ライフサイエンスコーパス: chromaffin

1 differed markedly in reporter expression in chromaffin and neuroblastoma cells, whereas site-directe

2 ation of filopodia-like structures in bovine chromaffin and PC12 cells driving the footprint expansio

3 y recording showed that during exocytosis in chromaffin and PC12 cells, fusion pores formed by smalle

4 which in Rim1 strongly enhances secretion in chromaffin and PC12 cells.

5 e was measured from bovine adrenal medullary chromaffin cell (CC) cultures maintained over a period o

6 e via desensitization/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that norma

7 ssociated with the effects of CIH on adrenal chromaffin cell catecholamine secretion.

8 are increased by Sp and that elevate 5-HT in chromaffin cell cultures, suggesting direct metabolic si

9 of NGF signaling for sympathetic neural and chromaffin cell development.

10 l sympathetic neuroblast hyperplasia, blocks chromaffin cell differentiation, and ultimately triggers

11 ar mechanisms by which PGE(2) might modulate chromaffin cell function.

12 exhibiting differential mobility shifting to chromaffin cell nuclear proteins during EMSA, binding of

13 ytomas and paragangliomas are rare tumors of chromaffin cell origin.

14 Internalisation of PrP(d) from the chromaffin cell plasma membrane occurred in association

15 The bovine chromaffin cell procedure should yield approximately 10-

16 medullary slices that permit separating the chromaffin cell secretion from sympathetic input.

17 Stimulation of chromaffin cell secretion in vitro triggers not only sec

18 CG10 by synthetic siRNAs virtually abolished chromaffin cell secretion of a transfected CHGA-EAP chim

19 revented the effects of IH on hypoxia-evoked chromaffin cell secretion.

20 extraordinary accumulation of solutes inside chromaffin cell secretory vesicles, although this has ye

21 ndogenous proteins are expressed in separate chromaffin cell subpopulations.

22 eterogeneous release of catecholamine at the chromaffin cell surface.

23 ltered transmission at the preganglionic --> chromaffin cell synapse.

24 ificity for the diagnosis of adrenomedullary chromaffin cell tumors can be jeopardized by physiologic

25 grams down-regulate SCP-gene and up-regulate chromaffin cell-gene networks.

26 e mice, expressing Cre recombinase under the chromaffin cell-specific phenylethanolamine N-methyltran

27 In a chromaffin cell-transfected CHGA 3'-UTR/luciferase repor

28 ic vesicle, and a medium size vesicle in the chromaffin cell.

29 Adrenal chromaffin cells (ACCs), stimulated by the splanchnic ne

30 Mouse chromaffin cells (MCCs) fire spontaneous action potentia

31 e changes in the surface membrane of adrenal chromaffin cells after stimulation of exocytosis with a

32 Ganglion neurons and adrenal chromaffin cells also show strong expressions.

33 In addition to the catecholamines, chromaffin cells also synthesize a range of peptides, in

34 onitoring of exocytotic events from cultured chromaffin cells and adrenal slices.

35 in the purified large dense-core vesicles of chromaffin cells and associated with synaptotagmin-1.

36 an directly affect the secretory capacity of chromaffin cells and contribute, in part, to elevated ca

37 nsmission on sympathetic neurons and adrenal chromaffin cells and elevates cytosolic ROS.

38 and vesicular catecholamine transporters of chromaffin cells and facilitates localization of the pri

39 investigated this question in mouse adrenal chromaffin cells and found that SNAP-25 inhibits Ca(2+)

40 nergic receptors are found on bovine adrenal chromaffin cells and have been implicated in the facilit

41 irst study of EP receptor signaling in mouse chromaffin cells and identifies a molecular mechanism fo

42 s, in vesicle docking and secretion in mouse chromaffin cells and in cell-free assays.

43 tory capacity measured amperometrically from chromaffin cells and in the expression of tyrosine hydro

44 nd [Ca2+]i responses in neonatal rat adrenal chromaffin cells and involves reactive oxygen species (R

45 Using adrenal chromaffin cells and neurons, we now find that both over

46 th catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons.

