ライフサイエンスコーパス: cholic acid

1 nullizygous mice and was further elevated by cholic acid.

2 all molecules, such as (-)-santonin and beta-cholic acid.

3 to bind Cibacron blue columns and elute with cholic acid.

4 h fat, high cholesterol diet containing 0.5% cholic acid.

5 d serum contained predominantly unconjugated cholic acid.

6 by the binary combination of cholesterol and cholic acid.

7 tion of glycine followed by conjugation with cholic acid.

8 d specifically induced by the bile component cholic acid.

9 repress the mdrT promoter in the presence of cholic acid.

10 dimethylammonio]-1-propanesulfonic acid, and cholic acid.

11 enic diet containing 1% cholesterol and 0.5% cholic acid.

12 iating detergents such as octyl glucoside or cholic acid.

13 acids before PEBD consisted predominantly of cholic acid.

14 the use of spermidine, spermine, lysine, and cholic acid.

15 /g and comprised mainly chenodeoxycholic and cholic acids.

16 Some mice were placed on diets containing cholic acid (1%) or cholestyramine (2%) or high-fat diet

17 were fed a control diet or control diet plus cholic acid (1%) or ursodeoxycholic acid (1%) for 10 day

18 igs by PET/CT using the tracers derived from cholic acid (3alpha-OH, 7alpha-OH, 12alpha-OH), ursodeox

19 while bile from gallstone subjects contained cholic acid, 45%; chenodeoxycholic acid, 43%; deoxycholi

20 acid composition changed from predominantly cholic acid (57%) in wild-type to chenodeoxycholic acid

21 treatments with cholesterol (-41%, P < .05), cholic acid (-72%, P < .005), and deoxycholic acid (-62%

22 inous xanthomatosis (CTX) subjects contained cholic acid, 85%; chenodeoxycholic acid, 7%; deoxycholic

23 Simulated annealing and docking of cholic acid, a natural substrate, onto the protein surfa

24 .8% of the bile acids in duodenal bile, with cholic acid accounting for 82.4% +/- 5.5% of the total.

25 purified to homogeneity using 2', 5'-ADP and cholic acid-agarose affinity chromatography.

26 Lysophosphatidylcholine (20:4) and cholic acid also contributed significantly to the differ

27 lithogenic diet (LD; 1.0% cholesterol, 0.5% cholic acid and 17% triglycerides), as well as distal in

28 evere effects of a diet containing both 0.5% cholic acid and 2% cholesterol.

29 baseline revealed predominantly unconjugated cholic acid and absence of the usual glycine and taurine

30 nied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well as hepatic

31 In contrast, treatment with cholic acid and BM 15.766 further inhibited delta 7-redu

32 l cholestatic parameters, taurine species of cholic acid and chenodeoxycholic acid correlated with se

33 Conjugated cholic acid and chenodeoxycholic acid were synthesized i

34 fold and fourfold increases in the uptake of cholic acid and chenodeoxycholic acid, respectively, ove

35 primary products of bile acid biosynthesis, cholic acid and chenodeoxycholic acid, were capable of m

36 alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over c

37 n was achieved using a combined treatment of cholic acid and distilled water.

38 ifically, conjugates have been prepared from cholic acid and spermine in which the hydrophilic face o

39 icity associated with a diet containing 0.5% cholic acid and the much more severe effects of a diet c

40 on limits of approximately 40 femtomole (for cholic acid) and identification through CEC/MS/MS.

41 ogenic diet (containing 1% cholesterol, 0.5% cholic acid, and 15% dairy fat), small-intestinal transi

42 fed the Paigen diet (1.25% cholesterol, 0.5% cholic acid, and 15% fat) without or with ezetimibe (7 m

43 in their gallbladders, bile more enriched in cholic acid, and a 13% decrease in plasma cholesterol le

44 ted free cholesterol, cholesterol esters and cholic acid, and associated changes to metabolism of sph

45 herogenic (Ath) diet containing cholesterol, cholic acid, and fat, but the effect of these components

46 Cholesterol, cholic acid, and lovastatin, alone or in combinations, w

47 We show that MdrT can export cholic acid, and that DeltamdrT bacteria are significant

48 The diffusion coefficient of the 1:1 cholic acid/beta-cyclodextrin complex, K(a) = 5900 +/- 8

49 ylase (12 alpha-hydroxylase) is required for cholic acid biosynthesis.

50 MnhF mediates the efflux of radiolabeled cholic acid both in S. aureus and when heterologously ex

51 gamma-lyase was decreased when mice were fed cholic acid but increased when they were placed on diets

52 c carboxylic compounds, arachidonic acid and cholic acid, but not by their non-carboxylic analogues.

