ライフサイエンスコーパス: chondrocyte differentiation

1 study, we established a role for lncRNAs in chondrocyte differentiation.

2 ein and subsequently disrupting hypertrophic chondrocyte differentiation.

3 h) and of collagen type X--all indicative of chondrocyte differentiation.

4 f columns, and acceleration of periarticular chondrocyte differentiation.

5 inase-13 (MMP-13) expression during terminal chondrocyte differentiation.

6 ession of different types of collagen during chondrocyte differentiation.

7 nitor cell to promote osteoblast and prevent chondrocyte differentiation.

8 and redundant in major steps of growth plate chondrocyte differentiation.

9 these factors are central to the control of chondrocyte differentiation.

10 artilage tissue-specific gene expression and chondrocyte differentiation.

11 elopment, where c-Maf is required for normal chondrocyte differentiation.

12 nail-related transcription repressors during chondrocyte differentiation.

13 n the regulation of Agc expression following chondrocyte differentiation.

14 gnals are essential for repressing articular chondrocyte differentiation.

15 dicating that Cbfa1 may control hypertrophic chondrocyte differentiation.

16 tion between these signaling pathways during chondrocyte differentiation.

17 s have established that Sox9 is required for chondrocyte differentiation.

18 molecules have been implicated in regulating chondrocyte differentiation.

19 MAPK in transmitting PTH signals to regulate chondrocyte differentiation.

20 letal element length due to an inhibition of chondrocyte differentiation.

21 esignated HiPER1, has a role in growth plate chondrocyte differentiation.

22 hat PTHrP and its receptor are essential for chondrocyte differentiation.

23 ing chondrocyte proliferation and by slowing chondrocyte differentiation.

24 iption factor SOX-9 lead to abnormalities in chondrocyte differentiation.

25 ion caused by delayed cell cycle exit during chondrocyte differentiation.

26 ive feedback loop that modulates the rate of chondrocyte differentiation.

27 the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.

28 for PTHrP as an inhibitor of the program of chondrocyte differentiation.

29 CDS-associated abnormalities in hypertrophic chondrocyte differentiation.

30 etic program that induces chondrogenesis and chondrocyte differentiation.

31 TGF-beta1-induced Smad2 phosphorylation and chondrocyte differentiation.

32 nces collagen fibrillogenesis, and modulates chondrocyte differentiation.

33 cle and entered the prehypertrophic phase of chondrocyte differentiation.

34 ep1, Hivep2, and Hivep3 in osteoblast and/or chondrocyte differentiation.

35 downstream mediator of Wnt in repression of chondrocyte differentiation.

36 s the TGFbeta pathway to efficiently promote chondrocyte differentiation.

37 ecific inhibitor of PHD2, promoted articular chondrocyte differentiation.

38 h factor beta (TGFbeta), a potent agonist of chondrocyte differentiation.

39 miR-365 abolishes mechanical stimulation of chondrocyte differentiation.

40 ortant in the early stages of osteoblast and chondrocyte differentiation.

41 ssion is regulated in vitro as a function of chondrocyte differentiation.

42 important transcription factors that control chondrocyte differentiation.

43 in promoting both growth plate and articular chondrocyte differentiation.

44 is one of key downstream molecules of GEP in chondrocyte differentiation.

45 iferation, its inactivation is essential for chondrocyte differentiation.

46 s therefore to control general regulators of chondrocyte differentiation.

47 roles as both a regulator and an effector of chondrocyte differentiation.

48 f BMP2, and it is required for BMP2-mediated chondrocyte differentiation.

49 full proteolytic activity and inhibition of chondrocyte differentiation.

50 nces osteoblast differentiation and inhibits chondrocyte differentiation.

51 sor proliferation and inhibited hypertrophic chondrocyte differentiation.

52 verexpression of Wdr5 in osteoblasts affects chondrocyte differentiation.

53 f GSK-3alpha induced markers of neuronal and chondrocyte differentiation.

54 o repress transcription of genes involved in chondrocyte differentiation.

55 ntagonizes the Wnt/beta-catenin signaling in chondrocyte differentiation.

56 ial cartilage proteoglycan and key marker of chondrocyte differentiation.

