leading to accumulation of cholesterol-rich particles in the circulation.

214 parameters, although the composition of the cholesterol-rich phase varies as a function of the lipid

215 e identified as a phospholipid-rich phase, a cholesterol-rich phase, and a condensed complex-rich pha

216 Lipid-lipid interactions across cholesterol-rich phospholipid bilayers were investigated

217 ncipal protein component of triglyceride and cholesterol-rich plasma lipoproteins.

218 Furthermore, 121 proteins from cholesterol-rich plasma membrane domains (caveolar and l

219 Recently, sphingolipid- and cholesterol-rich plasma membrane lipid microdomains, ter

220 In this report, we investigate the role of cholesterol-rich plasma membrane microdomains (caveolae

221 ted PP2A, and PP2A/Balpha are co-enriched in cholesterol-rich plasma membrane microdomains/rafts puri

222 Because cholesterol-rich, plasma membrane rafts serve as platfor

223 ffect of flow was inhibited by disruption of cholesterol-rich plasmalemma domains and deletion of PEC

224 tially partition into sphingomyelin-rich and cholesterol-rich plasmalemmal microdomains, thereby acqu

225 Thus CD47-alpha(v)beta(3) complexes in cholesterol-rich raft domains appear to engage in G(i)-d

226 imulations in the presence of a pure POPC or cholesterol-rich raft model membrane.

227 22, but not a demyristoylated form, binds to cholesterol-rich raft-like domains in planar-supported m

228 sing PrP-sen reconstituted into sphingolipid-cholesterol-rich raft-like liposomes (SCRLs).

229 nraft) domains and excludes DHA from SM-rich/cholesterol-rich (raft) domains.

230 sion molecule of Entamoeba, were enriched in cholesterol-rich (raft-like) fractions, whereas EhCP5, a

231 Sphingolipid/cholesterol-rich rafts are membrane domains thought to e

232 Both CD47 and IgV-GPI were found in cholesterol-rich rafts prepared in the absence of deterg

233 Signaling cascades that localize to cholesterol-rich regions of the plasma membrane include

234 of lipids in the outer leaf increases in the cholesterol-rich regions, so the areal density of lipids

235 that NAP-22 binding may be employed to image cholesterol-rich regions, such as caveolae/rafts, on the

236 ficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation

237 myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocy

238 endothelial P2Y receptors are organized into cholesterol-rich signaling domains, such as caveolae and

239 suggest that the functional organization of cholesterol-rich signaling microdomains allows agonist-s

240 sterol, a role of potential significance for cholesterol-rich tissues with high oxidative stress.

241 The balance of cholesterol-rich to local hexagonal order is proposed to

242 Sphingolipid and cholesterol-rich Triton X-100-insoluble membrane fragmen

243 ially associated with actin and localized in cholesterol-rich vesicles.

244 2 orders of magnitude, to <10(3) s(-1), in a cholesterol-rich virus envelope-mimetic membrane ("viral

245 ses a high-curvature isotropic phase to both cholesterol-rich virus-mimetic membranes and 1,2-dimyris

246 or anionic bacterial membranes as opposed to cholesterol-rich zwitterionic mammalian membranes.