ライフサイエンスコーパス: chondrogenic

1 The direct effect of VEGF on the in vitro chondrogenic ability of mouse MDSCs was tested using a p

2 er these conditions, the cells showed robust chondrogenic activity in micromass culture, and generate

3 In vitro chondrogenic activity was measured as glycosaminoglycan

4 ells that can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages.

5 rious lineages of cells, such as osteogenic, chondrogenic, adipogenic, myogenic, and neurogenic cells

6 ced to redifferentiate into cells expressing chondrogenic, adipogenic, myogenic, and osteogenic marke

7 here was a significant reduction in in vitro chondrogenic and adipogenic activity in cultures of pati

8 hat Wnt/beta-catenin signaling regulates the chondrogenic and adipogenic differentiation of pericytes

9 Overexpression of sox9 rescued the zebrafish chondrogenic and craniofacial phenotype generated by ddr

10 ilage nodule formation and overexpression of chondrogenic and matrix genes in limb bud mesenchymal ce

11 n upstream of Pax genes in the regulation of chondrogenic and myogenic differentiation of paraxial me

12 , which implicates MMP9 in the regulation of chondrogenic and osteogenic cell differentiation during

13 e isolated and induced to differentiate into chondrogenic and osteogenic cells in vitro, and encapsul

14 en treated with BMP-2, these cells underwent chondrogenic and osteogenic differentiation, respectivel

15 or neuronal differentiation while decreasing chondrogenic and osteogenic differentiation.

16 tion are based on the experimentally studied chondrogenic and osteogenic effects of bone morphogeneti

17 Using chondrogenic and osteogenic markers we show that rediffe

18 the time the limb mesenchyme segregates into chondrogenic and perichondrogenic condensations.

19 ormal telomere lengths and osteoblastogenic, chondrogenic, and adipogenic differentiation potentials.

20 Cs were able to differentiate to adipogenic, chondrogenic, and neurogenic lineages.

21 entiation of pericytes along the adipogenic, chondrogenic, and osteogenic lineages may contribute to

22 loping chick limb bud, myogenic, fibrogenic, chondrogenic, and osteogenic tissues are derived from em

23 for tri-lineage differentiation (adipogenic, chondrogenic, and osteogenic).

24 nd was induced during the differentiation of chondrogenic ATDC5 and N1511 cells.

25 he conditioned medium of the differentiating chondrogenic ATDC5 cell line.

26 After Chadl shRNA knockdown, chondrogenic ATDC5 cells increased their differentiation

27 The majority of studies have focused on chondrogenic (but not specifically articular cartilage)

28 To test roles for such Wnt-mediated anti-chondrogenic capacity in vivo, we created conditional mu

29 gative effects of GDF11 on both myogenic and chondrogenic cell differentiation.

30 egulated during differentiation of the mouse chondrogenic cell line ATDC5 and overexpression of exoge

31 By using a chondrogenic cell line, ATDC5, we investigated the TGF-b

32 d the RCJ3.1C5.18 nontransformed mesenchymal chondrogenic cell line, which, over 2 weeks of culture,

33 expression pattern, we used the ATDC5 mouse chondrogenic cell line.

34 ress cartilage matrix production in a murine chondrogenic cell line.

35 own previously to be expressed in developing chondrogenic cell lineages during embryogenesis.

36 experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes nec

37 ox9 and its target genes required for normal chondrogenic cell proliferation and differentiation.

38 MP) signaling was activated with the ectopic chondrogenic cells and chondrocytes, as indicated by pho

39 differentiate into myogenic, osteogenic and chondrogenic cells in culture.

40 Here we show that Smpd3 expression in ATDC5 chondrogenic cells is downregulated by parathyroid hormo

41 re all significantly lower in CypA knockdown chondrogenic cells than in wild-type cells, indicating t

42 ne the minimum effective atRA concentration, chondrogenic cells transfected with a retinoic acid resp

43 This results in fewer chondrogenic cells within the developing vertebral body,

44 s (smooth muscle, adipogenic, osteogenic and chondrogenic cells).

45 9), one of the earliest markers of committed chondrogenic cells, is reduced in Cav3.2(-/-) tracheas.

46 d differentiate into smooth muscle cells and chondrogenic cells, thus contributing to vascular remode

47 Using the RCJ3.1C5.18 chondrogenic cells, which in culture progresses from und

48 expression and function in developing ATDC5 chondrogenic cells.