57 ignaling regulation of the cell cycle during chondrocyte differentiation.

58 id changes in PTHrP expression and articular chondrocyte differentiation.

59 in B is a regulator of Runx2 function during chondrocyte differentiation.

60 f Sox9, a transcription factor essential for chondrocyte differentiation.

61 about the cytoskeletal components regulating chondrocyte differentiation.

62 lates chondrocyte proliferation but inhibits chondrocyte differentiation.

63 to osteoblasts or by a specific hypertrophic chondrocyte differentiation ability of Cbfa1, we used th

64 Moreover, abnormal chondrocyte differentiation affects mineralization of ca

65 trophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formati

66 alyses of growth plates demonstrated delayed chondrocyte differentiation and accelerated mineralizati

67 rly in mesenchymal progenitor cells promoted chondrocyte differentiation and blocked the activity of

68 lated during chondrocyte hypertrophy, normal chondrocyte differentiation and bone development were ob

69 ow-grade joint inflammation promotes altered chondrocyte differentiation and cartilage catabolism.

70 containing transcription factor required for chondrocyte differentiation and cartilage formation.

71 t transcription factor that is essential for chondrocyte differentiation and cartilage formation.

72 ed high mobility group-Box gene 9) regulates chondrocyte differentiation and cartilage-specific expre

73 y transcription factor that is essential for chondrocyte differentiation and chondrocyte-specific gen

74 eservation of postnatal growth plate through chondrocyte differentiation and Col II deposition and fu

75 As calcium also instructs chondrocyte differentiation and collagen synthesis, calc

76 arch cartilage elements due to reductions in chondrocyte differentiation and condensation.

77 e report that ADAMTS-7 is upregulated during chondrocyte differentiation and demonstrates the tempora

78 cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression thro

79 Here, we show that aberrant chondrocyte differentiation and ectopic cartilage format

80 ADAMTS-7 potently inhibits chondrocyte differentiation and endochondral bone format

81 -like signals with the potential to modulate chondrocyte differentiation and function in OA progressi

82 Pthlh regulates chondrocyte differentiation and Gli activity in a Sufu-d

83 esses, whereas suppression of ECM1 enhances, chondrocyte differentiation and hypertrophy in vitro and

84 Cell cycle regulation is critical for chondrocyte differentiation and hypertrophy.

85 This features a delay in chondrocyte differentiation and in bone collar formation

86 t coordinated levels of MGP are required for chondrocyte differentiation and matrix mineralization.

87 by Hedgehog and beta-catenin signalling, to chondrocyte differentiation and matrix synthesis by SoxE

88 suggest that cartilage matrix has a role in chondrocyte differentiation and maturation.

89 Low oxygen tension (hypoxia) regulates chondrocyte differentiation and metabolism.

90 Our protocol should facilitate studies of chondrocyte differentiation and of cell replacement ther

91 By 7 weeks, the delays in chondrocyte differentiation and ossification have largel

92 ding to a seeming reversal in the pattern of chondrocyte differentiation and ossification.

93 /-) embryos exhibited delays in hypertrophic chondrocyte differentiation and osteoblast differentiati

94 tion of the skeleton is complex, and impacts chondrocyte differentiation and osteoclast formation in

95 nockdown of SMAD 1/5/8 impaired NICD-induced chondrocyte differentiation and p57 expression.

96 alance in the regulatory network controlling chondrocyte differentiation and proliferation.

97 Rapamycin promotes chondrocyte differentiation and restores these defects i

98 Cell-matrix interactions regulate chondrocyte differentiation and survival.

99 indings that PHD2 is a negative regulator of chondrocyte differentiation and that hypoxia signaling i

100 novel critical role of GEP growth factor in chondrocyte differentiation and the molecular events bot

101 directly controls the pace and synchrony of chondrocyte differentiation and thereby coordinates deve

102 ular to columnar chondrocytes (periarticular chondrocyte differentiation) and thereby regulates the l

103 te proliferation, inhibition of hypertrophic chondrocyte differentiation, and a delay in the formatio

104 rtant in the regulation of limb development, chondrocyte differentiation, and degeneration of articul

