ライフサイエンスコーパス: choline

1 other ligands (for example, pilocarpine and choline).

2 he bioactive lysophosphatidic acid (LPA) and choline.

3 , glutamine, myo-inositol, NAA, creatine and choline.

4 ely 50% more binding energy for ACh than for choline.

5 i cells after the addition of its precursor, choline.

6 s or increased metabolization of transported choline.

7 between this aromatic ring and both ACh and choline.

8 rostate cancer lesions than with PET/CT with choline.

9 h potential benefit over commonly used (11)C-choline.

10 uired for INO1 expression in the presence of choline.

11 and a low affinity for its metabolic product choline.

12 02 +/- 0.032 mum(2)/ms, P = 0.018) and total choline (0.142 +/- 0.031 mum(2)/ms, P = 0.044) compared

13 with control by the following effect sizes: choline, 0.35 (95% CI: 0.12, 0.57); betaine, 0.29 (95% C

14 fed either a control diet, a diet containing choline (1.2%) or a diet containing TMAO (0.12%) startin

15 regnant (NP) women consuming 480 or 930 mg/d choline (22% as choline-d9, with d9 indicating a deutera

16 groups by median concentrations of TMAO and choline (4.36 and 9.7 mumol/L, respectively).

17 Unlike (18)F-choline, (64)CuCl2 was not excreted or accumulated in th

18 te cancer include those directed to glucose, choline, acetate, prostate-specific membrane antigen, bo

19 al muscles, we show the presence of numerous choline acetyl transferase-like immunoreactive en plaque

20 cence displacement sensor for discriminating choline, acetylcholine, L-carnitine, and glycine betaine

21 ated by immunohistochemical visualization of choline acetyltransferase (ChAT) and the low-affinity ne

22 sion of the critical neurotransmitter enzyme choline acetyltransferase (ChAT) by in vitro motor neuro

23 , abnormally ubiquitinated proteins, reduced choline acetyltransferase (ChAT) enzyme expression, frag

24 ex by using retrograde tracing combined with choline acetyltransferase (ChAT) immunohistochemistry in

25 s Q140 males at 1 and 4 months of age, using choline acetyltransferase (ChAT) immunolabeling to ident

26 ed axons and interneurons immunoreactive for choline acetyltransferase (ChAT) in regions of the execu

27 Immunohistochemistry 14 d after MI revealed choline acetyltransferase (ChAT) in stellate sympathetic

28 edium spiny neurons (MSNs) and D2-expressing choline acetyltransferase (ChAT) interneurons express Sl

29 enzyme glutamic acid decarboxylase (GAD) and choline acetyltransferase (ChAT) revealed that all CG ne

30 been reported to potentiate the activity of choline acetyltransferase (ChAT), the enzyme that produc

31 ither vesicular acetylcholine transporter or choline acetyltransferase (ChAT).

32 , glutamate decarboxylases (gad1, gad2), and choline acetyltransferase (chat).

33 We found that upregulated translation of choline acetyltransferase in the CPEB2 KO dorsal motor n

34 sin (eNpHR), or channelrhodopsin-2 (ChR2) in Choline acetyltransferase neurons (ChAT(+)) or Arch in L

35 Choline acetyltransferase neurons in the vertical diagon

36 me in the production of acetylcholine (i.e., choline acetyltransferase).

37 detection of NOS with tyrosine hydroxylase, choline acetyltransferase, calbindin, calretinin, and se

38 uorescence staining using antibodies against choline-acetyltransferase and neurofilament was performe

39 ngs of the current study do not support that choline, administered at a dose of 625 mg/d for 6 wk, is

40 Importantly, choline also enhances swarming-associated colony expansi

41 anism whereby low maternal dietary intake of choline alters brain development.