49 tic protein 2 pretreated ATDC5 and C3H10T1/2 chondrogenic cells.

50 staining for the presence of osteogenic and chondrogenic cells.

51 g, cell migration, and cell proliferation in chondrogenic cells.

52 Condensation of pre-osteogenic, or pre-chondrogenic, cells is the first of a series of processe

53 the presumptive cranial base did not undergo chondrogenic commitment as determined by the loss of Sox

54 repressor induced by Shh, is able to confer chondrogenic competence in somites.

55 The digit pre-chondrogenic condensates also become wider, thicker and

56 Normally, these cells surrounding the chondrogenic condensation are exposed to IHH, as evidenc

57 s, Ddrgk1-/- mice displayed delayed limb bud chondrogenic condensation, decreased SOX9 protein expres

58 homozygous embryos are defective in forming chondrogenic condensations in vitro.

59 ity of Hoxa13(-/-) mesenchymal cells to form chondrogenic condensations in vivo and in vitro.

60 on hindlimb buds then develop transitory pre-chondrogenic condensations of the tibia, fibula, and foo

61 Although Ihh(-/-) cells organize into chondrogenic condensations similar in size and shape to

62 tterning of tissues adjacent to craniofacial chondrogenic condensations.

63 expression result in profoundly mispatterned chondrogenic condensations.

64 pon seeding, and constructs were cultured in chondrogenic conditions for 28 d.

65 uration, intramembranous bone formation, and chondrogenic condylar growth.

66 llagen mRNA revealed a high level of mRNA in chondrogenic constructs compared with that in undifferen

67 Addition of CHL2 protein to a chondrogenic culture system reduced cartilage matrix dep

68 icate for the first time that SIRT1 supports chondrogenic development of MSCs at least in part throug

69 e as a means of assessing the progression of chondrogenic development of the tissues.

70 in mouse limbs supports a role for DOT1L in chondrogenic differentiation and adult articular cartila

71 findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage reg

72 d with female MDSCs, male MDSCs display more chondrogenic differentiation and better cartilage regene

73 somerase previously shown to be required for chondrogenic differentiation and endochondral ossificati

74 we unveil the role of CypA in signal-induced chondrogenic differentiation and endochondral ossificati

75 ional factor, which plays a critical role in chondrogenic differentiation and endochondral ossificati

76 entiation and, in particular, adipogenic and chondrogenic differentiation are poorly defined.

77 down of Rab23 also resulted in inhibition of chondrogenic differentiation as well as down-regulation

78 This regulation of MPC chondrogenic differentiation by the MAP kinases involves

79 tured with primary OA chondrocytes underwent chondrogenic differentiation even in the absence of grow

80 oint synovium that undergo proliferation and chondrogenic differentiation following injury in vivo.

81 that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells.

82 eoblast differentiation and leads to ectopic chondrogenic differentiation in the bone-forming region

83 tant cells are defective in osteoblastic and chondrogenic differentiation in tri-lineage differentiat

84 one morphogenetic proteins (BMPs) to promote chondrogenic differentiation in vitro.

85 hondrogenesis, but also strongly potentiates chondrogenic differentiation in vitro.

86 erexpression of Sox9 restores the defects in chondrogenic differentiation induced by Kindlin-2 deleti

87 The control of angiogenesis during chondrogenic differentiation is an important issue affec

88 Chondrogenic differentiation is pivotal in the active re

89 Expression levels of the chondrogenic differentiation markers and transcriptional

90 f neuronal fates in chicken neural explants, chondrogenic differentiation of 10T1/2 cells, and Gli ac

91 vity of the Runx2 gene within the context of chondrogenic differentiation of a mesenchymal progenitor

92 the influence of other growth factors on the chondrogenic differentiation of ADAS cells is not fully

93 emical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells.

94 th NB250 and NB260, as well as Nodal, induce chondrogenic differentiation of human adipose-derived st

95 Chondrogenic differentiation of human bone marrow derive

96 trate the functional role of miR-146b in the chondrogenic differentiation of human bone marrow derive

97 fate (CS) and their ability to stimulate the chondrogenic differentiation of human bone marrow-derive

98 ith cell-mediated degradation aligned to the chondrogenic differentiation of human mesenchymal stem c

99 orphogenetic signals from OA chondrocytes on chondrogenic differentiation of human mesenchymal stem c

100 terials support the survival and promote the chondrogenic differentiation of human mesenchymal stem c

101 the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem c

102 sion pattern of miR-140 was monitored during chondrogenic differentiation of human MSCs in pellet cul

103 ect of OA chondrocyte-secreted morphogens on chondrogenic differentiation of human MSCs was evaluated

104 ng a small number of chondrocytes to promote chondrogenic differentiation of human MSCs while prevent

105 cence staining were used to characterize the chondrogenic differentiation of human MSCs.