105 upregulation, acceleration of periarticular chondrocyte differentiation, and elongation of the colum

106 ndrocyte proliferation, delayed hypertrophic chondrocyte differentiation, and endochondral bone forma

107 racteristic concave shape, exhibited ectopic chondrocyte differentiation, and occasionally adhered to

108 ter activity was detectable at all stages of chondrocyte differentiation, and Sdc4 deficiency inhibit

109 Similar changes in endochondral chondrocyte differentiation are essential for physiologi

110 PTHrP and Ihh in regulating earlier steps in chondrocyte differentiation are unclear.

111 sion of collagen X, a marker of growth plate chondrocyte differentiation (assessed by immunohistochem

112 hibitor, was able to induce pre-hypertrophic chondrocyte differentiation both in vitro and in vivo.

113 hedgehog are implicated in the regulation of chondrocyte differentiation, but the specific cellular t

114 nail (Sna) and Slug (Slugh), are involved in chondrocyte differentiation by controlling the expressio

115 LOXL2 promotes chondrocyte differentiation by mechanisms that are likel

116 ession of Wdr5 in the perichondrium promotes chondrocyte differentiation by modulating the expression

117 Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease camp

118 In addition to the acceleration of chondrocyte differentiation, conventional transgenic mic

119 cription factor c-Maf is required for normal chondrocyte differentiation during endochondral bone dev

120 ese results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic

121 Chondrocyte differentiation factor Sox-9 was detected in

122 Herein we report that GEP stimulates chondrocyte differentiation from mesenchymal stem cells

123 In an in vitro model of chondrocyte differentiation, human dermal fibroblasts (h

124 collagen II, an early and abundant marker of chondrocyte differentiation, identified a minimal DNA el

125 ive activation of the BMP receptor-IA blocks chondrocyte differentiation in a similar manner as misex

126 ophic chondrocyte phenotypes revealed normal chondrocyte differentiation in c-Raf(f/f);ColII-Cre(+) m

127 vels of Col2a1 and other specific markers of chondrocyte differentiation in culture, we then asked wh

128 as uncoupled from the usual tight linkage to chondrocyte differentiation in the epiphyseal growth pla

129 t proliferation of prechondrogenic cells and chondrocyte differentiation in the phalangeal region are

130 of columns and stimulation of periarticular chondrocyte differentiation in these models were still o

131 Wdr5 accelerates osteoblast and chondrocyte differentiation in vitro, and is development

132 BP1 mRNA expression was downregulated during chondrocyte differentiation in vitro.

133 induction of sclerotomal gene expression and chondrocyte differentiation in vitro.

134 THrP) has also been demonstrated to regulate chondrocyte differentiation in vivo.

135 Altered chondrocyte differentiation, including development of ch

136 ted markers of chondrocyte proliferation and chondrocyte differentiation increased, although these ch

137 information on transcriptional regulation of chondrocyte differentiation induced by DBP.

138 d for the normal progression of hypertrophic chondrocyte differentiation into bone in the developing

139 Chondrocyte differentiation is abnormal in the Six2-null

140 Thus, chondrocyte differentiation is controlled at multiple st

141 Proper regulation of chondrocyte differentiation is necessary for the morphog

142 ecreased approximately 10%, and hypertrophic chondrocyte differentiation is perturbed.

143 sis and of the genes expressed as markers of chondrocyte differentiation is poorly understood.

144 AGGRECAN, a matrix protein expressed during chondrocyte differentiation, is also expressed.

145 x9 cooperatively activated expression of the chondrocyte differentiation marker Col2a1 in 10T1/2 and

146 ration, and the expression of mRNAs encoding chondrocyte differentiation markers and growth factors.

147 ression of HDAC4 reverses miR-1 induction of chondrocyte differentiation markers Col X and Ihh.

148 ion of HDAC4 reverses miR-365 stimulation of chondrocyte differentiation markers including Ihh, Col X

149 he small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentrat

150 nt for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1.

151 In vivo, early limb development and chondrocyte differentiation occurred normally in Tgfbr2-

152 vement of a MEK/ERK/Ets1 pathway in blocking chondrocyte differentiation of cardiac neural crest.