42 Maternal diets low in choline, an essential nutrient, increase the risk of neu

43 [(14)C]Choline and [(3)H]palmitate tracking shows that SMS1 ove

44 ocognitive development, we hypothesized that choline and betaine could also be positively related to

45 lism.We evaluated the associations of plasma choline and choline-related compounds with cardiometabol

46 vitro phosphatidylcholine formation from CDP-choline and diacylglycerol, and full activity required d

47 young children is associated with low serum choline and elevated betaine-to-choline and TMAO-to-chol

48 n constants (Kd ) in the nanomolar range for choline and glycine betaine, micromolar Kd for stachydri

49 The relation between serum choline and its closely related metabolites with linear

50 s to characterize the relation between serum choline and its closely related metabolites, betaine and

51 e (higher LDL cholesterol and triglycerides).Choline and its metabolites have differential associatio

52 Metabolites derived from dietary choline and L-carnitine, such as trimethylamine N-oxide

53 inolenic acid (ALA), or ratios of betaine to choline and LA to ALA.The findings supported our hypothe

54 Combined with other studies of choline and nutritional interventions in this population

55 introduction of eggs significantly improved choline and other markers in its methyl group metabolism

56 gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, i

57 ajor phospholipid classes, i.e. phosphatidyl-choline and phosphatidyl-inositol, were differentially a

58 d when extracellular Na(+) was replaced with choline and significantly reduced by an NHE inhibitor, c

59 th low serum choline and elevated betaine-to-choline and TMAO-to-choline ratios.

60 crease in the average diffusivities of total choline and total creatine, correlate with systemic lupu

61 turb several biochemical pathways, including choline and tryptophan metabolism, while also increasing

62 sured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphi

63 s oocytes can be activated by acetylcholine, choline, and nicotine, inhibited by the channel blockers

64 uated for cardiac brain natriuretic peptide, choline, and TMAO levels.

65 was an increase in the urinary excretion of choline- and amino-acid-derived metabolites.

66 lutamate/glutamine, reduced myo-inositol and choline are hyperammonemia-associated astrocytic changes

67 nion helicate receptor whose selectivity for choline arises from a similar binding mechanism.

68 Choline at levels found in the amniotic fluid is an agon

69 entify other possible substrates such as CDP-choline, ATP, and ADP.

70 A total of 67 choline-avid metastases were identified: 44 bone lesions

71 alities because degenerative changes are not choline-avid; however, the agent may accumulate in recen

72 of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL).

73 mbryonic liver, with lower concentrations of choline, betaine and phosphocholine.

74 Plasma concentrations of free choline, betaine, and phosphatidylcholine were measured

75 We measured serum choline, betaine, and TMAO concentrations by using liqui

76 Median (25th, 75th percentile) serum choline, betaine, and TMAO concentrations were 6.4 (4.8,

77 n correlation coefficients of age with serum choline, betaine, and TMAO were -0.57 (P < 0.0001), -0.2

78 ive immunoassay and plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fa

79 icients of height-for-age z score with serum choline, betaine-to-choline ratio, and TMAO-to-choline r

80 of 930 mg/d restored partitioning of dietary choline between betaine and CDP-PC among NP (MTHFR rs180

81 iated endocytosis (CME) and independently of choline binding protein A (CbpA)/laminin receptor, CbpA/

82 s-1, RrgA, binds both receptors, whereas the choline binding protein PspC binds, but to a lower exten

83 is head group via an aromatic box, a typical choline-binding motif.

84 rnitine, and glycine betaine effectively.The choline-binding protein ChoX exhibits a synergistic dual

85 2) featuring a cavity resembling that of the choline-binding protein ChoX, as revealed by crystal and

86 uoromethyl sulfonyl)imide ([Hbet][Tf2N]) and choline bis(trifluoromethylsulfonyl)imide ([choline][Tf2

87 , is produced from the metabolism of dietary choline by the gut microbiome.

88 Choline can be irreversibly converted to betaine, a majo

89 zyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE

90 Different combinations of DES consisting of choline chloride (ChCl) in various mixing ratios with su

91 p eutectic solvent (DES) formed by mixing of choline chloride and phenol was used as an extraction so

92 eously, the reaction could be carried out in choline chloride urea as a natural deep eutectic solvent

93 ES for proposed extraction was performed and choline chloride-based DES containing oxalic acid as a h

94 ibitory property, whereas the supernatant of choline chloride-treated R36A, containing CBPs, was mark

95 The nanostructure of a series of choline chloride/urea/water deep eutectic solvent mixtur

96 concentration for N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr).

97 is, nucleotide and amino acid synthesis, and choline (Cho) metabolism.

