ライフサイエンスコーパス: choriocapillaris

1 e across Bruch's membrane (BrM) to reach the choriocapillaris.

2 r RPE-derived VEGF in the maintenance of the choriocapillaris.

3 using behavior was observed in the subfoveal choriocapillaris.

4 , but perhaps also in the maintenance of the choriocapillaris.

5 al pigment epithelium (RPE)-Bruch's membrane-choriocapillaris.

6 d RPE is a critical function mediated by the choriocapillaris.

7 GA, RPE atrophy was more severe than loss of choriocapillaris.

8 No area was completely devoid of choriocapillaris.

9 neurosensory retina, and reperfusion of the choriocapillaris.

10 between the retinal pigmented epithelium and choriocapillaris.

11 es in a thinned retina with abnormal RPE and choriocapillaris.

12 nal pigment epithelium (RPE), and underlying choriocapillaris.

13 onstrated that the bolus of dye perfused the choriocapillaris.

14 ypically more sluggish in CNV than in normal choriocapillaris.

15 ike deposits in Bruch's membrane, as well as choriocapillaris.

16 ed to OCTA flow deficits at the level of the choriocapillaris.

17 AMN may result from a vascular insult in the choriocapillaris.

18 a of RPE loss showed persistent but rarefied choriocapillaris.

19 n face image averaging on OCTA images of the choriocapillaris.

20 ment epithlium (RPE) defects and loss of the choriocapillaris.

21 xuses but also a vascular rarefaction of the choriocapillaris.

22 eration of the RPE, and secondary leakage of choriocapillaris.

23 ffectiveness may be limited by damage to the choriocapillaris.

24 scularization) compared with nonpathological choriocapillaris (205.1 +/- 46.9 PMNs/mm2 in pathologica

25 ent epithelial (RPE) complex, 78.22 (24.39); choriocapillaris, 25.77 (17.57); Sattler layer, 18.59 (1

26 HGF/SF was most intense at the level of the choriocapillaris, a finding that is significant because

27 Age and hypertension affect the choriocapillaris, a flat layer of capillaries that may s

28 aked 4 h after LPS injection in the temporal choriocapillaris and 4 and 36 h after LPS injection in t

29 terol is localized mainly to deposits in the choriocapillaris and Bruch's membrane and on the surface

30 g of the ligand-modified quantum dots in the choriocapillaris and intraretinal capillaries upon i.v.

31 source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and

32 c administration may impair functions of the choriocapillaris and retina.

33 be another oxidative injury stimulus to the choriocapillaris and RPE, and may explain the associatio

34 er 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 link

35 pvOCT imaging of the microvasculature of the choriocapillaris and the anterior choroidal vasculature

36 likely to disseminate, can be traced to the choriocapillaris and the draining vortex veins and 2) HG

37 en the number of hyperreflective foci in the choriocapillaris and the Sattler layer and disease durat

38 eir blind-ended capillary branches enter the choriocapillaris and the walls of large veins.

39 AC was localized to Bruch's membrane and the choriocapillaris and was detectable at low levels as ear

40 al and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related

41 Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and phot

42 tive foci in the Bruch membrane/RPE complex, choriocapillaris, and Sattler layer increased proportion

43 prominent at the Bruch membrane/RPE complex, choriocapillaris, and Sattler layer, correlate with dise

44 olved images of the retinal vasculature, the choriocapillaris, and the vessels in Sattler's and Halle

45 municates with the central retinal vein, the choriocapillaris, and with large veins of the optic nerv

46 inal angiogram, outer retinal angiogram, and choriocapillaris angiogram.

