ライフサイエンスコーパス: cholinergic agonist

1 by increasing concentrations of carbachol, a cholinergic agonist.

2 larization by both elevated K+ and nicotinic cholinergic agonist.

3 duction of LTD, including LTD triggered by a cholinergic agonist.

4 wing in vivo stimulation with pilocarpine, a cholinergic agonist.

5 those resulting from injection of muscarinic cholinergic agonists.

6 these mice failed to show AHR in response to cholinergic agonists.

7 sleep, which is similar to that produced by cholinergic agonists.

8 ncytium upon stimulation with adrenergic and cholinergic agonists.

9 use and human ASM contraction in response to cholinergic agonists.

10 vefold decrease in sensitivity to muscarinic cholinergic agonists.

11 e muscarinic receptors that are activated by cholinergic agonists.

12 D stellate cells tested were insensitive to cholinergic agonists.

13 sensitive cells responded to both classes of cholinergic agonist, 29% responded exclusively to nicoti

14 iminish in strength (short-term depression), cholinergic agonist (5-10 microM carbachol (CCh)) reduce

15 nd type II HCs during the application of the cholinergic agonists, acetylcholine and carbachol, and t

16 A prior study showed that cholinergic agonists activate phospholipase D (PLD).

17 Cholinergic agonists activate PLD1 through Rho and ROCK,

18 This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrener

19 ), by hemicholinium-3 (HC3) and by nicotinic cholinergic agonists - all of which inhibit ACh loading

20 In nocturnal species cholinergic agonists alter circadian rhythm phase when i

21 Cholinergic agonists amplify insulin release by several

22 d cognitive impairment of PSP, but trials of cholinergic agonists and cholinesterase inhibitors have

23 and rat cultured conjunctival goblet cells, cholinergic agonists and EGF activate MAPK with a simila

24 protein kinase (MAPK) activity stimulated by cholinergic agonists and growth factors that could accou

25 nicotine exposure they remained sensitive to cholinergic agonists and retained high levels of recepto

26 pment of airway hyperresponsiveness (AHR) to cholinergic agonists and severe asthmatic symptoms.

27 circadian rhythm of neuronal firing rate by cholinergic agonists and to identify the receptor subtyp

28 matory potential of both the vagus nerve and cholinergic agonists, and abrogate their potential to in

29 n with secretin, forskolin, HCO(3)(-)/CO(2), cholinergic agonists, and beta-adrenergic agonists, with

30 Cholinergic agonist application has been found previousl

31 uron response can occur within seconds after cholinergic agonist application, to date the increase in

32 racellular phosphorylation cascades and that cholinergic agonists are effective for treating patients

33 that mediates the phase shifts observed when cholinergic agonists are injected intraventricularly.

34 attention further if more specific nicotinic cholinergic agonists are used, or if cholinesterase inhi

35 atrial myocytes indicate that withdrawal of cholinergic agonist can directly increase Ca2+ influx vi

36 These cells were incubated with the cholinergic agonist carbachol (10(-4) M) or EGF (10(-8)

37 cini were incubated with EGF (10(-7) M), the cholinergic agonist carbachol (10(-4) M), or the alpha(1

38 etween SP neurons in the LH and the RVM, the cholinergic agonist carbachol (125 nmol) was microinject

39 [Ca(2+)](i) with a brief application of the cholinergic agonist carbachol (25 microM) or elevated KC

40 ed to lever-press for microinjections of the cholinergic agonist carbachol (30-500 pmol per infusion)

41 edulla were stimulated by microinjecting the cholinergic agonist carbachol (5 microg) into sites in t

42 In all neuronal compartments, the cholinergic agonist carbachol (5 microM) increased resti

43 combination of kainate (KA, 200 nm) and the cholinergic agonist carbachol (Cb, 10 mum) fast network

44 physiologic and pathologic responses to the cholinergic agonist carbachol (Cch) and cholecystokinin

45 Importantly, the cholinergic agonist carbachol (CCh) induces gamma oscill

46 re, we examined the effect of the muscarinic cholinergic agonist carbachol (CCh) on ICa-L and contrac

47 We studied the effect of the cholinergic agonist carbachol (CCh) on this pattern of a

48 and MAPK activity after stimulation with the cholinergic agonist carbachol (Cch) or epidermal growth

49 The cholinergic agonist carbachol (Cch) stimulated the secre

50 , or C3 exotoxin before stimulation with the cholinergic agonist carbachol (Cch, 10(-4) M) for 5 minu

51 The cholinergic agonist carbachol altered the circadian rhyt

52 Concomitant application of the cholinergic agonist carbachol and nanomolar doses of kai

53 tude similar to the increases induced by the cholinergic agonist carbachol at 10(-6) to 10(-4) M.

