ライフサイエンスコーパス: cholinergic receptor

1 is inhibition was specific for the nicotinic cholinergic receptor.

2 a known candidate gene, the beta3 nicotinic cholinergic receptor.

3 sis via stimulation of endothelial nicotinic cholinergic receptors.

4 g direct effects on AC mediated by nicotinic cholinergic receptors.

5 exerts part of its actions through nicotinic cholinergic receptors.

6 ding the 5-hydroxytryptamine2 and muscarinic cholinergic receptors.

7 receptors, the nicotinic and the muscarinic cholinergic receptors.

8 y paralleling the concentration of nicotinic cholinergic receptors.

9 beta gamma subunit complex, or m1 muscarinic cholinergic receptors.

10 ver, lymphocytes also express adrenergic and cholinergic receptors.

11 e activation by agonist of the m1 muscarinic cholinergic receptor, a prototypical class I G(q)-couple

12 raphy to test the hypothesis that muscarinic cholinergic receptors activate G proteins in C57BL/6J (B

13 We examined how cholinergic receptor activation affects temporal and spa

14 The summation was unaffected by cholinergic receptor activation by carbachol.

15 suggests that concurrent beta-adrenergic and cholinergic receptor activation enhances LTP induction b

16 While cholinergic receptor activation has long been known to d

17 The creation of nitric oxide in response to cholinergic receptor activation may provide a mechanism

18 he effects of concurrent beta-adrenergic and cholinergic receptor activation on the induction of long

19 Previous studies have shown that nicotinic cholinergic receptor activation sharpens mitral cell che

20 triggered by depolarizing stimuli following cholinergic receptor activation.

21 n produced by concurrent beta-adrenergic and cholinergic receptor activation.

22 have on SC inputs in hippocampal CA1 during cholinergic receptor activation.

23 principal cells, are modulated similarly by cholinergic receptor activation.

24 e involved in the antinociceptive effects of cholinergic receptor activation.

25 asynchrony is related to an increase in the cholinergic receptor activity.

26 Reverse dialysis of the cholinergic receptor agonist carbachol (1 mM) into the S

27 receptor agonist isoproterenol (ISO) and the cholinergic receptor agonist carbachol had no effect on

28 We iontophoretically applied the general cholinergic receptor agonist carbachol onto neurons in d

29 ellular Ca2+ by ionophore or by a muscarinic cholinergic receptor agonist increases cAMP in cells tra

30 The centrally acting muscarinic cholinergic receptor agonist, arecoline, resulted in an

31 Central application of the non-selective cholinergic receptor agonist, carbachol, induces water i

32 drenergic receptor agonist, and carbachol, a cholinergic receptor agonist.

33 Cholinergic receptor agonists, including acetylcholine,

34 ed the selective expression of the nicotinic cholinergic receptor alpha2 (Chrna2) in mice to genetica

35 The alpha7-nicotinic cholinergic receptor (alpha7-nAChR) is a key mediator of

36 This neurotransmitter can bind to the alpha7 cholinergic receptor (alpha7R) expressed by nonneuronal

37 roblems is impaired following blockade of OB cholinergic receptors, although the relative contributio

38 rats showed unchanged cardiac adrenergic and cholinergic receptor and IKACh-subunit gene expression,

39 the protracted decrease in the expression of cholinergic receptors and acetylcholinesterase in specif

40 tagonist binding kinetics of both muscarinic cholinergic receptors and phorbol ester receptors.

41 ulation of signaling kinases associated with cholinergic receptors and provided mechanistic explanati

42 Blockade of muscarinic cholinergic receptors and selective cholinergic lesions

43 kes the need for structural proximity of the cholinergic receptors and the Ca2+ release channels in t

44 changes in beta-adrenergic and m2-muscarinic cholinergic receptors and their linkage to AC.

45 Cholinergic receptor antagonism also attenuated the norm

46 Perfusion of the cholinergic receptor antagonist atropine accentuated the

47 ptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist dihydro-beta-erythroidin

48 s when it was co-infused with the muscarinic cholinergic receptor antagonist scopolamine or the nicot

49 mice were reduced by mecamylamine (nicotinic cholinergic receptor antagonist) and PPADS (P2X receptor

50 (NMDAR), dizocilpine (DZP), and a muscarinic cholinergic receptor antagonist, scopolamine (SCP).