106 t culture systems, we evaluated the in vitro chondrogenic differentiation of LacZ- and BMP-4-transduc

107 Histogenesis relies on cues that promote the chondrogenic differentiation of mesenchymal cells, where

108 In developing limb buds of mutant mice, chondrogenic differentiation of mesenchymal condensation

109 Two of these lncRNAs are upregulated during chondrogenic differentiation of mesenchymal stem cells (

110 et cultures, the nanofiber scaffolds enhance chondrogenic differentiation of mesenchymal stems cells

111 Actively steering the chondrogenic differentiation of mesenchymal stromal cell

112 ring endochondral bone development, both the chondrogenic differentiation of mesenchyme and the hyper

113 embers is a key requirement for the in vitro chondrogenic differentiation of MPCs.

114 drocytes, and its expression declined during chondrogenic differentiation of MSC.

115 the role of SIRT1-mediated signaling during chondrogenic differentiation of MSCs in vitro.

116 Chondrogenic differentiation of MSCs is currently trigge

117 ox9 may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells,

118 In micromass cultures, chondrogenic differentiation of mutant chondrocytes is d

119 pathway effectively promoted osteogenic and chondrogenic differentiation of PCDSCs in vitro and indu

120 transforming growth factor-beta3 induces the chondrogenic differentiation of pericytes by inducing Wn

121 n signaling inhibits adipogenic and enhances chondrogenic differentiation of pericytes.

122 thways that control the early osteogenic and chondrogenic differentiation of periosteal stem/progenit

123 g bone morphogenic protein 2 (BMP-2)-induced chondrogenic differentiation of pluripotent C3H10T1/2 ce

124 LacZ; the addition of TGFbeta1 did not alter chondrogenic differentiation of the BMP-4-transduced MDS

125 role for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated C

126 We hypothesized that MSCs undergoing chondrogenic differentiation produce an intermediate cyt

127 t effective mechanism by which to direct the chondrogenic differentiation program into either permane

128 A 3-week chondrogenic differentiation results demonstrated that c

129 In cells overexpressing hMGP, osteogenic and chondrogenic differentiation was inhibited indicating de

130 at up-regulation of Rab23 can indeed inhibit chondrogenic differentiation with a concomitant down-reg

131 nes in MDSCs that were stimulated to undergo chondrogenic differentiation with BMP-4 and transforming

132 ed to condense into cellular bodies, undergo chondrogenic differentiation, and form cartilagenous tis

133 3-transfected ATDC5 and N1511 cells promoted chondrogenic differentiation, but the suppression of end

134 ike cell-cell interaction and progression to chondrogenic differentiation, by the sequential up-regul

135 qualitative changes that are associated with chondrogenic differentiation, including production of Al

136 ass cultures, which faithfully mimic in vivo chondrogenic differentiation, loss of HMGN1 accelerates

137 During both osteogenic and chondrogenic differentiation, these miRNAs, in general,

138 ication, including stimulation of osteogenic/chondrogenic differentiation, vesicle release, apoptosis

139 level of Rab23 protein led to inhibition of chondrogenic differentiation, we characterized ATDC5 cel

140 mising strategy for enhanced hMSC growth and chondrogenic differentiation, which are critical compone

141 id scaffolds, SF clones displayed consistent chondrogenic differentiation, while BM clones were varia

142 g that muscle satellite cells have undergone chondrogenic differentiation.

143 tion status of MSC and that HMGB2 suppresses chondrogenic differentiation.

144 tiation both in vitro and in vivo and led to chondrogenic differentiation.

145 signals results in cell cycle withdrawal and chondrogenic differentiation.

146 roliferation or influencing their osteogenic/chondrogenic differentiation.

147 is necessary for mesenchymal aggregation and chondrogenic differentiation.

148 nd to regulate both COMP gene expression and chondrogenic differentiation.

149 or beta (TGF-beta) signals are necessary for chondrogenic differentiation.

150 c differentiation, but normal adipogenic and chondrogenic differentiation.

151 ressed CHL2, and its levels decreased during chondrogenic differentiation.