47 repinephrine released from adrenal medullary chromaffin cells and norepinephrine released locally fro

48 mega-shaped structure in live neuroendocrine chromaffin cells and pancreatic beta-cells, visualized u

49 ibitor of catecholamine release from adrenal chromaffin cells and postganglionic sympathetic axons.

50 protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endoth

51 entiation and increased apoptosis in adrenal chromaffin cells and sympathetic neurons.

52 hrough voltage-gated Ca2+ channels in bovine chromaffin cells and the domain of this receptor variant

53 n the development of sympathetic neurons and chromaffin cells and the mechanisms involved in Lin28B-i

54 proximity to the surface of adherent bovine chromaffin cells and to amperometrically record single e

55 (TH) in catecholamine-producing neurons and chromaffin cells and tyrosinase in melanocytes.

56 at controls epinephrine release from adrenal chromaffin cells and, consequently, hepatic glucose prod

57 Adrenal chromaffin cells are an important part of the neuroendoc

58 Adrenal medullary chromaffin cells are innervated by the sympathetic splan

59 Chromaffin cells are known to express functional GABA(A)

60 onclude that sympathetic neurons and adrenal chromaffin cells are more vulnerable to diabetes than pa

61 findings demonstrate that the fetal adrenal chromaffin cells are the source for acute hypoxaemia-ind

62 We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells,

63 d catestatin is secreted from neuroendocrine chromaffin cells as an autocrine regulator of nicotine-s

64 hromocytoma cells and bovine adrenomedullary chromaffin cells as detected by Northern blotting, Weste

65 ion did not evoke action potential firing in chromaffin cells but did cause a persistent subthreshold

66 or monitoring single vesicle exocytosis from chromaffin cells by constant potential amperometry as we

67 alin in secretory vesicles of neuroendocrine chromaffin cells by immunofluorescent confocal and immun

68 sponse element motif, an effect confirmed in chromaffin cells by site-directed mutagenesis on the tra

69 These results show that chromaffin cells can respond to depolarizing stimuli wit

70 Direct nicotinic stimulation of chromaffin cells caused catecholamine release and transg

71 o shrink the Omega-profile in neuroendocrine chromaffin cells containing approximately 300 nm vesicle

72 describes the primary culture of individual chromaffin cells derived by enzymatic digestion from the

73 We used amperometric recordings from chromaffin cells derived from mice that overexpress A30P

74 evoked secretion simultaneously from several chromaffin cells directly cultured on the device surface

75 owever, unlike hypothalamic nerve terminals, chromaffin cells do not display syntilla activation by d

76 synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect

77 surface membrane while secretory granules in chromaffin cells do not.

78 techolamine biosynthetic capacity of adrenal chromaffin cells during periods of sustained catecholami

79 rms, even upon high-frequency stimulation of chromaffin cells during stress responses.

80 Application of etomidate directly to the chromaffin cells elicited robust catecholamine secretion

81 Evidence suggests that chromaffin cells employ separate mechanisms for evoked e

82 e) Ca2+ and voltage-dependent K+ channels in chromaffin cells exhibit an inactivation that probably a

83 ously reported that N-type current in bovine chromaffin cells exhibits very little voltage-dependent

84 evious studies have shown that naive adrenal chromaffin cells express a nominal Ca(v)3.2-dependent co

85 d secretion from Munc18-1-null mouse adrenal chromaffin cells expressing Munc18-1 mutants designed to

86 residues, single exocytotic events in bovine chromaffin cells expressing R198Q, R198E, K201Q, or K201

87 Single exocytotic events in chromaffin cells expressing this mutant were characteriz

88 arge dense core vesicle (LDCV) exocytosis in chromaffin cells follows a well characterized process co

89 Stimulation of bovine chromaffin cells for 5 min with 6 mum free intracellular

90 at the plasma membrane and in the cytosol in chromaffin cells from adrenal medulla.

91 A30P or wild-type (WT) alpha-syn, as well as chromaffin cells from control and alpha-syn null mice, t

92 We show that adrenal chromaffin cells from CPX II knockout mice exhibit marke

93 Additionally, mRNA analyses of purified chromaffin cells from Gata3 mutants show that levels of

94 e have examined the kinetics of secretion in chromaffin cells from mice lacking phosphatidylinositol

95 ime and characterized in freshly dissociated chromaffin cells from mouse.

