ライフサイエンスコーパス: choroid

1 liary body, pre-equatorial or postequatorial choroid).

2 lanoma (ie, any uveal melanoma involving the choroid).

3 rrounding tissues (such as neural retina and choroid).

4 arization) associated with drusen and a thin choroid.

5 y, and the individual vascular layers of the choroid.

6 wed by atrophy of the outer retina, RPE, and choroid.

7 measurements of thickness and volume of the choroid.

8 lature), outer retina (to identify CNV), and choroid.

9 tomic landmarks in the vitreous, retina, and choroid.

10 in analyzing OCT findings of the retina and choroid.

11 lyzed to assess abnormalities of the RPE and choroid.

12 d EGR2 was expressed in the ciliary body and choroid.

13 elial growth factor (VEGF) in the retina and choroid.

14 ss of the retinal pigment epithelium and the choroid.

15 CT) permit an efficient visualization of the choroid.

16 lature in different layers of the retina and choroid.

17 ed to distinguish between the retina and the choroid.

18 orphological features and vasculature of the choroid.

19 for large-scale quantitative studies of the choroid.

20 71-999) and protein homogenates from rat RPE/choroid.

21 ER2::LUC bioluminescence rhythm in mouse RPE-choroid.

22 ion and abduction compress the peripapillary choroid.

23 ivascular inflammatory infiltrate within the choroid.

24 ng the internal and external layers, and the choroid.

25 in the retinal pigment epithelium (RPE) and choroid.

26 s of UM arising from the ciliary body and/or choroid.

27 l structure of underlying retinal layers and choroid.

28 r retina nourished by the profusely perfused choroid.

29 ut RNFL changes preceded those affecting the choroid.

30 thinnest and African Americans the thickest choroids.

31 ve the highest flare values and the thickest choroids.

32 tosis involved the sclera (92%), iris (17%), choroid (12%), eyelid (8%), and temporal fossa (1%).

33 ranulation of mast cells was observed in the choroid 15 minutes after the injection and increased up

34 conjunctiva (6/31, 19%), eyelid (2/31, 6%), choroid (2/31, 6%), and orbit (1/31, 3%).

35 , 197 mum) compared with the opposite normal choroid (243 mum).

36 19 photon counts/ms; P = 0.0003) and thicker choroids (379.15+/-44.75 mum vs. 346.3+/-43.27 mum; P =

37 Tumor location included choroid (88%), ciliary body (2%), and iris (10%), with b

38 Caucasians (98%) and primarily involving the choroid (90%), ciliary body (7%), or iris (2%).

39 The melanoma involved the choroid (938/1059, 89%), ciliary body (85/1059, 8%), or

40 l pigment epithelium, the presence of a thin choroid, a perivascular choroidal inflammatory infiltrat

41 inner choroid and (b) focal thinning of the choroid adjacent to PIC lesions.

42 The volume of choroid adjacent to the optic nerve was significantly re

43 The thinning of the macular choroid (affected or not by choroidal neovascularization

44 e of focal hyperreflective dots in the inner choroid and (b) focal thinning of the choroid adjacent t

45 iabetic patients without DR showed a thicker choroid and a thinner retina, particularly in inner laye

46 a Reference Algorithms were used to quantify choroid and choriocapillaris thicknesses.

47 ections of pvOCT data within the superficial choroid and clinical angiography images for regions of G

48 ively established a relationship between the choroid and glaucoma.

49 human retina, retinal pigment epithelium and choroid and in guiding the analysis of the genomic regio

50 n (QO2) relies on oxygen availability by the choroid and is contingent upon retinal tissue oxygen ten

51 actors independently associated with thicker choroid and larger choroidal volume.

52 is, esotropia, coloboma of the iris, retina, choroid and optic disc, and microcornea.

53 ncreased in retinal pigment epithelium (RPE)/choroid and positively correlated with choroidal degener

54 al thickness, while CSC patients had a thick choroid and predominantly nonvascularized, serous PEDs w

55 apy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anoma

56 ition, the inner and outer boundaries of the choroid and retinal pigment epithelium (RPE) as well as

57 efects in the photoreceptors, as well as the choroid and retinal pigment epithelium (RPE).