51 insensitivity to the amnesic effects of the cholinergic receptor antagonist, scopolamine.

52 are not blocked by metabotropic glutamate or cholinergic receptor antagonists and are not produced by

53 Systemic infusions of the muscarinic cholinergic receptor antagonists atropine and scopolamin

54 hed by simultaneous reverse microdialysis of cholinergic receptor antagonists into BF.

55 showed that NKCC1, Na+,K+-ATPase and the M3 cholinergic receptor are expressed on the basolateral me

56 fects on performance of cognitive tasks, and cholinergic receptors are being actively explored as pro

57 encoding-related activity may be reduced if cholinergic receptors are blocked by scopolamine.

58 These results show that muscarinic cholinergic receptors are involved in the learning of ne

59 A subset of muscarinic cholinergic receptors are linked to G-proteins that acti

60 Cholinergic receptors are localized to both presynaptic

61 GABA)ergic, N-methyl-d-aspartate (NMDA), and cholinergic receptors are thought to be involved in visu

62 contact-mediated, clustering of postsynaptic cholinergic receptors at the synaptic site requires tran

63 ynaptic inputs mediated by glutamatergic and cholinergic receptors, because co-application of the glu

64 cotinic (3H-cytisine) or muscarinic (3H-QNB) cholinergic receptor binding in the cortex or hippocampu

65 ng and after exposure, we assessed nicotinic cholinergic receptor binding in the midbrain, cerebral c

66 of cardiac beta-adrenergic and m2-muscarinic cholinergic receptor binding, and receptor linkages to a

67 ignaling, neurophysiological recordings, and cholinergic receptor blockade to delineate the cholinerg

68 transition duration and failure rate during cholinergic receptor blockade.

69 Ligation of cholinergic receptors blunts IC-triggered responses in t

70 Muscarinic and nicotinic cholinergic receptors both contributed specifically to g

71 determined by stimulation of the muscarinic/cholinergic receptor by the agonist pilocarpine, suggest

72 as well as stimulation of G-protein-coupled cholinergic receptors by carbachol and tyrosine kinase r

73 Stimulation of endothelial nicotinic cholinergic receptors causes endothelial cell proliferat

74 ed neurological functions including synaptic cholinergic receptor (CHRNA) families, dopamine receptor

75 an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5).

76 decreased function of the alpha 7-nicotinic cholinergic receptor could underlie the physiological de

77 With repeated release of ACh from the GCs, cholinergic receptors could become desensitized, particu

78 tabotropic (M2 muscarinic) but not nicotinic cholinergic receptors decreases their output.

79 ynapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs

80 synaptic inputs and the distribution of key cholinergic receptors (encoded by the genes acr-18, acr-

81 found that repeated activation of nicotinic cholinergic receptors enhanced cocaine intake in rats bu

82 , which express the inhibitory m2 muscarinic cholinergic receptor, exhibit a large increase in forsko

83 Nicotinic cholinergic receptors expressed on macrophages detect th

84 mportantly, we document increased muscarinic cholinergic receptor expression in Alexander disease mod

85 erved in the optic tectum, in which nicotine cholinergic receptor expression is delayed until E8-12.

86 nAChRs are cholinergic receptors forming ligand-gated ion channels

87 assessing whether a reduction in muscarinic cholinergic receptor function would improve depressive s

88 by altering nicotinic rather than muscarinic cholinergic receptor function.

89 chlear hair cells is mediated by 'nicotinic' cholinergic receptors functionally coupled to calcium-ac

90 al homologues); beta(1)-ARs, m(2)-muscarinic cholinergic receptors, Galpha(s), and cardiac types V/VI

91 xpressed genes included NeuroD and nicotinic cholinergic receptor gamma.

