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1 ic area, but there was no innervation by the cholinergic neurons.
2 has been used for many years for visualizing cholinergic neurons.
3 e excited by neighboring BF and/or brainstem cholinergic neurons.
4 in annelid worms by rhythmically activating cholinergic neurons.
5 networks of splicing events in GABAergic and cholinergic neurons.
6 eives cholinergic input from basal forebrain cholinergic neurons.
7 ral telencephalon give rise to GABAergic and cholinergic neurons.
8 from healthy and diseased human patients to cholinergic neurons.
9 c degeneration and a significant loss of PPN cholinergic neurons.
10 e development of telencephalic GABAergic and cholinergic neurons.
11 c neurons, along with the pronounced loss of cholinergic neurons.
12 holine (ACh) levels resulting from a loss of cholinergic neurons.
13 e physiological importance of this kinase in cholinergic neurons.
14 onnectivity of the remaining basal forebrain cholinergic neurons.
15 on of the RMP when expressed specifically in cholinergic neurons.
16 Cannabinoid receptors are located on cholinergic neurons.
17 ograms that differentiate these two types of cholinergic neurons.
18 excitatory responses to dopamine in striatal cholinergic neurons.
19 ntinued to be generated, except for striatal cholinergic neurons.
20 stry for choline acetyltransferase to reveal cholinergic neurons.
21 ocaudal gradient that is opposite to that of cholinergic neurons.
22 d loss of choline acetyltransferase-positive cholinergic neurons.
23 ctivate 5-HT(2) receptors on parasympathetic cholinergic neurons.
24 gested that SSS functions in wake-promoting, cholinergic neurons.
25 ing nAChR subtype in rodent, basal forebrain cholinergic neurons.
26 nist in the differentiation of the NPCs into cholinergic neurons.
27 signalling, some of which differentiate into cholinergic neurons.
28 iatum but no change in the number or size of cholinergic neurons.
29 pendent on the integrity of nbm corticopetal cholinergic neurons.
30 ess is sensed by the class IV multidendritic cholinergic neurons.
31 ithin the MLR: glutamatergic, GABAergic, and cholinergic neurons.
32 of local GABAergic and a minority of septal cholinergic neurons.
33 on the membrane potential of basal forebrain cholinergic neurons.
34 FFA3 is expressed in enteric cholinergic neurons.
35 tions for modulation of cortical function by cholinergic neurons.
36 release of GABA by knocking out Slc32a1 from cholinergic neurons.
37 nervous system displays little or no loss of cholinergic neurons.
38 modulating the excitability of medial septal cholinergic neurones.
40 delta reflect the action of nbm corticopetal cholinergic neurons, 2) nbm corticopetal cholinergic neu
41 l arborizations of the mesopontine tegmental cholinergic neurons, a cell group in which CHT expressio
42 tral PPN; in addition, they form, along with cholinergic neurons, a small, high-density cluster in th
43 the Abeta42 amyloid plaque burden, reversing cholinergic neuron abnormalities, and generating a neuro
45 and cholinergic neurons where, importantly, cholinergic neuron activation is gated by SubC activity.
46 acetylcholine released from septohippocampal cholinergic neurons acts to modulate hippocampal microci
48 nctional maturation and maintenance of these cholinergic neurons after the differentiation stage have
51 tal cholinergic neurons, 2) nbm corticopetal cholinergic neurons alter neural processes in direct and
52 se model of AD prevented the degeneration of cholinergic neurons, ameliorated corresponding deficits,
53 s disease (AD) prevented the degeneration of cholinergic neurons, ameliorated corresponding deficits,
56 y, graded signals that emanate from striatal cholinergic neurons and engage the canonical GDNF recept
57 le cells receive excitatory innervation from cholinergic neurons and inhibitory innervation from GABA
58 ion that destroyed 40-50% of basal forebrain cholinergic neurons and later, after extinction training
60 ographic mapping between the basal forebrain cholinergic neurons and their axonal projections to the
61 ular nucleus basalis significantly protected cholinergic neurons and their cortical projections again
62 omeric alpha7beta2-nAChRs on basal forebrain cholinergic neurons and their high sensitivity to blocka