98 thalamic volumes and N-acetylaspartate (NAA)/choline (Cho), and fractional anisotropy of white-matter

99 erve-muscle synapse is hydrolysed rapidly to choline (Cho), so endplate receptors (AChRs) are exposed

100 ral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafte

101 [Cit], spermine [Spm], and creatine [Cr] to choline [Cho] and Cho to Cr plus Spm) were correlated wi

102 spartyl-glutamate (NAA) to creatine (Cr) and choline compounds (Cho) to Cr in widespread cerebral cor

103 e glia, suggesting that the diffusivities of choline compounds and of total creatine are potentially

104 inantly glial creatine + phosphocreatine and choline compounds.

105 High TMAO and choline concentrations are associated with an advanced c

106 the median (n = 82), the group with TMAO and choline concentrations that were at least the median (n

107 Compared with the group with TMAO and choline concentrations that were less than the median (n

108 Serum choline concentrations were strongly and significantly a

109 units for healthy volunteers (P = .049); and choline concentrations, 0.17 (0.09-0.22) relative units

110 index, and plasma folate, vitamin B-12, and choline concentrations.

111 Mice harboring high levels of choline-consuming bacteria showed increased susceptibili

112 vious studies have found increased levels of choline-containing compounds (ie, glycerophosphocholine

113 Groups also were compared on NAA, choline-containing compounds, Cr, and mI concentrations

114 d smokers (n = 35), N-acetylaspartate (NAA), choline-containing compounds, creatine-containing compou

115 ethylamine (TMA) from carnitine, choline, or choline-containing compounds.

116 cipants in the choline group received 625 mg choline/d for 6 wk, whereas subjects in the placebo grou

117 en consuming 480 or 930 mg/d choline (22% as choline-d9, with d9 indicating a deuterated trimethyl am

118 -mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it

119 owever, the consequences of maternal dietary choline deficiency for the development and structural or

120 and recapitulating biochemical signatures of choline deficiency.

121 models of NASH, particularly the methionine-choline deficient (MCD) model, profound changes are seen

122 C57Bl/6 mice fed chow or a methionine and choline-deficient (MCD) diet for 1 week were divided int

123 (lipopolysaccharide) or fed a methionine and choline-deficient (MCD) diet to induce experimental NASH

124 c liver damage induced by CCl4 or methionine-choline-deficient (MCD) diet, liver injury and fibrosis

125 holic liver disease (ALD) and methionine and choline-deficient (MCD) diet-induced liver injury.

126 andard chow for 4 weeks or a methionine- and choline-deficient diet for 1, 4, 8, or 12 weeks to induc

127 arly fibrosis were induced by the methionine-choline-deficient diet in mice.

128 Western-type diet, mice on a methionine- and choline-deficient diet, mice on a high-fat diet given st

129 Db/db mice and methionine-choline-deficient diet-fed mice were administered BBR vi

130 chloride (CCl4) or placement on a methionine-choline-deficient diet.

131 damage in leptin-deficient ob/ob mice and in choline-deficient mice, two etiologically different mode

132 appaOR in the LHA attenuated both methionine choline-deficient, diet-induced and choline-deficient, h

133 murine models of chronic liver disease: the choline-deficient, ethionine-supplemented (CDE) diet ver

134 thionine choline-deficient, diet-induced and choline-deficient, high-fat diet-induced ER stress, infl

135 Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/wi

136 oline-trimethylamine lyase, is essential for choline degradation to trimethylamine by targeted mutage

137 ne can be synthesized in mammalian cells via choline dehydrogenase (CHDH; EC 1.1.99.1), we assessed w

138 tibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at

139 strategy to a (15) N2 -diazirine-containing choline derivative demonstrates the potential of (15) N2

140 An extensive lipidomic screen of choline derivatives showed that total phosphatidylcholin

141 H-bonds position ACh and choline differently in the aromatic cage to generate the

142 N-acetylaspartate, total creatine and total choline diffusion values from all patients with systemic

143 tabolites, e.g., amino acids, organic acids, choline esters and glucose.

144 es systemic glucose metabolism, we perturbed choline/ethanolamine phosphotransferase 1 (CEPT1), the t

145 pounds present distinct binding modes to the choline/ethanolamine-binding site of P. falciparum choli

146 Intakes of choline, folate, methionine, and vitamins B6 and B12 wer

147 64)CuCl2 is more suitable than that of (18)F-choline for exploring the pelvis and prostatic bed.

148 olate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expens

149 ptake revealed a deficit in the amount of d9-choline found inside NECL4-deficient Schwann cells, sugg

150 t amino acids, the compounds quantified were choline, glycerophosphocholine, phosphocholine, glycine

151 hemotaxis of S. meliloti towards betonicine, choline, glycine betaine, stachydrine and trigonelline.