92 Association between the M2 cholinergic receptor gene (CHRM2) and SD has recently be

93 kage to the alpha-7 subunit of the nicotinic cholinergic receptor gene in families with schizophrenia

94 q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell prol

95 contained purified recombinant m1 muscarinic cholinergic receptor, Gq, and 2-4 mol % [3H]phosphatidyl

96 l models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning

97 otent nicotinic antagonists at the nicotinic cholinergic receptor in PC-12 cells (IC(50) < or =37 nM)

98 Neural regulation via cholinergic receptors in isolated pancreatic acini and t

99 Here, we stimulated cholinergic receptors in prefrontal cortex and examined

100 s suggest the involvement of GABA, NMDA, and cholinergic receptors in rapid experience-dependent plas

101 study, we determined the role of presynaptic cholinergic receptors in regulation of the inhibitory GA

102 al information regarding the distribution of cholinergic receptors in relation to this circuitry.

103 cated changes in expression alpha7 nicotinic cholinergic receptors in the pathophysiology of traumati

104 eductal gray is mediated in part by NMDA and cholinergic receptors in the rostral ventromedial medull

105 To investigate whether noradrenergic and cholinergic receptor interactions regulate forms of syna

106 ety and antidepressant effects, although the cholinergic receptors involved are likely different for

107 The alpha7 nicotinic cholinergic receptor is a ligand-gated ion channel with

108 Stimulation of cholinergic receptors is being explored to create cognit

109 M15 cells, and, because annexins can act as cholinergic receptors, its conformation was tested in a

110 SIB-1663 exhibited modest affinities to cholinergic receptors (K(i) values displacing the bindin

111 uggesting that PX is one of the keratinocyte cholinergic receptors known to be targeted by disease-ca

112 ere both acetylcholinesterase activities and cholinergic receptors labeled with [(3)H]QNB.

113 Cholinergic receptors labeled with the ligands [(3)H]epi

114 ably including Alzheimer's disease, in which cholinergic receptor-linked signal transduction activity

115 e fSR/BA1 synapse is modulated by muscarinic cholinergic receptors located on gamma-aminobutyric acid

116 The functional significance of cholinergic receptors, located at the presynaptic nerve

117 ngths, "modes", of the human m(1) muscarinic cholinergic receptor, m(1)AChR.

118 3) loop of the G(q/11)-coupled M1 muscarinic cholinergic receptor (M1 mAChR; M1i3).

119 adrenergic receptor (beta2AR), m2 muscarinic cholinergic receptor (m2 mAChR), and rhodopsin.

120 In pancreatic beta cells, muscarinic cholinergic receptor M3 (M3R) stimulates glucose-induced

121 B/La, as well as the cell surface muscarinic cholinergic receptor (M3) are observed.

122 t, we found that the activated m2 muscarinic cholinergic receptor (MAChR) could facilitate the exchan

123 The internalization of the M(2) muscarinic cholinergic receptor (mAChR) proceeds through an atypica

124 neuroblastoma cells, we show that muscarinic cholinergic receptor (mAchR) stimulation triggers Arc sy

125 The muscarinic cholinergic receptor (mAChR) subtypes share high sequenc

126 in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and seques

127 The internalization of the M(2) muscarinic cholinergic receptors (mAChR) in HEK293 cells has been d

128 pressed human m1, m2 and chimeric muscarinic cholinergic receptors (MAChR) in tobacco plants and in c

129 choline release and activation of muscarinic cholinergic receptors (mAChRs) enhance synaptic plastici

130 oinositides in the endocytosis of muscarinic cholinergic receptors (mAChRs) has been investigated via

131 inergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs).

132 tgrowth elicited by activation of muscarinic cholinergic receptors (mAChRs).

133 te via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).

134 its toxic effects may involve the muscarinic cholinergic receptors (mAChRs).

135 amine signaling, these data suggest that NAc cholinergic receptors may gate the expression of cue-mot

136 esynaptic and postsynaptic specificity of m2 cholinergic receptors may help explain the differential

137 This suggested that non-cholinergic receptor-mediated mechanisms contributed to

138 lamine showed that uptake was not muscarinic cholinergic receptor-mediated.

139 esence of three (N-, L-, and B-) subtypes of cholinergic receptor mediating contraction of body wall

140 gest the potential for intervention based on cholinergic receptor modulation.

