ライフサイエンスコーパス: choline deficiency

1 and recapitulating biochemical signatures of choline deficiency.

2 (NAFLD) and steatohepatitis associated with choline deficiency.

3 encephaly in response to maternal folate and choline deficiency.

4 velopment of fatty liver under conditions of choline deficiency.

5 and to investigate the clinical sequelae of choline deficiency.

6 ) were not associated with susceptibility to choline deficiency.

7 developing organ dysfunction associated with choline deficiency.

8 termine the metabolic characteristics of the choline deficiency.

9 associated with increased susceptibility to choline deficiency.

10 pendent of obesity, caused by methionine and choline deficiency.

11 etabolism modify susceptibility of humans to choline deficiency.

12 line supplementation and reduced by prenatal choline deficiency.

13 ns may be selectively vulnerable to in utero choline deficiency.

14 o not have to be dividing to be sensitive to choline deficiency.

15 l biomarkers of fatty liver that result from choline deficiency, adding to the accumulating evidence

16 Choline deficiency also impaired mitochondria function,

17 ointestinal bacteria each respond to dietary choline deficiency, although the gut microbiota remains

18 s have implied a causal relationship between choline deficiency and carcinogenesis, the role of these

19 hether increasing choline intake may correct choline deficiency and improve growth and development.

20 ted with increased susceptibility to dietary choline deficiency and risk of breast cancer.

21 uces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruptio

22 In the nutritional cirrhosis of choline deficiency, and in acute toxic injury as well, t

23 Lipid emulsions, choline deficiency, and manganese toxicity are associate

24 uscle abnormalities have been described, and choline deficiency appears to activate cellular apoptosi

25 l nutrition therapy, develops as a result of choline deficiency because endogenous production of chol

26 cyte (CWSV-1) cells undergo apoptosis during choline deficiency (CD).

27 menopausal women are relatively resistant to choline deficiency compared with postmenopausal women an

28 Although prenatal choline deficiency compromises adult hippocampal plastic

29 Choline deficiency did not affect body or adipose depot

30 Choline deficiency during fetal development reduces prol

31 Severe dietary choline deficiency during pregnancy leads to birth defec

32 ine, and we previously reported that dietary choline deficiency during pregnancy reduces neurogenesis

33 -mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it

34 improvements in memory performance, whereas choline deficiency during this time impairs certain aspe

35 Ch) release from hippocampal slices, whereas choline deficiency during this time reduces this release

36 inomas of male F344 rats exposed to a cyclic choline deficiency-ethionine (CDE) diet (2 weeks on, 1 w

37 Prenatal choline deficiency failed to alter PLD activity.

38 owever, the consequences of maternal dietary choline deficiency for the development and structural or

39 asting enhancement of spatial memory whereas choline deficiency has the opposite effect.

40 against age-related memory decline, whereas choline deficiency impairs certain cognitive functions.

41 choline in utero might be beneficial during choline deficiency in adulthood.

42 erum CPK may be a useful clinical marker for choline deficiency in humans.

43 addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease

44 In mice on 30% fat diet, choline deficiency increased liver mRNA levels of the ra

45 period [postnatal days (P) 18-480], prenatal choline deficiency increased the expression of CHT mRNA

46 We previously demonstrated that choline deficiency induced apoptosis in PC12 cells and s

47 Choline deficiency induced widespread apoptosis in prima

48 crease in ceramide (Cer) was associated with choline deficiency-induced apoptosis in primary neurons.

49 spase is a common mediator of apoptosis, and choline deficiency-induced apoptosis was prevented compl

50 These data suggest that choline deficiency-induced changes in gene methylation c

51 nergistic effects of protein restriction and choline deficiency influence integrated metabolism and h

52 We investigated how diet standardization and choline deficiency influence the composition of the micr

53 In contrast, prenatal choline deficiency is associated with poor performance i

54 hose receiving parenteral nutrition) in whom choline deficiency is suspected.

55 We conclude that choline deficiency kills CWSV-1 hepatocytes in culture b

56 However, choline deficiency lowered fasting plasma insulin (from

57 Some of these increase the risk of choline deficiency many-fold.

58 CHT expression during the period of prenatal choline deficiency may be considered as a compensatory m

59 d aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural i

60 a role, whereas in both adults and children, choline deficiency may exacerbate IFALD.

61 resistance during high-fat feeding and that choline deficiency may shunt potentially toxic free fatt

62 ury, such as induced by allyl alcohol and to choline-deficiency models of hepatocarcinogenesis.

63 Thus, choline deficiency modulates fetal DNA methylation machi

64 likely than noncarriers to develop signs of choline deficiency (odds ratio, 7.0; 95% confidence inte

65 This study examined the effect of choline deficiency on muscle cells and the release of cr

66 synergistic roles of protein restriction and choline deficiency on the pleiotropic effects of rodent

67 erived from steatohepatitis, but not dietary choline deficiency or steatosis.

68 One of these, a choline deficiency oscillator (CDO) observed in chol-1 m

69 o most published studies using uninterrupted choline deficiency plus a carcinogen, hepatocellular car

70 Our goal was to determine whether choline deficiency results in a decreased capacity to me

71 Choline deficiency results in diminished concentrations

72 choline but was not associated with signs of choline deficiency, such as perturbed lipoprotein secret

73 he G9a and Suv39h1 genes was up-regulated by choline deficiency, suggesting that the expression of th

74 gan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)).

75 Choline deficiency, through disturbing methyl metabolism

76 ndividual contribution of dietary folate and choline deficiency to NTD incidence in this mouse model

77 Choline deficiency was observed in more than half of the

78 Criteria for clinical choline deficiency were a more than five times increase

79 Carbon tetrachloride and methionine/choline deficiency were used as chronic liver injury mod

80 had a protective effect on susceptibility to choline deficiency, while a second CHDH variant (+432 G-