58 and histology revealed malformations in the choroid and retinal pigmented epithelium, early cone pho

59 easurable; however, at the nevus margin, the choroid and sclera appeared normal.

60 tinoic acid-binding proteins secreted by the choroid and sclera during visually guided ocular growth.

61 on than do collections of fluid in the outer choroid and suprachoroidal space as seen in other forms

62 ing the PCAs showed no filling of the entire choroid and the optic disc in both groups of animals.

63 The choroids and lenses showed very low levels of carboplati

64 Quantitative analyses of the retina, choroid, and choroidal sublayers were performed, and ass

65 individual retinal layers, optic nerve head, choroid, and lamina cribrosa.

66 al border, location of the thickest point of choroid, and regions of focal choroidal thinning.

67 The retinal pigment epithelium and choroid are involved in severely affected patients.

68 t of the blood-aqueous barrier and thickened choroids are features of asymptomatic HCV patients, and

69 Choroids are thinner in longer, more myopic young adult

70 c findings in dome-shaped macula suggest the choroid as a target for possible treatment strategies.

71 uter retina, retinal pigment epithelium, and choroid, as well as frequent zonal progression.

72 r druse displayed hypertransmission into the choroid at week 52 on B-scan imaging and was classified

73 In a subgroup of the rabbit eyes, localized choroid atrophy was induced by cryopexy before TA-film i

74 Both nasal and temporal peripapillary choroid averaged 9-19 mum thinner in adduction and abduc

75 orizontal line scan can represent the entire choroid but subfoveal center point measurements are only

76 scleral interface with focal thinning of the choroid can be considered a normal variation without cli

77 Infant choroid can be imaged with a portable SD-OCT system with

78 thickness in a vascular tissue, such as the choroid, can be useful to evaluate the effect of obesity

79 or retina (PVRL) or the eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uvea

80 This study might imply the association of choroid circulation with ROP.

81 tudy and control groups for effect of IOP or choroid circulation.

82 h phase advances and phase delays of the RPE-choroid clock, thus suggesting that - as in other tissue

83 crophages and the retinal pigment epithelium/choroid complex.

84 luated for hyporeflective areas in the outer choroid consistent with collections of fluid using enhan

85 By tendency a thinner choroid correlates with larger retinal leakage areas.

86 ly inhibition of IL-1beta receptor preserved choroid, decreased subretinal hypoxia, and prevented RPE

87 gmentation approach was used to identify the choroid, defined as the layer between the outer border o

88 hrough the sclera and its termination in the choroid, directly beneath the lacquer cracks.

89 suggest that although outer portions of the choroid do not appear to be responsive to modest positio

90 ents of the vitreous membrane and peripheral choroid during accommodation, and age-related changes in

91 will spawn a search for additional roles of choroid ECs in RPE physiology and disease.

92 Here we study the contribution of choroid ECs to this process by comparing their gene expr

93 eyes (21%), juxtapapillary in 31 (31%), and choroid elsewhere in 47 (48%).

94 etinal pigment epithelium (RPE), fenestrated choroid endothelial cells (ECs) and Bruch's membrane, a

95 ies in a microvascular sprouting assay using choroid explants.

96 egulators of ventral optic cup formation and choroid fissure closure, and that bcl6a is a direct targ

97 tein A-I mRNA was significantly increased in choroids following retinoic acid treatment.

98 y, these findings define important roles for choroid gammadelta T cells in maintaining tissue homeost

99 sted at least one of the following: darkened choroid, glaucomatous optic nerve damage, or conjunctiva

100 Both RNFL and choroid had the same trend (increased thickness, followe

101 ufts of BVNs), and stalks of origin from the choroid in 26 eyes (55.3%, 26 stalks) on the en face pla

102 sory retina, retinal pigment epithelium, and choroid in 4 eyes (44%).

103 optical coherence tomography imaging of the choroid in both eyes at their last visit (14 years after

104 in cases 1, 3, and 4; the neural retina and choroid in case 1; and in the optic nerve in case 4.

105 orphological features and vasculature of the choroid in DR using SD-OCT.