63 ed to label preganglionic and postganglionic cholinergic neurons and their projections to lymphoid ti
64 paired integrity of pedunculopontine nucleus cholinergic neurons and their thalamic efferents play a
65 ory motoneurons and descending interneurons, cholinergic neurons, and intrinsic primary afferent neur
67 CR4 was co-expressed with ChAT, a marker for cholinergic neurons, and with GAD C38, a marker for GABA
68 ng green fluorescent protein specifically in cholinergic neurons (APP.PS1/CHGFP) and in wild-type lit
72 These data indicate that TASK channels in cholinergic neurons are molecular substrates for select
73 In Alzheimer's disease, the basal forebrain cholinergic neurons are selectively vulnerable, putative
76 ncies of the effector lines in aminergic and cholinergic neurons assessed here may help researchers t
77 We then asked if 5-HT-positive axons appose cholinergic neurons associated with motor functions: cen
78 employed optogenetics to control mesopontine cholinergic neurons at somata and at divergent projectio
81 the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during development and protec
82 ) synthesis and release from basal forebrain cholinergic neurons (BFCN) innervating the cerebral cort
83 choline and its release from basal forebrain cholinergic neurons (BFCN) that innervate the cerebral c
87 in PC12 cells, cultured rat basal forebrain cholinergic neurons (BFCNs), and BFCNs from a mouse mode
89 hysiology, and behavior, we demonstrate that cholinergic neurons, but not peptidergic neurons, of the
90 that orexin-A and -B excite basal forebrain cholinergic neurons, but orexin-producing neurons also m
91 explained by the topographic distribution of cholinergic neurons, but such heterogeneity might also a
92 ox gene Isl1 in the development of forebrain cholinergic neurons by conditionally deleting Isl1 using
93 t depending on their state of activation, BF cholinergic neurons can be excited or inhibited by signa
94 al EP3 receptors has a deleterious effect on cholinergic neurons causing neurite retraction and cell
95 evealed co-localisation of eGFP in intrinsic cholinergic neurons (choline acetyltransferase positive)
101 s the PD patients had significantly more PPN cholinergic neurons containing mtDNA deletion levels exc
102 t increased dopamine sensitivity of striatal cholinergic neurons contributes to the expression of LID
103 of "selective" optogenetic stimulation of BF cholinergic neurons could be mediated by local excitatio
104 h optogenetic stimulation of basal forebrain cholinergic neurons decreases the dependency that is com
105 tions in the PPN and show that GABAergic and cholinergic neurons define neurochemically distinct area
107 at Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological
108 n contrast, we found that GRK2 deficiency in cholinergic neurons does not alter cocaine-induced psych
112 ports survival of only a small proportion of cholinergic neurons during development; however, this si
113 splenial cortex) targets of nbm corticopetal cholinergic neurons during footshock induced operant sup
114 elatively selective trait of basal forebrain cholinergic neurons early in adult life, and increases i
115 roduction) was inhibited by ~50% in cultured cholinergic neurons exposed to low nanomolar concentrati
116 Anatomical analysis showed that forebrain cholinergic neurons express the GABA synthetic enzyme Ga
117 Our results showed that activation of BF cholinergic neurons expressing hM3Dq receptors significa
118 ht and dark phases, whereas inhibition of BF cholinergic neurons expressing hM4Di receptors significa
119 Furthermore, optogenetic stimulation of cholinergic neurons/fibers caused a mecamylamine- and at
120 presumably heteromeric alpha7beta2-nAChRs on cholinergic neurons freshly dissociated from medial sept
123 culture of skeletal muscle cells (C2C12) and cholinergic neurons, gliomaxneuroblastoma hybrid cells (
124 embryonic day (E)11.5, and the proportion of cholinergic neurons gradually increased during pre- and
126 l morphologies of individual basal forebrain cholinergic neurons has, until now, been technically bey
127 in presynaptic vesicles of monoaminergic and cholinergic neurons, has a regulatory role in dopamine h
128 we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the
130 are not well understood, the basal forebrain cholinergic neurons have been implicated in stress respo