152 ase (ChOx), a member of the glucose-methanol-choline (GMC) family, catalyzes the oxidation of the sub

153 Participants in the choline group received 625 mg choline/d for 6 wk, wherea

154 ining whether gut microbiota and the dietary choline --> TMAO pathway contribute to increased heart f

155 pancies of cation-pi interactions between PC choline headgroups and protein tyrosines vary as a funct

156 de cell adhesion molecule, NECL4, regulating choline homeostasis and lipid biogenesis.

157 w PET imaging probe in comparison with (11)C-choline in 2 prostate cancer tumor xenograft models (DU-

158 eory (DFT)-optimized structures, which binds choline in a unique dual-site-binding mode.

159 There is a potential role of choline in cardiovascular and cerebrovascular disease th

160 e significantly elevated compared with (11)C-choline in DU-145 (TBR: 1.92 +/- 0.11 for (11)C-sarcosin

161 Maternal dietary intake of choline in mice regulates development of the cerebral co

162 gher diffusivity of total creatine and total choline in patients with NPSLE, as well as the positive

163 bolic tumor volume (MTV) and total uptake of choline in the lesion, were studied.

164 contrast, cortical levels of cholesterol and choline increased over time in Li-treated mice.

165 tes with phosphocholine, however, attenuated choline-induced ion current changes, suggesting that pho

166 Treatment compliance and mean dietary choline intake were not predictive of treatment outcomes

167 n with these risk genotypes may benefit from choline intakes exceeding current recommendations.

168 Choline intakes of 930 mg/d restored partitioning of die

169 al trial, we explored the effectiveness of a choline intervention for children with FASDs who were ag

170 Choline is a crucial methyl donor necessary for epigenet

171 Choline is an essential nutrient and methyl donor requir

172 Choline is an essential nutrient for cell structure, cel

173 Here, we demonstrate that choline is an important growth substrate for representat

174 Because another 1-CM nutrient, choline is essential for fetal neurocognitive developmen

175 Dietary intake of choline is marginal in many adolescents and may be a pub

176 esis pathway combining conserved prokaryotic choline kinase and CTP:phosphocholine cytidylyltransfera

177 veals a mode of action for two P. falciparum choline kinase inhibitors both in vitro and in vivo.

178 e/ethanolamine-binding site of P. falciparum choline kinase, reflecting different types of inhibition

179 -3-phosphate acyltransferase GPAM along with choline kinase-alpha (CHKA), the enzymes that catabolize

180 efforts selectively targeting P. falciparum choline kinase.

181 Choline kinases (ChKs) could also be critical in the ear

182 olecular PET/CT imaging with (11)C- or (18)F-choline-labeled derivatives is increasingly being used,

183 ncreased abundance of taurine, isoglutamine, choline, lactate, phenylalanine and tyrosine and decreas

184 we fed mouse dams either control (CT) or low-choline (LC) diets and investigated the effects of choli

185 We show that intracellular choline levels are significantly elevated in NECL4-defic

186 regnancy to increase maternal amniotic fluid choline levels would enhance fetal development of cerebr

187 asma concentrations of trimethylamine, TMAO, choline, lipids, phospholipids, and methyl metabolites w

188 blood through hydrolysis of lysophosphatidyl choline (LPC).

189 bilis as a model, we investigate the role of choline metabolism and demonstrate that the cutC gene, e

190 Together, our study reveals choline metabolism as an adaptation strategy for P. mira

191 y to examine the impact of candidate SNPs on choline metabolism in a long-term, randomized, controlle

192 ere, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology

193 veal an underappreciated effect of bacterial choline metabolism on host metabolism, epigenetics, and

194 Within the visual cortex, choline metabolism was perturbed along with increasing d

195 pathways such as phospholipid biosynthesis, choline metabolism, and lipoprotein metabolism.

196 ed plasma concentrations of the gut bacteria choline metabolite trimethylamine N-oxide (TMAO) are ass

197 Maternal folate and choline metabolites and gene expression in folate-relate

198 Balance of labile methyl groups (choline, methionine, betaine, and folate) is important f

199 leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, embryonic growth delay and me

200 .5 embryos, pups and dams were collected for choline/methyl metabolite measurements, immunoblotting o

201 tive to other NPPs, alk-SMase recognizes the choline moiety of its substrates via an NPP7-specific ar

202 xposure were randomly assigned to either the choline (n = 29) or placebo (n = 26) treatment arms.