106 ation), along with the significantly thicker choroid in exudative AMD eyes before treatment initiatio

107 zation of pathologic features of the RPE and choroid in eyes with chronic CSCR not usually appreciate

108 led morphologic and vascular features of the choroid in eyes with high myopia.

109 y, and the individual vascular layers of the choroid in eyes with Stargardt disease on SD OCT.

110 morphologic features and vasculature of the choroid in healthy eyes from 1-line raster scans obtaine

111 ectral domain OCT for a detailed analysis of choroid in healthy eyes.

112 The choroid in high myopic eyes was thickest temporally comp

113 tatively demonstrated the involvement of the choroid in LHON pathology.

114 The role of the choroid in ROP remains unknown and existing studies of c

115 n embryonic retinal pigment epithelium (RPE)/choroid in the absence of light.

116 al retina in all patients, but the subfoveal choroid in the hypopigmented region was slightly thinner

117 is not well understood, and the role of the choroid in the pathogenesis of AMN remains controversial

118 f vascular flow abnormality in the retina or choroid in this elusive disease.

119 IL-1beta was found to be cytotoxic to choroid in vitro, ex vivo, and in vivo.

120 riable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all l

121 On FA, there was a "dark choroid" in 21 out of 29 patients.

122 Changes in the choroid, in particular its thickness, are believed to be

123 re evaluated for morphologic features of the choroid, including the shape of the choroid-scleral bord

124 the outer retina-retinal pigment epithelium-choroid interface, during periods of inflammatory activi

125 deposits, ready to bind proteins at the RPE/choroid interface.

126 the outer retina-retinal pigment epithelium-choroid interface.

127 ning extracellular lipid droplets at the RPE/choroid interface; proteins and lipids then attach to th

128 A thinner choroid is associated with worse vision in these patient

129 Conversely, thinning of the choroid is the common outcome in chronic LHON and in DOA

130 he studies determined that the peripapillary choroid is thinner in glaucoma patients, two others fail

131 a few subsets of glaucoma, the peripapillary choroid is thinner when compared with normals.

132 chment, the choroidal stalks were all in the choroid layer.

133 eptor, retinal pigment epithelium (RPE), and choroid layers (standardized beta = -0.412 to -0.611, al

134 A thin choroid may be added to the diagnostic features of nonar

135 uggest that vascular compromise of the inner choroid may be involved in the pathogenesis of AMN.

136 dy melanoma in 29% of patients (67/235), and choroid melanoma in <1% of patients (6/4731).

137 was located in the ciliary body (n = 17) or choroid (n = 3).

138 peared to be in the ciliary body (n = 17) or choroid (n = 3).

139 oxygen-induced retinopathy and laser-induced choroid neovascularization.

140 oxygen-induced retinopathy and laser-induced choroid neovascularization.

141 In 1 patient, moderate detachment of the choroid occurred postoperatively, and it resolved sponta

142 hyperreflective dots were seen in the inner choroid of 68.5% of patients, with 17.1% of eyes present

143 degenerative changes in the retina, RPE, and choroid of Cd46(-/-) mice that are consistent with human

144 tein synthesis were markedly up-regulated in choroids of chick eyes during the recovery from induced

145 onal retina, retinal pigment epithelium, and choroid) of wild-type (WT) C57BL/6J mice.

146 rotein detected in the conditioned medium of choroid or sclera had an apparent Mr of 27,000 Da.

147 -shaped lesion arises from the sclera, outer choroid, or both and the overlying choroidal vasculature

148 Eyes with serous RD had thicker choroid (P = .004) and tended to have thicker sclera (P

149 We propose that regional differences between choroid plexi contribute to dynamic signaling gradients

150 ogeneity between telencephalic and hindbrain choroid plexi contributes to region-specific, age-depend

151 onal identities of mouse, macaque, and human choroid plexi derive from gene expression domains that p

152 st predictor of higher log(sCD27) levels and choroid plexitis was the best predictor of higher log(NF

153 icular abnormalities, namely ependymitis and choroid plexitis were seen in HIV- but not in HIV+ subje

154 the source of cerebrospinal fluid (CSF), the choroid plexus (ChP) has been one of the most understudi

155 od circulation, the epithelial layers of the choroid plexus (CP) are constitutively populated with CD

156 The choroid plexus (CP) forms the blood-cerebrospinal fluid

157 cells to the CNS involves activation of the choroid plexus (CP) of the brain for leukocyte trafficki

158 SVZ stem cell niche is the lateral ventricle choroid plexus (LVCP), a primary producer of CSF.

159 rogenesis and reestablished IFN-II-dependent choroid plexus activity, which is lost in aging.