54 Calcium ionophore A23187 and the muscarinic cholinergic agonist carbachol both promote the dissociat

55 myocytes expressing WT eNOS, the muscarinic cholinergic agonist carbachol completely abrogated the s

56 y within the ILn, improved DMTP, whereas the cholinergic agonist carbachol impaired performance at th

57 ancreata secreted insulin in response to the cholinergic agonist carbachol in a glucose-dependent man

58 at intra-ventral tegmental injections of the cholinergic agonist carbachol induce reward; such inject

59 eep can be activated by the injection of the cholinergic agonist carbachol into a circumscribed regio

60 Transient infusion of the cholinergic agonist carbachol into hippocampal slices in

61 For example, injection of the cholinergic agonist carbachol into the dorsomedial pons

62 w experimentally that direct infusion of the cholinergic agonist carbachol into the striatum, but not

63 We found that modest doses of the cholinergic agonist carbachol normally decorrelate spont

64 or without increasing concentrations of the cholinergic agonist carbachol or VIP.

65 Cells were stimulated with the cholinergic agonist carbachol or with the cytokine TNF-a

66 yocytes, we demonstrated that the muscarinic cholinergic agonist carbachol promotes the translocation

67 The cholinergic agonist carbachol suppressed each of the syn

68 The cholinergic agonist carbachol was infused into the media

69 To test this hypothesis, the cholinergic agonist carbachol was microinjected into the

70 toxin-sensitive inhibition by the muscarinic cholinergic agonist carbachol was unaltered in myocytes

71 ental model, we have recently shown that the cholinergic agonist carbachol, but not platelet-derived

72 ortical astrocytes previously exposed to the cholinergic agonist carbachol, displayed longer neurites

73 ylbenzoyl)adenosine 5' triphosphate (BzATP), cholinergic agonist carbachol, or the activator of conve

74 rc inhibitor PP1 before stimulation with the cholinergic agonist carbachol, the alpha(1D)-adrenergic

75 eversed either spontaneously or by using the cholinergic agonist carbachol.

76 ppressed IPSCs induced by application of the cholinergic agonist carbachol.

77 Injections of cholinergic agonists carbachol or muscarine into HVc str

78 phosphorylation of pp66 is increased by the cholinergic agonist, carbachol, and by the PKC activator

79 iched parietal cells in response to both the cholinergic agonist, carbachol, and the calcium ionophor

80 d rats in which pontine microinjections of a cholinergic agonist, carbachol, can repeatedly elicit RE

81 the atonia produced by microinjections of a cholinergic agonist, carbachol, into the dorsal pontine

82 ed hyperactivity of fusiform cells using the cholinergic agonist, carbachol.

83 Conversely, the cholinergic agonist carbamylcholine decreased I(M) in th

84 tion was observed between genotypes, but the cholinergic agonist carbamylcholine enhanced glucose-ind

85 gic agonist isoproterenol and the muscarinic cholinergic agonist carbamylcholine.

86 eated gastric chief cells, incubation with a cholinergic agonist (carbamylcholine), a regulatory pept

87 ition of endothelial cell activation by both cholinergic agonists, confirming the antiinflammatory ro

88 By contrast, the cholinergic agonist did not alter high-frequency gamma o

89 This cholinergic agonist enhanced spatial attention effects o

90 Cholinergic agonists evoked no permeation.

91 Likewise, vagus nerve and cholinergic agonists fail to control inflammation in spl

92 ministration of oxotremorine, an unselective cholinergic agonist, Gnal(+/-) mice developed more abnor

93 Pretreatment with a cholinergic agonist improved learning ability on visual

94 used a strategy of combining M40 with an M1 cholinergic agonist in rats lesioned with the cholinergi

95 nflammatory potential of the vagus nerve and cholinergic agonists in immunocompromised and septic ani

96 ectrical stimulation as well as injection of cholinergic agonists in this area produces analgesia.

97 persistent gamma rhythms evoked in vitro by cholinergic agonists) in which individual principal cell

98 o an inhibitor of acetylcholinesterase and a cholinergic agonist, indicating altered synaptic functio

99 whereas separate in vitro studies show that cholinergic agonists induce high-frequency oscillations

100 lly reversed the inhibitory effect of PMA on cholinergic agonist-induced Ca2+ elevation.