47 Defects in RPE, photoreceptors, and the choriocapillaris are characteristic of age-related macul

48 We quantified "percent choriocapillaris area of nonperfusion" (PCAN) in eyes wi

49 al FAs and with incomplete RPE repopulation, choriocapillaris atrophy, and outer retinal degeneration

50 a progressive degeneration characterized by choriocapillaris atrophy, RPE and BrM abnormalities, cul

51 minent outer collagenous layer deposits, and choriocapillaris basement membrane duplication/splitting

52 Quantitative analysis of the area of the choriocapillaris bed and RPE was performed by automated

53 To study choriocapillaris blood flow in age-related macular degen

54 e was to examine the feasibility of rotating choriocapillaris, Bruch's membrane (BM), and retinal pig

55 oxidized lipoprotein deposits located in the choriocapillaris, Bruch's membrane, and retinal pigment

56 in AMD retina and significantly lower in the choriocapillaris, Bruch's membrane, and RPE basal lamina

57 lasma LDL readily enters the RPE through the choriocapillaris but is not found homogeneously througho

58 dest positional or hydrostatic pressure, the choriocapillaris capacity is, and this is measurable in

59 udy was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial cha

60 structural and functional maturation of the choriocapillaris (CC) and to determine when fenestration

61 stood, particularly the relationship between choriocapillaris (CC) dysfunction and phenotypic variabi

62 coherence tomography angiography allows for choriocapillaris (CC) imaging.

63 (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform

64 In advanced AMD, new vessels from choriocapillaris (CC) invade through the Bruch's membran

65 graphy angiography (OCTA) of the retinal and choriocapillaris (CC) vasculatures in normal subjects an

66 The retinal layers, choriocapillaris (CC), Sattler's layer (SL), Haller's la

67 t epithelium (RPE) in the maintenance of the choriocapillaris (CC).

68 d with secondary sequellae involving RPE and choriocapillaris cell loss.

69 Peripheral choriocapillaris closure was observed as well as dilated

70 ssive age-related changes in the RPE-Bruch's-choriocapillaris complex that have features that may be

71 nges in the retinal pigment epithelium (RPE)/choriocapillaris complex were quantified in dry and wet

72 l choriocapillaris in 25 (83%), and abnormal choriocapillaris confined to the tumor apex in 17 (58%).

73 wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic

74 The peripheral choriocapillaris density displayed the same pattern as i

75 gic analysis revealed a similar reduction in choriocapillaris density in the irradiated area of eyes

76 The submacular choriocapillaris density was higher in eyes with AMD (0.

77 structural aging to the RPE-Bruch's membrane-choriocapillaris developed in mice treated with low-dose

78 VEGF188/188 mice exhibited normal choriocapillaris development.

79 trate that RPE-derived VEGF is essential for choriocapillaris development.

80 upport the view that the human HVS, like the choriocapillaris, develops by hemo-vasculogenesis, the p

81 e formation of outer retinal tubulations and choriocapillaris dropout.

82 Choriocapillaris dysfunction can be detected in the nonn

83 on of C5a peptides may lead to activation of choriocapillaris endothelial cells in AMD.

84 However, choriocapillaris endothelial cells in organ culture resp

85 ssess severity of deposits, BrM changes, and choriocapillaris endothelial morphology.

86 The choriocapillaris endothelium displayed fenestration loss

87 The choriocapillaris endothelium was variably hypertrophic.

88 ), choroidal thickness (in micrometers), and choriocapillaris-equivalent thickness (CCET, in micromet

89 scans (CV 8.0%) and good reproducibility of choriocapillaris-equivalent thickness (CV 27.9%).

90 ve analysis of the choroidal vasculature and choriocapillaris-equivalent thickness demonstrated excel

91 ation of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and

92 e interval [CI] 163.7-180.5 mum) and average choriocapillaris-equivalent thickness was 23.1 mum (95%

93 hickness was 8.0% (95% CI 6.3%-9.4%), and of choriocapillaris-equivalent thickness was 27.9% (95% CI

94 Choriocapillaris-equivalent thickness was thinner in hea

95 Local choroidal vasculature and choriocapillaris-equivalent thicknesses were determined.

96 variation (CV) of choroidal vasculature and choriocapillaris-equivalent thicknesses.

97 The retinal pigment epithelium and choriocapillaris exhibited regional preservation.

98 rated from photoreceptor outer segments, and choriocapillaris fenestrations were decreased.

99 En-face slabs of choriocapillaris flow (CC-slab) or outer nuclear layer s

100 En-face analysis of SS-OCTA choriocapillaris flow voids provide a non-invasive metho

101 ution of microspheres revealed little if any choriocapillaris flow.