160 tigated the influx of leukocytes through the choroid plexus and acute induction of nuclear factor-kap

161 tor of cerebrospinal fluid (CSF) both at the choroid plexus and at the astrocytic end feet and defect

162 ated with antiviral response, at the brain's choroid plexus and demonstrate its negative influence on

163 s that inhabit the parenchyma, meninges, and choroid plexus and discuss their roles in CNS homeostasi

164 structural changes in the epithelium of the choroid plexus and in the ependyma, such as asymmetrical

165 in the cell nuclei of the epithelium of the choroid plexus and in the ependymal cells surrounding th

166 lia and perivascular macrophages, as well as choroid plexus and meningeal macrophages, dendritic cell

167 several regions of the brain, including the choroid plexus and meninges.

168 n this research was the visualization of the choroid plexus and ventricular system, which seems to be

169 rain inflammation, our findings pinpoint the choroid plexus as an important target for future researc

170 Aquaporin 4 (AQ4) is not expressed in the choroid plexus but is expressed in the astrocytic end fe

171 Temporary disruption of the choroid plexus by microbubble-enhanced ultrasound is the

172 Since the choroid plexus can mediate interaction between periphera

173 ma (n = 1), glioblastoma multiforme (n = 1), choroid plexus carcinoma (n = 2), and Burkitt lymphoma (

174 Here we report the generation of a choroid plexus carcinoma cell line; Children's Cancer Ho

175 reshly isolated mouse ependymoma, glioma and choroid plexus carcinoma cells expressing red fluorescen

176 Choroid plexus carcinomas (CPCs) are poorly understood a

177 all survival in a cohort of 29 patients with choroid plexus carcinomas, a characteristic LFS tumor (P

178 tion rate in children presenting with ACC or choroid plexus carcinomas, and in females with breast ca

179 Endoscopic third ventriculostomy with choroid plexus cauterization (ETV-CPC) is an alternative

180 l types (eg, neurons, endothelial cells, and choroid plexus cells), most notably microglia and/or mac

181 oductive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvemen

182 F barrier (BCSFB) consists of a monolayer of choroid plexus epithelial (CPE) cells that maintain CNS

183 Transcriptome analysis of FACS-purified choroid plexus epithelial cells also predicts their cell

184 This BCSFB is formed by the choroid plexus epithelial cells and is important in main

185 A sheet of choroid plexus epithelial cells extends into each cerebr

186 CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blo

187 Native 5-HT2C receptors in choroid plexus epithelial cells were evaluated using flu

188 32 receptors/mum(2) on the apical surface of choroid plexus epithelial cells.

189 Recently, the remote brain choroid plexus epithelium (CP) was identified as a porta

190 The choroid plexus epithelium (CPE) secretes higher volumes

191 Our data identify the choroid plexus epithelium as a novel source of IL-6 in E

192 to increase the permeability of immortalized choroid plexus epithelium monolayers in vitro.

193 However, the choroid plexus epithelium remains an obstacle to deliver

194 derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-CSF barri

195 adial glia, mature astrocytes, ependyma, and choroid plexus epithelium, but not in neurons.

196 We analyzed postmortem choroid plexus from FXTAS and control subjects, and foun

197 arise, in part, from regional differences in choroid plexus gene expression, we defined the transcrip

198 macrophages accumulated in the meninges and choroid plexus in early inflammation and in the perivasc

199 Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS.

200 Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal macrophag

201 e populations, with the notable exception of choroid plexus macrophages, which had dual origins and a

202 expression of simian virus 40 (SV40) TAg in choroid plexus or intestinal villi requires at least one

203 temporal lobe regions (amygdala, hippocampus/choroid plexus region of interest) compared to younger c

204 tes from its primary production sites at the choroid plexus through the brain ventricles to reach the

205 , we serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from comp

206 d-cerebrospinal fluid barrier in the brain's choroid plexus was impaired.