141 progress in the field, such as glutamate and cholinergic receptor modulators, circadian regulators, a

142 In addition, early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reverse

143 ors: SSTR2 (somatostatin receptor 2), CHRM2 (cholinergic receptor, muscarinic 2), and RXFP1 (relaxin/

144 g of the chromosome 6 QTLs identified Chrm2 (cholinergic receptor, muscarinic 2, cardiac) as a candid

145 lop an array of alpha(7)-selective nicotinic cholinergic receptor (nAChR)-based imaging agents for PE

146 ates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic choline

147 P2X receptors and nicotinic cholinergic receptors (nAChRs) are linked in a mutually

148 Nicotinic cholinergic receptors (nAChRs) are present in ganglia in

149 mpared with neuronal nicotinic acetylcholine cholinergic receptors (nAChRs) assembled from alpha and

150 esult of nicotine interacting with nicotinic cholinergic receptors (nAChRs) during lung development,

151 e GABAergic neurons at RVM express nicotinic cholinergic receptors (nAChRs) is not known.

152 ly selective ligand at alpha3beta4 nicotinic cholinergic receptors (nAChRs) that was reported to decr

153 bound sites mapped to sites flanking CHRNA7 (cholinergic receptor nicotinic alpha 7) encoding the cho

154 The discovery of genetic variants in the cholinergic receptor nicotinic CHRNA5-CHRNA3-CHRNB4 gene

155 gic receptor nicotinic alpha 7) encoding the cholinergic receptor, nicotinic, alpha 7.

156 Activation of muscarinic cholinergic receptors on pyramidal cells of the cerebral

157 bicuculline, by ligands for D2 or muscarinic cholinergic receptors or by low calcium buffer, tetrodot

158 us be improved by more specific targeting of cholinergic receptors or nuclei.

159 Antibodies to muscarinic cholinergic receptor proteins m1 to m4 were used in stri

160 ch as frizzled and smoothened, the nicotinic cholinergic receptors, receptor tyrosine kinases, and cy

161 ggest that coactivation of noradrenergic and cholinergic receptors regulates LTP induction via conver

162 netic linkage of poor P50 suppression to the cholinergic receptor's alpha7 nicotinic subunit.

163 Interactions between noradrenergic and cholinergic receptor signaling may be important in some

164 entration capable of blocking the effects of cholinergic receptor stimulation.

165 Some nicotinic cholinergic receptor subtypes are lost in AD, making the

166 The muscarinic cholinergic receptor system has been implicated in the p

167 Here, we examined the role of the NAc cholinergic receptor system in cue-motivated behavior us

168 nformation will help to understand how these cholinergic receptor systems might be regulating neurona

169 ut are due to alterations in D1 dopamine and cholinergic receptor systems.

170 ardiovascular system, such as the muscarinic cholinergic receptors that regulate heart rate, might be

171 essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signa

172 that contained purified Gq and m1 muscarinic cholinergic receptors, the most active tails increased a

173 reliably activate both pre- and postsynaptic cholinergic receptors, thereby controlling TRN neuronal

174 ligand galantamine (Gal) modulates nicotinic cholinergic receptors to increase acetylcholine release

175 their cell-surface nicotinic and muscarinic cholinergic receptors to mediate the autocrine and parac

176 specific for serotonergic, noradrenergic and cholinergic receptors uncovered differences.

177 Nicotinic cholinergic receptors undergo desensitization upon repea

178 G(q) and m1 muscarinic cholinergic receptor were co-reconstituted into proteoli

179 rs, beta-adrenergic receptors and muscarinic cholinergic receptors were not involved in generating th

180 2a, or an antagonist of the alpha7 nicotinic cholinergic receptor, whereas it was induced at metestru

181 Antagonism of cholinergic receptors which typically impairs learning d

182 This ligand binds to the alpha 7 nicotinic, cholinergic receptor, which has been implicated in hippo

183 rences in expression of the alpha7 nicotinic cholinergic receptor, which may be generally expressed b

184 ased in response to activation of muscarinic cholinergic receptors, which increases intracellular cal

185 e activity of an unusual class of ionotropic cholinergic receptor with that of nearby calcium-depende

186 ovo and was inhibited by blocking muscarinic cholinergic receptors with atropine.

187 tdTomato mice, pharmacological activation of cholinergic receptors with bath application of carbachol

188 ed iontophoretic pharmacological analysis of cholinergic receptors with single cell recordings in V1