102 pigment epithelium (RPE), and (4) masking of choriocapillaris flow.

103 ies and vascular dropout observed within the choriocapillaris for pvOCT are compared with regional GA

104 utine visualization of retinal capillary and choriocapillaris hemodynamics of the intact eye.

105 After averaging, en face choriocapillaris images showed a meshwork appearance.

106 The 9 registered choriocapillaris images were then averaged.

107 this transformation was then applied to the choriocapillaris images.

108 n 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal v

109 oid" spots were detected at the level of the choriocapillaris in 15 patients (88.2%).

110 ralesional granularity in 14 (47%), abnormal choriocapillaris in 25 (83%), and abnormal choriocapilla

111 t be targeted to prevent damage to the aging choriocapillaris in AMD.

112 Surviving choriocapillaris in areas with complete RPE loss was hig

113 Qualitatively, the choriocapillaris in areas with RPD showed focal dark reg

114 luation, GA eyes showed persisting, rarefied choriocapillaris in correspondence of retinal pigment ep

115 Treatments to protect the choriocapillaris in early AMD are needed.

116 in the retinal pigment epithelium (RPE) and choriocapillaris in eyes of deceased donors with age-rel

117 RPE basal lamina, intercapillary septa, and choriocapillaris in eyes with AMD may be permissive for

118 otal number of PMNs was increased within the choriocapillaris in five diabetic eyes (170.9 +/- 12.9 P

119 An evaluation of the status of choriocapillaris in the 2 groups was performed.

120 The presence of lesions in the choriocapillaris in the absence of retinal pigment epith

121 Surviving choriocapillaris in the area of RPE atrophy was signific

122 ents with STGD revealed an extensive loss of choriocapillaris in the central area with persisting tis

123 RPE atrophy was significantly narrower than choriocapillaris in the control subject and in normal ar

124 generate local, repetitive angiograms of the choriocapillaris in the rat and to assess the similarity

125 inal layers, retinal pigment epithelium, and choriocapillaris in treatment and control eyes were unre

126 Imaging of the choriocapillaris in vivo is challenging with existing te

127 Histologically, CNV extended from the choriocapillaris into the subretinal space.

128 helium (RPE) and retinal disruption, without choriocapillaris involvement.

129 n ciliary body, retinal pigmented epithelium-choriocapillaris, iris, and neurosensory retina are pred

130 n ciliary body, retinal pigmented epithelium-choriocapillaris, iris, and neurosensory retina.

131 l abnormalities supports the hypothesis that choriocapillaris is the primary site of pathology in SC,

132 subfoveal medium choroidal vessel layer and choriocapillaris layer thickness were significantly redu

133 subfoveal medium choroidal vessel layer and choriocapillaris layer thicknesses are significantly red

134 nd that of the medium choroidal vessel layer-choriocapillaris layer was 52.9 +/- 20.6 mum beneath the

135 from modest to extensive thickenings of the choriocapillaris layer.

136 s and metabolites between the retina and the choriocapillaris, leading to photoreceptor dysfunction a

137 To examine and quantify choriocapillaris lesions in active and quiescent serpigi

138 In inactive scars, the areas of retinal and choriocapillaris lesions were similar and did not change

139 En face SS-OCT imaging at the choriocapillaris level showed focally enlarged vessels i

140 Clusters of choriocapillaris lobules were observed and appeared simi

141 Multimodal imaging is most consistent with choriocapillaris loss exceeding photoreceptor loss.

142 ICG angiograms revealed choriocapillaris loss in large lesions and in some 500-m

143 vessels were preserved; in 200 mum lesions, choriocapillaris loss was not detectable.

144 In contrast, after 4 days of hyperoxia the choriocapillaris lumenal diameters and percent vascular

145 r contour (n = 15) and thinned or compressed choriocapillaris (n = 2), thinned (n = 3) or thickened (

146 However, methods to study the choriocapillaris noninvasively have been inadequate in t

147 with RPD have significantly larger areas of choriocapillaris nonperfusion compared with eyes with dr

148 n VEGFrpe-/- mice) results in the absence of choriocapillaris, occurrence of microphthalmia, and the

149 tive evaluation of endothelial injury in the choriocapillaris of live animals, which detects disease

150 ies and especially strongly expressed in the choriocapillaris of the human eye.

