ライフサイエンスコーパス: chromaffin granule

1 in in secretory vesicles of adrenal medulla (chromaffin granules).

2 retory vesicles of adrenal medulla (known as chromaffin granules).

3 of neuropeptide-containing chromaffin cells (chromaffin granules).

4 cytosis of neurosecretory vesicles including chromaffin granules.

5 ells without any detectable association with chromaffin granules.

6 statin radioimmunoassay of size-fractionated chromaffin granules.

7 n 1 of 68-70 kDa was present within isolated chromaffin granules.

8 tivated by endogenous glutathione present in chromaffin granules.

9 rovided by endogenous reduced glutathione in chromaffin granules.

10 e also detected in several systems including chromaffin granules.

11 Moreover, examination of chromaffin granule abundance in PC12 cells exposed to ba

12 7-fold more sensitive than the conventional chromaffin granule aggregation assay in terms of thresho

13 Sorcin is able to inhibit synexin-mediated chromaffin granule aggregation in a manner saturable wit

14 Using chromaffin granules and liposomes we now show that alpha

15 (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholami

16 Furthermore, a size mismatch between chromaffin granules ( approximately 300-nm diameter) and

17 se model led to decreased size and number of chromaffin granules as well as hypertension in these ani

18 nophil granules match the residence times of chromaffin granules at the plasma membrane in intact cel

19 ation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and t

20 a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholami

21 myosin II facilitate release from individual chromaffin granules by accelerating dissociation of cate

22 transports electrons across the membrane of chromaffin granules (CG) present in the adrenal medulla,

23 tein (APP) in the lumen of adrenal medullary chromaffin granules (CG).

24 Stimulated cosecretion of endopin 1 with chromaffin granule components, [Met]enkephalin and a cys

25 co-aggregate efficiently with pituitary and chromaffin granule content proteins at concentrations we

26 f calcium is required for the aggregation of chromaffin granule content.

27 lation of the CHGA gene in the mouse reduced chromaffin granule cotransmitter concentrations by appro

28 stent with the cleavage specificities of the chromaffin granule cysteine protease "PTP" that particip

29 reduction kinetics, similar to those of the chromaffin granule Cyt b(561).

30 le myosin II and cortical actin filaments in chromaffin granule exocytosis were studied by confocal f

31 in L is the responsible cysteine protease of chromaffin granules for converting proenkephalin to the

32 t a full-length CgA/EAP chimera is sorted to chromaffin granules for exocytosis.

33 was present in isolated secretory vesicles (chromaffin granules) from chromaffin cells as a glycopro

34 Our results show that liposomes and chromaffin granules fuse with GUVs containing activated

35 al and non-neuronal cells, and into resealed chromaffin granule ghosts efficiently through passive di

36 While the transport of catecholamines into chromaffin granule ghosts has been extensively character

37 Structure-activity studies with bovine chromaffin granule ghosts show that 3'-hydroxy-MPP(+) is

38 ibition of [3H]dopamine uptake into purified chromaffin granule ghosts showed IC50 values of approxim

39 ation of dopamine (DA) was studied in bovine chromaffin granule ghosts.

40 n addition, we determined that the V-pump of chromaffin granules has only the SFDalpha isoform in its

41 s catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DC

42 image analysis to determine the position of chromaffin granules immediately adjacent to the plasma m

43 be biotinylated at the C-terminus in intact chromaffin granules, indicating that it is a transmembra

44 ectrochemical proton gradient created by the chromaffin granule membrane H+-ATPase, and that the accu

45 ) values in the microM range, for the bovine chromaffin granule membrane monoamine transporter(s) (bV

46 phosphatidylinositol 4-kinase is an integral chromaffin granule membrane protein, PtdIns-4,5-P(2) imp

47 have been evaluated for inhibition of bovine chromaffin granule membrane V-ATPase.

48 2) important in exocytosis may reside on the chromaffin granule membrane.

49 Analysis of [125I]TBZ-AIPP-labeled chromaffin granule membranes by SDS-PAGE and autoradiogr

50 in PC12 cells and in a fraction enriched in chromaffin granule membranes from the adrenal medulla.

51 lex with sorcin and recruits this protein to chromaffin granule membranes in a Ca2+-dependent manner.

52 Incubation of [125I]TBZ-AIPP-photolabeled chromaffin granule membranes in the presence of the glyc

53 olar membranes of Neurospora crassa and from chromaffin granule membranes of Bos taurus.

54 ipped clathrin-coated vacuolars and purified chromaffin granule membranes were treated with KI in the

55 synthesized and used to photoaffinity label chromaffin granule membranes.

56 Neuroendocrine chromaffin granules of adrenal medulla represent regulat

57 Moreover, endopin 1 inhibited the chromaffin granule prohormone thiol protease (involved i

58 is concluded that a significant fraction of chromaffin granules re-seal after exocytosis, and retain

59 After exocytosis, chromaffin granules release essentially all their catech

60 phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c)

61 c vesicles, pancreatic zymogen granules, and chromaffin granules, suggests GAIP's possible involvemen

62 catalytic cysteine protease complex, PTP, in chromaffin granules that may be involved in the proteoly

63 In chromaffin granules, the major form of catestatin is cle

64 Chromaffin granule ultrastructure revealed a approximate

65 associated with the Manduca sexta and bovine chromaffin granule V-ATPase.

66 ar V-ATPase and at 0.4 to >10 microM for the chromaffin granule V-ATPase.

67 ibits the N. crassa V-ATPase better than the chromaffin granule V-ATPase.

68 that secretion of solAPPcyt was mediated by chromaffin granule vesicles.

69 reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoamine transporter (VMAT

70 A decrease in the buoyant density of chromaffin granules was observed after downregulation of

71 well within the physiological range found in chromaffin granules, we conclude that catecholaminergic

72 s with V pump from bovine brain, kidney, and chromaffin granule, whereas an anti-G2 antibody reacts o

73 n catestatin was cleaved in pheochromocytoma chromaffin granules, with the major form, human chromogr