101 PMA completely inhibited the cholinergic agonist-induced plateau of [Ca2+]i.

102 Cholinergic agonists inhibit cytokine synthesis and prot

103 Thus, vagus nerve and cholinergic agonists inhibit systemic inflammation by ac

104 Electrical stimulation and cholinergic agonist injection into the mesopontine retic

105 Infusion of muscarinic cholinergic agonists into the MSDB enhance learning and

106 Treatment of Alzheimer's disease with a cholinergic agonist is associated with a decrease in the

107 Nicotine, a selective cholinergic agonist, is more efficient than acetylcholin

108 t binds with high affinity in the absence of cholinergic agonist (K(eq) = 0.5 microM) and weakly (K(e

109 In naive animals, acute exposure to cholinergic agonists led to the efficient stimulation of

110 or mutants with decreased sensitivity to the cholinergic agonist levamisole.

111 Present therapies for the CMS include cholinergic agonists, long-lived open-channel blockers o

112 y of chromaffin cells, our data suggest that cholinergic agonists may stimulate the release of this A

113 , consistent with its modest response to the cholinergic agonist nicotine.

114 which mediates the attenuation by muscarinic cholinergic agonists of beta-adrenergic stimulation of L

115 The effects of a pharmacological cholinergic agonist on gut barrier integrity were studie

116 One of the more prominent effects of cholinergic agonists on hippocampal physiology is the po

117 The effects of adrenergic and cholinergic agonists on protein secretion were evaluated

118 Simultaneous addition of cholinergic agonists or growth factors with cAMP-depende

119 The therapeutic potential of most cholinergic agonists or of agents that increase synaptic

120 However, in CA1 hippocampus in vitro, cholinergic agonists or the optogenetic release of endog

121 intravenous administration of bethanechol, a cholinergic agonist, or intralumenal instillation of lip

122 could potentiate the effects of arecoline, a cholinergic agonist, or L-glutamate, a glutamatergic ago

123 ) BLA, and given infusions of the muscarinic cholinergic agonist oxotremorine (OXO) immediately after

124 Calcium current modulation by the muscarinic cholinergic agonist oxotremorine methiodide (oxo-M) was

125 Incubation of cells with the cholinergic agonist oxotremorine-M (Oxo-M) induced an ap

126 r systemic or intrastriatal injection of the cholinergic agonist oxotremorine.

127 ations in the context of administration of a cholinergic agonist (physostigmine) during a spatial vis

128 The cholinergic agonist pilocarpine and electrostimulation o

129 experiment we found that treatment with the cholinergic agonist pilocarpine, which is effective in m

130 timulation or by microinjection of opioid or cholinergic agonists produces antinociception that is me

131 neuropharmacological studies have shown that cholinergic agonists promote REM sleep and muscarinic an

132 Cholinergic agonists raise cytosolic Ca2+ levels and sti

133 on Ca2+ transients to high concentrations of cholinergic agonists seen in these cells.

134 ouch model, both vagus nerve stimulation and cholinergic agonists significantly blocked leukocyte mig

135 Cholinergic agonist-stimulated protein secretion was not

136 tion of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activati

137 n that activation of muscarinic receptors by cholinergic agonists stimulates the nonamyloidogenic, al

138 ation, despite overall normal responses to a cholinergic agonist, suggestive of altered neuronal sign

139 te that most T stellate cells are excited by cholinergic agonists through three types of receptors, w

140 Cholinergic agonists, through M2 and/or M3 muscarinic re

141 nerally inhibitory, we used centrally acting cholinergic agonists to augment central cholinergic tone

142 elucidate the molecular mechanisms allowing cholinergic agonists to inhibit PV IgG-induced acantholy

143 lish splenic protection and the potential of cholinergic agonists to rescue immunocompromised animals

144 y, this activation is receptor mediated, and cholinergic agonists transactivate the EGF receptor.

145 We investigated responses to cholinergic agonist treatment vs. neurostimulation by el

146 The effects of cholinergic agonists upon intracellular free Ca2+ levels

147 It was concluded that cholinergic agonists use Ca(2+) and PKC to phosphorylate

148 rpose of this study was to determine whether cholinergic agonists use the PLD pathway to alter protei

149 frequency of Ca(2+) oscillations induced by cholinergic agonist was lowered by more than 30%.

150 n generated by tracheal rings in response to cholinergic agonists was also significantly increased by

151 ovelty, in these studies carbachol, a direct cholinergic agonist, was infused into IC before conditio

152 tolysis of caged carbachol, a broad-spectrum cholinergic agonist, we mapped alpha7 nAChR-mediated cur

153 generate theta oscillations in vitro without cholinergic agonists, we performed simultaneous field an

154 electrical activity in developing neocortex, cholinergic agonists were applied to immature rat cortic

155 if the rational design of subtype selective cholinergic agonists will provide novel analgesic agents

156 with xanomeline, an M1 selective muscarinic cholinergic agonist, would be associated with a decrease