152 s Wnt signal does indeed function to promote chondrogenic differentiation.

153 nce during which time BMP signals can induce chondrogenic differentiation.

154 later exposure to BMPs, which act to trigger chondrogenic differentiation.

155 rthritis (OA) and their potential to support chondrogenic differentiation.

156 icating that CypA plays a functional role in chondrogenic differentiation.

157 orted the conclusion that CypA is needed for chondrogenic differentiation.

158 r verified the effects of CypA deficiency on chondrogenic differentiation.

159 0.15 kPa in stem cells to 0.71 kPa following chondrogenic differentiation.

160 Turing-like mechanism generating stripes of chondrogenic domains.

161 We have recently reported the chondrogenic effect of bone morphogenetic protein-2 (BMP

162 10 ng/mL PDGF) supplementation of serum-free chondrogenic expansion medium enhances the post-expansio

163 associated with persistent expression of the chondrogenic factor Sox9 and down-regulation of beta-cat

164 e that expression of the gene for the master chondrogenic factor Sox9 is stimulated by FGFs in chondr

165 s function in a molecular hierarchy in which chondrogenic factors dominate.

166 revents chondrogenesis in these cells, while chondrogenic factors Nkx3.2 and Sox9 act downstream of T

167 ensitive to sequential addition of the three chondrogenic factors PDGF, TGFbeta and BMP.

168 persists; accordingly, cells maintain their chondrogenic fate and the developed digits are shorter t

169 ions providing novel molecular insights into chondrogenic fate commitment and differentiation.

170 The results show that chondrogenic function of SoxE regulators can be traced t

171 35a, miR-205, and miR-217) also regulate the chondrogenic GATA transcription factor tricho-rhino-phal

172 qPCR and TaqMan qPCR were used to assess chondrogenic gene and miRNA expression.

173 rdependence of cytoskeletal organization and chondrogenic gene expression is regulated, at least in p

174 apy improved the BMP-4- and TGFbeta3-induced chondrogenic gene expression of MDSCs in vitro and impro

175 In this study, the pre-chondrogenic gene expression profile was used as a start

176 GF7), substituted for ectoderm in inhibiting chondrogenic gene expression, with some combinations of

177 uired for Sox9 to control chondrogenesis and chondrogenic gene expression.

178 activation of mTOR, cell proliferation, and chondrogenic gene expression.

179 r collagen (ColA) genes--suggesting that the chondrogenic gene regulatory network evolved in the comm

180 sFlt-1 treatment improved the expression of chondrogenic genes in MDSCs that were stimulated to unde

181 th PGC-1alpha and Sox9 induced expression of chondrogenic genes, including Col2a1, followed by chondr

182 , cartilage tissue growth, and expression of chondrogenic genes, including Indian hedgehog (Ihh), a c

183 Furthermore, ECM1 and progranulin chondrogenic growth factor constitute an interaction net

184 ion by associating with and inactivating GEP chondrogenic growth factor.

185 GDF5 is a pro-chondrogenic growth factor.

186 ny generated using such small molecules were chondrogenic in vitro, and expressed trunk paraxial meso

187 The polypeptide responsible, called the chondrogenic-inducing agent (CIA), has been isolated fro

188 Concurrent chondrogenic induction in the apical compartment enabled

189 the molecular signals that are required for chondrogenic induction in the trunk and head.

190 alginate cultures of MSCs were treated with chondrogenic induction medium with/without the SIRT1 inh

191 ts, and describe a tailorable system for the chondrogenic induction of hMSCs without necessitating cu

192 provide an advantageous environment for the chondrogenic induction of human mesenchymal stem cells (

193 scs in Transwell inserts following isotropic chondrogenic induction with transforming growth factor b

194 lizarin-red-stainable nodules, indicative of chondrogenic induction.

195 ated cultures with Shh rescues cultures from chondrogenic inhibition.

196 apoptosis and inhibited both osteogenic and chondrogenic lineage commitment.

197 senchymal precursors that are destined for a chondrogenic lineage during endochondral ossification.

198 their in vivo survival and commitment to the chondrogenic lineage in a microenvironment comprising ch

199 ox9 is required for the determination of the chondrogenic lineage in CNC cells.