203 (11)C-sarcosine vs. 1.41 +/- 0.13 for (11)C-choline [n = 10; P < 0.002]) and PC-3 tumors (TBR: 1.89

204 (11)C-sarcosine vs. 1.34 +/- 0.16 for (11)C-choline [n = 7; P < 0.002]).

205 oxel (basal ganglia) N-acetylaspartate (NAA)/Choline, NAA/Creatine and myo-inositol/Creatine ratios w

206 omparative transcriptomics demonstrated that choline not only induces choline-trimethylamine lyase bu

207 e (LC) diets and investigated the effects of choline on cortical development in the offspring.

208 tide fractions interacted more strongly with choline on the liposome surfaces.

209 Feeding flies choline or inhibiting acetylcholinesterase in Pn enhance

210 d in mice fed diets supplemented with either choline or the gut microbe-dependent metabolite TMAO.

211 In animal studies, dietary choline or TMAO significantly accelerates atheroscleroti

212 Animal model studies employing dietary choline or TMAO, germ-free mice, and microbial transplan

213 ecursor trimethylamine (TMA) from carnitine, choline, or choline-containing compounds.

214 antitative determination of both glucose and choline over a wide concentration range.

215 o a similarly high selectivity of host 2 for choline over its derivatives, as demonstrated by the NMR

216 binding mode that allows it to discriminate choline over structural analogues.

217 ing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nano

218 ected two enzymes (glucose dehydrogenase and choline oxidase) that react with their respective model

219 synthesis via the cytidine diphosphate (CDP)-choline pathway at the expense of betaine synthesis even

220 the regulated and rate-limiting step in the choline pathway for PC biosynthesis was catalyzed by CTP

221 Eugene Kennedy in the 1950s established the choline pathway for phosphatidylcholine (PC) biosynthesi

222 hatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema.

223 ng on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fat

224 ing prospective clinical trial, hybrid (18)F-choline PET/CT and multiparametric 3T MRI (mpMRI) of the

225 The DRs of (18)F-choline PET/CT and multiparametric MRI were 56% and 74%,

226 Furthermore, the role of (11)C-choline PET/CT as a diagnostic tool for monitoring castr

227 For N staging, (11)C- or (18)F-choline PET/CT can provide potentially useful informatio

228 Choline PET/CT could be of help in discriminating patien

229 etection of bone metastases, (11)C- or (18)F-choline PET/CT has had promising results; however, in te

230 (64)CuCl2 PET/CT had a higher DR than (18)F-choline PET/CT in patients with a PSA of less than 1 ng/

231 Finally, the role of (11)C-choline PET/CT in the prediction of survival in both cas

232 tiveness, the routine use of (11)C- or (18)F-choline PET/CT is still debatable.

233 (11)C- or (18)F-choline PET/CT might be used in high-risk PC before radi

234 etween the DRs of (64)CuCl2 PET/CT and (18)F-choline PET/CT was statistically significant (P < 0.001)

235 l patients underwent (64)CuCl2 PET/CT, (18)F-choline PET/CT, and multiparametric MRI within 15 d of e

236 unctional MRI is superior to (11)C- or (18)F-choline PET/CT.

237 T shows a significantly higher DR than (18)F-choline PET/CT.

238 e of fusion (18)F-fluoromethylcholine ((18)F-choline) PET/MRI for image-guided (targeted) prostate bi

239 terionic methacrylate monomers, specifically choline phosphate structures, and show the utility of th

240 esignated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phospho

241 sferase activities with a 1,2-diacylglycerol choline phosphotransferase that is common in eukaryotes.

242 rol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step

243 mino acid glycine and a metabolic product of choline, plays an important role for prostate cancer agg

244 or fewer extracranial metastatic lesions on choline positron emission tomography-computed tomography

245 oteolysis and increases in microbial dietary choline processing were observed.

246 oline, betaine-to-choline ratio, and TMAO-to-choline ratio were 0.31 (P < 0.0001), -0.24 (P < 0.0001)

247 r-age z score with serum choline, betaine-to-choline ratio, and TMAO-to-choline ratio were 0.31 (P <

248 and elevated betaine-to-choline and TMAO-to-choline ratios.