96 SCR-1 calcium-insensitive mutant or by using chromaffin cells from PLSCR-1(-)/(-) mice prevents outwa

97 We electrically stimulated chromaffin cells in adrenal tissue slices at the sympath

98 ime-lapse imaging of Lifeact-GFP-transfected chromaffin cells in combination with fluorescent 70 kDa

99 lar sites expressed in intact bovine adrenal chromaffin cells in culture.

100 small and different subpopulations of bovine chromaffin cells in culture.

101 -R(KT) mAb was observed in adrenal medullary chromaffin cells in murine and human tissue.

102 es and other hormones, released from adrenal chromaffin cells in response to Ca(2+) influx through vo

103 s on T-type Ca(v)3.2 calcium influx in mouse chromaffin cells in situ.

104 catecholamines and a neuropeptide from mouse chromaffin cells in vitro.

105 0 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CH

106 ociated with distinctive membrane changes of chromaffin cells including increased electron density, a

107 pression of Ca(v)3.2 channels in MPC 9/3L-AH chromaffin cells induced low-threshold secretion that co

108 ominant calcium signal regulating release in chromaffin cells is generated by the cooperative action

109 Transient stimulation of secretion in calf chromaffin cells is invariably followed by rapid endocyt

110 Exocytosis in adrenal chromaffin cells is strongly influenced by the pattern o

111 heteromeric nAChR expressed by human adrenal chromaffin cells is the alpha3beta4* subtype (asterisk i

112 In chromaffin cells isolated from a PICK1 knockout (KO) mou

113 Chromaffin cells isolated from transgenic mice that over

114 analyzed their role in LDCV exocytosis using chromaffin cells lacking individual isoforms.

115 equently, the absence of Snapin in embryonic chromaffin cells leads to a significant reduction of cal

116 These findings suggest one way in which chromaffin cells may regulate cargo release is via diffe

117 Thus, chromaffin cells may regulate release of different trans

118 e docking, neither synchronized secretion in chromaffin cells nor Ca(2+)-triggered SUV-GUV fusion was

119 also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked c

120 To specifically delete GRK2 in the chromaffin cells of the adrenal gland, we crossed PNMTCr

121 Chromaffin cells of the adrenal medulla (AM) represent t

122 Chromaffin cells of the adrenal medulla are a primary ne

123 Chromaffin cells of the adrenal medulla are innervated b

124 c neurons are severely depleted in CIPA, but chromaffin cells of the adrenal medulla are spared.

125 ium channels are expressed in neurosecretory chromaffin cells of the adrenal medulla.

126 opening of a narrow fusion pore, in adrenal chromaffin cells of wild-type and Rab3A(-/-) mice.

127 gs of quantal exocytosis from bovine adrenal chromaffin cells on the device.

128 By culturing chromaffin cells on the VAL-PVC/SiNW-FET, the conductanc

129 ak amplitude of nicotine-induced currents in chromaffin cells or in human embryonic kidney cells ecto

130 cement of exocytosis by PMA in either bovine chromaffin cells or the INS-1 insulin-secreting cell lin

131 suggest that PROG inhibits CA secretion from chromaffin cells predominantly by rapidly inhibiting nAC

132 Adrenal chromaffin cells release hormones and neuropeptides that

133 wise, inactivation of the V0 a1-I subunit in chromaffin cells resulted in a decreased frequency and p

134 comparable with those of bPAC1hop in bovine chromaffin cells resulted in acquisition by PC12-G cells

135 hat overexpression of neuronal AP-3 in mouse chromaffin cells results in a striking decrease in the n

136 rometric measurements of exocytosis in mouse chromaffin cells revealed that syb2 TMD mutations altere

137 r with time, that vesicles in bovine adrenal chromaffin cells segregate into distinct populations, ba

138 We provide data to show that chromaffin cells selectively release catecholamine under

139 l firing rates, set by the sympathetic tone, chromaffin cells selectively release catecholamines at a

140 Neuroendocrine chromaffin cells selectively secrete a variety of transm

141 Chromaffin cells stimulated with high KCl showed both sl

142 medulla gland and of cultured human adrenal chromaffin cells that demonstrated prominent expression

143 chains supported secretion in permeabilized chromaffin cells that had been allowed to rundown.