200 nd and differentiate adult stem cells into a chondrogenic lineage is an important step in the develop

201 The effects of I-PTH on the chondrogenic lineage of the mandibular condylar cartilag

202 inted oMSCs could be differentiated down the chondrogenic lineage to generate cartilage-like structur

203 utgrowth, these progenitors segregate into a chondrogenic lineage, located in the center of the limb

204 r cell proliferation after commitment to the chondrogenic lineage.

205 differentiate to adipogenic, osteogenic, and chondrogenic lineages was analyzed after immunomagnetic

206 a later role in formation of somite-derived chondrogenic lineages, and suggest that scleraxis target

207 erentiated along adipogenic, osteogenic, and chondrogenic lineages, even after sorting and expansion

208 rd the osteogenic, adipogenic, myogenic, and chondrogenic lineages.

209 iR-199a(*) increased the expression of these chondrogenic marker genes.

210 e in depth, analyzing histological and early chondrogenic markers, as well as the patterns of cell de

211 zed by the expression of both osteogenic and chondrogenic markers.

212 velopment and led to decreased levels of the chondrogenic master transcription factor sox9 and its do

213 MSCs cultured in adipogenic, osteogenic, or chondrogenic media differentiated, respectively, into ad

214 a pellet culture system for 14 days in basal chondrogenic medium (CM), CM with TGFbeta1, CM with BMP-

215 ge matrix proteins in vitro when cultured in chondrogenic medium containing TGFss3 or BMP2.

216 ures were predifferentiated for 2 weeks in a chondrogenic medium, and hypertrophy was induced by with

217 at high density in the presence of a defined chondrogenic medium, pericytes formed well-defined pelle

218 ox9-null CNC cells were unable to contribute chondrogenic mesenchymal condensations.

219 b buds or the Sox9 gene is inactivated after chondrogenic mesenchymal condensations.

220 in the NH2-propeptide and is synthesized by chondrogenic mesenchyme and perichondrium.

221 Since the chondrogenic mesenchyme does not express Tmem16a at any

222 and subsequent signaling interactions enable chondrogenic mesenchyme to undergo histogenesis and morp

223 on of cellular polarity within the early pre-chondrogenic mesenchyme, when skeletal shape is establis

224 suggest that activation of this ancient core chondrogenic network underlies the parallel evolution of

225 number and intensity of Alcian blue stained chondrogenic nodules in micromass cultures derived from

226 GFP) heterozygous cells to condense and form chondrogenic nodules in vitro, which is consistent with

227 ein we report on the rapid condensation into chondrogenic nodules of cultured ank/ank bone marrow str

228 tic mesoderm (PSM) cells will adopt either a chondrogenic or lateral plate mesoderm fate.

229 d using 4-color flow cytometry, and standard chondrogenic, osteogenic, and adipogenic assays were use

230 produce adherent cell monolayers capable of chondrogenic, osteogenic, and adipogenic differentiation

231 The presence of these chondrogenic/osteogenic amelogenin-polypeptides in denti

232 est and significantly altered expression for chondrogenic/osteogenic lineage markers.

233 apsule and indicate that for some genes, the chondrogenic otic capsule is composed of distinct domain

234 d specification and prospective isolation of chondrogenic paraxial mesoderm progeny from human plurip

235 It requires its SOX5/SOX6 chondrogenic partners to robustly activate E195 and addi

236 stem cells induced to differentiate along a chondrogenic pathway.

237 ud precartilage mesenchymal cells undergoing chondrogenic patterning.

238 In chondrogenic pellet culture, cells synthesized cartilage

239 ble coincidence of LOXL2 expression with the chondrogenic phase of fracture healing was found, prompt

240 We demonstrate that induction of the chondrogenic phenotype and endogenous Nkx3.2 expression

241 canonical markers is tenuously linked to the chondrogenic phenotype at the single-cell level.

242 type-II and CS can be used to promote a more chondrogenic phenotype in the absence of growth factors,

243 on of chondrogenesis, but cannot reverse the chondrogenic phenotype once it has been initiated, as ev

244 this by driving progenitor cells to adopt a chondrogenic phenotype through the tailoring of scaffold

245 may especially be relevant for retaining the chondrogenic phenotype, which has important implications

246 r hypoxic oxygen levels (</=8%) promotes the chondrogenic phenotype.

247 altered osteoblastic function than enhanced chondrogenic potential and is not dependent on Vanin-1;

248 Osteogenic, adipogenic, and chondrogenic potential assays revealed retained differen

249 ed synovial cells were also tested for their chondrogenic potential by culturing them as aggregates i

250 e had enhanced osteogenic potential but less chondrogenic potential compared with controls.