249 uated the associations of plasma choline and choline-related compounds with cardiometabolic risk fact

250 us or based on the indirect determination of choline released during PLD-catalyzed phosphatidylcholin

251 esearch provides important information about choline's therapeutic window.

252 The combined glutamate and glutamine and choline showed no changes in drug-off or drug-on conditi

253 with several brain metabolites including the choline species, glutamate, glutathione, and GABA.

254 Choline status has been associated with stunting among y

255 a clinical population to investigate whether choline supplementation can ameliorate the severity of m

256 .05, each) worse in mice fed either TMAO- or choline-supplemented diets when compared with the contro

257 As a result of a low choline supply between embryonic day (E)11 and E17 of ge

258 Bis-choline tetrathiomolybdate (WTX101) is an oral first-in-

259 choline bis(trifluoromethylsulfonyl)imide ([choline][Tf2N]) showed that (1) the specific energy of t

260 selective production of IgM anti-phosphoryl choline, these data suggest that human B-1 cells might b

261 tepwise increases of sarcosine, glycine, and choline tissue levels from benign prostate tissue to loc

262 Proteus mirabilis can rapidly utilize choline to enhance growth rate and cell yield in broth c

263 Supplementation of choline to inositol-depleted growth medium led to decrea

264 ng of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide addi

265 However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear.

266 with these variants partitioned more dietary choline toward phosphatidylcholine (PC) biosynthesis via

267 asic, trial-based increases in extracellular choline (transients), resulting from the hydrolysis of n

268 cortical choline transporter (CHT)-mediated choline transport in GTs, paralleled by a redistribution

269 Furthermore, pharmacological inhibition of choline transport induced sign-tracking behavior.

270 on of the basal forebrain increased cortical choline transporter (CHT)-mediated choline transport in

271 e presynaptic sodium-dependent high-affinity choline transporter 1 (CHT), which is known to be mutate

272 cular ACh transporter, and the high-affinity choline transporter CHT1.

273 cantly reduced, but not completely abrogated choline transporter function.

274 Here, we reported that a choline transporter gene, CTL1, controls ionome homeosta

275 underscore the essential role played by the choline transporter in sustaining acetylcholine neurotra

276 The presynaptic, high-affinity choline transporter is a critical determinant of signall

277 a broad clinical phenotype due to homozygous choline transporter missense mutations.

278 l outcomes arising from different classes of choline transporter mutation with distinct disease proce

279 he trafficking of the Caenorhabditis elegans choline transporter orthologue revealed deficits in tran

280 ive frameshift mutation at the C-terminus of choline transporter that was associated with significant

281 Characterizing choline transporter-like 1 (CTL1) as a new regulator of

282 tern blotting techniques, we have identified choline transporter-like 1 (CTL1) as a putative complexi

283 The choline transporter-like 1 (CTL1) protein is localized t

284 The CTL1 gene encodes a choline transporter-like protein with an expression patt

285 s demonstrated that choline not only induces choline-trimethylamine lyase but also genes encoding she

286 d demonstrate that the cutC gene, encoding a choline-trimethylamine lyase, is essential for choline d

287 pond to stimulation by elevating presynaptic choline uptake and releasing acetylcholine is attenuated

288 (18)F-choline uptake measures were obtained from the MR target

289 Neither increases in choline uptake nor translocation of CHTs occurred in STs

290 The analysis of extracellular d9-choline uptake revealed a deficit in the amount of d9-ch

291 Our results indicate that choline-utilizing bacteria compete with the host for thi

292 ng a microbial community that lacks a single choline-utilizing enzyme.

293 crobe, Romano et al. (2017) demonstrate that choline-utilizing gut bacteria compete with their host f

294 f acetylcholine by acetylcholinesterase into choline was monitored in real-time for a range of acetyl

295 Plasma choline was significantly and positively associated with

296 ar pathology.Higher concentrations of plasma choline were associated with an unfavorable cardiometabo

297 sine and its natural precursors, glycine and choline, were performed from independent human prostate

298 lproic acid, theophylline-7-acetic acid, and choline, were synthesized and evaluated in SH-SY5Y (huma

299 thesized betaine in vitro in the presence of choline, whereas this failed to occur in Chdh(-/-) oocyt

300 Preclinical animal studies have shown that choline, which is an essential nutrient, can attenuate t