133 tion is poorly understood because identified cholinergic neurons have never been recorded during beha
134 charge profile and thus precise roles of the cholinergic neurons have remained uncertain because they
136 dult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation
137 ce, with TASK channel deletion restricted to cholinergic neurons, immobilizing actions of the inhaled
145 from modulation by optogenetic activation of cholinergic neurons in basal forebrain, which led to a m
146 cularly sensitive to the effects of lead and cholinergic neurons in both regions depend upon nerve gr
150 treatment with Premarin was observed in the cholinergic neurons in either ovariectomized young or mi
151 nderscore the causal role of basal forebrain cholinergic neurons in fast, bidirectional modulation of
152 optical stimulation of basal forebrain (BF) cholinergic neurons in mice increases local acetylcholin
153 ability of the magnocellular basal forebrain cholinergic neurons in neurodegenerative diseases, such
154 2-amino acid isoform, within basal forebrain cholinergic neurons in normal young, normal aged and Alz
155 and arousal, and in view of the loss of its cholinergic neurons in PD, the PPN could be involved in
156 regulates cholinergic function in rat septal cholinergic neurons in primary cultures from E18.5 embry
157 traditional methods, the precise role of BF cholinergic neurons in regulating the sleep-wake cycle r
158 oteins appear to be coexpressed with ChAT by cholinergic neurons in several motor and reticular nucle
159 njection of mu-p75-sap produced depletion of cholinergic neurons in the basal forebrain and decreased
161 Premarin has selective beneficial effects on cholinergic neurons in the basal forebrain but that thes
163 effect of estrogen on the number and size of cholinergic neurons in the basal forebrain was examined
164 , GPR30 in expressed by the vast majority of cholinergic neurons in the basal forebrain, and appears
165 branes of the somata, dendrites and axons of cholinergic neurons in the basal forebrain, striatum and
166 Previously it has been found that principal cholinergic neurons in the brain express high concentrat
167 istribution of glutamatergic, GABAergic, and cholinergic neurons in the brain of the African cichlid
171 level, we found reduced firing of identified cholinergic neurons in the brainstem pedunculopontine te
172 We also review and discuss the presence of cholinergic neurons in the BST, and of neuron population
174 HT) is a protein integral to the function of cholinergic neurons in the central nervous system (CNS).
175 rated in the late L1 and are postsynaptic to cholinergic neurons in the dorsal nerve cord but do not
177 s also expressed in both cholinergic and non-cholinergic neurons in the ENS of mouse, rat and human.
178 xpression of alpha-synuclein in the axons of cholinergic neurons in the guinea pig and human distal g
180 ;R26R-YFP mice to examine the development of cholinergic neurons in the gut of embryonic and postnata
181 (NBM) of middle-aged monkeys, the number of cholinergic neurons in the intermediate region (Ch4i) wa
182 of neurons surround Bar: rostral-dorsomedial cholinergic neurons in the laterodorsal tegmental nucleu
183 he phenotypic maintenance of basal forebrain cholinergic neurons in the mature and fully differentiat
188 duced by selective optogenetic activation of cholinergic neurons in the nucleus accumbens (NAc) are i
189 ore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (P
190 nculopontine tegmental nuclei (LDT and PPT), cholinergic neurons in the pontomesencephalic tegmentum
193 nd demonstrate a role for MC4Rs expressed in cholinergic neurons in the regulation of insulin levels
195 e(+) transgenic rats, we selectively labeled cholinergic neurons in the rostral PPN, caudal PPN, and
196 NGF)-dependent neurons including sympathetic cholinergic neurons in the skin, causing anhidrosis.
199 rm depression (LTD)-related disinhibition of cholinergic neurons in the vestibular nuclei--suppresses
201 eceptor kinase A (TrkA) expression in septal cholinergic neurons in vitro and in vivo, resulting in r
202 more, re-expression of MC4Rs specifically in cholinergic neurons (including sympathetic preganglionic
203 and activation of cortically projecting, non-cholinergic neurons, including the GABAergic/PV neurons.