251 xamethasone, in various combinations, on the chondrogenic potential of ADAS cells in alginate beads.

252 udy was undertaken to determine the in vitro chondrogenic potential of bone morphogenetic protein 7 (

253 expansion medium enhances the post-expansion chondrogenic potential of costochondral cells, evidenced

254 Chondrogenic potential of CVC was evidenced by expressio

255 ll marker Sca1 and in vitro expansion on the chondrogenic potential of M- and F-MDSCs was also determ

256 Long-term culture did not affect the chondrogenic potential of M-MDSCs but did influence F-MD

257 Sca1 purification influenced the chondrogenic potential of MDSCs, especially M-MDSCs.

258 To study the chondrogenic potential of MSC and identify the condition

259 cteristics, were compared for their in vitro chondrogenic potential using pellet culture.

260 We compared the roles of increased chondrogenic potential versus altered osteoblast functio

261 The chondrogenic potential was measured by quantitative reve

262 There was no decline in chondrogenic potential with age in cells obtained from i

263 ation of Sox9 causes CNC cells to lose their chondrogenic potential.

264 owth factor beta1 (TGFbeta1) to assess their chondrogenic potential.

265 f gastrulation before becoming restricted to chondrogenic precursor cells at embryonic day 9.5.

266 terior gene expression and failure to expand chondrogenic precursor cells, leading to severe truncati

267 e mutant mice more readily differentiated to chondrogenic precursors, providing a plausible explanati

268 n and to ensure progressive establishment of chondrogenic primordia along the PD axis.

269 We further conclude that chondrogenic primordia formation, marked by initial Sox9

270 Previously, ectopic expression of this "chondrogenic" profile has been implicated in vascular ca

271 Chondrogenic progenitor cells (CPCs) produced high level

272 emarkably, deletion of Tgfbr2 in myogenic or chondrogenic progenitor cells does not manifest in midli

273 that the migrating cell population included chondrogenic progenitor cells that were drawn to injured

274 death stimulated the emergence and homing of chondrogenic progenitor cells, in part via HMGB-1 releas

275 potent and expressed markers associated with chondrogenic progenitor cells.

276 copy, and migrating cells were evaluated for chondrogenic progenitor characteristics.

277 understand signal-induced chondrogenesis of chondrogenic progenitors in physiological and pathophysi

278 hile simultaneously impairing adipogenic and chondrogenic programs.

279 n signaling to promote osteogenic, and block chondrogenic, programs of cell fate specification.

280 have developed a reproducible and efficient chondrogenic protocol to redifferentiate chondrocytes is

281 -5a, Wnt-5b and Wnt-4 genes are expressed in chondrogenic regions of the chicken limb: Wnt-5a is expr

282 ng from hPS cells showed a relatively weaker chondrogenic response in vitro, and formed more of the f

283 The chondrogenic response of alginate-encapsulated ADAS cell

284 levels of endogenous Shh and suppresses the chondrogenic response of the mesenchyme cells, while sup

285 phenotype and border function, restrain pro-chondrogenic signaling proteins including BMPs, and rest

286 s understanding of the mode of action of the chondrogenic Sox trio.

287 ns (ORNs) of the olfactory epithelium and in chondrogenic structures surrounding the nasal cavity.

288 ver, Sox9 expression is detected not only in chondrogenic tissue but also in nonchondrogenic tissues,

289 stribution of bone morphogenetic proteins in chondrogenic tissue.

290 o 95-97% (HUES7 and HUES8 cells) express the chondrogenic transcription factor SOX9.

291 Sox9b, a critical chondrogenic transcription factor, was the most signific

292 ation to identify the roles of the redundant chondrogenic transcription factors Sox5 and Sox6 in this

293 Moreover, DBP increased gene expression of chondrogenic transcription factors SOX9 (160% of control

294 Only BM-derived MSCs exhibited a chondrogenic transcriptional program with hypomethylatio

295 Numerous chondrogenic transcripts were misregulated by TCDD in th

296 hondrogenesis of ank/ank BMSCs and increased chondrogenic transdifferentiation and calcification by a

297 mesenchymal precursors and P(i) donor-driven chondrogenic transdifferentiation and calcification of a

298 ese results reveal a central role for TG2 in chondrogenic transformation of vascular smooth muscle an

299 The chondrogenic trio is required and sufficient to mediate

300 the target genes and modes of action of this chondrogenic trio.