144 Src family kinases (SFKs) are abundant in chromaffin cells that reside in the adrenal medulla and

145 irectly activated GABA(A) receptors found in chromaffin cells thereby elevating [Ca(2+)](i).

146 Stimulation causes chromaffin cells to fire action potentials, leading to t

147 We used bovine chromaffin cells to investigate the effects of PROG on C

148 tentials delivered at 0.5 Hz) causes adrenal chromaffin cells to selectively release catecholamines t

149 hetic tone, basal synaptic excitation drives chromaffin cells to selectively secrete modest levels of

150 ies have demonstrated that adrenal medullary chromaffin cells transplanted into the spinal subarachno

151 ection of catecholamine release from adrenal chromaffin cells trapped in a microfluidic network.

152 ne release in individual quantal events from chromaffin cells using cell-attached patch amperometry.

153 s of exocytosis from populations of mast and chromaffin cells using chemoreceptive neuron MOS (CnuMOS

154 We investigated its role in chromaffin cells using Doc2b knock-out mice and high tem

155 Experiments on diI-stained bovine adrenal chromaffin cells using polarized TIRFM demonstrate rapid

156 strate that CIH increases the RRP in adrenal chromaffin cells via ROS-mediated activation of PKC and

157 Secretion of catestatin intermediates from chromaffin cells was accompanied by the cosecretion of c

158 ing of individual exocytotic fusion pores in chromaffin cells was imaged electrochemically with high

159 We show that bovine adrenal chromaffin cells were excited by etomidate at clinically

160 Bovine adrenal chromaffin cells were induced to express Rab3AQ81L and g

161 Bovine adrenal chromaffin cells were loaded into the microfluidic chann

162 Bovine adrenal chromaffin cells were superfused with a variety of GABA(

163 Small populations of chromaffin cells were trapped in the microfluidic device

164 y monitoring CME of single vesicles in mouse chromaffin cells with cell-attached capacitance measurem

165 Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecret

166 s and whole-cell recordings from rat adrenal chromaffin cells with parallel experiments on inactivati

167 Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocke

168 foundly impairs priming of granules in mouse chromaffin cells without altering catecholamine release

169 that is found in neurons, platelets, adrenal chromaffin cells, and a few other neurosecretory cells.

170 ed transcriptional mechanisms in transfected chromaffin cells, and concluded with observations on blo

171 n of individual secretory granules in living chromaffin cells, and related their mobilities to postfu

172 When secretion was measured from chromaffin cells, brief depolarizations triggered peptid

173 nt from mature secretory vesicles in adrenal chromaffin cells, but localizes to a compartment near th

174 ls (a rat insulinoma cell line) and cultured chromaffin cells, but not in AtT-20 cells (derived from

175 ediating SNARE-dependent exocytosis in mouse chromaffin cells, but the role of a closely related calc

176 In chromaffin cells, CHGA and KLKB1 proteins co-localized i

177 s highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 ph

178 evealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and e

179 ated exocytic function in Mecp2(-/y) adrenal chromaffin cells, indicating that the Mecp2 null mutatio

180 In chromaffin cells, inhibition of H(+)-ATPase diverted CHG

181 In chromaffin cells, IRM detects the fusion of individual g

182 on of neurotransmitters and neuropeptides in chromaffin cells, is poorly understood.

183 own to accumulate mainly in association with chromaffin cells, occasional nerve endings and macrophag

184 In cultured chromaffin cells, reducing endogenous CHGA expression by

185 est that a spontaneous syntilla, at least in chromaffin cells, releases Ca2+ into a cytosolic microdo

186 In summary, PAI-1 is expressed in chromaffin cells, sorted into the regulated pathway of s

187 gnals was severalfold faster than in adrenal chromaffin cells, suggesting profound differences in the

188 In bovine chromaffin cells, syntaxin and SNAP-25 colocalize in def

189 In cultured chromaffin cells, the total cytosolic catechol concentra

190 , high-affinity nAChRs expressed in cultured chromaffin cells, they do not appear to be involved in f