204 ave shown that "selective" stimulation of BF cholinergic neurons increases transitions between NREM s
205 GABAergic and glycinergic neurons; however, cholinergic neurons indicated down-regulation of the sam
206 hat has both parvocellular and magnocellular cholinergic neurons, indicates an unusual sleep phenomen
207 se (AD), usually ascribed to degeneration of cholinergic neurons induced by the amyloid-beta peptide
208 on of this inhibitory olfactory microcircuit.Cholinergic neurons innervate multiple layers in the mai
209 ic deficits occur in Parkinson's disease and cholinergic neurons innervate regions, such as the limbi
211 ts on the specification of glutamatergic and cholinergic neurons into a nervous system-wide regulator
214 -related neuroplasticity of septohippocampal cholinergic neurons is capable of increasing neuronal ex
215 riodic pulses of acetylcholine released from cholinergic neurons is indeed able to coordinate the act
217 dings reveal that the primary function of BF cholinergic neurons is to inhibit EEG delta activity thr
218 Acetylcholine, the neurotransmitter used by cholinergic neurons, is synthesized from choline and ace
219 t causes defects in axon pruning, whereas in cholinergic neurons it causes highly abnormal larval loc
220 Thus, the formation of acetylcholine in cholinergic neurons largely depends on both the levels o
221 we demonstrated that optical stimulation of cholinergic neurons locally increased acetylcholine leve
222 activity, as "W/PS-max active neurons." Like cholinergic neurons, many GABAergic and glutamatergic ne
223 positive varicosities along motor-associated cholinergic neurons may contribute to the locomotor impr
224 , excitatory input from the Pf onto striatal cholinergic neurons may facilitate behavioral flexibilit
225 attern was observed in which the position of cholinergic neurons measured along a rostral to caudal e
226 , we selectively removed MeCP2 function from cholinergic neurons (MeCP2 ChAT KO), which recapitulated
227 s basalis magnocellularis (nbm) corticopetal cholinergic neurons modulate anxiety-like states, but co
229 hodopsin or halorhodopsin in basal forebrain cholinergic neurons of mice with optic fibers directed i
230 ial activity of cholinergic interneurons and cholinergic neurons of the brainstem during reward-relat
232 gic neurons of the substantia nigra (SN) and cholinergic neurons of the dorsal motor nucleus of the v
239 effects of cell-selective manipulation of BF cholinergic neurons on the sleep-wake behavior and elect
242 of hearing, descending (efferent) input from cholinergic neurons originating in the brainstem inhibit
244 n output neurons, chemogenetic inhibition of cholinergic neurons produced similar perturbations in ol
247 ife and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for
249 brain and its specific removal in excitatory cholinergic neurons recapitulates the female courtship b
251 demonstrate that the elimination of GRK2 in cholinergic neurons reduces sensitivity to select muscar
256 ome lines, restoration of FruM expression in cholinergic neurons restores fertility or reduces male-m
259 on of neural progenitor cells and new mature cholinergic neurons, revealing an important mitogenic ro
261 Finally, we found that activation of BF cholinergic neurons significantly increased c-Fos expres
262 itulated in mice with pan-neuron-specific or cholinergic neuron-specific ablation of the cpeb2 gene.
263 ent in vitro study from our group found that cholinergic neurons strongly excite neighboring GABAergi
265 AbetaOs selectively bind to ~50% of cultured cholinergic neurons, suggesting that ChAT is fully inhib
266 rs to the mPFC follow four pathways and that cholinergic neurons take these routes depending on their
267 ouse gastrointestinal tract co-localize with cholinergic neurons that express the neuropeptide neurom
268 itionally characterized by its population of cholinergic neurons that have local and wide-ranging con
269 is therefore a feature specific to principal cholinergic neurons that innervate the central nervous s
270 insulin release by activating non-ganglionic cholinergic neurons that innervate the islets, presumabl
271 autonomous program of synapse elimination in cholinergic neurons that likely occurs when protein prod
272 nucleus of the vagus (DMV), a population of cholinergic neurons that show signs of pathology in the
275 /SI region, and dynorphin-A inhibits MCPO/SI cholinergic neurons through kappa-opioid receptors by (1
276 precise contributions of the medial septum's cholinergic neurones to these functions remain unknown.
278 ne in mice (CHT(+/-)) limits the capacity of cholinergic neurons to sustain acetylcholine (ACh) relea
279 complicated by the widespread projections of cholinergic neurons to telencephalic structures that the
282 mato in medial septum/diagonal band of Broca cholinergic neurons using Cre recombinase-dependent aden
283 on their activity might support, we recorded cholinergic neurons using optogenetic identification in
284 rmined the effects of dynorphin-A on MCPO/SI cholinergic neurons using patch-clamp recordings in brai
286 ynorphin-A directly inhibits basal forebrain cholinergic neurons via kappa-opioid receptors, and decr
287 ensity of axodendritic thalamic terminals on cholinergic neurons was due to their dendritic territory
288 eep deprivation resulting from activation of cholinergic neurons was sufficient to elicit subsequent
294 olinergic basal forebrain population-but not cholinergic neurons-were correlated with trial-to-trial
295 excitatory interaction between the SubC and cholinergic neurons where, importantly, cholinergic neur
299 to convert human fetal lung fibroblasts into cholinergic neurons with high purity (>90%) and efficien
300 hannelrhodopsin is endogenously expressed in cholinergic neurons with Htr3a-Cre mice, in which Cre is
301 rect effects of estradiol on basal forebrain cholinergic neurons, with corresponding effects on cogni
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