207 macrophages were present in the meninges and choroid plexus with AIDS.

208 ll as around it (in the meningeal spaces and choroid plexus) has been shown to be important for brain

209 ide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the c

210 are highly expressed in rodent meninges and choroid plexus, anatomical regions relevant to CSF physi

211 and hair follicles, gall bladder epithelium, choroid plexus, and biliary epithelium.

212 human brain, with relatively high levels in choroid plexus, hippocampus and prefrontal cortex.

213 expression of the prolactin receptor in the choroid plexus, it has been hypothesized that the recept

214 The choroid plexus, located in brain ventricles, has receive

215 as binding of (11)C-dihydroergotamine in the choroid plexus, pituitary gland, and venous sinuses as e

216 Epithelial cells of the choroid plexus, where initial CCL20-induced leukocyte re

217 m Cell, Silva-Vargas et al. (2016) show that choroid plexus, within the lateral ventricles of the adu

218 n, Cre activity was mainly restricted to the choroid plexus, without significant recombination detect

219 inding sites overlapped in kidney and in the choroid plexus.

220 ephalic) versus fourth ventricle (hindbrain) choroid plexus.

221 lt2st3 was found in the olfactory organs and choroid plexus.

222 xpression profiles were observed within each choroid plexus.

223 oparticles (NPs) using SVCT2 transporters of choroid plexus.

224 es, astroglial cells, leptomeninges, and the choroid plexus.

225 e perilesional cortex, lesion core zone, and choroid plexus.

226 (PSGL-1-receptor) was mainly detected at the choroid plexus.

227 ession in the epithelial cells of testis and choroid plexus.

228 original spouting vessels (stalks) from the choroid, polypoidal structures, and BVNs on OCTA.

229 Ocular injury to the retina or choroid, poorer visual acuity, and pupillary defect were

230 lifespan of an organism, we believe that RPE-choroid preparation may represent a new and unique tool

231 eveloped a retinal pigment ephithelium (RPE)-choroid preparation to monitor the circadian clock using

232 d hyper-reflective deposits primarily in the choroid, retina pigment epithelium (RPE), and inner segm

233 by approximately 1.0 mm, pulling forward the choroid, retina, vitreous zonule, and the neighboring vi

234 ugh the sclera, without penetrating into the choroid/retina, in order to target injection into the su

235 tive and quantitative characteristics of the choroid, retinal pigment epithelium, and retina were com

236 he development of ischemic infarction of the choroid, retinal pigment epithelium, outer part of the r

237 geographical protein expression in the human choroid-retinal pigment epithelial (RPE) complex may exp

238 oreceptor-like cells was detected in "sclera+choroid+RPE" eyecup explants derived from adult animals.

239 Explant culture of "sclera+choroid+RPE" eyecup was used to examine whether cells wi

240 htness and reflectivity of the pixels in the choroid, RPE band, and overlying vitreous to be quantifi

241 ib levels in the vitreous humor, retina, and choroid-RPE at the end of the study were 4.5, 5, and 2.5

242 The choroid-RPE complex underwent biopsy from beneath the fo

243 res in anatomically sensitive regions of the choroid-RPE complex.

244 The findings give mechanistic insight into choroid-RPE function, reveal important choroid-RPE proce

245 into choroid-RPE function, reveal important choroid-RPE processes, and prioritize new pathways for t

246 ein signaling pathways unique to each of the choroid-RPE regions.

247 Experimental study of choroid-RPE tissue from 3 nondiseased eyes.

248 each of the foveal, macular, and peripheral choroid-RPE tissues.

249 and isoform B) in MEFs and human retina-RPE-choroid samples (n = 83).

250 transcript splice isoforms among retina-RPE-choroid samples carrying different genotypes at variants

251 the level of ARMS2 transcripts in retina-RPE-choroid samples.

252 tissues were manually segmented (prelamina, choroid, sclera, and lamina cribrosa [LC]).