191 In Cplx 2-null adrenal chromaffin cells, we also find decreased and desynchroni

192 In bovine adrenal chromaffin cells, we found Rac1, but not Cdc42, to be ra

193 ophysiological measurements in mouse adrenal chromaffin cells, we show that PI(4,5)P2 uncaging potent

194 In individual chromaffin cells, we tracked conformational changes in S

195 red how alpha-syn overexpression in PC12 and chromaffin cells, which exhibit low endogenous alpha-syn

196 s to hypoxia by the carotid body and adrenal chromaffin cells, which regulate cardio-respiratory func

197 wo sequential priming steps in mouse adrenal chromaffin cells.

198 holamines released from small populations of chromaffin cells.

199 echolamines, exclusively, from fetal adrenal chromaffin cells.

200 iated fusion pore expansion in mouse adrenal chromaffin cells.

201 ippocampus, dorsal root ganglia, and adrenal chromaffin cells.

202 augmented T-type Ca2+ current in IH-treated chromaffin cells.

203 correlation, confirming similar findings in chromaffin cells.

204 stimulated catecholamine release in cultured chromaffin cells.

205 ventional active zones and in neuroendocrine chromaffin cells.

206 spatial distribution of calcium channels in chromaffin cells.

207 d released by exocytosis in PC12 and primary chromaffin cells.

208 adapted from a model for fast exocytosis in chromaffin cells.

209 typical transmitter storage and release from chromaffin cells.

210 nd neuronal cells, including sympathoadrenal chromaffin cells.

211 on with a D1-like receptor on bovine adrenal chromaffin cells.

212 omosyn-syntaxin 1A complexes in live adrenal chromaffin cells.

213 type/reporter plasmids were transfected into chromaffin cells.

214 receptors on exocytosis from bovine adrenal chromaffin cells.

215 se frequency of catecholamine in dissociated chromaffin cells.

216 ant (>90%) mode of secretion in calf adrenal chromaffin cells.

217 e nerve and form postsynaptic neuroendocrine chromaffin cells.

218 le priming and secretory amplitude in living chromaffin cells.

219 calcium-triggered catecholamine release from chromaffin cells.

220 Ca) was produced by P2Y receptors in adrenal chromaffin cells.

221 motions related to the secretory response in chromaffin cells.

222 e in the Ca2+-cooperativity of exocytosis in chromaffin cells.

223 ficant reduction in DCG formation in adrenal chromaffin cells.

224 human embryonic kidney HEK293-S3 and adrenal chromaffin cells.

225 is a rare, but clinically important tumor of chromaffin cells.

226 18-1/syntaxin1A interaction in HEK293-S3 and chromaffin cells.

227 ive anion equilibrium potential, depolarizes chromaffin cells.

228 coupling after this peptidergic stimulus to chromaffin cells.

229 1-L61) were transiently expressed in adrenal chromaffin cells.

230 secretory response triggered by the toxin in chromaffin cells.

231 athetic neurons appears to represent adrenal chromaffin cells.

232 ion is severely inhibited in Ophn1 knock-out chromaffin cells.

233 hn1 knock-out mice and OPHN1-silenced bovine chromaffin cells.

234 ipid microdomains at the exocytotic sites in chromaffin cells.

235 he nAChR subtypes expressed by human adrenal chromaffin cells.

236 and is also essential for vesicle docking in chromaffin cells.

237 med during catecholamine exocytosis in mouse chromaffin cells.

238 nk exocytosis to compensatory endocytosis in chromaffin cells.

239 duced bulk endocytosis also occurs in bovine chromaffin cells.

240 tivator (tPA) (over many seconds) in adrenal chromaffin cells.

241 large, dense core vesicles (LDCVs) in mouse chromaffin cells.

242 nergic stimulated catecholamine release from chromaffin cells.

243 mice, we find that NPY is synthesized by all chromaffin cells.

244 es in a millisecond time resolution in mouse chromaffin cells.

245 successfully from multiple individual living chromaffin cells.

246 AP-25 x synaptotagmin-1 interaction in mouse chromaffin cells.

247 uptake at the synaptic terminals and adrenal chromaffin cells.