53 ther DCA or UCA, and intact rabbits fed 0.5% cholic acid (CA) (enlarged endogenous bile acid pool) we

54 (CYP8b1) is required for the biosynthesis of cholic acid (CA) and hence helps determine the ratio of

55 gene (Cyp8b1) results in complete absence of cholic acid (CA) and its derivatives.

56 rmer approach to describe the interaction of cholic acid (CA) and phenol (PhOH) with ceria NPs with a

57 -PXR double null or FPXR-null) mice fed a 1% cholic acid (CA) diet.

58 mice were fed a diet supplemented with 0.5% cholic acid (CA) for 21 days.

59 The role of cholic acid (CA) in cholesterol absorption in humans rem

60 [14C]chenodeoxycholic acid (CDCA), and [14C]cholic acid (CA) in cultured human fibroblasts was nonsa

61 diates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynt

62 e therefore measured the kinetics of DCA and cholic acid (CA) using stable isotopes, serum sampling,

63 Total biliary bile acids, cholic acid (CA), and CA/chenodeoxycholic acid (CDCA) ra

64 e uptake and efflux, respectively, of CGamF, cholic acid (CA), glycoCA (GCA), tauroCA, and taurolitho

65 ning diet for bile acid depletion, or a 0.2% cholic acid (CA)-containing diet for 1 week before treat

66 (HF) diets are frequently supplemented with cholic acid (CA).

67 ar polyethylene glycol (PEG) block dendritic cholic acids (CA) copolymers (telodendrimers), for the t

68 dels of liver injury (bile duct ligation, 1% cholic acid [CA] fed, and the Mdr2(-/-) mouse).

69 rol or triglyceride levels in these mice; 1% cholic acid caused a redistribution of cholesterol from

70 om AGS patients had greater chenodeoxycholic/cholic acid (CDCA/CA), bile salt, cholesterol and phosph

71 nine physiologically relevant derivatives of cholic acid, chenodeoxycholic acid, and deoxycholic acid

72 A BA overload, feeding 0.5% cholic acid chow for 6 days, resulted in adaptive respon

73 undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the

74 or-knockout mice (Ldlr+/-) fed a cholesterol/cholic acid-containing diet also had increased aortic le

75 Unconjugated cholic acid continued to be present in high concentratio

76 ted with increased 12alpha-hydroxylated BAs (cholic acid, deoxycholic acid, and their conjugated form

77 ding oleic acid, 1-hydroxy-2-naphthoic acid, cholic acid, deoxycholic acid, dioctylsulfosuccinic acid

78 No significant changes were detected for cholic acid, deoxycholic acid, or chenodeoxycholic acid.

79 molecular umbrella conjugates, derived from cholic acid, deoxycholic acid, spermidine, lysine, and 5

80 n rats treated with cholesterol, sitosterol, cholic acid, deoxycholic acid, ursodeoxycholic acid, cho

81 Mice challenged with cholic acid developed hypercholanemia and a hepatic gene

82 KO mice on a cholic acid diet had higher hepatic and serum bile acid

83 bile acid levels by feeding mice with a 0.2% cholic acid diet strongly promoted N-nitrosodiethylamine

84 ice (Ghr(-/-)) fed with a diet containing 1% cholic acid displayed an increase in hepatocyte ROS prod

85 lar overall affinity, but the derivatives of cholic acid displayed much higher Hill coefficients, a m

86 Hepatic expression of G9a-DN in mice fed cholic acid disrupted bile acid homeostasis, resulting i

87 ne supplemented with 1% cholesterol and 0.5% cholic acid (ECD).

88 educed only 20%, indicating that the smaller cholic acid-enriched bile acid pool was sufficient to fa

89 After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more s

90 stration of epiallopregnanolone sulfate with cholic acid exacerbated the hypercholanemia and resulted

91 e triglycerides and raise HDL in cholesterol/cholic acid fed rats.

92 Transporter protein and mRNA levels in cholic acid-fed rats increased approximately threefold a

93 rocholate uptake into membrane vesicles from cholic acid-fed rats increased twofold above uptake into

94 Cholic acid feeding resulted in greatly increased propor

95 Cholic acid feeding reverses hepatomegaly and hypertrigl

96 e in 55%, P < 0.01; and liver radiation plus cholic acid followed by cell transplantation was most ef

97 the terminal amino groups of spermidine with cholic acid, followed by condensation with bis(3-O-[N-1,

98 57BL/6J-db/db mice and their lean mates with cholic acid for 12 weeks.

99 andard chow or a diet supplemented with 0.5% cholic acid for 2 weeks.