253 3.27 mum and 3.15 +/- 3.07 mum; and for the choroid-sclera junction was -3.90 +/- 15.93 mum and 21.3

254 had a so-called bowl or convex shape to the choroid-sclera junction, and the thickest point of the c

255 een the outer border of the RPE band and the choroid-sclera junction.

256 in plasma and in retinal pigment epithelium/choroid/sclera, establishing that human CFH regulates ac

257 s of the choroid, including the shape of the choroid-scleral border, location of the thickest point o

258 tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some

259 dge of the retinal pigment epithelium to the choroid-scleral junction at 500-mum intervals up to 2500

260 The choroid showed an age-related decline in thickness of 2

261 The affected choroid showed smooth anterior contour (n = 15) and thin

262 roducible when measured to the border of the choroid stroma (SCT) than the vascular lumen (VCT) or sc

263 n (vascular choroidal thickness, VCT), outer choroid stroma (stromal choroidal thickness, SCT), or in

264 al vessel lumen, (2) the outer border of the choroid stroma, and (3) the inner border of the sclera,

265 pole, even in eyes with a markedly thickened choroid, such as those found in individuals with Sturge-

266 Males tended to have a thicker choroid than females; however, the difference was not si

267 al eyes showed significantly thinner macular choroids than eyes of a control group after adjusting oc

268 Eyes with advanced AMD had thinner choroids than eyes without AMD (posterior mean, -73.8; 9

269 s for the high-risk CFH genotype had thinner choroids than low-risk homozygotes (P < 0.05).

270 ) can cause severe changes in the retina and choroid that may result in marked visual impairment in i

271 r (RNFL), the ganglion cell layer (GCL), and choroid thickness (CT) in patients who have migraines, w

272 (RPE) layer atrophy or absence, followed by choroid thickness in absence of subretinal drusenoid dep

273 , both with aura and without aura, patients' choroid thinning should be considered when evaluating op

274 say (ELISA) analysis on young, aged, and AMD choroids to determine the abundance of the membrane atta

275 Improved visualization of the inner choroid using EDI-OCT may allow noninvasive assessment o

276 Integrity of the choroid varied from one eye to another and was not relat

277 The subfoveal choroid was a mean 23% thicker in the involved eye, with

278 The thickest point of the choroid was displaced from under the fovea, and focal ch

279 reretinal pocket and the outer border of the choroid was graded by independent masked observers for e

280 The choroid was imaged using enhanced-depth imaging spectral

281 Thinner peripapillary choroid was independently associated with thinner RNFL g

282 The choroid was involved in 21 cases (95.5%), and 1 case (4.

283 The choroid was irregularly shaped in 26 of 41 eyes (64%) wi

284 d 20% (n = 4) of eyes affected by STGD; dark choroid was present in 0% of GA eyes and 65% of STGD eye

285 Choroid was significantly thicker under the fovea (242.2

286 vary between ethnic groups but the temporal choroid was significantly thinner in black subjects (P <

287 terms of distribution profile, peripapillary choroid was thickest (150.04 +/- 59.72 mum) at the super

288 The choroid was thickest temporally (134 mum), then subfovea

289 The overlying choroid was thinned (mean thickness, 32 mum; range, 0-52

290 The choroid was thinner in AMD eyes.

291 lera junction, and the thickest point of the choroid was under the fovea in 88.0% of the subjects.

292 urface; en face SS-OCT images of the RPE and choroid were extracted at varying depths every 3.5 mum (

293 hyporeflective tubular structures within the choroid were observed in the vortex vein.

294 Objective measurements of the choroid were obtained with automated segmentation of the

295 te neovascularization in both the retina and choroid, which suggests that inhibition of this pathway

296 e vitreoretinal interface first and then the choroid, while averaging 100 separate OCT scans.

297 e manifests hypopigmentation of the iris and choroid with imaging features showing a slight reduction

298 ues, including extended depth imaging of the choroid with optical coherence tomography, have demonstr

299 helpful to understand the association of the choroid with ROP by measuring the choroidal thickness in

300 uter retina, retinal pigment epithelium, and choroid, with outer retinal tubulations frequently obser