151 he feasibility of noninvasively studying the choriocapillaris of the living rat using the technique o

152 rat and to assess the similarity between the choriocapillaris of the rat and that of the subhuman pri

153 ge choroidal vessels and at the level of the choriocapillaris on OCT (P < 0.001).

154 e averaging can improve visualization of the choriocapillaris on OCTA images, transforming the images

155 ry detail, they do not adequately reveal the choriocapillaris or other microvascular features beneath

156 CA IV immunostaining is limited to the choriocapillaris overlying the retina, whereas CA XIV is

157 sional granularity (P = .0005), and abnormal choriocapillaris (P = .0001).

158 The number of rolling microspheres in the choriocapillaris peaked 4-10 h after LPS injection.

159 ks, average inner retinal PO2, normalized to choriocapillaris PO2, was higher in diabetic rats than i

160 Choriocapillaris regeneration appeared nearly normal by

161 was found to cause significant inhibition of choriocapillaris regeneration without apparent effect on

162 RPE/choriocapillaris regions contained approximately four ti

163 The choroidal vessels and choriocapillaris remained patent in the transplant bed.

164 space up to 3 months after surgery, and the choriocapillaris remains patent in the transplant bed, a

165 Inhibition of choriocapillaris revascularization by genistein was sign

166 of the retina and retinal pigment epithelium-choriocapillaris (RPE-CC) complex and increased reflecti

167 The choriocapillaris segmentation of OCT-A revealed the pres

168 In the normal monkey eye the RPE and choriocapillaris show generalized recovery with preserva

169 In the SAM P(8), vascular casts of the choriocapillaris showed a mild but significant decrease

170 The vascular density of the choriocapillaris showed a trend toward decreasing in ass

171 voids forms a scale invariant pattern in the choriocapillaris starting at a size much smaller than a

172 the role of RPE-derived soluble VEGF on the choriocapillaris survival, we used mice that produce onl

173 al thickness, resulting in rescue of the RPE/choriocapillaris that continues to perfuse, hence sparin

174 We show that as a result of the form of the choriocapillaris, the blood flow is decomposed into a te

175 dly leads to vision loss and ablation of the choriocapillaris, the major blood supply for the outer r

176 Algorithms were used to quantify choroid and choriocapillaris thicknesses.

177 (35%) choroidal shadowing deep to the nevus, choriocapillaris thinning overlying the nevus (94%), ret

178 choroidal nevi were found to have overlying choriocapillaris thinning.

179 e similarity between the rat and the primate choriocapillaris, thus indicating that the rat is an acc

180 VEGFR2 was detected in the choriocapillaris underlying the RPE.

181 electin glycoprotein ligand-Ig (rPSGL-Ig) in choriocapillaris using a scanning laser ophthalmoscope (

182 ments that comprise each lobular area of the choriocapillaris vascular plexus.

183 im of this study was to evaluate retinal and choriocapillaris vessel density using optical coherence

184 r lesions that destroyed photoreceptors, the choriocapillaris was also compromised, even when no chan

185 The choriocapillaris was imaged with better resolution of mi

186 Quantitative analysis of area of choriocapillaris was performed by automated image analys

187 ntrols in CRVO group (p < 0.001) and PFVD of choriocapillaris was significantly reduced compared to c

188 RPE and choriocapillaris were analyzed by transmission electron

189 cular features of the retinal plexus and the choriocapillaris were analyzed on OCTA and compared with

190 FVD and overall PFVD of choriocapillaris were significantly reduced compared to

191 betic and nondiabetic choroidal capillaries (choriocapillaris) were analyzed in the flat perspective

192 a reticulum of flattened laminae, and in the choriocapillaris where ovoid-to-spindle-shaped SM cells

193 ebrates branched geometries predominate, the choriocapillaris, which is the microvascular bed that is

194 y slower subsequent revascularization of the choriocapillaris, which paralleled the RPE wound healing

195 sed numbers of PMNs were present in areas of choriocapillaris with pathological changes (loss in APas