153 found that TGF-beta1 significantly inhibits chondrocyte differentiation of wild-type metatarsal rudi

154 he hypothesis that two critical steps of the chondrocyte differentiation pathway are sensitive to Sox

155 t SOX9 is essential for several steps of the chondrocyte differentiation pathway, we asked whether Ct

156 9 is required during sequential steps of the chondrocyte differentiation pathway.

157 ntrolling the progression of cells along the chondrocyte differentiation pathway.

158 hese and perhaps other genes involved in the chondrocyte differentiation pathway.

159 In contrast to Ihh mutants (Ihh(n)/Ihh(n)), chondrocyte differentiation proceeds normally.

160 and that Sox9 can subsequently initiate the chondrocyte differentiation program in a variety of cell

161 e and developing cartilage, can activate the chondrocyte differentiation program in somitic mesoderm

162 x3.2, Nkx3.2-N200Q is unable to activate the chondrocyte differentiation program in somitic mesoderm,

163 ned skeletal elements, without affecting the chondrocyte differentiation program.

164 y through SEs, to implement the growth plate chondrocyte differentiation program.

165 s are crucial regulators of the hypertrophic chondrocyte differentiation program.

166 ers concomitant with the reexpression of the chondrocyte differentiation program.

167 ox9 expression, suggestive of an accelerated chondrocyte differentiation program.

168 dlin-2 and a mechanism for regulation of the chondrocyte differentiation programme and chondrogenesis

169 This study shows that miR-140 has a chondrocyte differentiation-related expression pattern.

170 BMPR-IA regulates chondrocyte differentiation, serving as a downstream med

171 d intramembranous ossification as well as in chondrocyte differentiation, similar to but less severe

172 w that the mutant receptor caused a block in chondrocyte differentiation specifically at the prehyper

173 n and the relationship of these effects with chondrocyte differentiation stage.

174 te dihydrate, underlying the significance of chondrocyte differentiation state and the factors regula

175 ssion of Wdr5 in the perichondrium regulates chondrocyte differentiation, studies were undertaken usi

176 he DNA enhancer element in genes involved in chondrocyte differentiation, such as Col11a2 and Col9a2,

177 blast differentiation as well as accelerated chondrocyte differentiation, suggesting that overexpress

178 We also show that GEP activates chondrocyte differentiation through Erk1/2 signaling and

179 signaling inhibits bone growth by inhibiting chondrocyte differentiation through the MAPK pathway and

180 (PTHrP) which negatively regulates terminal chondrocyte differentiation through the PTH/PTHrP recept

181 s (OA) pathogenesis by regulating a shift in chondrocyte differentiation to hypertrophy.

182 r of chondroprogenitor cells and accelerated chondrocyte differentiation to hypertrophy.

183 drogenesis, and reducing SOX9 dosage allowed chondrocyte differentiation to proceed and significantly

184 late endochondral ossification by inhibiting chondrocyte differentiation toward hypertrophy.

185 mesenchymal progenitor cells in vitro causes chondrocyte differentiation under conditions allowing on

186 e microRNA found to adversely regulate early chondrocyte differentiation via direct targeting of the

187 hanically responsive microRNA that regulates chondrocyte differentiation via directly targeting HDAC4

188 lation and mice with reduced PPR expression, chondrocyte differentiation was accelerated not only at

189 rowth in these animals, the role of Hdac3 in chondrocyte differentiation was evaluated.

190 ern of expression of genes known to regulate chondrocyte differentiation was not perturbed in Pbx1-de

191 In contrast, suppressed chondrocyte differentiation was observed throughout the

192 Chondrocyte differentiation was promoted by Hivep3 overe

193 unx2, which plays a major role in late stage chondrocyte differentiation, was enhanced in Hmgb2(-/-)

194 The expression of Twist-1, which regulates chondrocyte differentiation, was increased in Col I-Wdr5

195 ssential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP r

196 Because Sox9 is essential for chondrocyte differentiation, we propose that FGFs and th

197 -independent pathways, Runx2 expression and chondrocyte differentiation were analyzed using bones fr

198 tion, the expression patterns of markers for chondrocyte differentiation were not altered in vertebra