100 r high-fat diet with FXR agonists (GW4064 or cholic acid) for 1 week; 2) C57BLKS/J-db/db mice and the

101 steroidal bis-(N-phenyl)ureas, derived from cholic acid, form crystals in the P6(1) space group with

102 e deoxycholic acid > chenodeoxycholic acid > cholic acid > hyodeoxycholic acid > ursodeoxycholic acid

103 trate that mice fed a diet supplemented with cholic acid have reduced fertility subsequent to testicu

104 After liver radiation or cholic acid, hepatic lipid peroxidation levels increased

105 ession was repressed by a diet containing 1% cholic acid in male mice but was induced by the same die

106 mulated in a dose-response manner by dietary cholic acid in rats.

107 decreased by 80% and selectively enriched in cholic acid in the Slc10a2-/- mice.

108 e causes a structural change in A22 and that cholic acid inhibits this change.

109 Since a bile acid (cholic acid) is required for the diet induced changes in

110 series of molecular umbrellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to

111 (HET), and wildtype (WT) mice a cholesterol/cholic acid lithogenic diet (LD) for up to 56 days and d

112 of these amphiphiles, which are derived from cholic acid, lysine, and p-phenylenediamine, can produce

113 dle' for binding of nucleic acids, while the cholic acid moieties are likely to interact with the lip

114 ies of novel cationic amphiphiles containing cholic acid moieties linked via alkylamino side chains.

115 a derivative (amphiphile 5) containing four cholic acid moieties.

116 holestanoic acid, the 27-carbon precursor of cholic acid, must be activated to its CoA derivative bef

117 In contrast, neither cholic acid nor conjugated bile acids affected the level

118 Long-term treatment with cholic acid normalized liver enzymes and prevented progr

119 ced on standard diets, diets containing 0.5% cholic acid or 1.25% cholesterol, or lithogenic diets.

120 tly attenuated both in vitro when exposed to cholic acid or bile, and in vivo in the gallbladders and

121 1(-/-) mice are fed a diet containing either cholic acid or chenodeoxycholic acid, expression of CYP7

122 ed AOM-induced neurological decline, whereas cholic acid or deoxycholic acid feeding worsened AOM-ind

123 Thus, only cholesterol and not cholic acid or lovastatin could reduce elevated plasma 7

124 t of animals with the hydrophobic bile salt, cholic acid, or liver radiation before cell transplantat

125 sis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic acid in the bile.

126 Cholic acid plus chenodeoxycholic acid levels measured b

127 healthy animals in which liver radiation and cholic acid produced hepatic steatosis and loss of injur

128 A diet containing 1% cholic acid reduced the expression of the human gene in

129 ats preconditioned with liver radiation plus cholic acid resulted in less hepatic copper, indicating

130 vity increased 66% (P < 0.05) with increased cholic acid synthesis (P < 0.01).

131 a-hydroxylase activity 54%, mRNA levels 86%, cholic acid synthesis 38%, and hepatic LDL receptor-medi

132 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays a critical role in intes

133 Bile acid depletion stimulated cholic acid synthesis by up-regulating cholesterol 7alph

134 Cholic acid synthesis decreased at 24 hours but returned

135 ted elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, and hepatic LDL receptor binding

136 droxylase), the specific enzyme required for cholic acid synthesis.

137 e/CYP8b1 is the specific enzyme required for cholic acid synthesis.

138 al bile drainage for 5 days, which maximized cholic acid synthesis.

139 bile acid to approximately 80% and decreased cholic acid to 3% of the total biliary bile acids, the r

140 levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrop

141 levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrop

142 in the early period, whereas the addition of cholic acid to chow prevented deaths in the later period

143 is enzyme to activate the primary bile acid, cholic acid, to its CoA derivative.

144 The hydroxyl at the C-3 of cholic acid was converted to an amino group, and the res

145 logy revealed only minor pathology, although cholic acid was elevated in the serum of mutant mice, an

146 A DNA that binds either Cibacron blue or cholic acid was isolated and partially characterized.

147 [14C]Cholic acid was taken up in similar amounts by strain DH

148 roup, and the resulting amino-functionalized cholic acid was used as a monomer to prepare amide-linke

149 r PET of the endogenous glycine conjugate of cholic acid, we report here a radiosynthesis of N-(11)C-

150 ort oligos that bind either Cibacron blue or cholic acid were enriched from random oligonucleotide po

151 re strikingly sensitive to a diet containing cholic acid, which results in toxic accumulation of hepa

152 The complexes of cyclohexylacetic acid and cholic acid with beta-cyclodextrin were studied by NMR d

153 lational level by free or taurine-conjugated cholic acid within the small intestine.