248 iNW-FET) to detect the K(+)-efflux from live chromaffin cells.

249 Two Syt isoforms are expressed in chromaffin cells: Syt-1 and Syt-7.

250 CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered fo

251 n of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels

252 icate an essential role of CgA in regulating chromaffin DCG biogenesis and catecholamine storage in v

253 Moreover, examination of chromaffin granule abundance in PC12 cells exposed to ba

254 ation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and t

255 a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholami

256 lation of the CHGA gene in the mouse reduced chromaffin granule cotransmitter concentrations by appro

257 stent with the cleavage specificities of the chromaffin granule cysteine protease "PTP" that particip

258 reduction kinetics, similar to those of the chromaffin granule Cyt b(561).

259 le myosin II and cortical actin filaments in chromaffin granule exocytosis were studied by confocal f

260 al and non-neuronal cells, and into resealed chromaffin granule ghosts efficiently through passive di

261 Structure-activity studies with bovine chromaffin granule ghosts show that 3'-hydroxy-MPP(+) is

262 ibition of [3H]dopamine uptake into purified chromaffin granule ghosts showed IC50 values of approxim

263 ation of dopamine (DA) was studied in bovine chromaffin granule ghosts.

264 ) values in the microM range, for the bovine chromaffin granule membrane monoamine transporter(s) (bV

265 have been evaluated for inhibition of bovine chromaffin granule membrane V-ATPase.

266 Analysis of [125I]TBZ-AIPP-labeled chromaffin granule membranes by SDS-PAGE and autoradiogr

267 Incubation of [125I]TBZ-AIPP-photolabeled chromaffin granule membranes in the presence of the glyc

268 olar membranes of Neurospora crassa and from chromaffin granule membranes of Bos taurus.

269 synthesized and used to photoaffinity label chromaffin granule membranes.

270 phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c)

271 Chromaffin granule ultrastructure revealed a approximate

272 associated with the Manduca sexta and bovine chromaffin granule V-ATPase.

273 ar V-ATPase and at 0.4 to >10 microM for the chromaffin granule V-ATPase.

274 ibits the N. crassa V-ATPase better than the chromaffin granule V-ATPase.

275 reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoamine transporter (VMAT

276 (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholami

277 Furthermore, a size mismatch between chromaffin granules ( approximately 300-nm diameter) and

278 transports electrons across the membrane of chromaffin granules (CG) present in the adrenal medulla,

279 Using chromaffin granules and liposomes we now show that alpha

280 se model led to decreased size and number of chromaffin granules as well as hypertension in these ani

281 nophil granules match the residence times of chromaffin granules at the plasma membrane in intact cel

282 myosin II facilitate release from individual chromaffin granules by accelerating dissociation of cate

283 in L is the responsible cysteine protease of chromaffin granules for converting proenkephalin to the

284 t a full-length CgA/EAP chimera is sorted to chromaffin granules for exocytosis.

285 Our results show that liposomes and chromaffin granules fuse with GUVs containing activated

286 image analysis to determine the position of chromaffin granules immediately adjacent to the plasma m

287 Neuroendocrine chromaffin granules of adrenal medulla represent regulat

288 is concluded that a significant fraction of chromaffin granules re-seal after exocytosis, and retain

289 After exocytosis, chromaffin granules release essentially all their catech

290 A decrease in the buoyant density of chromaffin granules was observed after downregulation of

291 s catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DC

292 be biotinylated at the C-terminus in intact chromaffin granules, indicating that it is a transmembra

293 well within the physiological range found in chromaffin granules, we conclude that catecholaminergic

294 cytosis of neurosecretory vesicles including chromaffin granules.

295 cedure is to perform studies in a continuous chromaffin (pheochromocytoma) cell line, such as PC12, a

296 d CgB proteolytic fragments that function in chromaffin secretory vesicles for release of bioactive m

297 dent maintenance of pH gradients in isolated chromaffin vesicles and that the WT protein was signific

298 Chromaffin vesicles contain very high concentration of C

299 e electrochemical response to single adrenal chromaffin vesicles filled with catecholamine hormones a

300 h of the catecholamine compared with adrenal chromaffin vesicles.